Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.0039 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.6622 | 0.8363 |
Echinococcus granulosus | protein kinase c iota type | 0.0069 | 0.1328 | 0.1293 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0069 | 0.1328 | 0.1293 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.004 | 0.0039 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0075 | 0.1595 | 0.1903 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.0039 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0075 | 0.1595 | 0.1977 |
Echinococcus multilocularis | protein kinase c iota type | 0.0069 | 0.1328 | 0.1293 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0075 | 0.1595 | 0.1562 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0075 | 0.1595 | 0.1562 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.0039 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0187 | 0.6622 | 0.6609 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0194 | 0.6929 | 0.8753 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0187 | 0.6622 | 0.6609 |
Entamoeba histolytica | protein kinase, putative | 0.004 | 0.0039 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0187 | 0.6622 | 0.6609 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.7427 | 0.7417 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7427 | 0.7417 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 1 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0075 | 0.1595 | 0.1562 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Toxoplasma gondii | AGC kinase | 0.004 | 0.0039 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0233 | 0.8712 | 0.8707 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.791 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0222 | 0.8217 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7427 | 0.7417 |
Trichomonas vaginalis | AGC family protein kinase | 0.004 | 0.0039 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0233 | 0.8712 | 0.8707 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7427 | 0.7417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.