Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0993 | 0.0993 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.2586 | 0.2586 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.4353 | 0.6632 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 0.4353 | 0.4353 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.6564 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.6564 | 0.6564 |
Brugia malayi | hypothetical protein | 0.0148 | 0.5618 | 0.5618 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5618 | 0.5618 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0307 | 0.0307 |
Brugia malayi | RNA binding protein | 0.0124 | 0.4353 | 0.4353 |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 0.4353 | 0.4353 |
Onchocerca volvulus | 0.0148 | 0.5618 | 1 | |
Brugia malayi | TAR-binding protein | 0.0124 | 0.4353 | 0.4353 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.2586 | 0.2586 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0138 | 0.5069 | 0.5069 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0489 | 0.0489 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0993 | 0.0993 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0138 | 0.5069 | 0.5069 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.4353 | 0.6632 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0308 | 0.0469 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 0.4353 | 0.4353 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 0.4353 | 0.4353 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.2894 | 0.2894 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.4353 | 0.6632 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0993 | 0.0993 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0308 | 0.0469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.4353 | 0.6632 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.6564 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.2894 | 0.2894 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 0.4353 | 0.4353 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.2972 | 0.4528 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.2894 | 0.2894 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 0.4353 | 0.4353 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2894 | 0.2894 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.2894 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0308 | 0.0308 |
Echinococcus multilocularis | geminin | 0.0166 | 0.6564 | 0.6564 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.4353 | 0.6632 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0993 | 0.0993 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.