Detailed information for compound 1548831

Basic information

Technical information
  • TDR Targets ID: 1548831
  • Name: N-[2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoe thyl]-N-methylimidazo[1,2-a]pyridine-2-carbox amide
  • MW: 372.806 | Formula: C18H17ClN4O3
  • H donors: 1 H acceptors: 3 LogP: 3.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CN(C(=O)c1nc2n(c1)cccc2)C)Cl
  • InChi: 1S/C18H17ClN4O3/c1-22(18(25)14-10-23-8-4-3-5-16(23)20-14)11-17(24)21-13-9-12(19)6-7-15(13)26-2/h3-10H,11H2,1-2H3,(H,21,24)
  • InChiKey: KSEKZEUEZMRTCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(5-chloro-2-methoxy-phenyl)amino]-2-oxo-ethyl]-N-methyl-imidazo[1,2-a]pyridine-2-carboxamide
  • N-[2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl]-N-methyl-2-imidazo[1,2-a]pyridinecarboxamide
  • N-[2-[(5-chloro-2-methoxy-phenyl)amino]-2-keto-ethyl]-N-methyl-imidazo[1,2-a]pyridine-2-carboxamide
  • T5350181

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Trypanosoma brucei unspecified product 0.0021 0.0021 0.1266
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0027
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0054 0.006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0455 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0595 0.4009
Brugia malayi hypothetical protein 0.0134 0.0542 0.0604
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0209 0.0233
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0209 0.0233
Echinococcus multilocularis carboxylesterase 5A 0.1974 0.8962 0.8962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0027
Brugia malayi Carboxylesterase family protein 0.0334 0.1453 0.1622
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.1295 1
Onchocerca volvulus 0.0052 0.0163 0.0649
Echinococcus multilocularis musashi 0.0062 0.0209 0.0209
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0012 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0001 0.0034
Onchocerca volvulus 0.0486 0.215 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0038 0.0099 0.011
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0209 0.0233
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0166 0.7413
Echinococcus granulosus para nitrobenzyl esterase 0.0334 0.1453 0.1453
Schistosoma mansoni cpg binding protein 0.0064 0.0221 0.0221
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0166 0.0166
Brugia malayi hypothetical protein 0.0038 0.0099 0.011
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.1295 1
Echinococcus multilocularis acetylcholinesterase 0.1974 0.8962 0.8962
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0057 0.0941
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0025 0.0025
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0166 0.3649
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0057 1
Echinococcus multilocularis acetylcholinesterase 0.1974 0.8962 0.8962
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0025 0.0025
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0055 0.0177 0.0197
Echinococcus multilocularis aryl hydrocarbon receptor 0.0055 0.0177 0.0177
Brugia malayi heat shock protein 90 0.0036 0.009 0.01
Brugia malayi CXXC zinc finger family protein 0.0061 0.0205 0.0229
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0166 0.0166
Brugia malayi jmjC domain containing protein 0.006 0.0202 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0224 0.1415
Brugia malayi Carboxylesterase family protein 0.1974 0.8962 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0057 0.0279
Schistosoma mansoni single-minded 0.0016 0.0001 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.003 0.0034
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0205 0.0229
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0001 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0017 0.0004 0.0004
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0059 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0595 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0045 0.2689
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.1084 0.1084
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0057 0.0385
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Loa Loa (eye worm) heat shock protein 90 0.0036 0.009 0.01
Loa Loa (eye worm) hypothetical protein 0.0118 0.0466 0.052
Onchocerca volvulus Protein cycle homolog 0.0039 0.0103 0.0368
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0276 0.0276
Brugia malayi Carboxylesterase family protein 0.0334 0.1453 0.1622
Entamoeba histolytica hypothetical protein 0.0076 0.0276 0.1998
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0224 0.1415
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0078 0.0087
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0045 0.2689
Brugia malayi hypothetical protein 0.0253 0.1084 0.1209
Schistosoma mansoni BC026374 protein (S09 family) 0.0334 0.1453 0.1453
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.1084 0.1084
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Loa Loa (eye worm) hypothetical protein 0.0069 0.0241 0.0269
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0078 0.0087
Schistosoma mansoni lozenge 0.0061 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Brugia malayi steroid hormone receptor 0.0021 0.0025 0.0027
Schistosoma mansoni endoplasmin 0.0036 0.009 0.009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0452 0.0505
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0025 0.0025
Schistosoma mansoni gliotactin 0.0334 0.1453 0.1453
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.003 0.0066
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0052 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0359 0.1571 0.1571
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0025 0.0025
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0017 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0013 0.0013
Echinococcus granulosus aryl hydrocarbon receptor 0.0055 0.0177 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0027
Schistosoma mansoni hypothetical protein 0.0036 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.011
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0057 0.0385
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0202 0.0202
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0334 0.1453 0.1453
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0141
Loa Loa (eye worm) hypothetical protein 0.0115 0.0452 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0027
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.009 0.0539
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.009 0.5411
Brugia malayi PAS domain containing protein 0.0016 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0218 0.0218
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.009 0.5411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0224 0.0224
Schistosoma mansoni survival motor neuron protein 0.0052 0.0163 0.0163
Echinococcus granulosus flap endonuclease 1 0.0028 0.0054 0.0054
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0119 0.047 0.0524
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0093 0.0093
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0057 0.0248
Echinococcus multilocularis dnaJ subfamily B 0.0867 0.3896 0.3896
Plasmodium falciparum endoplasmin, putative 0.0022 0.0027 0.1607
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0286 0.0319
Schistosoma mansoni hypothetical protein 0.0036 0.0093 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.2201 1 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0166 1
Treponema pallidum heat shock protein 90 0.0028 0.0057 0.0206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0093 0.0104
Brugia malayi hypothetical protein 0.0486 0.215 0.2399
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0166 0.0185
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0025 0.0025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0025 0.0027
Brugia malayi nuclear hormone receptor 0.0021 0.0025 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Trichomonas vaginalis spcc417.12 protein, putative 0.0334 0.1453 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0224 0.4922
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0118 0.0466 0.052
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0001 0.0034
Entamoeba histolytica hypothetical protein 0.0076 0.0276 0.1998
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0045 0.2689
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.009 0.5411
Echinococcus granulosus dna polymerase eta 0.0048 0.0146 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0093 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0224 0.1415
Brugia malayi Carboxylesterase family protein 0.1974 0.8962 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Brugia malayi hypothetical protein 0.0054 0.0173 0.0193
Loa Loa (eye worm) hypothetical protein 0.0134 0.0542 0.0604
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0027 0.018
Trichomonas vaginalis heat shock protein, putative 0.0036 0.009 0.0614
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0027 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0218 0.0243
Schistosoma mansoni aryl hydrocarbon receptor 0.0017 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0153 0.0626 0.0699
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Echinococcus multilocularis dna polymerase eta 0.0048 0.0146 0.0146
Schistosoma mansoni cpg binding protein 0.0061 0.0205 0.0205
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Brugia malayi nuclear receptor NHR-88 0.0021 0.0025 0.0027
Brugia malayi hypothetical protein 0.0017 0.0003 0.0003
Echinococcus granulosus acetylcholinesterase 0.1974 0.8962 0.8962
Loa Loa (eye worm) hypothetical protein 0.0486 0.215 0.2399
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0334 0.1453 0.6721
Plasmodium vivax endoplasmin, putative 0.0036 0.009 0.5411
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0093 0.0104
Schistosoma mansoni lamin 0.0062 0.0209 0.0209
Echinococcus granulosus lamin 0.0062 0.0209 0.0209
Onchocerca volvulus 0.0334 0.1453 0.6721
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0166 0.0166
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0054 0.3256
Onchocerca volvulus 0.0062 0.0209 0.0866
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0001 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Plasmodium vivax heat shock protein 86, putative 0.0036 0.009 0.5411
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0054 0.0368
Loa Loa (eye worm) hypothetical protein 0.0253 0.1084 0.1209
Echinococcus granulosus carboxylesterase 5A 0.1974 0.8962 0.8962
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.0146 0.0163
Schistosoma mansoni coup transcription factor 0.0021 0.0025 0.0025
Brugia malayi hypothetical protein 0.0334 0.1453 0.1622
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.003 0.0206
Schistosoma mansoni hypothetical protein 0.0359 0.1571 0.1571
Schistosoma mansoni hypothetical protein 0.0036 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0061 0.0204 0.0227
Leishmania major hypothetical protein, conserved 0.0026 0.0045 0.1993
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0146 0.8783
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Schistosoma mansoni hypothetical protein 0.0079 0.0286 0.0286
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.009 0.1974
Loa Loa (eye worm) hypothetical protein 0.0026 0.0045 0.005
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.003 0.0206
Onchocerca volvulus 0.0334 0.1453 0.6721
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0039 0.0103 0.0115
Plasmodium falciparum flap endonuclease 1 0.0028 0.0054 0.3256
Onchocerca volvulus 0.0334 0.1453 0.6721
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0027
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0021
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Schistosoma mansoni acetylcholinesterase 0.0334 0.1453 0.1453
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0076 0.0276 0.0276
Schistosoma mansoni ap endonuclease 0.0023 0.003 0.003
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0057 0.0248
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0027
Echinococcus granulosus neuroligin 0.0334 0.1453 0.1453
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0021
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0334 0.1453 1
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.009 0.5411
Onchocerca volvulus Huntingtin homolog 0.0134 0.0542 0.2432
Schistosoma mansoni memapsin-2 (A01 family) 0.0229 0.0975 0.0975
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0626 0.0626
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1266
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0054 0.2414
Echinococcus granulosus heat shock protein 0.0036 0.009 0.009
Echinococcus granulosus acetylcholinesterase 0.1974 0.8962 0.8962
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0146 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0025 0.0025
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0025 0.0025
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.011
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0001 0.0034
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Loa Loa (eye worm) hypothetical protein 0.0134 0.0542 0.0604
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.003 0.1839
Loa Loa (eye worm) carboxylesterase 0.0334 0.1453 0.1622
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0218 0.0218
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0001 0.0034
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0166 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0027
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0163 0.067 0.0748
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0526 0.0587
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0057 0.3407
Echinococcus multilocularis lamin dm0 0.0062 0.0209 0.0209
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0025 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Echinococcus multilocularis cpg binding protein 0.0064 0.0221 0.0221
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0025 0.0025
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0202 0.0202
Schistosoma mansoni jumonji domain containing protein 0.006 0.0202 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0025 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0334 0.1453 0.1453
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0054 0.0054
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Loa Loa (eye worm) runx1 0.0061 0.0206 0.0229
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0023 0.1379
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0021
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.009 0.5411
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.009 0.5411
Onchocerca volvulus 0.0061 0.0205 0.085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0045 0.2689
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0334 0.1453 0.1453
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0166 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0166 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.003 0.1363
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0023 0.0034 0.5
Echinococcus multilocularis endoplasmin 0.0028 0.0057 0.0057
Echinococcus granulosus transcription factor eb 0.0119 0.047 0.047
Echinococcus granulosus GPCR family 2 0.0036 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0027
Echinococcus granulosus geminin 0.0359 0.1571 0.1571
Brugia malayi isocitrate dehydrogenase 0.0052 0.0166 0.0185
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0334 0.1453 0.1453
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0039 0.0103 0.0115
Schistosoma mansoni heat shock protein 0.0036 0.009 0.009
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1266
Loa Loa (eye worm) hypothetical protein 0.0153 0.0626 0.0699
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.003 0.1839
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0062 0.0209 0.0233
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0045 0.2689
Echinococcus multilocularis Protein lozenge 0.0061 0.0206 0.0206
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4408 0.4408
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.009 0.5411
Mycobacterium ulcerans carboxylesterase, LipT 0.0334 0.1453 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0081 0.1772
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0093 0.0093
Schistosoma mansoni lamin 0.0062 0.0209 0.0209
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.003 0.1839
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Brugia malayi Carboxylesterase family protein 0.0334 0.1453 0.1622
Loa Loa (eye worm) hypothetical protein 0.0128 0.0513 0.0572
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0039 0.0103 0.0115
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0025 0.0027
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0939
Brugia malayi hypothetical protein 0.0026 0.0045 0.005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0063 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0166 0.3649
Loa Loa (eye worm) hypothetical protein 0.1974 0.8962 1
Brugia malayi intermediate filament protein 0.0062 0.0209 0.0233
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Loa Loa (eye worm) hypothetical protein 0.1974 0.8962 1
Schistosoma mansoni hypothetical protein 0.0867 0.3896 0.3896
Schistosoma mansoni cpg binding protein 0.0064 0.0221 0.0221
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0224 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0027
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0001 0.0034
Echinococcus multilocularis BC026374 protein (S09 family) 0.0334 0.1453 0.1453
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.009 0.5411
Onchocerca volvulus 0.0062 0.0209 0.0866
Loa Loa (eye worm) hypothetical protein 0.0079 0.0286 0.0319
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0166 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.009 0.0539
Toxoplasma gondii exonuclease III APE 0.0023 0.003 0.0671
Echinococcus granulosus endoplasmin 0.0028 0.0057 0.0057
Brugia malayi Carboxylesterase family protein 0.0334 0.1453 0.1622
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0146 0.8783
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0224 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0025 0.0027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0093 0.0093
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0224 0.0224
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.009 0.0539
Brugia malayi MH2 domain containing protein 0.0131 0.0526 0.0587
Echinococcus granulosus muscleblind protein 0.0153 0.0626 0.0626
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0057 0.0385
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1295 1
Echinococcus granulosus heat shock protein 90 0.0028 0.0057 0.0057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.003 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0025 0.0027
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0057 0.2526
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0081 0.4856
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.0452 0.0505
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0025 0.0025
Giardia lamblia Grp94/Hsp90 0.0028 0.0057 0.0279
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0939
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0276 0.0276
Echinococcus granulosus heat shock protein 90 0.0036 0.009 0.009
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0334 0.1453 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0334 0.1453 0.1453
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0045 0.0981
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.003 0.003
Echinococcus multilocularis GPCR, family 2 0.0036 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0064
Brugia malayi hypothetical protein 0.0076 0.0276 0.0308
Loa Loa (eye worm) carboxylesterase 0.0334 0.1453 0.1622
Onchocerca volvulus 0.0054 0.0173 0.0698
Echinococcus granulosus intermediate filament protein 0.0062 0.0209 0.0209
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0054 0.3256
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.011
Leishmania major protein kinase, putative 0.0016 0.0001 0.0025
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0036 0.0093 0.0093
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0054 0.1188
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0163 0.0181
Leishmania major protein kinase, putative 0.0016 0.0001 0.0025
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0218 0.0218
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0025
Mycobacterium tuberculosis Carboxylesterase LipT 0.0334 0.1453 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Schistosoma mansoni flap endonuclease-1 0.0025 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.003 0.1839
Echinococcus granulosus dnaJ subfamily B 0.0867 0.3896 0.3896
Loa Loa (eye worm) endoplasmin 0.0036 0.009 0.01
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0025 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.003 0.0066
Brugia malayi ecdysteroid receptor 0.0021 0.0025 0.0027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.003 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0013 0.0014
Echinococcus multilocularis muscleblind protein 0.0153 0.0626 0.0626
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0166 1
Brugia malayi hypothetical protein 0.0039 0.0103 0.0115
Schistosoma mansoni microtubule-associated protein tau 0.2201 1 1
Onchocerca volvulus 0.0334 0.1453 0.6721
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0027
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1974 0.8962 0.8962
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0166 1
Echinococcus multilocularis transcription factor eb 0.0119 0.047 0.047
Toxoplasma gondii heat shock protein HSP90 0.0036 0.009 0.1974
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0276 0.0276
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0023
Loa Loa (eye worm) hypothetical protein 0.0486 0.215 0.2399
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0013 0.0013
Leishmania major DNA polymerase eta, putative 0.0034 0.0081 0.36
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0034 0.0084 0.0093
Echinococcus multilocularis heat shock protein 90 0.0028 0.0057 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Echinococcus granulosus BC026374 protein S09 family 0.0334 0.1453 0.1453
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0141
Echinococcus multilocularis geminin 0.0359 0.1571 0.1571
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Echinococcus multilocularis heat shock protein 0.0036 0.009 0.009
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.003 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0025 0.0025
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0054 0.3256
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0064
Leishmania major DNA polymerase eta, putative 0.0048 0.0146 0.6511
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Plasmodium falciparum heat shock protein 90 0.0036 0.009 0.5411
Brugia malayi Flap endonuclease-1 0.0028 0.0054 0.006
Schistosoma mansoni intermediate filament proteins 0.0062 0.0209 0.0209
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0025
Brugia malayi Endoplasmin precursor 0.0036 0.009 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0057 0.3407
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0166 0.1011
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0054 0.0259
Echinococcus multilocularis lamin 0.0062 0.0209 0.0209
Echinococcus granulosus lamin dm0 0.0062 0.0209 0.0209
Loa Loa (eye worm) carboxylesterase 0.1974 0.8962 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0045 0.2689
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0595 0.4009
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0093 0.0104
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0166 0.0185
Echinococcus granulosus cpg binding protein 0.0064 0.0221 0.0221
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0025
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0054 0.0259
Loa Loa (eye worm) hypothetical protein 0.0054 0.0173 0.0193
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0093 0.0093
Echinococcus multilocularis heat shock protein 90 0.0036 0.009 0.009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.003 0.1839
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.003 0.0075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.011
Echinococcus multilocularis neuroligin 0.0334 0.1453 0.1453
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0334 0.1453 0.1453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1295 0.8912
Onchocerca volvulus Huntingtin homolog 0.0134 0.0542 0.2432
Loa Loa (eye worm) hypothetical protein 0.0334 0.1453 0.1622
Loa Loa (eye worm) acetylcholinesterase 1 0.1974 0.8962 1
Schistosoma mansoni heat shock protein 0.0036 0.009 0.009
Leishmania major heat shock protein 83-1 0.0036 0.009 0.4011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0025 0.0027
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1295 1
Entamoeba histolytica hypothetical protein 0.0076 0.0276 0.1998
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0025
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0202 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0027
Schistosoma mansoni neuroligin 3 (S09 family) 0.0334 0.1453 0.1453
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0334 0.1453 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0016 0.0016
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0526 0.0587
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0039 0.0103 0.0103
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0057 0.0057
Brugia malayi jmjC domain containing protein 0.0064 0.0218 0.0243
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0025 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0518 0.0518
Schistosoma mansoni DNA polymerase eta 0.0048 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0076 0.0276 0.1998
Schistosoma mansoni ap endonuclease 0.0023 0.003 0.003
Brugia malayi Muscleblind-like protein 0.0153 0.0626 0.0699
Trypanosoma brucei heat shock protein, putative 0.0036 0.009 0.5411
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0025 0.0027
Schistosoma mansoni endoplasmin 0.0036 0.009 0.009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0452 0.0505

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0336 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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