Detailed information for compound 1547913

Basic information

Technical information
  • TDR Targets ID: 1547913
  • Name: N-[3-(tetrazol-1-yl)phenyl]-4-(trifluoromethy l)benzamide
  • MW: 333.268 | Formula: C15H10F3N5O
  • H donors: 1 H acceptors: 4 LogP: 2.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)C(F)(F)F)Nc1cccc(c1)n1cnnn1
  • InChi: 1S/C15H10F3N5O/c16-15(17,18)11-6-4-10(5-7-11)14(24)20-12-2-1-3-13(8-12)23-9-19-21-22-23/h1-9H,(H,20,24)
  • InChiKey: OQENBGSCPDJWGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-(1-tetrazolyl)phenyl]-4-(trifluoromethyl)benzamide
  • N-[3-(1,2,3,4-tetrazol-1-yl)phenyl]-4-(trifluoromethyl)benzamide
  • ZINC07646222
  • T5569850

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0117 0.1367 0.1471
Loa Loa (eye worm) hypothetical protein 0.0117 0.1367 0.3522
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0166 0.1165
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0166 0.0997
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0184 0.0572
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0054 0.0158
Brugia malayi Inositol-1 0.0083 0.0956 0.2436
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0607 0.0634
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.1342
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0054 0.0341
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.011 0.0583
Loa Loa (eye worm) hypothetical protein 0.0037 0.0387 0.0935
Chlamydia trachomatis DNA ligase 0.001 0.0054 0.0428
Mycobacterium ulcerans esterase/lipase LipP 0.0117 0.1367 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0038 0.0006
Brugia malayi mbt repeat family protein 0.0048 0.0524 0.1296
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0541 0.3926
Loa Loa (eye worm) hypothetical protein 0.0152 0.1808 0.4685
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0467 0.3151
Mycobacterium leprae Probable monophosphatase 0.0009 0.0039 0.0038
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0184 0.1591
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0059 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0059 0.0068
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0034 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.0956 0.6974
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.004 0.0112
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.011 0.0583
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0166 0.2023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0184 0.0993
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.1962 0.5093
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.011 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0123
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0166 0.1165
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0387 0.6019
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0166 0.0509
Toxoplasma gondii exonuclease III APE 0.0021 0.0184 0.1135
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0166 0.0147
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.011 0.0086
Echinococcus granulosus beta LACTamase domain containing family member 0.0117 0.1367 0.2709
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0378 0.0347
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0362 0.0363
Brugia malayi beta-NAC-like protein 0.0035 0.0366 0.0879
Schistosoma mansoni ferritin light chain 0.0009 0.0038 0.0106
Schistosoma mansoni topbp1 0.001 0.0054 0.015
Schistosoma mansoni hypothetical protein 0.0009 0.0039 0.0108
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0166 0.1165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0524 0.1296
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2557 0.6664
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0059 0.0068
Onchocerca volvulus 0.0243 0.2919 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0059 0.0068
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0166 0.3305
Leishmania major cytochrome p450-like protein 0.0008 0.0033 0.0186
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0607 0.4414
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0059 0.0068
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1754 0.1727
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.011 0.0086
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0038 0.0006
Brugia malayi hypothetical protein 0.0238 0.2868 0.7483
Echinococcus multilocularis GPCR, family 2 0.0052 0.0574 0.0543
Echinococcus multilocularis Smad4 0.0008 0.0034 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.1367 0.465
Toxoplasma gondii hypothetical protein 0.0009 0.0039 0.0046
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.011 0.0759
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0059 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0117 0.1367 1
Plasmodium falciparum glutathione reductase 0.0055 0.0607 1
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0091
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0378 0.0702
Mycobacterium ulcerans hypothetical protein 0.0117 0.1367 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.011 0.0483
Schistosoma mansoni ferritin light chain 0.0009 0.0038 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.011 0.0086
Schistosoma mansoni hypothetical protein 0.0296 0.3583 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0034 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0059 0.0026
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0524 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0315 0.088
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0059 0.0068
Onchocerca volvulus 0.0049 0.0541 0.1744
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0315 0.0574
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0524 0.1462
Mycobacterium leprae conserved hypothetical protein 0.0117 0.1367 0.8272
Mycobacterium tuberculosis Probable monophosphatase 0.0009 0.0039 0.0007
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0083 0.0956 0.6917
Brugia malayi MH2 domain containing protein 0.0008 0.0034 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0508 0.1418
Trichomonas vaginalis inositol monophosphatase, putative 0.0009 0.0039 0.0072
Loa Loa (eye worm) inositol-1 0.0083 0.0956 0.2436
Mycobacterium tuberculosis Probable lipase LipE 0.0117 0.1367 0.1471
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0315 0.088
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0103 0.0187
Loa Loa (eye worm) hypothetical protein 0.0117 0.1367 0.3522
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0054 0.013
Schistosoma mansoni cpg binding protein 0.0031 0.0313 0.0875
Brugia malayi topoisomerase 0.001 0.0054 0.0056
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0083 0.0956 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0059 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0541 0.1342
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1474 0.1589
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.011 0.0759
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0038 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0059 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0059 0.0068
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.011 0.0086
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0086 0.0058
Echinococcus granulosus tumor protein p63 0.0408 0.4958 1
Mycobacterium tuberculosis Probable hydrolase 0.0117 0.1367 0.1471
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0524 0.0997
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0054 0.015
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1646 0.1778
Brugia malayi AMP-binding enzyme family protein 0.0015 0.011 0.0205
Mycobacterium ulcerans lipase LipD 0.0117 0.1367 1
Mycobacterium tuberculosis Monophosphatase CysQ 0.0009 0.0039 0.0007
Brugia malayi Pre-SET motif family protein 0.0213 0.2557 0.6664
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.011 0.0583
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0166 0.0997
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.1367 0.3815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0059 0.0068
Onchocerca volvulus 0.0015 0.011 0.0249
Schistosoma mansoni apoferritin-2 0.0009 0.0038 0.0106
Schistosoma mansoni thyroid hormone receptor 0.001 0.0059 0.0163
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0166 0.0997
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0059 0.0068
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.011 0.0158
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.011 0.0086
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0467 0.155
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0184 0.1584
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0009 0.0039 0.0231
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0054 0.0056
Echinococcus multilocularis tar DNA binding protein 0.021 0.2522 0.2497
Echinococcus granulosus inositol monophosphatase 1 0.0083 0.0956 0.1874
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0541 0.0561
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0117 0.1367 0.1471
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0184 0.13
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.011 0.0583
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0508 0.0477
Echinococcus multilocularis transcription factor btf3 0.0035 0.0366 0.0334
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0059 0.0068
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0059 0.0053
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0366 0.2495
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Schistosoma mansoni tar DNA-binding protein 0.021 0.2522 0.7038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0541 0.548
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.0956 0.6917
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0059 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.1962 0.5093
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0541 0.3811
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0009 0.0039 0.0006
Loa Loa (eye worm) hypothetical protein 0.0113 0.132 0.3397
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0059 0.0069
Loa Loa (eye worm) hypothetical protein 0.006 0.0667 0.1675
Loa Loa (eye worm) hypothetical protein 0.0015 0.011 0.0205
Loa Loa (eye worm) hypothetical protein 0.0117 0.1367 0.3522
Brugia malayi AMP-binding enzyme family protein 0.0015 0.011 0.0205
Loa Loa (eye worm) TAR-binding protein 0.021 0.2522 0.657
Brugia malayi nuclear hormone receptor 0.001 0.0059 0.0068
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0054 0.0158
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0083 0.0956 0.3232
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.132 0.3397
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0033 0.0186
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0034 0.0001
Brugia malayi Cytochrome P450 family protein 0.003 0.0305 0.072
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0387 0.2538
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0033 0.0186
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0166 0.0997
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0315 0.2118
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0184 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0541 0.3811
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0315 0.088
Brugia malayi hypothetical protein 0.0036 0.0378 0.0912
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0607 0.1167
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.011 0.0086
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0166 0.2023
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0387 0.0935
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0083 0.0956 1
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0524 0.0997
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0745 0.9103 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0166 0.0134
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.3702
Mycobacterium ulcerans monophosphatase CysQ 0.0009 0.0039 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0059 0.0163
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0052 0.0574 0.1429
Loa Loa (eye worm) RNA binding protein 0.021 0.2522 0.657
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2919 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0059 0.0068
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0574 0.1429
Onchocerca volvulus 0.0117 0.1367 0.4612
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.1342
Loa Loa (eye worm) hypothetical protein 0.0238 0.2868 0.7483
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1474 0.1589
Loa Loa (eye worm) hypothetical protein 0.0117 0.1367 0.3522
Echinococcus multilocularis muscleblind protein 1 0.0316 0.3821 0.3801
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0541 0.1342
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0034 0.0001
Leishmania major hypothetical protein, conserved 0.0117 0.1367 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0063
Echinococcus granulosus smad 0.0008 0.0034 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0059 0.0069
Schistosoma mansoni hypothetical protein 0.0052 0.0574 0.1602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0508 0.1255
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.011 0.0759
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0059 0.0163
Trichomonas vaginalis inositol monophosphatase, putative 0.0009 0.0039 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.1367 1
Onchocerca volvulus 0.0117 0.1367 0.4612
Schistosoma mansoni transcription factor btf3 0.0035 0.0366 0.102
Loa Loa (eye worm) hypothetical protein 0.0117 0.1367 0.3522
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.0956 0.6974
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.011 0.0308
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0541 0.3926
Brugia malayi CXXC zinc finger family protein 0.0031 0.0313 0.0741
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0059 0.0068
Mycobacterium tuberculosis Conserved protein 0.0117 0.1367 0.1471
Echinococcus multilocularis inositol monophosphatase 0.0009 0.0039 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.011 0.0086
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0054 0.0123
Treponema pallidum NADH oxidase 0.0019 0.0166 0.8745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0541 0.0561
Echinococcus multilocularis tumor protein p63 0.0408 0.4958 0.4941
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0059 0.0053
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0054 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0574 0.1429
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0366 0.3564
Loa Loa (eye worm) beta-lactamase 0.0117 0.1367 0.3522
Loa Loa (eye worm) acetyltransferase 0.0148 0.1754 0.4544
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.011 0.0205
Trichomonas vaginalis esterase, putative 0.0117 0.1367 0.465
Trypanosoma brucei hypothetical protein, conserved 0.0117 0.1367 1
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0366 0.2495
Onchocerca volvulus 0.0015 0.011 0.0249
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.011 0.0086
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0034 0.0004
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0387 0.0391
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0184 0.13
Brugia malayi beta-lactamase family protein 0.0117 0.1367 0.3522
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0508 0.0966
Trichomonas vaginalis inositol monophosphatase, putative 0.0083 0.0956 0.3232
Brugia malayi Smad1 0.0008 0.0034 0.0004
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0009 0.0039 0.0012
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.011 0.0483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.011 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0059 0.0068
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0009 0.0039 0.0038
Entamoeba histolytica hypothetical protein 0.0035 0.0366 0.3564
Echinococcus granulosus FTZ F1 alpha 0.001 0.0059 0.0053
Brugia malayi beta-lactamase 0.0117 0.1367 0.3522
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.011 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0059 0.0068
Onchocerca volvulus 0.0031 0.0315 0.096
Echinococcus granulosus nibrin 0.001 0.0054 0.0043
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0166 0.1165
Mycobacterium tuberculosis Probable esterase LipL 0.0117 0.1367 0.1471
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0034 0.0003
Schistosoma mansoni nuclear hormone receptor 0.001 0.0059 0.0163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0508 0.1255
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.011 0.0086
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0293 0.0529
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0059 0.0053
Toxoplasma gondii ABC1 family protein 0.0117 0.1367 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0117 0.1367 0.3522
Leishmania major trypanothione reductase 0.0055 0.0607 0.4414
Onchocerca volvulus 0.0049 0.053 0.1707
Brugia malayi MH1 domain containing protein 0.0008 0.0034 0.0004
Leishmania major cytochrome p450-like protein 0.0008 0.0033 0.0186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0362 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Echinococcus multilocularis muscleblind protein 0.0316 0.3821 0.3801
Onchocerca volvulus 0.0048 0.0524 0.1684
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0095
Schistosoma mansoni hypothetical protein 0.0052 0.0574 0.1602
Loa Loa (eye worm) hypothetical protein 0.0031 0.0315 0.0746
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1646 0.1778
Loa Loa (eye worm) MBCTL1 0.0055 0.0606 0.1513
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.011 0.0205
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0054 0.0123
Schistosoma mansoni Smad4 0.0008 0.0034 0.0095
Schistosoma mansoni cytochrome P450 0.0008 0.0033 0.0091
Toxoplasma gondii thioredoxin reductase 0.0055 0.0607 0.4308
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0054 0.0158
Mycobacterium tuberculosis Conserved protein 0.0117 0.1367 0.1471
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2868 0.2844
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0524 0.1462
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.1367 0.465
Onchocerca volvulus 0.0015 0.011 0.0249
Onchocerca volvulus 0.001 0.0054 0.0052
Echinococcus multilocularis cpg binding protein 0.0033 0.0335 0.0304
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0166 0.1391
Brugia malayi RNA binding protein 0.021 0.2522 0.657
Schistosoma mansoni apoferritin-2 0.0009 0.0038 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0508 0.1418
Brugia malayi mbt repeat family protein 0.0048 0.0524 0.1296
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0059 0.0026
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0366 0.5631
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0083 0.0956 0.3232
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1646 1
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0166 0.0509
Loa Loa (eye worm) hypothetical protein 0.0117 0.1367 0.3522
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0095
Schistosoma mansoni ferritin 0.0009 0.0038 0.0106
Loa Loa (eye worm) hypothetical protein 0.0055 0.0606 0.1513
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0524 0.1684
Trichomonas vaginalis ferritin, putative 0.0009 0.0038 0.0069
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.011 0.0583
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0056
Brugia malayi beta-lactamase family protein 0.0117 0.1367 0.3522
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0541 0.3811
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0184 0.0572
Brugia malayi Pre-SET motif family protein 0.0031 0.0315 0.0746
Leishmania major cytochrome p450-like protein 0.0008 0.0033 0.0186
Mycobacterium tuberculosis Probable lipase LipD 0.0117 0.1367 0.1471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0387 0.0935
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0166 0.1165
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0166 0.1391
Brugia malayi AMP-binding enzyme family protein 0.0015 0.011 0.0205
Loa Loa (eye worm) hypothetical protein 0.0037 0.0387 0.0935
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0184 0.04
Mycobacterium ulcerans monophosphatase CysQ 0.0009 0.0039 0.0046
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0034 0.0004
Loa Loa (eye worm) glutathione reductase 0.0055 0.0607 0.1517
Brugia malayi nuclear receptor NHR-88 0.001 0.0059 0.0068
Onchocerca volvulus 0.006 0.0667 0.2182
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0606 0.1513
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.004 0.0015
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0166 0.0997
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0038 0.0034
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0009 0.0039 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0366 0.1198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0059 0.0068
Schistosoma mansoni ferritin 0.0009 0.0038 0.0106
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1646 0.1778
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0423 1
Schistosoma mansoni inositol monophosphatase 0.0083 0.0956 0.2667
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0083 0.0956 0.6917
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0423 0.6665
Brugia malayi RNA recognition motif domain containing protein 0.021 0.2522 0.657
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0541 0.3811
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.1367 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0607 0.0577
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0009 0.0039 0.0231
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0059 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0508 0.0966
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1474 0.1589
Plasmodium falciparum thioredoxin reductase 0.0019 0.0166 0.2023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0166 0.0997
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0366 0.2635
Echinococcus granulosus GPCR family 2 0.0052 0.0574 0.1099
Brugia malayi hypothetical protein 0.001 0.0054 0.0056
Schistosoma mansoni hypothetical protein 0.0049 0.053 0.148
Loa Loa (eye worm) hypothetical protein 0.0049 0.0541 0.1342
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0033 0.0186
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.2316 0.4637
Schistosoma mansoni pap-inositol-14-phosphatase 0.0009 0.0039 0.0108
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0059 0.0163
Echinococcus granulosus muscleblind protein 0.0316 0.3821 0.7692
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0574 0.1099
Brugia malayi MH2 domain containing protein 0.0008 0.0034 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0541 0.1342
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1754 0.4544
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0508 0.1418
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0184 0.0152
Brugia malayi DKFZp564C0469 protein 0.001 0.0054 0.0056
Echinococcus granulosus transcription factor btf3 0.0035 0.0366 0.0676
Brugia malayi MH2 domain containing protein 0.0122 0.1437 0.3706
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0074 0.0848 0.0899
Brugia malayi hypothetical protein 0.001 0.0054 0.0056
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0038 0.0041
Schistosoma mansoni myo inositol monophosphatase 0.0009 0.0039 0.0108
Schistosoma mansoni DNA ligase IV 0.001 0.0054 0.015
Echinococcus granulosus ferritin 0.0009 0.0038 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0313 0.0741
Schistosoma mansoni ferritin 0.0009 0.0038 0.0106
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0059 0.0163
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0315 0.0283
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.011 0.0759
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1474 0.1589
Echinococcus granulosus Smad4 0.0008 0.0034 0.0003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0184 0.0167
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0467 0.3259
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1754 0.4896
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.011 0.0583
Mycobacterium leprae Probable lipase LipE 0.0117 0.1367 0.8272
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0117 0.1367 0.1471
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0467 0.0883
Schistosoma mansoni hypothetical protein 0.0036 0.0378 0.1055
Echinococcus granulosus cpg binding protein 0.0033 0.0335 0.0614
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0362 0.0363
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1703 0.3392
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0607 0.1517
Plasmodium falciparum thioredoxin reductase 0.0055 0.0607 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Mycobacterium tuberculosis Conserved protein 0.0117 0.1367 0.1471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0059 0.0068
Brugia malayi Muscleblind-like protein 0.0316 0.3821 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0166 0.0997
Schistosoma mansoni ap endonuclease 0.0021 0.0184 0.0514
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0059 0.0163
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0541 0.548
Schistosoma mansoni ap endonuclease 0.0021 0.0184 0.0514
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.011 0.0583
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0606 0.1164
Echinococcus granulosus inositol monophosphatase 0.0009 0.0039 0.0012
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.011 0.0583
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.1367 0.465
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0033 0.0186
Brugia malayi Thioredoxin reductase 0.0055 0.0607 0.1517
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.3702
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0103 0.0187
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0009 0.0039 0.0046
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.011 0.0483
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.011 0.0086
Schistosoma mansoni thyroid hormone receptor 0.001 0.0059 0.0163
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0054 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0059 0.0068
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1437 0.3706
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.011 0.0583
Loa Loa (eye worm) hypothetical protein 0.0015 0.011 0.0205
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0054 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0508 0.0477
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1437 0.3706
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.004 0.0008
Echinococcus multilocularis expressed protein 0.0009 0.0038 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0541 0.3811
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0059 0.0068
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0524 0.0493
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0607 0.4217
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.011 0.0759
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0387 0.2656
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0184 0.04
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.021 0.2522 0.657
Treponema pallidum DNA ligase (lig) 0.001 0.0054 0.107
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0423 0.4189
Leishmania major basic transcription factor 3a, putative 0.0035 0.0366 0.2635
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0606 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0366 0.1198
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0166 0.027
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0524 0.1296
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.1367 0.3815
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0054 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0054 0.0341
Plasmodium vivax SET domain protein, putative 0.0031 0.0315 0.1991
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.004 0.0008
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0009 0.0039 0.0046
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2868 0.5756
Toxoplasma gondii propionate-CoA ligase 0.0015 0.011 0.0583
Brugia malayi glutathione reductase 0.0055 0.0607 0.1517
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0166 0.0462
Onchocerca volvulus 0.0152 0.1808 0.6142
Brugia malayi ecdysteroid receptor 0.001 0.0059 0.0068
Echinococcus multilocularis ferritin 0.0009 0.0038 0.0005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0184 0.1135
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0184 0.13
Schistosoma mansoni topbp1 0.001 0.0054 0.015
Mycobacterium ulcerans hypothetical protein 0.0049 0.0541 0.3811
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0059 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0059 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0366 0.1198
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0574 0.1429
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0059 0.0053
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0184 0.3782
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0059 0.0069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0059 0.0053
Echinococcus multilocularis nibrin 0.001 0.0054 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0305 0.072
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.1367 0.465
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0714 0.5104
Echinococcus granulosus expressed protein 0.0009 0.0038 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0123
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0059 0.0163
Schistosoma mansoni smad 0.0008 0.0034 0.0095
Echinococcus granulosus tar DNA binding protein 0.021 0.2522 0.5054
Schistosoma mansoni survival motor neuron protein 0.0049 0.053 0.148
Mycobacterium ulcerans monophosphatase 0.0009 0.0039 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0056
Onchocerca volvulus 0.0015 0.011 0.0249
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.011 0.0759
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0056
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0524 0.1462
Onchocerca volvulus 0.0031 0.0313 0.0954
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0054 0.0341
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0667 0.1862
Echinococcus multilocularis beta LACTamase domain containing family member 0.0117 0.1367 0.1339
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0059 0.0026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0059 0.0163
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.011 0.0205
Leishmania major myo-inositol-1 phosphatase, putative 0.0009 0.0039 0.0231
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.3702
Loa Loa (eye worm) Smad1 0.0008 0.0034 0.0004
Brugia malayi TAR-binding protein 0.021 0.2522 0.657
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.011 0.0086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0467 0.155
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.011 0.0432
Schistosoma mansoni tar DNA-binding protein 0.021 0.2522 0.7038
Brugia malayi Inositol monophosphatase family protein 0.0009 0.0039 0.0016
Brugia malayi MH1 domain containing protein 0.0008 0.0034 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0541 0.3811
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.011 0.0078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0184 0.0307
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.004 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0184 0.2354
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0541 0.3811
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0467 0.3259
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0606 0.169
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0166 0.0853
Plasmodium vivax hypothetical protein, conserved 0.0117 0.1367 1
Schistosoma mansoni inositol monophosphatase 0.0083 0.0956 0.2667
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0315 0.088
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0063 0.0081
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0009 0.0039 0.0231
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0054 0.0341
Trypanosoma brucei trypanothione reductase 0.0055 0.0607 0.4308
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0366 0.2375
Schistosoma mansoni hypothetical protein 0.0113 0.132 0.3683
Loa Loa (eye worm) hypothetical protein 0.0037 0.0387 0.0935
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.1962 0.5093
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0083 0.0956 0.6974
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.2316 0.2291
Schistosoma mansoni cpg binding protein 0.0033 0.0335 0.0936
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0166 0.0997
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0166 0.0351
Onchocerca volvulus 0.0117 0.1367 0.4612
Schistosoma mansoni cpg binding protein 0.0033 0.0335 0.0936
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0074 0.0848 0.5057
Echinococcus multilocularis inositol monophosphatase 1 0.0083 0.0956 0.0926
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0009 0.0039 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0166 0.0997
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0184 0.1135
Schistosoma mansoni tar DNA-binding protein 0.021 0.2522 0.7038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.053 0.1314
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0541 0.548
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0574 0.1099
Onchocerca volvulus 0.001 0.0059 0.0069
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0059 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0756 0.2109
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0541 0.3153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0117 0.1367 0.3522
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0009 0.0039 0.0072
Giardia lamblia Replication factor C, subunit 1 0.001 0.0054 0.0388
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0033 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0059 0.0068
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.011 0.0205
Loa Loa (eye worm) hypothetical protein 0.0316 0.3821 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.011 0.0583
Schistosoma mansoni tar DNA-binding protein 0.021 0.2522 0.7038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0059 0.0026
Mycobacterium tuberculosis Probable reductase 0.0125 0.1474 0.1589
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0315 0.0283
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0033 0.0186
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0059 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0541 0.3153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0059 0.0053
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0606 0.1164
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0366 0.0879
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0054 0.0021
Schistosoma mansoni hypothetical protein 0.0052 0.0574 0.1602
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.011 0.0583
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0059 0.0026
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0574 0.0543
Loa Loa (eye worm) oxidoreductase 0.0015 0.011 0.0205
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0378 0.1055
Brugia malayi hypothetical protein 0.0152 0.1808 0.4685
Plasmodium vivax glutathione reductase, putative 0.0055 0.0607 0.4217
Loa Loa (eye worm) hypothetical protein 0.0165 0.1962 0.5093
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0166 0.0853
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.1367 0.465
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0059 0.0053
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.011 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0054 0.0123
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0062 0.0077
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0366 0.2635
Schistosoma mansoni hypothetical protein 0.0009 0.0039 0.0108
Schistosoma mansoni coup transcription factor 0.001 0.0059 0.0163
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1474 0.1589
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0054 0.0163
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0059 0.0026
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.011 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0059 0.0068
Schistosoma mansoni tar DNA-binding protein 0.021 0.2522 0.7038
Echinococcus granulosus replication factor c subunit 1 0.001 0.0054 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0387 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.011 0.0205
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0606 0.0575
Echinococcus multilocularis smad 0.0008 0.0034 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0541 0.3926
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0016
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.011 0.0583
Schistosoma mansoni hypothetical protein 0.0052 0.0574 0.1602
Schistosoma mansoni ferritin 0.0009 0.0038 0.0106
Brugia malayi steroid hormone receptor 0.001 0.0059 0.0068
Entamoeba histolytica hypothetical protein 0.001 0.0054 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0059 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0574 0.0543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0362 0.0363
Plasmodium falciparum glutathione reductase 0.0019 0.0166 0.2023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0166 0.3645
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1474 0.8933
Brugia malayi Inositol monophosphatase family protein 0.0009 0.0039 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0166 0.1165
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.3702
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0054 0.0123
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.011 0.0759
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.011 0.0782
Mycobacterium ulcerans beta-lactamase 0.0117 0.1367 1
Loa Loa (eye worm) hypothetical protein 0.0316 0.3821 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.