Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium berghei | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, putative | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0113 | 0.6542 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1665 | 0.1665 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0123 | 0.7148 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0303 | 0.0113 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.1562 | 0.2018 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0113 | 0.6542 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0113 | 0.6542 | 1 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0036 | 0.1928 | 0.2555 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.001 | 0.0344 | 0.0156 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.1665 | 0.1503 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0123 | 0.7148 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.6542 | 1 |
Entamoeba histolytica | glucosamine-6-phosphate isomerase, putative | 0.001 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0039 | 0.2099 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0074 | 0.4182 | 0.2502 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.1562 | 0.2027 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0123 | 0.7148 | 1 |
Schistosoma mansoni | glucosamine-6-phosphate isomerase | 0.001 | 0.0344 | 0.0344 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0123 | 0.7148 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0123 | 0.7148 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.6542 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.6542 | 1 |
Onchocerca volvulus | 0.003 | 0.1562 | 0.5 | |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0113 | 0.6542 | 0.6475 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.001 | 0.0344 | 0.0344 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.001 | 0.0344 | 0.5 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0074 | 0.4182 | 0.6192 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0191 | 0.0191 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0123 | 0.7148 | 1 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.001 | 0.0344 | 0.0156 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.6542 | 0.6542 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.001 | 0.0344 | 0.0067 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0113 | 0.6542 | 0.6475 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0064 | 0.3605 | 0.3605 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0037 | 0.1993 | 0.266 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.001 | 0.0344 | 0.0275 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.1665 | 0.1503 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1562 | 0.1562 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.001 | 0.0344 | 0.0344 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0113 | 0.6542 | 1 |
Brugia malayi | 6-phosphogluconolactonase family protein | 0.001 | 0.0344 | 0.0078 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0123 | 0.7148 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0113 | 0.6542 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0303 | 0.0113 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1665 | 0.1665 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 17.6 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] | ChEMBL. | No reference |
IC50 (functional) | > 80 uM | PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] | ChEMBL. | No reference |
IC50 (functional) | > 80 uM | PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] | ChEMBL. | No reference |
IC50 (functional) | > 80 uM | PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.