Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0706 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0706 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0706 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0706 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0706 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0706 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0706 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0706 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0706 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0706 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0706 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0706 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.00013 M | In vitro antiviral activity against herpes simplex virus type 2 (HSV-2) in Vero cells. | ChEMBL. | 3950908 |
ED50 (functional) | = 0.00025 M | In vitro antiviral activity against vaccinia virus in Vero cells. | ChEMBL. | 3950908 |
ED50 (functional) | = 0.0005 M | In vitro antiviral activity against parainfluenza type 3 virus in Vero cells. | ChEMBL. | 3950908 |
ED50 (functional) | > 0.005 M | In vitro antiviral activity against measles virus in Vero cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000017 M | In vitro inhibitory effect of the compound on growth of lewis lung carcinoma cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000025 M | In vitro inhibitory effect of the compound on growth of L1210 leukemia cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000025 M | In vitro inhibitory effect of the compound on growth of L1210 leukemia cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000044 M | In vitro inhibitory effect of the compound on growth of P388 leukemia cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000044 M | In vitro inhibitory effect of the compound on growth of P388 leukemia cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000063 M | In vitro inhibitory effect of the compound on growth of B16 melanoma cells | ChEMBL. | 3950908 |
ID50 (functional) | = 0.0000063 M | In vitro inhibitory effect of the compound on growth of B16 melanoma cells | ChEMBL. | 3950908 |
MTC (functional) | > 0.005 M | Maximum tolerated concentration against Vero cells. | ChEMBL. | 3950908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.