Detailed information for compound 1546626

Basic information

Technical information
  • TDR Targets ID: 1546626
  • Name: ZINC00125179
  • MW: 290.203 | Formula: C8H8BrN3S2
  • H donors: 0 H acceptors: 2 LogP: 2.67 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(nnc1SC)c1ccc(s1)Br
  • InChi: 1S/C8H8BrN3S2/c1-12-7(10-11-8(12)13-2)5-3-4-6(9)14-5/h3-4H,1-2H3
  • InChiKey: VZQIMUIKXQUWKC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • Maybridge3_003841
  • IDI1_015228
  • MLS000859237
  • SMR000459416
  • 3-(5-bromo-2-thienyl)-4-methyl-5-(methylsulfanyl)-4H-1,2,4-triazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0132 0.0088
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.2794 0.4054
Echinococcus granulosus importin subunit beta 1 0.0032 0.0629 0.0629
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.122 0.1402
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.2794 0.3541
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.1267 0.4264
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0134 0.3704 0.3704
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.2839 0.2839
Onchocerca volvulus 0.0034 0.0698 0.0884
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.004 0.0861 0.0861
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0629 0.0629
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.1267 0.4264
Schistosoma mansoni importin beta-1 0.0032 0.0629 0.0629
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0891 0.0891
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0891 0.0978
Brugia malayi TAR-binding protein 0.0076 0.1975 0.2866
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0284 0.0284
Loa Loa (eye worm) oxidoreductase 0.0016 0.0132 0.0132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0891 0.0891
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0923 0.2971
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0098 0.0098
Trypanosoma brucei protein kinase, putative 0.0059 0.1441 0.4917
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.1267 0.161
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1975 0.2866
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0168 0.4744 0.4744
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0795 0.0977
Onchocerca volvulus 0.0041 0.0891 0.1129
Echinococcus granulosus lamin 0.003 0.0566 0.0566
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0566 0.0566
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0134 0.3704 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.003 0.0566 0.0566
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0134 0.3704 1
Schistosoma mansoni bromodomain containing protein 0.0076 0.1973 0.1973
Loa Loa (eye worm) hypothetical protein 0.0052 0.1219 0.1219
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.1267 0.161
Brugia malayi Bromodomain containing protein 0.0091 0.2401 0.3484
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0508 0.1413
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1441 0.1687
Brugia malayi DnaJ domain containing protein 0.0141 0.3918 0.5686
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0132 0.0192
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.2794 0.2794
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0041 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0795 0.0977
Brugia malayi AMP-binding enzyme family protein 0.0053 0.1267 0.1839
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0923 0.1019
Toxoplasma gondii preprocathepsin c precursor, putative 0.0134 0.3704 1
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0891 0.2125
Schistosoma mansoni hypothetical protein 0.0053 0.1269 0.1269
Echinococcus multilocularis dnaJ subfamily C 6 0.0141 0.3918 0.3918
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.1321 0.1321
Echinococcus multilocularis lamin 0.003 0.0566 0.0566
Brugia malayi beta-lactamase family protein 0.0041 0.0891 0.1293
Loa Loa (eye worm) hypothetical protein 0.0085 0.2244 0.2244
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0132 0.0192
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0414 0.0414
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0698 0.1583
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0132 0.0088
Onchocerca volvulus 0.0016 0.0132 0.0168
Loa Loa (eye worm) hypothetical protein 0.0046 0.1062 0.1062
Mycobacterium tuberculosis Conserved protein 0.0041 0.0891 0.1106
Entamoeba histolytica hypothetical protein 0.0026 0.0446 0.1178
Leishmania major importin beta-1 subunit, putative 0.0026 0.0446 0.1178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.2839 0.2839
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0132 0.0088
Echinococcus multilocularis muscleblind protein 0.0174 0.4936 0.4936
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.1267 1
Schistosoma mansoni hypothetical protein 0.0018 0.0219 0.0219
Onchocerca volvulus 0.0016 0.0132 0.0168
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.1267 1
Onchocerca volvulus 0.0272 0.7889 1
Toxoplasma gondii ABC1 family protein 0.0041 0.0891 0.2125
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0132 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0081
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0484 0.0484
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.7522 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0115 0.3135 0.3135
Schistosoma mansoni intermediate filament proteins 0.003 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0049 0.1149 0.1149
Echinococcus multilocularis GPCR, family 2 0.0053 0.1269 0.1269
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0373 0.0906
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0132
Giardia lamblia Kinase, PLK 0.0104 0.2794 0.7267
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0016 0.0132 0.0088
Schistosoma mansoni ran 0.0024 0.0373 0.0373
Schistosoma mansoni inositol monophosphatase 0.0042 0.0923 0.0923
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.2794 0.2794
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.1441 0.1441
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.1267 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.2794 1
Schistosoma mansoni zinc finger protein 0.0018 0.0219 0.0219
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0973 0.0973
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.1267 1
Echinococcus granulosus zinc finger protein 0.0024 0.0376 0.0376
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.1441 0.4917
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0891 0.1106
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0134 0.3704 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0132
Brugia malayi Bromodomain containing protein 0.0046 0.106 0.1538
Loa Loa (eye worm) hypothetical protein 0.0029 0.055 0.055
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0923 0.6967
Loa Loa (eye worm) inositol-1 0.0042 0.0923 0.0923
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0923 0.0923
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0923 0.2971
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0861 0.204
Toxoplasma gondii cathepsin CPC1 0.0134 0.3704 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.0132 0.0088
Brugia malayi Importin beta-1 subunit 0.0032 0.0629 0.0913
Plasmodium vivax SET domain protein, putative 0.0034 0.0698 0.1583
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.1269 0.1269
Trichomonas vaginalis esterase, putative 0.0041 0.0891 0.0978
Brugia malayi hypothetical protein 0.0018 0.0208 0.0302
Leishmania major hypothetical protein, conserved 0.0018 0.0219 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1975 0.1975
Trichomonas vaginalis set domain proteins, putative 0.0272 0.7889 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0891 0.1106
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0833 0.1962
Mycobacterium tuberculosis Conserved protein 0.0041 0.0891 0.1106
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0373 0.0906
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0446 0.0404
Loa Loa (eye worm) hypothetical protein 0.0174 0.4936 0.4936
Brugia malayi AMP-binding enzyme family protein 0.0053 0.1267 0.1839
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0508 0.1053
Loa Loa (eye worm) hypothetical protein 0.0041 0.0891 0.0891
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0891 0.6686
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0923 0.0923
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0508 0.1053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0132 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0861 0.6421
Loa Loa (eye worm) hypothetical protein 0.004 0.0861 0.0861
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.1267 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0373 0.0675
Schistosoma mansoni hypothetical protein 0.0053 0.1269 0.1269
Entamoeba histolytica Ran family GTPase 0.0024 0.0373 0.0906
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0659 0.0659
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0795 0.0977
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0132 0.0132
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0923 0.2971
Loa Loa (eye worm) RNA binding protein 0.0076 0.1975 0.1975
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0891 0.0978
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.1321 0.1321
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.0833 0.0833
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.0373
Loa Loa (eye worm) beta-lactamase 0.0041 0.0891 0.0891
Loa Loa (eye worm) hypothetical protein 0.0032 0.0629 0.0629
Brugia malayi Inositol-1 0.0042 0.0923 0.1339
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.0132 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.3135 0.455
Echinococcus granulosus muscleblind protein 0.0174 0.4936 0.4936
Plasmodium falciparum importin beta, putative 0.0032 0.0629 0.1391
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.1267 0.4264
Echinococcus multilocularis musashi 0.003 0.0566 0.0566
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1975 0.1975
Onchocerca volvulus 0.0016 0.0132 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1975 0.1975
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0446 0.1178
Loa Loa (eye worm) hypothetical protein 0.0053 0.1267 0.1267
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0861 0.1065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.2839 0.2839
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1441 0.1687
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1975 0.1975
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1842 0.1842
Trichomonas vaginalis protein kinase inhibitor, putative 0.0141 0.3918 0.488
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.1267 0.4264
Brugia malayi hypothetical protein 0.0028 0.0508 0.0738
Leishmania major hypothetical protein, conserved 0.0028 0.0508 0.1413
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0833 0.1962
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.1441 0.4917
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0484 0.0484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.2839 0.2839
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1842 0.1842
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0891 0.1106
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.0132 0.0088
Schistosoma mansoni ran 0.0024 0.0373 0.0373
Schistosoma mansoni kinase 0.0053 0.1261 0.1261
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0484 0.0484
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2794 1
Schistosoma mansoni hypothetical protein 0.0053 0.1269 0.1269
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0373 0.0675
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0791 0.5801
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0923 0.2971
Leishmania major hypothetical protein, conserved 0.0039 0.0833 0.2633
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.1267 0.4264
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0174 0.4936 0.4936
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.4744 0.6884
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.1441 0.1441
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.1441 0.4917
Mycobacterium ulcerans beta-lactamase 0.0041 0.0891 0.6686
Mycobacterium ulcerans lipase LipD 0.0041 0.0891 0.6686
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1441 0.1687
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0923 0.2971
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1975 0.1975
Loa Loa (eye worm) hypothetical protein 0.0041 0.0891 0.0891
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0566 0.0822
Leishmania major GTP-binding protein, putative 0.0024 0.0373 0.0906
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.2839 0.4121
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0833 0.2633
Loa Loa (eye worm) hypothetical protein 0.0028 0.0508 0.0508
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0891 0.1106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0891 0.0891
Brugia malayi beta-lactamase 0.0041 0.0891 0.1293
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.1269 0.1269
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0284 0.0284
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.1267 1
Schistosoma mansoni hypothetical protein 0.0013 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0132 0.0192
Schistosoma mansoni hypothetical protein 0.0141 0.3918 0.3918
Loa Loa (eye worm) hypothetical protein 0.0055 0.1321 0.1321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.2839 0.2839
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0891 0.0978
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.0132 0.0088
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.0833 0.0833
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0923 0.1019
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0833 0.2633
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0891 0.0891
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.1267 1
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0833 0.1962
Echinococcus granulosus tar DNA binding protein 0.0076 0.1975 0.1975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.2839 0.2839
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1975 0.1975
Brugia malayi Latrophilin receptor protein 2 0.0053 0.1269 0.1841
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0891 0.0978
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0795 0.0977
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0891 0.1106
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.2794 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0132 0.0132
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0923 0.5
Echinococcus granulosus dnaJ subfamily C 6 0.0141 0.3918 0.3918
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0446 0.0404
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.1441 0.3205
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.122 0.1402
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0833 0.2633
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0306 0.0306
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0891 0.2851
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0833 0.1962
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0132 0.0192
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0891 0.0891
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.1269 0.1269
Loa Loa (eye worm) hypothetical protein 0.0041 0.0891 0.0891
Onchocerca volvulus 0.003 0.0566 0.0718
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.1321 0.1321
Brugia malayi Augmenter of liver regeneration 0.0039 0.0833 0.1209
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0891 0.2851
Trichomonas vaginalis ran, putative 0.0024 0.0373 0.0311
Echinococcus multilocularis lamin dm0 0.003 0.0566 0.0566
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0629 0.1391
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0629 0.1867
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0891 0.6686
Trypanosoma brucei ISWI complex protein 0.0018 0.0219 0.0328
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.1441 0.3664
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.2839 0.2839
Brugia malayi Pre-SET motif family protein 0.0239 0.689 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0376 0.0376
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0134 0.3704 1
Schistosoma mansoni hypothetical protein 0.0053 0.1269 0.1269
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0508 0.1053
Leishmania major hypothetical protein, conserved 0.0041 0.0891 0.2851
Loa Loa (eye worm) hypothetical protein 0.0053 0.1267 0.1267
Mycobacterium tuberculosis Conserved protein 0.0041 0.0891 0.1106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.1267 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1975 0.1975
Schistosoma mansoni inositol monophosphatase 0.0042 0.0923 0.0923
Onchocerca volvulus 0.0041 0.0891 0.1129
Schistosoma mansoni hypothetical protein 0.0342 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0891 0.1293
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0146 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.2794 0.2794
Loa Loa (eye worm) DnaJ domain-containing protein 0.0141 0.3918 0.3918
Loa Loa (eye worm) hypothetical protein 0.0053 0.1267 0.1267
Brugia malayi Pre-SET motif family protein 0.0034 0.0698 0.1012
Brugia malayi MAP kinase sur-1 0.0059 0.1441 0.2091
Echinococcus granulosus intermediate filament protein 0.003 0.0566 0.0566
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.1269 0.1269
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0791 0.0971
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0891 0.6686
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0373 0.0373
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0098 0.0098
Echinococcus granulosus GPCR family 2 0.0053 0.1269 0.1269
Loa Loa (eye worm) hypothetical protein 0.004 0.0861 0.0861
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0698 0.0698
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0041 0.0041
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0833 0.2633
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.1267 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.1269 0.1269
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.1441 0.1441
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.1269 0.1841
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0053 0.1269 0.1269
Onchocerca volvulus 0.0041 0.0891 0.1129
Brugia malayi RNA, U transporter 1 0.0091 0.2415 0.3504
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.0675
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0284 0.0284
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.2839 0.2839
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0134 0.3704 1
Echinococcus multilocularis muscleblind protein 1 0.0174 0.4936 0.4936
Loa Loa (eye worm) hypothetical protein 0.0041 0.0891 0.0891
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0132 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.1441 0.1687
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0284 0.0284
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.2794 0.2794
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.1441 0.4917
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0891 0.1106
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.0542
Onchocerca volvulus 0.0016 0.0132 0.0168
Mycobacterium leprae Probable lipase LipE 0.0041 0.0891 0.6686
Schistosoma mansoni lamin 0.003 0.0566 0.0566
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.1441 0.1441
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0891 0.0891
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Loa Loa (eye worm) hypothetical protein 0.0014 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0115 0.3135 0.3135
Brugia malayi PHD-finger family protein 0.003 0.0571 0.0828
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0629 0.1867
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0446 0.0404
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0861 0.5
Trypanosoma cruzi ISWI complex protein 0.0018 0.0219 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0134 0.3704 0.4604
Echinococcus multilocularis snurportin 1 0.0342 1 1
Brugia malayi beta-lactamase family protein 0.0041 0.0891 0.1293
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0132 0.0192
Loa Loa (eye worm) intermediate filament protein 0.003 0.0566 0.0566
Echinococcus granulosus lamin dm0 0.003 0.0566 0.0566
Onchocerca volvulus 0.003 0.0566 0.0718
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.1321 0.1321
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.4744 0.4744
Onchocerca volvulus 0.0053 0.1267 0.1606
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0891 0.2851
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Trypanosoma brucei polo-like protein kinase 0.0104 0.2794 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0629 0.1391
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0132 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0053 0.1267 0.1839
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.4744 0.6884
Schistosoma mansoni hypothetical protein 0.0025 0.0414 0.0414
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.1441 0.4917
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0698 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.1267 0.4264
Mycobacterium ulcerans hypothetical protein 0.0053 0.1267 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.1441 0.4917
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.2794 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0373 0.0906
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0923 0.1019
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0508 0.1413
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.0132 0.0088
Trypanosoma cruzi ISWI complex protein 0.0018 0.0219 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0698 0.0698
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0508 0.1413
Brugia malayi RNA binding protein 0.0076 0.1975 0.2866
Brugia malayi intermediate filament protein 0.003 0.0566 0.0822
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0891 0.0978
Mycobacterium ulcerans hypothetical protein 0.0041 0.0891 0.6686
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1975 0.1975
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.2794 0.3431
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0132 0.0132
Schistosoma mansoni zinc finger protein 0.0024 0.0376 0.0376
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.0132 0.0132
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.689 0.689
Loa Loa (eye worm) hypothetical protein 0.004 0.0861 0.0861
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.1441 0.4917
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0508 0.1053
Brugia malayi Muscleblind-like protein 0.0174 0.4936 0.7164
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0861 0.204
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0923 0.2214
Schistosoma mansoni lamin 0.003 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0041 0.0891 0.0891
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0891 0.1106
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0146 0.0212

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1694 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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