Detailed information for compound 154855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.491 | Formula: C24H29NO5
  • H donors: 0 H acceptors: 1 LogP: 5.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)c1c(C)c(nc2c1c(OC)c(c(c2)OC)OC)C(C)C
  • InChi: 1S/C24H29NO5/c1-13(2)22-14(3)20(15-9-10-17(26-4)18(11-15)27-5)21-16(25-22)12-19(28-6)23(29-7)24(21)30-8/h9-13H,1-8H3
  • InChiKey: JMCJRXDPAVJZCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0023 0.0148 0.1637
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.0042
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0023 0.0143 0.1555
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Echinococcus granulosus intestinal type alkaline phosphatase 0.046 0.9162 1
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi G-protein coupled receptor 0.0048 0.0655 0.1313
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0655 0.0599
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.006 0.0059
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0023 0.0143 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0655 0.0682
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0655 0.0682
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0048 0.0655 0.1173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0023 0.0143 0.1914
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0107 0.0047
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0107 0.0158
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0044 0.0587 0.0608
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0224 0.4285 0.4658
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.1245 0.2607
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0143 0.1555
Echinococcus multilocularis tar DNA binding protein 0.0036 0.0417 0.036
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0655 0.0654
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0036 0.0409 0.5294
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0023 0.0143 0.0077
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0655 0.0599
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0655 0.0682
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Schistosoma mansoni hypothetical protein 0.0239 0.4604 0.5008
Brugia malayi Serotonin receptor 0.0048 0.0655 0.1313
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0107 0.0082
Onchocerca volvulus 0.0023 0.0143 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0107 0.0158
Loa Loa (eye worm) hypothetical protein 0.005 0.0708 0.1482
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0894 0.1817
Onchocerca volvulus 0.0023 0.0143 0.0077
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0587 0.0531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0023 0.0143 0.0091
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7885
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0107 0.0082
Trichomonas vaginalis steroid dehydrogenase, putative 0.0023 0.0143 0.1555
Loa Loa (eye worm) RNA binding protein 0.0036 0.0417 0.0873
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus granulosus sodium bile acid cotransporter 0.0247 0.4776 0.5181
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0143 0.5
Schistosoma mansoni amine GPCR 0.0048 0.0655 0.0682
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0107 0.0082
Echinococcus granulosus retinol dehydrogenase 11 0.0023 0.0143 0.0091
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0023 0.0143 0.5
Echinococcus multilocularis integrin alpha 3 0.0019 0.007 0.0011
Echinococcus multilocularis intestinal type alkaline phosphatase 0.046 0.9162 0.9157
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.003
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.0143 0.0083
Onchocerca volvulus 0.0023 0.0143 0.0077
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0023 0.0143 0.1914
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0587 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0098 0.1688 0.1638
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0143 0.1914
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0044 0.0587 0.7885
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0107 0.0047
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0044 0.0587 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0023 0.0143 0.5
Schistosoma mansoni myosin xvIII 0.0048 0.0655 0.0682
Schistosoma mansoni sodium-bile acid cotransporter related 0.0247 0.4776 0.5196
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Echinococcus multilocularis neuropeptide s receptor 0.0309 0.6056 0.6032
Brugia malayi nuclear hormone receptor 0.0021 0.0107 0.0158
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.0143 0.0083
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.046 0.9162 0.9157
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0587 0.117
Echinococcus multilocularis geminin 0.0201 0.3821 0.3784
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0023 0.0143 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0107 0.0158
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0023 0.0143 0.0121
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus granulosus somatostatin receptor 0.0048 0.0655 0.0654
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0023 0.0143 0.1995
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7885
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0367 0.0707
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0044 0.0587 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0023 0.0143 0.0298
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0143 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Trypanosoma cruzi short chain dehydrogenase, putative 0.0023 0.0143 0.1914
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.046 0.9162 0.9157
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0023 0.0143 0.0234
Brugia malayi Dopamine receptor 0.0048 0.0655 0.1313
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0023 0.0143 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0107 0.0223
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0041 0.0526 0.6931
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0023 0.0143 0.0083
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0046 0.0617 0.1233
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Echinococcus multilocularis serotonin receptor 0.0048 0.0655 0.0599
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0029 0.0271 0.2902
Echinococcus multilocularis neuropeptide receptor A26 0.0309 0.6056 0.6032
Schistosoma mansoni amine GPCR 0.0048 0.0655 0.0682
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus granulosus allatostatin A receptor 0.0048 0.0655 0.0654
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0655 0.0654
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Onchocerca volvulus 0.0048 0.0655 0.1173
Loa Loa (eye worm) hypothetical protein 0.005 0.0708 0.1482
Brugia malayi steroid hormone receptor 0.0021 0.0107 0.0158
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0655 0.0599
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0044 0.0587 0.0608
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus hormone sensitive lipase 0.0224 0.4285 0.4642
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus sodium bile acid cotransporter 0.0247 0.4776 0.5181
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0107 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Onchocerca volvulus 0.0023 0.0143 0.0077
Entamoeba histolytica hypothetical protein 0.002 0.0096 0.09
Onchocerca volvulus Sepiapterin reductase homolog 0.0023 0.0143 0.0077
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Echinococcus granulosus sodium bile acid cotransporter 0.0247 0.4776 0.5181
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0107 0.0082
Brugia malayi putative neuropeptide receptor 0.0048 0.0655 0.1313
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0107 0.0223
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Entamoeba histolytica hypothetical protein 0.002 0.0096 0.09
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni transcription factor LCR-F1 0.002 0.0096 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0655 0.0654
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0655 0.0599
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0143 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0309 0.6056 0.6587
Brugia malayi RNA binding protein 0.0036 0.0417 0.0812
Brugia malayi Dehydrogenases, short chain protein 30 0.0023 0.0143 0.0234
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0044 0.0587 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0587 0.0608
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.0587 0.0531
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0023 0.0143 0.1914
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0107 0.0082
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Onchocerca volvulus 0.0048 0.0655 0.1173
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0023 0.0143 0.0083
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0023 0.0143 0.1914
Schistosoma mansoni neuropeptide receptor 0.0048 0.0655 0.0682
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0023 0.0143 0.0091
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0218
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0023 0.0143 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0143 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0655 0.0682
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Onchocerca volvulus Neuropeptide F receptor homolog 0.0048 0.0655 0.1173
Onchocerca volvulus 0.0247 0.4776 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0098 0.1688 0.1814
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0655 0.0654
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Mycobacterium leprae Probable oxidoreductase 0.0023 0.0143 0.5
Echinococcus granulosus tar DNA binding protein 0.0036 0.0417 0.0393
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.046 0.9162 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0655 0.0654
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0107 0.0052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0052 0.0744 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.006 0.0059
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0052 0.0744 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0655 0.0654
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0587 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0587 0.0579
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0655 0.0599
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0107 0.0082
Echinococcus granulosus neuropeptide receptor 0.0048 0.0655 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0107 0.0158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0107 0.0052
Onchocerca volvulus 0.0048 0.0655 0.1173
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0107 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0143 0.5
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0044 0.0587 1
Brugia malayi TAR-binding protein 0.0036 0.0417 0.0812
Echinococcus multilocularis somatostatin receptor 0.0048 0.0655 0.0599
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0029 0.0272 0.0233
Brugia malayi G protein-coupled receptor 0.0048 0.0655 0.1313
Onchocerca volvulus 0.0048 0.0655 0.1173
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0068 0.107 0.2187
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0655 0.0599
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0023 0.0143 0.1995
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0587 0.0531
Echinococcus granulosus neuropeptide receptor 0.0048 0.0655 0.0654
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0655 0.137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0256 0.0246
Loa Loa (eye worm) dehydrogenase 0.0023 0.0143 0.0298
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.046 0.9162 1
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Schistosoma mansoni biogenic amine receptor 0.0048 0.0655 0.0682
Brugia malayi hypothetical protein 0.0023 0.0143 0.0234
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.0143 0.0083
Onchocerca volvulus 0.0048 0.0655 0.1173
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.002 0.0096 0.004
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0023 0.0143 0.1995
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0143 0.1914
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0029 0.0271 0.2902
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0044 0.0587 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0107 0.0052
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0023 0.0143 0.0077
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0655 0.0682
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.0143 0.1995
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Loa Loa (eye worm) dehydrogenase 0.0023 0.0143 0.0298
Echinococcus granulosus g protein coupled receptor 0.0048 0.0655 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0107 0.0158
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0023 0.0143 0.1555
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0107 0.0158
Echinococcus granulosus WW domain containing oxidoreductase 0.0023 0.0143 0.0091
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Echinococcus multilocularis sex peptide receptor 0.0048 0.0655 0.0599
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0655 0.0599
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0655 0.1313
Onchocerca volvulus 0.0023 0.0143 0.0077
Onchocerca volvulus 0.0023 0.0143 0.0077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0107 0.0223
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0143 0.5
Echinococcus granulosus integrin alpha 3 0.0019 0.007 0.0012
Schistosoma mansoni sodium-bile acid cotransporter 0.0147 0.2707 0.293
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0107 0.0047
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0044 0.0587 0.0608
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0107 0.0047
Echinococcus multilocularis steroid dehydrogenase 0.0023 0.0143 0.0083
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0655 0.0682
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0023 0.0143 0.1914
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.002 0.0096 0.0037
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0655 0.1313
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Trypanosoma brucei oxidoreductase-like protein 0.0023 0.0143 0.1995
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0655 0.0654
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0655 0.1313
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0655 0.0654
Echinococcus granulosus oxidoreductase 0.0023 0.0143 0.0091
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0655 0.0654
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0655 0.0599
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.003
Brugia malayi Dehydrogenases, short chain protein 2 0.0023 0.0143 0.0234
Schistosoma mansoni sodium-bile acid cotransporter related 0.01 0.1742 0.1874
Echinococcus granulosus sex peptide receptor 0.0048 0.0655 0.0654
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Echinococcus granulosus hypothetical protein 0.0023 0.0143 0.0091
Schistosoma mansoni hypothetical protein 0.004 0.0508 0.0521
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0023 0.0143 0.1914
Echinococcus multilocularis retinol dehydrogenase 13 0.0023 0.0143 0.0083
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0025 0.019 0.1075
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0023 0.0143 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0023 0.0143 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) integrin alpha pat-2 0.0089 0.15 0.3141
Echinococcus granulosus orexin receptor type 2 0.0048 0.0655 0.0654
Schistosoma mansoni hypothetical protein 0.0201 0.3821 0.415
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0655 0.0599
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0107 0.0158
Brugia malayi Sodium Bile acid symporter family protein 0.0247 0.4776 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.0587 0.058
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Schistosoma mansoni hypothetical protein 0.002 0.0096 0.007
Echinococcus multilocularis serotonin receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0143 0.1914
Brugia malayi neuropeptide F receptor 0.0048 0.0655 0.1313
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0044 0.0587 0.058
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0029 0.0272 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0894 0.1871
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0052 0.0744 1
Schistosoma mansoni amine GPCR 0.0048 0.0655 0.0682
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0107 0.0158
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0587 0.0579
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.0143 0.1995
Brugia malayi hypothetical protein 0.0023 0.0143 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0023 0.0143 0.1914
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0023 0.0143 0.0091
Echinococcus granulosus geminin 0.0201 0.3821 0.4132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0023 0.0143 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0052 0.0744 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Onchocerca volvulus 0.0048 0.0655 0.1173
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.006 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0143 0.1914
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0655 0.0599
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0107 0.0047
Loa Loa (eye worm) hypothetical protein 0.0059 0.0894 0.1871
Entamoeba histolytica hypothetical protein 0.002 0.0096 0.09
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.0143 0.1995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0272 0.0569
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0655 0.0654
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Onchocerca volvulus 0.0048 0.0655 0.1173
Schistosoma mansoni retinal dehydrogenase 0.0023 0.0143 0.0121
Brugia malayi G-protein coupled receptor 0.0048 0.0655 0.1313
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0107 0.0158
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0655 0.0682
Loa Loa (eye worm) TAR-binding protein 0.0036 0.0417 0.0873
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0023 0.0143 0.0121
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0655 0.1313
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0023 0.0143 0.1914
Entamoeba histolytica hypothetical protein 0.0023 0.0143 0.1555
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0655 0.137
Brugia malayi nuclear receptor NHR-88 0.0021 0.0107 0.0158
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0044 0.0587 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0036 0.0417 0.0873
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0655 0.0654
Echinococcus granulosus retinol dehydrogenase 11 0.0023 0.0143 0.0091
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0224 0.4285 0.4658
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0655 0.137
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0044 0.0587 0.7885
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0655 0.0654
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0655 0.0682
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0044 0.0587 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0744 0.1502
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0036 0.0409 0.5294
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni adenoreceptor 0.0048 0.0655 0.0682
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0029 0.0271 0.4318
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0655 0.0599
Echinococcus granulosus integrin alpha ps 0.004 0.0501 0.0485
Echinococcus granulosus carbonyl reductase 1 0.0023 0.0143 0.0091
Brugia malayi neuropeptide F receptor 0.0048 0.0655 0.1313
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0107 0.0223
Schistosoma mansoni integrin alpha-ps 0.0021 0.0104 0.0079
Entamoeba histolytica hypothetical protein 0.0041 0.0526 0.6931
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0143 0.1914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0655 0.0682
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0655 0.137
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0107 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0023 0.0143 0.5
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0044 0.0587 0.1171
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0417 0.0422
Onchocerca volvulus 0.0023 0.0143 0.0077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0655 0.0599
Schistosoma mansoni hypothetical protein 0.0048 0.0655 0.0682
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0894 0.1817
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0042 0.0547 0.0491
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0655 0.0682
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Loa Loa (eye worm) hypothetical protein 0.0068 0.107 0.2239
Brugia malayi hypothetical protein 0.005 0.0708 0.1425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0107 0.0223
Brugia malayi Dopamine receptor protein 1 0.0048 0.0655 0.1313
Onchocerca volvulus 0.0048 0.0655 0.1173
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0107 0.0158
Loa Loa (eye worm) hypothetical protein 0.0224 0.4285 0.8971
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Brugia malayi dehydrogenases, short chain protein 9 0.0023 0.0143 0.0234
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi sulfakinin receptor protein 0.0048 0.0655 0.1313
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0655 0.0599
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0023 0.0143 0.1914
Schistosoma mansoni carbonyl reductase 0.0023 0.0143 0.0121
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0143 0.5
Onchocerca volvulus 0.0048 0.0655 0.1173
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0655 0.0599
Schistosoma mansoni neuropeptide receptor 0.0048 0.0655 0.0682
Echinococcus multilocularis retinol dehydrogenase 11 0.0023 0.0143 0.0083
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0655 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0107 0.0158
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.0143 0.1995
Mycobacterium tuberculosis Probable dehydrogenase 0.0023 0.0143 0.5
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0031 0.0304 0.0636
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0107 0.0082
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0023 0.0143 0.1914
Onchocerca volvulus 0.0048 0.0655 0.1173
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0655 0.0599
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Echinococcus multilocularis hormone sensitive lipase 0.0224 0.4285 0.4251
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0218
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0023 0.0143 0.0091
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0044 0.0587 1
Schistosoma mansoni carbonyl reductase 0.0023 0.0143 0.0121
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0023 0.0143 0.1995
Brugia malayi RE15519p 0.0048 0.0655 0.1313
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Trypanosoma cruzi short chain dehydrogenase, putative 0.0023 0.0143 0.1914
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0028 0.0256 0.0536
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0044 0.0587 0.7885
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0655 0.0682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0224 0.4285 0.4658
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0655 0.137
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0744 1
Echinococcus multilocularis oxidoreductase 0.0023 0.0143 0.0083
Echinococcus multilocularis integrin alpha ps 0.004 0.0501 0.0444
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0655 0.0599
Onchocerca volvulus 0.0048 0.0655 0.1173
Onchocerca volvulus 0.0048 0.0655 0.1173
Brugia malayi oxidoreductase 0.0023 0.0143 0.0234
Schistosoma mansoni integrin alpha-ps 0.004 0.0501 0.0514
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0655 0.0682
Echinococcus multilocularis alkaline phosphatase 0.046 0.9162 0.9157
Echinococcus multilocularis conserved hypothetical protein 0.0023 0.0143 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni carbonyl reductase 0.0023 0.0143 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0655 0.0682
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0256 0.0216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0107 0.0047
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0023 0.0143 0.1995
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0044 0.0587 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0655 0.0654
Loa Loa (eye worm) oxidoreductase 0.0023 0.0143 0.0298
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0107 0.0082
Brugia malayi GnHR receptor homolog 0.0048 0.0655 0.1313
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0417 0.0422
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0044 0.0587 0.5
Echinococcus granulosus carbonyl reductase 1 0.0023 0.0143 0.0091
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0023 0.0143 0.1914
Echinococcus multilocularis integrin alpha ps 0.004 0.0501 0.0444
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0143 0.1914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Echinococcus granulosus carbonyl reductase 1 0.0023 0.0143 0.0091
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus multilocularis sodium bile acid cotransporter 0.0247 0.4776 0.4745
Echinococcus granulosus steroid dehydrogenase 0.0023 0.0143 0.0091
Schistosoma mansoni neuropeptide receptor 0.0048 0.0655 0.0682
Onchocerca volvulus 0.0048 0.0655 0.1173
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0029 0.0272 0.3371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0029 0.0272 0.0569
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0655 0.0682
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0107 0.0082
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0655 0.137
Schistosoma mansoni histamine h1 receptor 0.0048 0.0655 0.0682
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0029 0.0271 0.3647
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0023 0.0143 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Onchocerca volvulus 0.0023 0.0143 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0298
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0034 0.0367 0.0338
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0655 0.0599
Schistosoma mansoni neuropeptide receptor 0.0048 0.0655 0.0682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0107 0.0223
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0655 0.137
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0655 0.137
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0655 0.0599
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0417 0.0422
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0107 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Echinococcus multilocularis integrin alpha ps 0.0019 0.007 0.0011
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Loa Loa (eye worm) hypothetical protein 0.0044 0.0587 0.123
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0655 0.0654
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0031 0.0304 0.0636
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0143 0.5
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus g protein coupled receptor 0.0048 0.0655 0.0654
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0655 0.137
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0655 0.1313
Entamoeba histolytica short chain dehydrogenase family protein 0.0023 0.0143 0.1555
Brugia malayi ORL1-like opioid receptor 0.0048 0.0655 0.1313
Echinococcus granulosus alkaline phosphatase 0.046 0.9162 1
Brugia malayi Melatonin receptor type 1A 0.0048 0.0655 0.1313
Schistosoma mansoni integrin alpha 0.004 0.0501 0.0514
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0023 0.0143 0.5
Echinococcus multilocularis sodium bile acid cotransporter 0.0247 0.4776 0.4745
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0023 0.0143 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0655 0.0654
Onchocerca volvulus 0.0048 0.0655 0.1173
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.0143 0.1555
Onchocerca volvulus 0.0103 0.1792 0.3609
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0023 0.0143 0.1555
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0655 0.0599
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0587 0.0608
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0655 0.0682
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0655 0.0682
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7885
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0655 0.0599
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0107 0.0158
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0655 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0107 0.0052
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7885
Entamoeba histolytica hypothetical protein 0.002 0.0096 0.09
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0143 0.5
Loa Loa (eye worm) hypothetical protein 0.0247 0.4776 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0107 0.0158
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0655 0.0599
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0044 0.0587 0.0608
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0029 0.0271 0.3647
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Schistosoma mansoni opsin-like receptor 0.0048 0.0655 0.0682
Schistosoma mansoni biogenic amine receptor 0.0048 0.0655 0.0682
Schistosoma mansoni amine GPCR 0.0048 0.0655 0.0682
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0655 0.137
Schistosoma mansoni hypothetical protein 0.0201 0.3821 0.415
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Brugia malayi larval opioid receptor 0.0048 0.0655 0.1313
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0107 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0655 0.1313
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0023 0.0143 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0107 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0417 0.0422
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0023 0.0143 0.1914
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.0143 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni tar DNA-binding protein 0.0036 0.0417 0.0422
Echinococcus granulosus fmrfamide receptor 0.0048 0.0655 0.0654
Schistosoma mansoni hypothetical protein 0.0048 0.0655 0.0682
Echinococcus granulosus hypothetical protein 0.0048 0.0655 0.0654
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0655 0.137
Onchocerca volvulus 0.0048 0.0655 0.1173
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0023 0.0143 0.1914
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus neuropeptide s receptor 0.0309 0.6056 0.6587
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0034 0.0367 0.0309
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Schistosoma mansoni biogenic amine receptor 0.0048 0.0655 0.0682
Brugia malayi MH2 domain containing protein 0.0076 0.1245 0.2558
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0655 0.1313
Brugia malayi hypothetical protein 0.002 0.0096 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi dehydrogenases, short chain protein 2 0.0023 0.0143 0.0234
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0223
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0023 0.0143 0.5
Echinococcus granulosus g protein coupled receptor 0.0048 0.0655 0.0654
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0023 0.0143 0.0234
Echinococcus granulosus hypothetical protein 0.0023 0.0143 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0147
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0017 0.0032 0.0426
Echinococcus granulosus carbonyl reductase 1 0.0023 0.0143 0.0091
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0655 0.0599
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0023 0.0143 0.0121
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0655 0.0654
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0655 0.0654
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0655 0.0654
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0029 0.0272 0.3371
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0508 0.1003
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0587 0.7791
Schistosoma mansoni hypothetical protein 0.0048 0.0655 0.0682
Brugia malayi RNA recognition motif domain containing protein 0.0036 0.0417 0.0812
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0023 0.0143 0.5
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0023 0.0143 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0023 0.0143 0.1555
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.1469 0.3076
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0655 0.0654
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0023 0.0143 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0107 0.0047
Brugia malayi Integrin alpha pat-2 precursor 0.004 0.0501 0.0989
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0107 0.0223
Schistosoma mansoni alkaline phosphatase 0.046 0.9162 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0655 0.0682
Schistosoma mansoni alkaline phosphatase 0.046 0.9162 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0655 0.0599
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0052 0.0744 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0655 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0107 0.0158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Echinococcus multilocularis retinol dehydrogenase 11 0.0023 0.0143 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0655 0.0599
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0023 0.0143 0.1914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0107 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0256 0.0246
Brugia malayi Dopamine receptor protein 2 0.0048 0.0655 0.1313
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0023 0.0143 0.5
Onchocerca volvulus 0.0023 0.0143 0.0077
Brugia malayi AKH receptor 0.0048 0.0655 0.1313
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0023 0.0143 0.1555
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.003
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0044 0.0587 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0106
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0655 0.0682
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0029 0.0272 0.0569
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0655 0.0654
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0655 0.0682
Schistosoma mansoni steroid dehydrogenase 0.0023 0.0143 0.0121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi ecdysteroid receptor 0.0021 0.0107 0.0158
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0655 0.0654
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0655 0.0599
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0107 0.0082
Onchocerca volvulus 0.0023 0.0143 0.0077
Echinococcus granulosus integrin alpha ps 0.0019 0.007 0.0012
Brugia malayi Serotonin receptor 0.0048 0.0655 0.1313
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Onchocerca volvulus 0.0048 0.0655 0.1173
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0655 0.0599
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0655 0.0654
Loa Loa (eye worm) hypothetical protein 0.0034 0.0367 0.0769
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0023 0.0143 0.0234
Brugia malayi Retinol dehydrogenase 12 0.0023 0.0143 0.0234
Schistosoma mansoni opsin-like receptor 0.0048 0.0655 0.0682
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0044 0.0587 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0107 0.0158
Brugia malayi hypothetical protein 0.0048 0.0655 0.1313
Schistosoma mansoni hypothetical protein 0.0048 0.0655 0.0682
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0028 0.0256 0.0473
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0655 0.0654
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.0143 0.1995
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0655 0.0599
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0023 0.0143 0.0077
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0098 0.1688 0.1789
Onchocerca volvulus 0.0048 0.0655 0.1173
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0023 0.0143 0.1914
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Schistosoma mansoni amine GPCR 0.0048 0.0655 0.0682
Schistosoma mansoni coup transcription factor 0.0021 0.0107 0.0082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0107 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0655 0.137
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0655 0.1313
Schistosoma mansoni opsin-like receptor 0.0048 0.0655 0.0682
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0143 0.0234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0107 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0107 0.0052
Schistosoma mansoni hypothetical protein 0.0019 0.006 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0256 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0655 0.0654
Echinococcus multilocularis sodium bile acid cotransporter 0.0247 0.4776 0.4745
Schistosoma mansoni eyes absent homolog 0.005 0.0708 0.0741
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0107 0.0047
Onchocerca volvulus 0.0023 0.0143 0.0077
Schistosoma mansoni short chain dehydrogenase 0.0023 0.0143 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0028 0.0256 0.0246
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.005 0.0713 0.9555
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0655 0.0599
Loa Loa (eye worm) hypothetical protein 0.004 0.0508 0.1063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0028 0.0256 0.0198
Onchocerca volvulus 0.0023 0.0143 0.0077
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0023 0.0143 0.0121
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.0143 0.1555
Onchocerca volvulus 0.0023 0.0143 0.0077
Echinococcus multilocularis steroid dehydrogenase 0.0023 0.0143 0.0083
Loa Loa (eye worm) transcription factor SMAD2 0.0076 0.1245 0.2607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0028 0.0256 0.0216
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0655 0.1313
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0023 0.0143 0.1555
Echinococcus granulosus serotonin receptor 0.0048 0.0655 0.0654

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 21.4 % In vitro for inhibition of [14C]-taurocholate uptake in baby hamster kidney cells transfected with the cDNA of human Bile acid transporter (H14 cells) at 50 uM ChEMBL. 10698453
Inhibition (binding) = 21.4 % In vitro for inhibition of [14C]-taurocholate uptake in baby hamster kidney cells transfected with the cDNA of human Bile acid transporter (H14 cells) at 50 uM ChEMBL. 10698453

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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