Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8744 | 0.8744 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.4511 | 0.4511 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2247 | 0.2247 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.3922 | 0.7399 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.4511 | 0.4511 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.8744 | 0.8744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8744 | 0.8744 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.8744 | 0.8744 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3922 | 0.3922 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.8744 | 0.8744 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.4511 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8744 | 0.8744 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.3922 | 0.3922 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.8744 | 0.8744 |
Trypanosoma brucei | unspecified product | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.1658 | 0.1658 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8744 | 0.8744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.8744 | 0.8744 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3922 | 0.3922 |
Brugia malayi | RNA binding protein | 0.0076 | 0.8744 | 0.8744 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3922 | 0.3922 |
Schistosoma mansoni | chromobox protein | 0.0084 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.8744 | 0.8744 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.1658 | 0.1658 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.8744 | 0.8744 |
Schistosoma mansoni | chromobox protein | 0.0084 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.8744 | 0.8744 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.