Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.004 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 0.3115 |
Schistosoma mansoni | alpha-glucosidase | 0.0156 | 0.821 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0182 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2558 | 0.2558 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0182 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0156 | 0.821 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 0.3115 |
Onchocerca volvulus | 0.0105 | 0.4581 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1054 | 0.1284 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2558 | 0.2558 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2558 | 0.2558 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 0.3115 |
Leishmania major | alpha glucosidase II subunit, putative | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2558 | 0.2558 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0182 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1054 | 0.1054 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2558 | 0.2558 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1054 | 0.1054 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2558 | 0.2558 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2558 | 0.2558 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1054 | 0.1284 |
Trypanosoma brucei | glucosidase, putative | 0.004 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 0.3115 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1054 | 0.1054 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1054 | 0.1054 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.004 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1054 | 0.1054 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0182 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 0.3115 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1054 | 0.1284 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2558 | 0.2558 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1054 | 0.1054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.