Detailed information for compound 1549334

Basic information

Technical information
  • TDR Targets ID: 1549334
  • Name: (2S)-2-[4-[(1S)-1-amino-3-methylbutyl]triazol -1-yl]-3-(4-hydroxyphenyl)-1-piperazin-1-ylpr opan-1-one hydrochloride
  • MW: 422.952 | Formula: C20H31ClN6O2
  • H donors: 3 H acceptors: 4 LogP: 1.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C[C@@H](c1nnn(c1)[C@H](C(=O)N1CCNCC1)Cc1ccc(cc1)O)N)C.Cl
  • InChi: 1S/C20H30N6O2.ClH/c1-14(2)11-17(21)18-13-26(24-23-18)19(12-15-3-5-16(27)6-4-15)20(28)25-9-7-22-8-10-25;/h3-6,13-14,17,19,22,27H,7-12,21H2,1-2H3;1H/t17-,19-;/m0./s1
  • InChiKey: PSMGOGYUMMWNAF-QQTWVUFVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[4-[(1S)-1-amino-3-methyl-butyl]triazol-1-yl]-3-(4-hydroxyphenyl)-1-piperazin-1-yl-propan-1-one hydrochloride
  • (2S)-2-[4-[(1S)-1-amino-3-methylbutyl]-1-triazolyl]-3-(4-hydroxyphenyl)-1-(1-piperazinyl)propan-1-one hydrochloride
  • (2S)-2-[4-[(1S)-1-amino-3-methyl-butyl]-1,2,3-triazol-1-yl]-3-(4-hydroxyphenyl)-1-piperazin-1-yl-propan-1-one hydrochloride
  • CD-MONO-LY-DP
  • MLS000560550
  • SMR000327453

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major importin beta-1 subunit, putative 0.0028 0.0017 0.0435
Schistosoma mansoni ran 0.0026 0.0014 0.0039
Echinococcus granulosus zinc finger protein 0.0022 0.001 0.0027
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0048 0.0153
Toxoplasma gondii hypothetical protein 0.0069 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0054 0.101
Loa Loa (eye worm) hypothetical protein 0.0196 0.0202 0.0638
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0015 0.0269
Echinococcus multilocularis Niemann Pick C1 protein 0.1625 0.1777 0.1775
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0028 0.0786
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Brugia malayi hypothetical protein 0.0062 0.0054 0.0173
Brugia malayi protein C24B5.3 0.0069 0.0062 0.0198
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0031 0.0905
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0395 0.1258
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Echinococcus multilocularis geminin 0.0547 0.0589 0.0587
Schistosoma mansoni hypothetical protein 0.047 0.0504 0.1605
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0058 0.0049 0.1492
Echinococcus multilocularis protein dispatched 1 0.0557 0.06 0.0598
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0024 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0015 0.008
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Loa Loa (eye worm) hypothetical protein 0.0062 0.0054 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0501
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0031 0.0562
Echinococcus granulosus Niemann Pick C1 protein 0.1625 0.1777 0.5673
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0049 0.1492
Schistosoma mansoni chromobox protein 0.0067 0.006 0.0185
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0057 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0196 0.0202 1
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0042 0.0135
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0082
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0004 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0226 0.0235 0.0745
Schistosoma mansoni transcription factor LCR-F1 0.0226 0.0235 0.0745
Echinococcus multilocularis excitatory amino acid transporter 3 0.2854 0.3131 0.3129
Loa Loa (eye worm) hypothetical protein 0.0051 0.0042 0.0129
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0309 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.0057 0.0177
Trichomonas vaginalis antibiotic synthetase, putative 0.0058 0.0049 0.0919
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0138 0.0138 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0196 0.0202 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0196 0.0202 0.1532
Brugia malayi DKFZp564C0469 protein 0.0062 0.0054 0.0173
Entamoeba histolytica hypothetical protein 0.0226 0.0235 0.1803
Echinococcus multilocularis chromobox protein 1 0.0067 0.006 0.0058
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0014 0.0039
Brugia malayi hypothetical protein 0.0466 0.0499 0.1595
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0042 0.0129
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0014 0.0341
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0062 0.0054 0.1513
Brugia malayi beta-lactamase family protein 0.0038 0.0028 0.0089
Brugia malayi hypothetical protein 0.0069 0.0062 0.0198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0048 0.1445
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0058 0.0049 0.736
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0015 0.0269
Loa Loa (eye worm) hypothetical protein 0.0062 0.0054 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0033 0.01
Schistosoma mansoni smad1 5 8 and 0.0017 0.0004 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0049 0.0157
Echinococcus multilocularis chromobox protein 1 0.0067 0.006 0.0058
Brugia malayi Patched protein homolog 1 0.0069 0.0062 0.0198
Leishmania major acetyl-CoA synthetase, putative 0.0058 0.0049 0.1492
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0014 0.0012
Onchocerca volvulus 0.0069 0.0062 0.0144
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0041 0.0125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0094 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0028 0.0082
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1265 0.138 0.1378
Onchocerca volvulus 0.025 0.0262 0.0786
Toxoplasma gondii ATPase, AAA family protein 0.0062 0.0054 0.8361
Echinococcus multilocularis protein patched 0.0488 0.0524 0.0522
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0196 0.0202 0.0561
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0048 0.2534
Echinococcus granulosus cpg binding protein 0.0032 0.0021 0.006
Loa Loa (eye worm) patched family protein 0.0069 0.0062 0.0191
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Leishmania major 4-coumarate:coa ligase-like protein 0.0196 0.0202 0.6484
Brugia malayi Bromodomain containing protein 0.004 0.003 0.0097
Leishmania major 4-coumarate:coa ligase-like protein 0.0196 0.0202 0.6484
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0048 0.0891
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0139 0.4425
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.0164 0.0519
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi protein C24B5.3 0.0069 0.0062 0.0198
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0058 0.0049 0.0069
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0054 0.101
Onchocerca volvulus 0.0069 0.0062 0.0144
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Schistosoma mansoni flap endonuclease-1 0.0023 0.0011 0.003
Schistosoma mansoni topbp1 0.0062 0.0054 0.0166
Echinococcus granulosus neutral amino acid transporter A 0.2854 0.3131 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0058 0.0049 0.1492
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0058 0.0049 0.0069
Loa Loa (eye worm) hypothetical protein 0.005 0.0041 0.0125
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0058 0.0049 0.0287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0041 0.0125
Leishmania major 4-coumarate:coa ligase-like protein 0.0196 0.0202 0.6484
Loa Loa (eye worm) hypothetical protein 0.0062 0.0054 0.0166
Loa Loa (eye worm) hypothetical protein 0.0062 0.0054 0.0166
Loa Loa (eye worm) hypothetical protein 0.0196 0.0202 0.0638
Toxoplasma gondii exonuclease III APE 0.0056 0.0048 0.7059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0048 0.2534
Onchocerca volvulus 0.0069 0.0062 0.0144
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0058 0.0049 0.0157
Toxoplasma gondii patched family protein 0.0069 0.0062 1
Toxoplasma gondii patched family protein 0.0069 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0466 0.0499 0.159
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0058 0.0049 0.1239
Schistosoma mansoni survival motor neuron protein 0.0095 0.0091 0.0283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0005 0.0072
Brugia malayi Patched related family protein 10 0.0069 0.0062 0.0198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0094 0.0301
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.1137 0.1239 0.1237
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0058 0.0049 0.0151
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0048 0.0046
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0014 0.0002
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0058 0.0049 0.1239
Loa Loa (eye worm) excitatory amino acid transporter 0.2854 0.3131 1
Onchocerca volvulus 0.0147 0.0148 0.0422
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0048 0.0146
Mycobacterium ulcerans hypothetical protein 0.0155 0.0156 0.738
Toxoplasma gondii propionate-CoA ligase 0.0058 0.0049 0.736
Onchocerca volvulus 0.0058 0.0049 0.0104
Loa Loa (eye worm) hypothetical protein 0.0062 0.0054 0.0166
Onchocerca volvulus Protein patched homolog 0.0069 0.0062 0.0144
Echinococcus granulosus Excitatory amino acid transporter 0.2854 0.3131 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0024 0.0071
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.2854 0.3131 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0028 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0226 0.0235 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0054 0.101
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0147 0.0145
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0014 0.0006
Leishmania major pantothenate kinase subunit, putative 0.0019 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi hypothetical protein 0.0027 0.0015 0.0049
Onchocerca volvulus 0.0069 0.0062 0.0144
Chlamydia trachomatis glutamate symporter 0.2854 0.3131 1
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0054 0.1648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0094 0.0294
Loa Loa (eye worm) hypothetical protein 0.0162 0.0164 0.0519
Loa Loa (eye worm) hypothetical protein 0.0111 0.0108 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0156 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0094 0.0294
Brugia malayi hypothetical protein 0.0069 0.0062 0.0198
Plasmodium vivax replication factor C subunit 1, putative 0.0062 0.0054 0.3002
Echinococcus granulosus GPCR family 2 0.0051 0.0042 0.0129
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0048 0.0065
Schistosoma mansoni topbp1 0.0062 0.0054 0.0166
Schistosoma mansoni hypothetical protein 0.0372 0.0395 0.1258
Brugia malayi MH2 domain containing protein 0.0243 0.0254 0.0811
Echinococcus multilocularis nibrin 0.0062 0.0054 0.0052
Onchocerca volvulus 0.0038 0.0028 0.0035
Echinococcus granulosus chromobox protein 1 0.0067 0.006 0.0185
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.1265 0.138 0.4404
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0196 0.0202 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.0253 0.0726
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0031 0.0562
Leishmania major GTP-binding protein, putative 0.0026 0.0014 0.0341
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0049 0.0069
Schistosoma mansoni ran 0.0026 0.0014 0.0039
Echinococcus granulosus replication factor c subunit 1 0.0062 0.0054 0.0166
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0031 0.0905
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0058 0.0049 0.0151
Echinococcus granulosus smad 0.0017 0.0004 0.0007
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0049 0.1492
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0014 0.0038
Echinococcus granulosus snurportin 1 0.0372 0.0395 0.1258
Brugia malayi Muscleblind-like protein 0.0146 0.0147 0.047
Schistosoma mansoni cpg binding protein 0.0032 0.0021 0.006
Echinococcus granulosus expressed conserved protein 0.1068 0.1163 0.3711
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0006 0.0012
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0048 0.1156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0138 0.0138 0.0357
Schistosoma mansoni hypothetical protein 0.0022 0.001 0.0025
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0058 0.0049 0.1492
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0138 0.0138 0.0357
Toxoplasma gondii patched family protein 0.0069 0.0062 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0081
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.2854 0.3131 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0058 0.0049 0.0069
Brugia malayi CHE-14 protein 0.0488 0.0524 0.1673
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0196 0.0202 1
Echinococcus granulosus neutral amino acid transporter A 0.2854 0.3131 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0094 0.0092
Schistosoma mansoni hypothetical protein 0.0095 0.0091 0.0283
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0024 0.0673
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0033 0.01
Brugia malayi AMP-binding enzyme family protein 0.0196 0.0202 0.0644
Echinococcus multilocularis tumor protein p63 0.1007 0.1096 0.1094
Trichomonas vaginalis chromobox protein, putative 0.0067 0.006 0.1125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0082
Echinococcus granulosus chromobox protein 1 0.0067 0.006 0.0185
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0057 0.0055
Schistosoma mansoni chromosome transmission fidelity factor 0.0062 0.0054 0.0166
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0006 0.0004
Echinococcus multilocularis muscleblind protein 0.0146 0.0147 0.0145
Loa Loa (eye worm) hypothetical protein 0.0075 0.0068 0.0212
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi AMP-binding enzyme family protein 0.0196 0.0202 0.0644
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Trypanosoma cruzi FHA domain containing protein, putative 0.0062 0.0054 0.1648
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Toxoplasma gondii ABC1 family protein 0.0038 0.0028 0.2848
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0139 0.4425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0041 0.0125
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0049 0.7236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0146 0.0147 0.6864
Schistosoma mansoni cpg binding protein 0.0028 0.0017 0.0048
Entamoeba histolytica hypothetical protein 0.0062 0.0054 0.0326
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0177
Plasmodium vivax acyl-CoA synthetase, putative 0.0146 0.0147 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.0164 0.0525
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0048 0.0891
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0058 0.0049 0.1239
Brugia malayi MH2 domain containing protein 0.0017 0.0004 0.0013
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0062 0.0054 0.0326
Onchocerca volvulus 0.0062 0.0054 0.0119
Echinococcus multilocularis cpg binding protein 0.0032 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0082
Echinococcus multilocularis smad 0.0017 0.0004 0.0002
Brugia malayi hypothetical protein 0.0062 0.0054 0.0173
Schistosoma mansoni hypothetical protein 0.0051 0.0042 0.0129
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0015 0.0376
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0057 0.0055
Schistosoma mansoni hypothetical protein 0.0226 0.0235 0.0745
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0005 0.0072
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Loa Loa (eye worm) patched family protein 0.0069 0.0062 0.0191
Entamoeba histolytica hypothetical protein 0.0226 0.0235 0.1803
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0048 0.0146
Loa Loa (eye worm) hypothetical protein 0.0147 0.0148 0.0468
Entamoeba histolytica acyl-coA synthetase, putative 0.0196 0.0202 0.1532
Brugia malayi Pre-SET motif family protein 0.022 0.0228 0.0729
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0021 0.1494
Schistosoma mansoni hypothetical protein 0.047 0.0504 0.1605
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0042 0.004
Echinococcus multilocularis neutral amino acid transporter A 0.2854 0.3131 0.3129
Schistosoma mansoni hypothetical protein 0.047 0.0504 0.1605
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0042 0.004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0048 0.1445
Echinococcus granulosus tumor protein p63 0.1007 0.1096 0.3495
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0062 0.0054 0.101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0017 0.0048
Schistosoma mansoni hypothetical protein 0.0051 0.0042 0.0129
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0049 0.1492
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0015 0.0223
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0017 0.0435
Schistosoma mansoni zinc finger protein 0.0022 0.001 0.0027
Echinococcus multilocularis zinc finger protein 0.0022 0.001 0.0008
Brugia malayi TAR-binding protein 0.0065 0.0057 0.0183
Brugia malayi Niemann-Pick C1 protein precursor 0.1137 0.1239 0.3958
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0031 0.0905
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0108 0.0345
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0028 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0177
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0177
Schistosoma mansoni chromobox protein 0.0067 0.006 0.0185
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0028 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0196 0.0202 0.1532
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0028 0.0089
Echinococcus granulosus Protein patched homolog 1 0.0488 0.0524 0.1667
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0049 0.1492
Echinococcus granulosus sterol regulatory element binding protein 0.0488 0.0524 0.1667
Plasmodium vivax acetyl-CoA synthetase, putative 0.0058 0.0049 0.2642
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0049 0.0157
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.0254 0.0805
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0094 0.0092
Brugia malayi RNA binding protein 0.0065 0.0057 0.0183
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0021 0.0019
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.2854 0.3131 0.3129
Echinococcus multilocularis neutral amino acid transporter A 0.2854 0.3131 0.3129
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0028 0.0506
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0017 0.0301
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0005 0.0072
Echinococcus multilocularis neutral amino acid transporter A 0.2854 0.3131 0.3129
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0049 0.0069
Brugia malayi Smad1 0.0017 0.0004 0.0013
Schistosoma mansoni smad 0.0017 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.0506
Mycobacterium ulcerans acyl-CoA synthetase 0.0196 0.0202 1
Onchocerca volvulus 0.0196 0.0202 0.0594
Brugia malayi Flap endonuclease-1 0.0026 0.0014 0.0045
Brugia malayi hypothetical protein 0.0069 0.0062 0.0198
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0094 0.0294
Echinococcus granulosus excitatory amino acid transporter 2 0.2854 0.3131 1
Echinococcus granulosus Smad4 0.0017 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0177
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Loa Loa (eye worm) hypothetical protein 0.0598 0.0645 0.2054
Treponema pallidum glutamate/aspartate transporter 0.1265 0.138 1
Echinococcus multilocularis Smad4 0.0017 0.0004 0.0002
Loa Loa (eye worm) patched family protein 0.0069 0.0062 0.0191
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0058 0.0049 0.0069
Plasmodium falciparum importin beta, putative 0.0035 0.0024 0.0763
Onchocerca volvulus 0.0058 0.0049 0.0104
Entamoeba histolytica hypothetical protein 0.0226 0.0235 0.1803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0028 0.0082
Brugia malayi PHD-finger family protein 0.0028 0.0017 0.0053
Loa Loa (eye worm) hypothetical protein 0.0058 0.0049 0.0151
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0058 0.0049 0.0069
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0058 0.0049 0.736
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0019 0.0007 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0017 0.0301
Schistosoma mansoni smad1 5 8 and 0.0017 0.0004 0.0007
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0054 0.1648
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0014 0.0341
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0062 0.0054 0.101
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0002 0.001
Brugia malayi Bromodomain containing protein 0.0081 0.0075 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0005 0.0072
Onchocerca volvulus 0.0069 0.0062 0.0144
Echinococcus multilocularis sodium:dicarboxylate symporter 0.2854 0.3131 0.3129
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0004 0.0007
Plasmodium falciparum acyl-CoA synthetase 0.0146 0.0147 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0048 0.1445
Loa Loa (eye worm) beta-lactamase 0.0038 0.0028 0.0082
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0196 0.0202 1
Onchocerca volvulus 0.0095 0.0091 0.0237
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0028 0.1023
Onchocerca volvulus 0.0043 0.0033 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0067 0.006 0.1125
Echinococcus multilocularis excitatory amino acid transporter 2 0.2854 0.3131 0.3129
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.004 0.0041
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0062 0.0054 0.0173
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0015 0.008
Echinococcus granulosus flap endonuclease 1 0.0026 0.0014 0.0039
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0058 0.0049 0.1239
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 0.0786
Plasmodium vivax importin-beta 2, putative 0.0035 0.0024 0.0763
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0053 0.0163
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0058 0.0049 0.1239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0058 0.0049 0.0157
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0015 0.008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0019 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0028 0.0026
Echinococcus granulosus Niemann Pick C1 protein 0.1137 0.1239 0.3954
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0028 0.0786
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0014 0.0039
Echinococcus multilocularis replication factor c subunit 1 0.0062 0.0054 0.0052
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.1265 0.138 0.4404
Schistosoma mansoni acetyl-CoA synthetase 0.0058 0.0049 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0138 0.0138 0.0357
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0082
Onchocerca volvulus Excitatory amino acid transporter homolog 0.2854 0.3131 1
Entamoeba histolytica hypothetical protein 0.0226 0.0235 0.1803
Echinococcus granulosus excitatory amino acid transporter 3 0.2854 0.3131 1
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.2854 0.3131 1
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.001 0.0025
Echinococcus multilocularis Excitatory amino acid transporter 0.2854 0.3131 0.3129
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0014 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0049 0.0157
Onchocerca volvulus 0.0069 0.0062 0.0144
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0058 0.0049 0.2642
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0062 0.0054 0.101
Brugia malayi beta-lactamase 0.0038 0.0028 0.0089
Loa Loa (eye worm) Smad1 0.0017 0.0004 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0228 0.0723
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0196 0.0202 1
Leishmania major hypothetical protein, conserved 0.0027 0.0015 0.0376
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0005 0.0072
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0042 0.0135
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0058 0.0049 0.1239
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0012
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0024 0.2125
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0062 0.0054 0.1648
Loa Loa (eye worm) hypothetical protein 0.0196 0.0202 0.0638
Mycobacterium ulcerans acetyl-CoA synthetase 0.0058 0.0049 0.1239
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0146 0.0147 0.0303
Onchocerca volvulus Protein patched homolog 0.0069 0.0062 0.0144
Brugia malayi Heterochromatin protein 1 0.0067 0.006 0.0192
Loa Loa (eye worm) patched family protein 0.0069 0.0062 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.0506
Schistosoma mansoni hypothetical protein 0.047 0.0504 0.1605
Brugia malayi chromobox protein homolog 3 0.0038 0.0027 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0027 0.0501
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0024 0.0022
Echinococcus granulosus excitatory amino acid transporter 2 0.2854 0.3131 1
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Echinococcus multilocularis GPCR, family 2 0.0051 0.0042 0.004
Onchocerca volvulus 0.0069 0.0062 0.0144
Echinococcus granulosus tar DNA binding protein 0.0065 0.0057 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Treponema pallidum glutamate transporter 0.1265 0.138 1
Echinococcus multilocularis snurportin 1 0.0372 0.0395 0.0394
Echinococcus multilocularis Excitatory amino acid transporter 0.2854 0.3131 0.3129
Schistosoma mansoni importin beta-1 0.0035 0.0024 0.0071
Plasmodium falciparum replication factor C subunit 1, putative 0.0062 0.0054 0.3002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0488 0.0524 0.1667
Loa Loa (eye worm) oxidoreductase 0.0058 0.0049 0.0151
Toxoplasma gondii patched family protein 0.0069 0.0062 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Leishmania major acetyl-CoA synthetase, putative 0.0058 0.0049 0.1492
Brugia malayi Myosin head containing protein 0.0069 0.0062 0.0198
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0024 0.0673
Brugia malayi topoisomerase 0.0062 0.0054 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0028 0.0506
Plasmodium falciparum lipid/sterol:H+ symporter 0.0069 0.0062 0.359
Trichomonas vaginalis replication factor C large subunit, putative 0.0062 0.0054 0.101
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.0254 0.0805
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0057 0.0176
Echinococcus granulosus sodium:dicarboxylate symporter 0.2854 0.3131 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0049 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0005 0.0072
Echinococcus granulosus survival motor neuron protein 1 0.0466 0.0499 0.159
Loa Loa (eye worm) hypothetical protein 0.1137 0.1239 0.3954
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0196 0.0202 0.0561
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0004 0.0007
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0006 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0014 0.0002
Brugia malayi MH1 domain containing protein 0.0017 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0488 0.0524 0.1667
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0309 1
Echinococcus granulosus neutral amino acid transporter 0.2854 0.3131 1
Trichomonas vaginalis ran, putative 0.0026 0.0014 0.0246
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0004 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0196 0.0202 0.0644
Treponema pallidum DNA ligase (lig) 0.0062 0.0054 0.0047
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0058 0.0049 0.1239
Schistosoma mansoni DNA ligase IV 0.0062 0.0054 0.0166
Echinococcus granulosus muscleblind protein 0.0146 0.0147 0.0464
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0017 0.0301
Brugia malayi hypothetical protein 0.0069 0.0062 0.0198
Loa Loa (eye worm) hypothetical protein 0.0038 0.0028 0.0082
Brugia malayi Pre-SET motif family protein 0.0032 0.0021 0.0068
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0062 0.0054 0.1513
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi hypothetical protein 0.0017 0.0005 0.0015
Schistosoma mansoni zinc finger protein 0.0016 0.0004 0.0005
Brugia malayi Excitatory amino acid transporter 0.2854 0.3131 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0051 0.0042 0.0129
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0057 0.0183
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0027 0.0034
Schistosoma mansoni hypothetical protein 0.0051 0.0042 0.0129
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0031 0.0044
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Schistosoma mansoni hypothetical protein 0.0547 0.0589 0.1875
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0062 0.0054 0.101
Schistosoma mansoni ap endonuclease 0.0056 0.0048 0.0146
Brugia malayi RNA, U transporter 1 0.0099 0.0095 0.0303
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0014 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0005 0.0072
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0042
Onchocerca volvulus 0.0038 0.0028 0.0035
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0048 0.1445
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0057 0.0177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0014 0.0341
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.1137 0.1239 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0041 0.123
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0091 0.029
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0062 0.0054 0.8361
Mycobacterium ulcerans hypothetical protein 0.0196 0.0202 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Echinococcus multilocularis survival motor neuron protein 1 0.0466 0.0499 0.0497
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0014 0.0012
Onchocerca volvulus 0.0038 0.0028 0.0035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0042 0.0129
Brugia malayi MH1 domain containing protein 0.0017 0.0004 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Loa Loa (eye worm) hypothetical protein 0.0058 0.0049 0.0151
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.006 0.0185
Brugia malayi beta-lactamase family protein 0.0038 0.0028 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0015 0.0376
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0058 0.0049 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0049 0.1239
Brugia malayi Importin beta-1 subunit 0.0035 0.0024 0.0078
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1155 0.1258 0.4016
Schistosoma mansoni cpg binding protein 0.0032 0.0021 0.006
Leishmania major hypothetical protein, conserved 0.0038 0.0028 0.0786
Loa Loa (eye worm) hypothetical protein 0.0062 0.0054 0.0166
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0014 0.0341
Trichomonas vaginalis esterase, putative 0.0038 0.0028 0.0506
Plasmodium vivax patched family protein, putative 0.0069 0.0062 0.359
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0031 0.0905
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0058 0.0049 0.1239
Toxoplasma gondii hypothetical protein 0.0047 0.0038 0.5006
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0014 0.0341
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0042 0.0129
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0014 0.0341
Schistosoma mansoni hypothetical protein 0.0547 0.0589 0.1875
Brugia malayi Patched related family protein 12 0.0069 0.0062 0.0198
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0091
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0196 0.0202 1
Onchocerca volvulus 0.003 0.0018 0.0005
Brugia malayi hypothetical protein 0.0226 0.0235 0.0751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0094 0.0294
Chlamydia trachomatis neutral amino acid transporter 0.1265 0.138 0.4309
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Schistosoma mansoni patched 1 0.0488 0.0524 0.1667
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0057 0.0177
Entamoeba histolytica hypothetical protein 0.0028 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0061
Echinococcus multilocularis sterol regulatory element binding protein 0.0488 0.0524 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0054 0.101
Echinococcus granulosus geminin 0.0547 0.0589 0.1875
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0048 0.8442
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0058 0.0049 0.1239
Trichomonas vaginalis set domain proteins, putative 0.025 0.0262 0.4986
Echinococcus multilocularis expressed conserved protein 0.1068 0.1163 0.1161
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0058 0.0049 0.1239
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0062 0.0054 0.002
Echinococcus granulosus Excitatory amino acid transporter 0.2854 0.3131 1
Schistosoma mansoni bromodomain containing protein 0.0068 0.0061 0.019
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1265 0.138 0.1378
Giardia lamblia Replication factor C, subunit 1 0.0062 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0147 0.0464
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0041 0.0039
Brugia malayi Pax transcription activation domain interacting protein 0.0062 0.0054 0.0173
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0196 0.0202 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0058 0.0049 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0488 0.0524 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0058 0.0049 0.0069
Schistosoma mansoni hypothetical protein 0.0111 0.0108 0.0338
Schistosoma mansoni ap endonuclease 0.0056 0.0048 0.0146
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0054 0.101
Brugia malayi MH2 domain containing protein 0.0017 0.0004 0.0013
Echinococcus multilocularis excitatory amino acid transporter 2 0.2854 0.3131 0.3129
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0058 0.0049 0.1239
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.0164 0.0525
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0146 0.0147 0.0385
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0049 0.0157
Schistosoma mansoni Smad4 0.0017 0.0004 0.0007
Loa Loa (eye worm) patched family protein 0.0069 0.0062 0.0191
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0062 0.0054 0.1648
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.0148 0.0468
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0004 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0094 0.0294
Onchocerca volvulus 0.0058 0.0049 0.0104
Plasmodium vivax SET domain protein, putative 0.0032 0.0021 0.0536
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0058 0.0049 0.0047
Brugia malayi Patched family protein 0.0069 0.0062 0.0198
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0058 0.0049 0.0151
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0309 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0048 0.0275
Onchocerca volvulus 0.0058 0.0049 0.0104
Echinococcus granulosus nibrin 0.0062 0.0054 0.0166
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0139 0.4425
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi Patched related family protein 4 0.0069 0.0062 0.0198
Schistosoma mansoni smad1 5 8 and 0.0017 0.0004 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0049 0.0069
Loa Loa (eye worm) hypothetical protein 0.0069 0.0062 0.0191
Brugia malayi CHD4 protein 0.0015 0.0002 0.0007
Brugia malayi CXXC zinc finger family protein 0.0028 0.0017 0.0054

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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