Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0385 | 0.6698 | 0.8363 |
Echinococcus granulosus | protein kinase C gamma type | 0.0464 | 0.8397 | 0.8397 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.8009 | 1 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0437 | 0.7826 | 0.9772 |
Brugia malayi | Protein kinase c protein 2 | 0.0459 | 0.8301 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0081 | 0.0133 | 0.0166 |
Echinococcus multilocularis | protein kinase c iota type | 0.0155 | 0.1736 | 0.1736 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0133 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0081 | 0.0133 | 0.016 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0081 | 0.0133 | 0.0133 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0081 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.6406 | 0.7998 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0076 | 0.0037 | 0.0037 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Brugia malayi | protein kinase C3,putative | 0.0076 | 0.0037 | 0.0045 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0081 | 0.0133 | 0.0166 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0081 | 0.0133 | 0.0133 |
Echinococcus granulosus | protein kinase c iota type | 0.0155 | 0.1736 | 0.1736 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0538 | 1 | 1 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0076 | 0.0037 | 0.0037 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0133 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0081 | 0.0133 | 0.016 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0167 | 0.1991 | 0.2486 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0133 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0167 | 0.1991 | 0.1991 |
Schistosoma mansoni | atypical protein kinase C | 0.0155 | 0.1736 | 0.1736 |
Brugia malayi | Protein kinase domain containing protein | 0.0081 | 0.0133 | 0.016 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0076 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0076 | 0.0037 | 0.0047 |
Echinococcus granulosus | unc 13 munc13 | 0.0086 | 0.0255 | 0.0255 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0086 | 0.0255 | 0.0255 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0081 | 0.0133 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0081 | 0.0133 | 0.016 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0081 | 0.0133 | 0.0133 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0538 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0133 | 0.0133 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0081 | 0.0133 | 0.0166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0464 | 0.8397 | 0.8397 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0076 | 0.0037 | 0.0047 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0081 | 0.0133 | 0.0133 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Toxoplasma gondii | AGC kinase | 0.0081 | 0.0133 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0081 | 0.0133 | 0.0133 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0081 | 0.0133 | 0.0133 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0076 | 0.0037 | 0.0045 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0538 | 1 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0076 | 0.0037 | 0.0037 |
Schistosoma mansoni | unc-13 (munc13) | 0.0086 | 0.0255 | 0.0255 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0371 | 0.6406 | 0.6406 |
Brugia malayi | RasGEF domain containing protein | 0.0363 | 0.6215 | 0.7486 |
Schistosoma mansoni | protein kinase C | 0.0086 | 0.0255 | 0.0255 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0081 | 0.0133 | 0.0133 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0371 | 0.6406 | 0.6406 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0167 | 0.1991 | 0.1991 |
Brugia malayi | Protein kinase domain containing protein | 0.0076 | 0.0037 | 0.0045 |
Entamoeba histolytica | protein kinase, putative | 0.0081 | 0.0133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0255 | 0.0318 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0133 | 0.0133 |
Brugia malayi | Protein kinase domain containing protein | 0.0081 | 0.0133 | 0.016 |
Brugia malayi | protein kinase C II. | 0.0167 | 0.1991 | 0.2399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0076 | 0.0037 | 0.0037 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0086 | 0.0255 | 0.0255 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0081 | 0.0133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0133 | 0.0166 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0081 | 0.0133 | 0.0166 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0081 | 0.0133 | 0.0133 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.1991 | 0.1991 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0081 | 0.0133 | 0.0133 |
Brugia malayi | C1-like domain containing protein | 0.0076 | 0.0037 | 0.0045 |
Onchocerca volvulus | 0.0086 | 0.0255 | 1 | |
Schistosoma mansoni | serine/threonine kinase | 0.0081 | 0.0133 | 0.0133 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0086 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0081 | 0.0133 | 0.0166 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0081 | 0.0133 | 0.0166 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0371 | 0.6406 | 0.6406 |
Schistosoma mansoni | unc-13 (munc13) | 0.0086 | 0.0255 | 0.0255 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0081 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0081 | 0.0133 | 0.0166 |
Echinococcus granulosus | NDR protein kinase | 0.0081 | 0.0133 | 0.0133 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.