Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1499 | 0.1499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4322 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1499 | 0.3468 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2168 | 0.2168 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4322 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1499 | 0.3468 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.4011 | 0.4011 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4322 | 0.4322 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.4011 | 0.4011 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2168 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2168 | 0.5015 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1499 | 0.1499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4322 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2168 | 0.5015 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0164 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2168 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.6175 | 0.6175 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1499 | 0.1499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4322 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1499 | 0.3468 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4322 | 0.4322 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4322 | 0.4322 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2168 | 0.2168 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2168 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.6175 | 0.6175 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4322 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0164 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.6175 | 0.6175 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1499 | 0.1499 |
Echinococcus multilocularis | muscleblind protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.4011 | 0.9279 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2168 | 0.2168 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.1499 | 0.1499 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4322 | 0.4322 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.1499 | 0.1499 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1499 | 0.1499 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.6175 | 0.6175 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4322 | 0.4322 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2168 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1499 | 0.1499 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1499 | 0.3468 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1499 | 0.1499 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4322 | 0.4322 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4322 | 0.4322 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1499 | 0.1499 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4322 | 0.4322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.