Detailed information for compound 1547266

Basic information

Technical information
  • TDR Targets ID: 1547266
  • Name: 6-(2,3-dihydro-1,4-benzoxazin-4-ylsulfonyl)-1 ,4-dimethylquinoxaline-2,3-dione
  • MW: 387.41 | Formula: C18H17N3O5S
  • H donors: 0 H acceptors: 4 LogP: 1.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c2cc(ccc2n(c(=O)c1=O)C)S(=O)(=O)N1CCOc2c1cccc2
  • InChi: 1S/C18H17N3O5S/c1-19-13-8-7-12(11-15(13)20(2)18(23)17(19)22)27(24,25)21-9-10-26-16-6-4-3-5-14(16)21/h3-8,11H,9-10H2,1-2H3
  • InChiKey: SNHONULEUANCQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(2,3-dihydro-1,4-benzoxazin-4-ylsulfonyl)-1,4-dimethyl-quinoxaline-2,3-dione
  • 6-(2,3-dihydro-1,4-benzoxazin-4-ylsulfonyl)-1,4-dimethyl-quinoxaline-2,3-quinone
  • BAS 14051626
  • A3956/0168556
  • ZINC04520663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0128
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0032 0.0313 0.0942
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0524 0.0524
Echinococcus multilocularis lamin dm0 0.0027 0.0248 0.0248
Entamoeba histolytica hypothetical protein 0.0032 0.0313 0.4919
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0045 0.0505 0.0505
Brugia malayi Protein kinase c protein 2 0.0246 0.3437 1
Echinococcus granulosus myotubularin protein 13 0.0032 0.0313 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.4683
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1923 0.1923
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0198 0.0577
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0524 0.0524
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.2436
Onchocerca volvulus 0.0038 0.0409 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.0778 0.0778
Echinococcus multilocularis musashi 0.0027 0.0248 0.0248
Echinococcus multilocularis raf serine:threonine protein kinase 0.0032 0.0313 0.0313
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0128 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0207 0.2865 0.2865
Entamoeba histolytica diacylglycerol kinase, putative 0.0032 0.0313 0.4919
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0033 0.0327 0.0953
Brugia malayi intermediate filament protein 0.0027 0.0248 0.0722
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0032 0.0313 0.0313
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0045 0.0505 0.0505
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.4683
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.015 0.2036 0.6121
Echinococcus multilocularis serine threonine protein kinase 0.0258 0.3614 0.3614
Onchocerca volvulus 0.0027 0.0248 0.606
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0585 0.1701
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0083
Echinococcus multilocularis N chimaerin 0.0032 0.0313 0.0313
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0778 0.0778
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0128 0.5
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0045 0.0505 0.1517
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0778 0.0778
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0198 0.0577
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0032 0.0313 0.0942
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0045 0.0505 0.0505
Brugia malayi Protein kinase domain containing protein 0.0045 0.0505 0.1468
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0248 0.0722
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0135 0.2573
Schistosoma mansoni diacylglycerol kinase theta 0.0032 0.0313 0.0313
Onchocerca volvulus 0.0032 0.0313 0.7655
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0032 0.0313 0.0313
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0083 0.0251
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0476
Loa Loa (eye worm) AGC/AKT protein kinase 0.0045 0.0505 0.1517
Brugia malayi Ras association domain family 1 isoform A 0.0032 0.0313 0.0912
Echinococcus multilocularis unc 13 (munc13) 0.0038 0.0409 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.1062 0.1062
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0083 0.0243
Loa Loa (eye worm) hypothetical protein 0.005 0.0585 0.1757
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0554
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0128 0.6335
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0045 0.0505 0.1517
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0135 0.0405
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0778 0.2338
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0198 0.0577
Schistosoma mansoni serine/threonine protein kinase 0.029 0.4076 0.4076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0596
Echinococcus multilocularis serine:threonine protein kinase N2 0.0045 0.0505 0.0505
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0032 0.0313 0.0313
Schistosoma mansoni rac gtpase activating protein 0.0032 0.0313 0.0313
Echinococcus granulosus N chimaerin 0.0032 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Schistosoma mansoni protein kinase C mu 0.0032 0.0313 0.0313
Toxoplasma gondii AGC kinase 0.0045 0.0505 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0045 0.0505 0.1517
Schistosoma mansoni vav2 0.0032 0.0313 0.0313
Brugia malayi diacylglycerol kinase 0.0032 0.0313 0.0912
Echinococcus multilocularis Protein kinase C, brain isozyme 0.029 0.4076 0.4076
Brugia malayi RhoGAP domain containing protein 0.0032 0.0313 0.0912
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0033 0.0327 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0778 0.0778
Echinococcus multilocularis protein kinase c iota type 0.0076 0.0967 0.0967
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0038 0.0409 0.0409
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0478 0.9469
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0198 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0135 0.6692
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.4683
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0353 0.1026
Echinococcus granulosus GPCR family 2 0.0016 0.0083 0.0083
Loa Loa (eye worm) AGC/NDR protein kinase 0.0045 0.0505 0.1517
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0332
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0505 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0505 0.0505
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0083 0.1062 0.3194
Schistosoma mansoni cytochrome P450 0.0011 0.0007 0.0007
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0033 0.0327 0.0327
Schistosoma mansoni unc-13 (munc13) 0.0038 0.0409 0.0409
Brugia malayi p70 ribosomal S6 kinase beta 0.0045 0.0505 0.1468
Loa Loa (eye worm) hypothetical protein 0.0045 0.0505 0.1517
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0478 0.0478
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0128 0.6335
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1983 0.1983
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0198 1
Echinococcus multilocularis myotubularin protein 13 0.0032 0.0313 0.0313
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0032 0.0313 0.0313
Schistosoma mansoni intermediate filament proteins 0.0027 0.0248 0.0248
Echinococcus granulosus serine:threonine protein kinase N2 0.0045 0.0505 0.0505
Echinococcus multilocularis protein kinase c epsilon type 0.0083 0.1062 0.1062
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0214 0.2975 0.8942
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0207 0.2865 0.2865
Schistosoma mansoni hypothetical protein 0.0032 0.0313 0.0313
Echinococcus granulosus Protein kinase C brain isozyme 0.029 0.4076 0.4076
Entamoeba histolytica protein kinase, putative 0.0045 0.0505 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0198 1
Brugia malayi Cytochrome P450 family protein 0.003 0.0286 0.0831
Onchocerca volvulus 0.0032 0.0313 0.7655
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0585 0.1701
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0248 0.0745
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0044 0.0491 0.9626
Echinococcus multilocularis protein kinase c eta type 0.0032 0.0313 0.0313
Brugia malayi Protein kinase domain containing protein 0.0033 0.0327 0.0953
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0083 0.0243
Brugia malayi C1-like domain containing protein 0.0033 0.0327 0.0953
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0107
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0135 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0128 0.6335
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0426 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0128 0.0372
Loa Loa (eye worm) hypothetical protein 0.0027 0.0248 0.0745
Schistosoma mansoni microtubule-associated protein tau 0.0696 1 1
Echinococcus granulosus muscleblind protein 0.015 0.2036 0.2036
Brugia malayi Cytochrome P450 family protein 0.0019 0.0135 0.0392
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0038 0.0409 0.0409
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0478 0.9298
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0327 0.0327
Echinococcus granulosus protein kinase c epsilon type 0.0083 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0129
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0286 0.0859
Echinococcus multilocularis muscleblind protein 0.015 0.2036 0.2036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0128 0.0385
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0596
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0478 0.9469
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0135 0.0405
Brugia malayi diacylglycerol kinase 0.0032 0.0313 0.0912
Echinococcus multilocularis 0.0011 0.0007 0.0007
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0033 0.0327 0.0984
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Echinococcus granulosus NDR protein kinase 0.0045 0.0505 0.0505
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0045 0.0505 0.1517
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0332
Echinococcus granulosus protein kinase c eta type 0.0032 0.0313 0.0313
Brugia malayi protein kinase C II. 0.0083 0.1062 0.3092
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0128
Entamoeba histolytica diacylglycerol kinase, putative 0.0032 0.0313 0.4919
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0426 1
Echinococcus granulosus protein kinase c iota type 0.0076 0.0967 0.0967
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0032 0.0313 0.0313
Loa Loa (eye worm) acetyltransferase 0.0146 0.1983 0.5961
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0064 0.0186
Schistosoma mansoni unc-13 (munc13) 0.0038 0.0409 0.0409
Schistosoma mansoni serine/threonine kinase 0.0045 0.0505 0.0505
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0248 0.0745
Echinococcus granulosus RNA directed DNA polymerase 0.0207 0.2865 0.2865
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0033 0.0327 0.0984
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0778 0.2338
Entamoeba histolytica protein kinase, putative 0.0045 0.0505 1
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0596
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1983 0.577
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0332
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Brugia malayi Cytochrome P450 family protein 0.0019 0.0135 0.0392
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0198 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0198 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0778 0.0778
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0313 0.0912
Echinococcus multilocularis Diacylglycerol kinase theta 0.0032 0.0313 0.0313
Echinococcus granulosus lamin dm0 0.0027 0.0248 0.0248
Leishmania major cytochrome p450-like protein 0.0019 0.0135 0.6692
Echinococcus multilocularis muscleblind protein 1 0.015 0.2036 0.2036
Brugia malayi cytochrome P450 0.0011 0.0007 0.0019
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0045 0.0505 0.0505
Echinococcus multilocularis microtubule associated protein 2 0.0696 1 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0198 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0524 0.1525
Echinococcus granulosus intermediate filament protein 0.0027 0.0248 0.0248
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0045 0.0505 0.0505
Schistosoma mansoni hypothetical protein 0.0034 0.0353 0.0353
Echinococcus multilocularis GPCR, family 2 0.0016 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0524 0.0524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0524 0.0524
Brugia malayi RhoGAP domain containing protein 0.0032 0.0313 0.0912
Loa Loa (eye worm) hypothetical protein 0.0038 0.0409 0.123
Onchocerca volvulus 0.0024 0.0198 0.4842
Brugia malayi Hr1 repeat family protein 0.0045 0.0505 0.1468
Schistosoma mansoni protein kinase C mu 0.0033 0.0327 0.0327
Brugia malayi Protein kinase domain containing protein 0.0045 0.0505 0.1468
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0198 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0478 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0135 0.0405
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Loa Loa (eye worm) AGC/PKN protein kinase 0.0045 0.0505 0.1517
Echinococcus multilocularis serine:threonine protein kinase N2 0.0045 0.0505 0.0505
Echinococcus granulosus protein kinase C gamma type 0.0258 0.3614 0.3614
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Echinococcus multilocularis lamin 0.0027 0.0248 0.0248
Toxoplasma gondii diacylglycerol kinase, putative 0.0032 0.0313 0.6157
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0064 0.0192
Echinococcus multilocularis Rac GTPase activating protein 1 0.0032 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0083
Echinococcus granulosus Diacylglycerol kinase theta 0.0032 0.0313 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0505 0.0505
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0778 0.2263
Entamoeba histolytica protein kinase, putative 0.0045 0.0505 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0198 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0128 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.0332
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0096 0.4683
Loa Loa (eye worm) hypothetical protein 0.0238 0.3326 1
Brugia malayi RNA binding protein 0.0064 0.0778 0.2263
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0778 0.0778
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.015 0.2036 0.6121
Brugia malayi RhoGEF domain containing protein 0.0032 0.0313 0.0912
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0251
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0045 0.0505 0.0505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0524 0.0524
Loa Loa (eye worm) raf kinase 0.0032 0.0313 0.0942
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0128 0.9466
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0045 0.0505 1
Schistosoma mansoni serine/threonine protein kinase 0.029 0.4076 0.4076
Brugia malayi Muscleblind-like protein 0.015 0.2036 0.5925
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0778 0.0778
Loa Loa (eye worm) hypothetical protein 0.0207 0.2865 0.8612
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Schistosoma mansoni lamin 0.0027 0.0248 0.0248
Echinococcus granulosus lamin 0.0027 0.0248 0.0248
Loa Loa (eye worm) cytochrome P450 0.0011 0.0007 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0198 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.011 0.5422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0524 0.0524
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0032 0.0313 0.0942
Loa Loa (eye worm) hypothetical protein 0.0034 0.0353 0.106
Toxoplasma gondii exonuclease III APE 0.0019 0.0128 0.2436
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0313 0.0313
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.011 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0128 0.0128
Echinococcus granulosus raf serine:threonine protein kinase 0.0032 0.0313 0.0313
Brugia malayi Pleckstrin Homology Domain 0.0032 0.0313 0.0912
Schistosoma mansoni atypical protein kinase C 0.0076 0.0967 0.0967
Loa Loa (eye worm) hypothetical protein 0.0027 0.0241 0.0724
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1983 0.1983
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0198 0.1863
Echinococcus multilocularis serine:threonine protein kinase 38 0.0045 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0505 0.0505
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0135 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0198 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0524 0.1575
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0585 0.1757
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0198 1
Echinococcus granulosus unc 13 munc13 0.0038 0.0409 0.0409
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0478 0.9298
Schistosoma mansoni protein kinase C 0.0038 0.0409 0.0409
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0198 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.0778 0.2338
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0313 0.0942
Schistosoma mansoni diacylglycerol kinase theta 0.0032 0.0313 0.0313
Brugia malayi TAR-binding protein 0.0064 0.0778 0.2263
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.011 0.5422
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0198 0.1863
Schistosoma mansoni lamin 0.0027 0.0248 0.0248
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0426 0.7912
Loa Loa (eye worm) RasGEF domain-containing protein 0.0032 0.0313 0.0942
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0327 0.0327
Brugia malayi protein kinase C3,putative 0.0033 0.0327 0.0953
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.9466
Onchocerca volvulus 0.0027 0.0248 0.606
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0505 1
Brugia malayi Protein kinase domain containing protein 0.0045 0.0505 0.1468
Trypanosoma brucei rac serine-threonine kinase, putative 0.0045 0.0505 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0198 0.1863
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0083
Brugia malayi Cytochrome P450 family protein 0.0011 0.0007 0.0019

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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