Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1998 | 0.1968 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0569 | 0.1541 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0138 | 0.0101 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0186 | 0.0149 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0138 | 0.0291 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0037 | 0.0099 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0569 | 0.1541 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0419 | 0.0383 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1621 | 0.4589 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0569 | 0.151 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1475 | 0.3914 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0138 | 0.0366 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1475 | 0.1443 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0336 | 0.0866 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0336 | 0.0866 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0037 | 0.0099 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0138 | 0.0291 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0138 | 0.0366 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0755 | 0.072 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1812 | 0.1782 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1807 | 0.1776 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0419 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2148 | 0.2119 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0138 | 0.0291 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1621 | 0.4589 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0138 | 0.0366 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0037 | 0.0099 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2714 | 0.2687 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0336 | 0.0891 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.469 | 0.467 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2714 | 0.2687 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0037 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1475 | 0.1443 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0138 | 0.0366 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.3769 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2714 | 0.2687 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2714 | 0.2687 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.3488 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.3488 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.4354 | 0.4333 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0138 | 0.0291 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 53 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.