Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | flavodoxin family protein | 0.025 | 0.3471 | 0.3471 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0122 | 0.1408 | 0.1408 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.025 | 0.3471 | 0.2514 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0652 | 1 | 1 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0074 | 0.0628 | 0.0628 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0074 | 0.0628 | 0.5 |
Loa Loa (eye worm) | diaphorase | 0.0074 | 0.0628 | 0.0628 |
Echinococcus granulosus | methionine synthase reductase | 0.0403 | 0.5955 | 0.5955 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.025 | 0.3471 | 0.3033 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0652 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0652 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0652 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0652 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0652 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0324 | 0.4673 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0652 | 1 | 1 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0074 | 0.0628 | 0.0628 |
Onchocerca volvulus | 0.0074 | 0.0628 | 0.5 | |
Plasmodium vivax | flavodoxin domain containing protein | 0.0578 | 0.8798 | 0.8717 |
Brugia malayi | FAD binding domain containing protein | 0.0403 | 0.5955 | 0.5955 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0074 | 0.0628 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0324 | 0.4673 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.025 | 0.3471 | 0.2514 |
Entamoeba histolytica | type A flavoprotein, putative | 0.025 | 0.3471 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0652 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0652 | 1 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0074 | 0.0628 | 0.0628 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0122 | 0.1408 | 0.1408 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0652 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0074 | 0.0628 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0652 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0652 | 1 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0074 | 0.0628 | 0.0628 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0403 | 0.5955 | 0.5955 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.025 | 0.3471 | 0.2514 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0122 | 0.1408 | 0.1408 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.025 | 0.3471 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0652 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0403 | 0.5955 | 0.5955 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0652 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0652 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0578 | 0.8798 | 0.8622 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0074 | 0.0628 | 0.0628 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0652 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0652 | 1 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0074 | 0.0628 | 0.0628 |
Schistosoma mansoni | cytochrome B5 | 0.0074 | 0.0628 | 0.0628 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0122 | 0.1408 | 0.1408 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.025 | 0.3471 | 0.2514 |
Plasmodium vivax | hypothetical protein, conserved | 0.025 | 0.3471 | 0.3033 |
Leishmania major | p450 reductase, putative | 0.0652 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.025 | 0.3471 | 0.3471 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.025 | 0.3471 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.025 | 0.3471 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.025 | 0.3471 | 0.3033 |
Brugia malayi | diaphorase | 0.0074 | 0.0628 | 0.0628 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0652 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0578 | 0.8798 | 1 |
Treponema pallidum | flavodoxin | 0.025 | 0.3471 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0329 | 0.4753 | 0.4753 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0652 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0403 | 0.5955 | 0.5955 |
Entamoeba histolytica | type A flavoprotein, putative | 0.025 | 0.3471 | 0.5 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.025 | 0.3471 | 0.3033 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0074 | 0.0628 | 0.0628 |
Entamoeba histolytica | type A flavoprotein, putative | 0.025 | 0.3471 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0578 | 0.8798 | 0.8717 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0134 | 0.159 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1146 | 0.1146 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0074 | 0.0628 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0578 | 0.8798 | 1 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0074 | 0.0628 | 0.0628 |
Entamoeba histolytica | type A flavoprotein, putative | 0.025 | 0.3471 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.025 | 0.3471 | 0.3033 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0324 | 0.4673 | 0.4673 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.025 | 0.3471 | 0.3033 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0652 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0074 | 0.0628 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0403 | 0.5955 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0134 | 0.159 | 0.159 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30.84 uM | Inhibitory concentration of the compound against polymerization in A17 double mutant HIV-1 RT using a template primer of poly rC/dG12-18 and [3H]-dGTP | ChEMBL. | 11591519 |
IC50 (binding) | = 30.84 uM | Inhibitory concentration of the compound against polymerization in A17 double mutant HIV-1 RT using a template primer of poly rC/dG12-18 and [3H]-dGTP | ChEMBL. | 11591519 |
IC50 (binding) | = 36.29 uM | Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]-dGTP | ChEMBL. | 11591519 |
IC50 (binding) | = 36.29 uM | Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]-dGTP | ChEMBL. | 11591519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.