Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.043 |
Echinococcus granulosus | dna polymerase eta | 0.0064 | 0.0236 | 0.2858 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.1298 | 0.7146 | 1 |
Leishmania major | trypanothione reductase | 0.0047 | 0.0142 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0837 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.0482 | 0.055 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0113 | 0.9455 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0142 | 0.1699 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.0094 | 0.3199 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.043 |
Echinococcus granulosus | dna polymerase kappa | 0.0039 | 0.0094 | 0.1131 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0042 | 0.0113 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0042 | 0.0113 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.0142 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0039 | 0.0094 | 0.1131 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0039 | 0.0094 | 0.1131 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0039 | 0.0094 | 0.1118 |
Giardia lamblia | Myb 1-like protein | 0.0042 | 0.0114 | 1 |
Trichomonas vaginalis | MYB3r3, putative | 0.0042 | 0.0113 | 0.9455 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0042 | 0.0113 | 0.9455 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.0142 | 0.0069 |
Schistosoma mansoni | DNA polymerase eta | 0.0064 | 0.0236 | 0.2858 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0509 | 0.2731 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.043 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0042 | 0.0113 | 0.9455 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.0546 | 0.6529 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Echinococcus multilocularis | dna polymerase kappa | 0.0039 | 0.0094 | 0.1131 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0142 | 0.1699 |
Echinococcus multilocularis | dna polymerase eta | 0.0064 | 0.0236 | 0.2858 |
Trichomonas vaginalis | MYB, putative | 0.0042 | 0.0114 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.0142 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.0549 | 0.0646 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0113 | 0.9455 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0094 | 0.3199 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1807 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0064 | 0.0236 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0094 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.0142 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.0142 | 0.5518 |
Trichomonas vaginalis | C-MYB, putative | 0.0042 | 0.0113 | 0.9455 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.0142 | 0.0208 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0509 | 0.2731 | 0.2662 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.043 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.0042 | 0.0114 | 0.0102 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0142 | 0.1699 |
Trichomonas vaginalis | MYB72, putative | 0.0042 | 0.0113 | 0.9455 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1807 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.0827 | 1 |
Brugia malayi | hypothetical protein | 0.0171 | 0.0837 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.0482 | 0.055 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0509 | 0.2731 | 0.3375 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0039 | 0.0094 | 0.1131 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.0546 | 0.6529 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.0482 | 0.055 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0113 | 0.9455 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.0482 | 0.055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Leishmania major | DNA polymerase eta, putative | 0.0064 | 0.0236 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0039 | 0.0094 | 0.1131 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.0549 | 0.0646 |
Echinococcus multilocularis | geminin | 0.017 | 0.0827 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0039 | 0.0094 | 0.043 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0114 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.043 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.0142 | 0.3694 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.0094 | 0.3199 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0142 | 0.1699 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0064 | 0.0236 | 0.2824 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0113 | 0.9455 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0113 | 0.9455 |
Trichomonas vaginalis | C-MYB, putative | 0.0042 | 0.0113 | 0.9455 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.0482 | 0.055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.0482 | 0.055 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0064 | 0.0236 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.0827 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0142 | 0.172 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.0549 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0236 | 0.2824 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.1298 | 0.7146 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1807 | 1 | 0.5 |
Onchocerca volvulus | 0.0171 | 0.0837 | 1 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0042 | 0.0113 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0042 | 0.0113 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0114 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.0094 | 0.3199 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0042 | 0.0113 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0042 | 0.0113 | 0.9455 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.0142 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.0549 | 0.0101 |
Echinococcus granulosus | geminin | 0.017 | 0.0827 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0142 | 0.172 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0039 | 0.0094 | 0.1118 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.0546 | 0.6529 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.