Detailed information for compound 1548265

Basic information

Technical information
  • TDR Targets ID: 1548265
  • Name: 1-(2-hydroxy-5-methoxyphenyl)-3-pyridin-3-ylp ropane-1,3-dione
  • MW: 271.268 | Formula: C15H13NO4
  • H donors: 1 H acceptors: 4 LogP: 2.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)C(=O)CC(=O)c1cccnc1)O
  • InChi: 1S/C15H13NO4/c1-20-11-4-5-13(17)12(7-11)15(19)8-14(18)10-3-2-6-16-9-10/h2-7,9,17H,8H2,1H3
  • InChiKey: DFPZOLOROANGTA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-hydroxy-5-methoxy-phenyl)-3-(3-pyridyl)propane-1,3-dione
  • 1-(2-hydroxy-5-methoxyphenyl)-3-(3-pyridyl)propane-1,3-dione
  • 1-(2-hydroxy-5-methoxy-phenyl)-3-pyridin-3-yl-propane-1,3-dione
  • 6951-15-1
  • NSC54648
  • NCIOpen2_002126

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0225 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Giardia lamblia DINP protein human, muc B family 0.002 0.0225 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Loa Loa (eye worm) hypothetical protein 0.002 0.0225 0.0316
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.7703 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Brugia malayi RNA binding protein 0.0076 0.4399 0.7277
Leishmania major cathepsin L-like protease 0.0065 0.3533 1
Leishmania major DNA polymerase eta, putative 0.002 0.0225 0.0614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0188 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0035 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.123
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0225 0.0493
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0035 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4399 0.7262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Echinococcus multilocularis dna polymerase eta 0.002 0.0225 0.0493
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0035 0.0076
Echinococcus granulosus dna polymerase kappa 0.002 0.0225 0.0493
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0188 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0225 0.0217
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0225 0.0614
Schistosoma mansoni DNA polymerase eta 0.002 0.0225 0.0217
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.2305 0.3778
Brugia malayi hypothetical protein 0.0043 0.1976 0.3269
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0008 0.0014
Loa Loa (eye worm) glutathione reductase 0.0048 0.2305 0.3778
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Entamoeba histolytica hypothetical protein 0.0043 0.1976 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.1086 0.1748
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4399 0.4394
Onchocerca volvulus 0.0017 0.0035 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0225 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0035 0.0116
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0225 0.0614
Leishmania major cathepsin L-like protease 0.0065 0.3533 1
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4399 0.4394
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0035 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0061
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0061
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0061
Trypanosoma brucei unspecified product 0.002 0.0225 0.0614
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0664 0.1861
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.2305 0.5232
Entamoeba histolytica hypothetical protein 0.0043 0.1976 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.7703 1
Entamoeba histolytica hypothetical protein 0.0043 0.1976 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0188 0.0312
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0061
Onchocerca volvulus 0.0017 0.0035 0.5
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0035 0.0116
Echinococcus multilocularis dna polymerase kappa 0.002 0.0225 0.0493
Toxoplasma gondii cathepsin CPL 0.0017 0.0035 0.0116
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.6808 0.8837
Loa Loa (eye worm) RNA binding protein 0.0076 0.4399 0.7262
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.3533 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Loa Loa (eye worm) hypothetical protein 0.0099 0.6044 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0188 0.0784
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.3533 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Schistosoma mansoni hypothetical protein 0.0031 0.1086 0.1078
Plasmodium falciparum thioredoxin reductase 0.0048 0.2305 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.1086 0.2453
Schistosoma mansoni hypothetical protein 0.0031 0.1086 0.1078
Plasmodium falciparum glutathione reductase 0.0048 0.2305 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0225 0.0372
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0225 0.0281
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0188 0.8311
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0225 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0225 0.0614
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.3749 0.6203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0664 0.1047
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0664 0.2855
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0225 1
Onchocerca volvulus 0.0017 0.0035 0.5
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0058
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0188 0.8311
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0188 0.0234
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0058
Leishmania major cathepsin L-like protease 0.0065 0.3533 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4399 0.4394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Schistosoma mansoni ap endonuclease 0.0019 0.0188 0.018
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4399 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.3749 0.6181
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.6044 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0225 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0188 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.1086 0.1796
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.6044 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0188 0.0511
Brugia malayi Thioredoxin reductase 0.0048 0.2305 0.3814
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0058
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.2305 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0035 0.0061
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.1086 0.1748
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.6808 0.8837
Schistosoma mansoni hypothetical protein 0.0043 0.1976 0.1969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0058
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0225 0.0614
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.1086 0.2453
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0225 0.0614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0225 0.0614
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.3533 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.123
Leishmania major hypothetical protein, conserved 0.0026 0.0664 0.1861
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0225 0.0281
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.1086 0.2453
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0188 0.0784
Plasmodium vivax glutathione reductase, putative 0.0048 0.2305 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0035 0.0061
Brugia malayi glutathione reductase 0.0048 0.2305 0.3814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0225 0.0372
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.1086 0.2453
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0225 0.0217
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0008 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0188 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0188 1
Echinococcus granulosus dna polymerase eta 0.002 0.0225 0.0493
Schistosoma mansoni hypothetical protein 0.0031 0.1086 0.1078
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0076
Trypanosoma brucei trypanothione reductase 0.0048 0.2305 0.6518
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0188 0.041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0225 0.0614
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0188 0.8311
Schistosoma mansoni hypothetical protein 0.0068 0.3749 0.3744
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0664 0.2855
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.6808 0.8837
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.2518 0.712
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0027
Onchocerca volvulus 0.0017 0.0035 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0188 0.8311
Plasmodium vivax vivapain-2 0.0017 0.0035 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1976 0.4481
Brugia malayi hypothetical protein 0.0026 0.0664 0.1099
Schistosoma mansoni hypothetical protein 0.0031 0.1086 0.1078
Brugia malayi Latrophilin receptor protein 2 0.0031 0.1086 0.1796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.2305 0.5232
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0664 0.1861
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0664 0.2855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.6808 0.8837
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.7703 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0225 0.0493
Brugia malayi TAR-binding protein 0.0076 0.4399 0.7277
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0225 0.0614
Echinococcus granulosus GPCR family 2 0.0031 0.1086 0.2453
Toxoplasma gondii exonuclease III APE 0.0019 0.0188 0.0784
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.6044 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0225 0.0614
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1976 0.4481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.3533 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.2305 0.2985
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1976 0.1969
Mycobacterium tuberculosis Probable reductase 0.0109 0.6808 0.8837
Onchocerca volvulus 0.0017 0.0035 0.5
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4399 0.4394
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4399 0.4394
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0076
Schistosoma mansoni ap endonuclease 0.0019 0.0188 0.018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.123
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.2305 0.6518
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0225 0.0979
Onchocerca volvulus 0.0017 0.0035 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0225 0.0614
Plasmodium vivax vivapain-2 0.0017 0.0035 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.3533 1
Entamoeba histolytica hypothetical protein 0.0043 0.1976 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0188 0.0511
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0225 0.0614
Onchocerca volvulus 0.0017 0.0035 0.5
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0225 0.0316
Echinococcus granulosus tar DNA binding protein 0.0076 0.4399 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4399 0.7277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.5
Echinococcus multilocularis GPCR, family 2 0.0031 0.1086 0.2453
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0664 0.2855
Toxoplasma gondii thioredoxin reductase 0.0048 0.2305 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4399 0.7262
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.6808 0.8837
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0035 0.0058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.7703 1
Leishmania major trypanothione reductase 0.0048 0.2305 0.6518
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.123
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0188 0.079
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.3121 0.8832
Echinococcus granulosus cathepsin l1 0.0017 0.0035 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0664 0.1861
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0188 0.041

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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