Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | No references |
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cardiolipin synthetase | 0.0043 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0338 | 0.1591 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0338 | 0.1591 | 0.114 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2003 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0338 | 0.1591 | 0.1591 |
Onchocerca volvulus | 0.0338 | 0.1591 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0338 | 0.1591 | 0.1591 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2003 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0409 | 0.0409 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0338 | 0.1591 | 0.1591 |
Onchocerca volvulus | 0.0338 | 0.1591 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0338 | 0.1591 | 0.1591 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0338 | 0.1591 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0338 | 0.1591 | 0.114 |
Echinococcus granulosus | carboxylesterase 5A | 0.2003 | 1 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.0509 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0338 | 0.1591 | 0.1591 |
Brugia malayi | Phospholipase d protein 1 | 0.0124 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Brugia malayi | Carboxylesterase family protein | 0.0338 | 0.1591 | 0.1591 |
Schistosoma mansoni | gliotactin | 0.0338 | 0.1591 | 0.114 |
Echinococcus multilocularis | phospholipase D | 0.011 | 0.0436 | 0.0436 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.029 | 0.029 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0338 | 0.1591 | 0.114 |
Brugia malayi | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Echinococcus granulosus | acetylcholinesterase | 0.2003 | 1 | 1 |
Echinococcus granulosus | phospholipase D1 | 0.0124 | 0.0509 | 0.0509 |
Loa Loa (eye worm) | hypothetical protein | 0.2003 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2003 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2003 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0338 | 0.1591 | 0.1591 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0338 | 0.1591 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0409 | 0.0409 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0338 | 0.1591 | 0.114 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0338 | 0.1591 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.029 | 0.029 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0338 | 0.1591 | 0.5 |
Echinococcus multilocularis | phospholipase D1 | 0.0124 | 0.0509 | 0.0509 |
Brugia malayi | Carboxylesterase family protein | 0.0338 | 0.1591 | 0.1591 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0338 | 0.1591 | 0.5 |
Onchocerca volvulus | 0.0338 | 0.1591 | 1 | |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.01 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0338 | 0.1591 | 0.1591 |
Brugia malayi | Carboxylesterase family protein | 0.2003 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0338 | 0.1591 | 0.1591 |
Schistosoma mansoni | acetylcholinesterase | 0.0338 | 0.1591 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Brugia malayi | Carboxylesterase family protein | 0.0338 | 0.1591 | 0.1591 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0043 | 0.01 | 0.5 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0338 | 0.1591 | 0.1591 |
Echinococcus granulosus | acetylcholinesterase | 0.2003 | 1 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.0509 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0043 | 0.01 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0338 | 0.1591 | 0.1591 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0043 | 0.01 | 0.01 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0043 | 0.01 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2003 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0338 | 0.1591 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Onchocerca volvulus | 0.0338 | 0.1591 | 1 | |
Onchocerca volvulus | 0.0338 | 0.1591 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0338 | 0.1591 | 0.114 |
Echinococcus multilocularis | acetylcholinesterase | 0.2003 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.1591 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.2003 | 1 | 1 |
Echinococcus granulosus | phospholipase D | 0.011 | 0.0436 | 0.0436 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.069 uM | PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 0.2 uM | PUBCHEM_BIOASSAY: PLD2 purified enzyme concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 2.06 uM | PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 5.48 uM | PUBCHEM_BIOASSAY: PLD1 purified enzyme concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.