TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 509.602 | Formula: C29H31N7O2
H donors: 1 H acceptors: 5 LogP: 5.14 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)C(c1nnnn1c1c(C)cccc1C)N1CCC(CC1)n1c(O)nc2c1cccc2
InChi: 1S/C29H31N7O2/c1-19-7-6-8-20(2)26(19)36-28(31-32-33-36)27(21-11-13-23(38-3)14-12-21)34-17-15-22(16-18-34)35-25-10-5-4-9-24(25)30-29(35)37/h4-14,22,27H,15-18H2,1-3H3,(H,30,37)
InChiKey: XJSNEBXJSTVPFC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Plasmodium vivax	DNA topoisomerase II, putative	0.0021	0.0062	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0475	0.1793
Echinococcus multilocularis	chromobox protein 1	0.0123	0.0987	0.098
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.0163	0.1678
Trypanosoma brucei	heat shock protein 90, putative	0.0131	0.1059	0.8766
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0021	0.0062	0.055
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0475	0.1793
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.4405
Treponema pallidum	heat shock protein 90	0.0115	0.0912	1
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.054	0.444
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.0146	0.1491
Echinococcus multilocularis	aspartyl tRNA synthetase, cytoplasmic	0.0015	0.0012	0.0005
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0021	0.0062	0.055
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0022	0.007	0.0642
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0021	0.0062	0.055
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.0146	0.1491
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0545
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0115	0.0912	0.754
Onchocerca volvulus		0.0067	0.0475	0.18
Schistosoma mansoni	hypothetical protein	0.0015	0.0012	0.0005
Onchocerca volvulus		0.0067	0.0475	0.18
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Echinococcus multilocularis	Chromobox protein 3	0.0067	0.0475	0.0468
Mycobacterium ulcerans	heat shock protein 90	0.0115	0.0912	1
Echinococcus granulosus	chromobox protein 1	0.0123	0.0987	0.098
Leishmania major	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Brugia malayi	SET domain containing protein	0.0067	0.0475	0.1769
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0021	0.0062	0.045
Trichomonas vaginalis	heat shock protein, putative	0.0115	0.0912	0.3418
Brugia malayi	lysyl-tRNA synthetase	0.0015	0.0012	0.0017
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0021	0.0062	0.055
Brugia malayi	Heterochromatin protein 1	0.0123	0.0987	0.3701
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Brugia malayi	BRCA2 repeat family protein	0.0062	0.0436	0.162
Onchocerca volvulus		0.0052	0.0347	0.1241
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.0163	0.1678
Trypanosoma cruzi	replication Factor A 28 kDa subunit, putative	0.0015	0.0012	0.0038
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Trypanosoma cruzi	Heat shock protein 83, putative	0.0131	0.1059	0.8766
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.0148	0.1206	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0021	0.0062	0.055
Loa Loa (eye worm)	hypothetical protein	0.003	0.0144	0.0543
Brugia malayi	heat shock protein 90	0.0131	0.1059	0.3974
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0118	0.0417
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0021	0.0062	0.055
Leishmania major	mitochondrial DNA topoisomerase II	0.0021	0.0062	0.045
Loa Loa (eye worm)	helicase	0.0067	0.0475	0.1793
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.0101	0.0988
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0062	0.0414
Trichomonas vaginalis	sensor histidine kinase, putative	0.0021	0.0062	0.0204
Entamoeba histolytica	heat shock protein 90, putative	0.0131	0.1059	0.9897
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0021	0.0062	0.055
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.002	0.0051	0.0362
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Plasmodium vivax	heat shock protein 90, putative	0.0061	0.0428	0.3479
Mycobacterium ulcerans	polyketide synthase Pks9	0.002	0.0055	0.047
Schistosoma mansoni	chromobox protein	0.0067	0.0475	0.0548
Mycobacterium ulcerans	two component sensor kinase MprB	0.0021	0.0062	0.055
Trypanosoma cruzi	heat shock protein 85, putative	0.0131	0.1059	0.8766
Echinococcus granulosus	Chromobox protein 3	0.0067	0.0475	0.0468
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Leishmania major	hypothetical protein, conserved	0.0021	0.0062	0.045
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0021	0.0062	0.0204
Entamoeba histolytica	hypothetical protein	0.0015	0.0012	0.0043
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0067	0.0475	0.0548
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0021	0.0062	0.055
Entamoeba histolytica	replication factor A protein 1, putative	0.0132	0.1069	1
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0067	0.0475	0.3902
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0021	0.0062	0.045
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0021	0.0062	0.045
Toxoplasma gondii	OB-fold nucleic acid binding domain-containing protein	0.0077	0.0573	0.4717
Plasmodium vivax	replication protein A1, large subunit, putative	0.0148	0.1206	1
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.4405
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0718	0.2707
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Giardia lamblia	Lysyl-tRNA synthetase	0.0015	0.0012	0.0043
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Entamoeba histolytica	hypothetical protein	0.0015	0.0012	0.0043
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0146	0.1491
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0067	0.0475	0.0548
Trichomonas vaginalis	aspartyl/lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0017
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0057	0.0389	0.1442
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Echinococcus granulosus	lysyl tRNA synthetase	0.0015	0.0012	0.0005
Toxoplasma gondii	Hsp90 domain-containing protein	0.0061	0.0428	0.3503
Trichomonas vaginalis	hypothetical protein	0.0067	0.0475	0.1769
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0111	0.0872	0.8226
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0021	0.0062	0.055
Entamoeba histolytica	replication factor A, putative	0.003	0.0145	0.1289
Schistosoma mansoni	lysyl-tRNA synthetase	0.0015	0.0012	0.0005
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0021	0.0062	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0475	0.1793
Plasmodium vivax	hypothetical protein, conserved	0.0067	0.0475	0.3879
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0067	0.0475	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0012	0.0046
Brugia malayi	Valyl-tRNA synthetase	0.0067	0.0475	0.1769
Chlamydia trachomatis	DNA gyrase subunit B	0.0021	0.0062	1
Toxoplasma gondii	heat shock protein HSP90	0.0131	0.1059	0.8766
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.0146	0.1491
Mycobacterium ulcerans	thioesterase	0.0025	0.0101	0.0988
Plasmodium vivax	heterochromatin protein 1, putative	0.0067	0.0475	0.3879
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0021	0.0062	0.045
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0146	0.1491
Echinococcus multilocularis	lysyl tRNA synthetase	0.0015	0.0012	0.0005
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.0364	0.1314
Echinococcus granulosus	Chromo domain	0.0067	0.0475	0.0468
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0021	0.0062	0.055
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0146	0.1491
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0021	0.0062	0.055
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.0068	0.0505
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0067	0.0475	0.0548
Leishmania major	hypothetical protein, conserved	0.0077	0.0565	0.4652
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0067	0.0475	0.0548
Entamoeba histolytica	hypothetical protein	0.0067	0.0475	0.4405
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0067	0.0475	0.0468
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0067	0.0475	0.3902
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0276	0.2361	1
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0021	0.0062	1
Mycobacterium ulcerans	putative regultory protein	0.0021	0.0062	0.055
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.0718	0.2686
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.0101	0.0988
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0021	0.0062	0.055
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Trypanosoma brucei	Heat shock protein 83, putative	0.0131	0.1059	0.8766
Leishmania major	asparaginyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Leishmania major	DNA topoisomerase ii	0.0021	0.0062	0.045
Schistosoma mansoni	heat shock protein	0.0131	0.1059	0.1231
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0061	0.0428	0.042
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.0146	0.1491
Giardia lamblia	Grp94/Hsp90	0.0115	0.0912	0.8601
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0475	0.1793
Trichomonas vaginalis	receptor histidine kinase, putative	0.0021	0.0062	0.0204
Trypanosoma cruzi	asparaginyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.0093	0.0902
Trichomonas vaginalis	chromobox protein, putative	0.0123	0.0987	0.3701
Echinococcus multilocularis	chromobox protein 2	0.1123	1	1
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0021	0.0062	0.055
Entamoeba histolytica	heat shock protein 90, putative	0.0131	0.1059	0.9897
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.0146	0.0524
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Brugia malayi	CHD4 protein	0.0067	0.0475	0.1769
Trypanosoma brucei	asparaginyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0021	0.0062	0.055
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0021	0.0062	0.0054
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.0129	0.1293
Entamoeba histolytica	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0043
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0021	0.0062	0.055
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0308	0.2652	1
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.0308	0.2652	0.2647
Brugia malayi	Associated with TFs and helicases family protein	0.0067	0.0475	0.1769
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0015	0.0012	0.0005
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.0163	0.1678
Plasmodium vivax	heat shock protein 86, putative	0.0131	0.1059	0.8762
Trypanosoma cruzi	heat shock protein 90, putative	0.0111	0.0872	0.7212
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Plasmodium falciparum	heterochromatin protein 1	0.0067	0.0475	0.3879
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0015	0.0012	0.0038
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.028	0.2981
Echinococcus multilocularis	Chromo domain	0.0067	0.0475	0.0468
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0021	0.0062	0.055
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Loa Loa (eye worm)	aspartyl-tRNA synthetase	0.0015	0.0012	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Echinococcus multilocularis	asparaginyl tRNA synthetase	0.0015	0.0012	0.0005
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0021	0.0062	0.055
Echinococcus multilocularis	heat shock protein 90	0.0111	0.0872	0.0865
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Schistosoma mansoni	endoplasmin	0.0131	0.1059	0.1231
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.028	0.2981
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.1769
Entamoeba histolytica	hypothetical protein	0.0067	0.0475	0.4405
Brugia malayi	Asparaginyl-tRNA synthetase, cytoplasmic	0.0015	0.0012	0.0017
Trypanosoma cruzi	heat shock protein 90, putative	0.0131	0.1059	0.8766
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Schistosoma mansoni	heat shock protein	0.0061	0.0428	0.0492
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.1769
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0067	0.0475	0.3902
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0021	0.0062	0.045
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0062	0.0233
Plasmodium falciparum	DNA gyrase subunit B	0.0021	0.0062	0.0414
Schistosoma mansoni	hypothetical protein	0.0067	0.0475	0.0548
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Onchocerca volvulus		0.0028	0.0129	0.0291
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Echinococcus multilocularis	endoplasmin	0.0115	0.0912	0.0905
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0129	0.0457
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.0129	0.0485
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0475	0.1769
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0021	0.0062	0.0204
Echinococcus granulosus	asparaginyl tRNA synthetase cytoplasmic	0.0015	0.0012	0.0005
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0021	0.0062	0.055
Entamoeba histolytica	DNA topoisomerase II, putative	0.0021	0.0062	0.0509
Trypanosoma brucei	heat shock protein 84, putative	0.0061	0.0428	0.3503
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0021	0.0062	0.055
Mycobacterium ulcerans	DNA gyrase subunit B	0.0021	0.0062	0.055
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0115	0.0912	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0331	0.1247
Trichomonas vaginalis	chromobox protein, putative	0.0096	0.0744	0.2784
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0096	0.0744	0.2968
Leishmania major	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Onchocerca volvulus		0.0067	0.0475	0.18
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0062	0.0233
Echinococcus granulosus	heat shock protein 90	0.0111	0.0872	0.0865
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0115	0.0912	1
Plasmodium falciparum	endoplasmin, putative	0.0078	0.0575	0.4709
Plasmodium falciparum	heat shock protein 90, putative	0.0061	0.0428	0.3479
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.0718	0.2686
Entamoeba histolytica	asparaginyl-tRNA synthetase, putative	0.0015	0.0012	0.0043
Brugia malayi	Protein cec-1.	0.0228	0.193	0.7268
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0021	0.0062	0.055
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0061	0.0428	0.3955
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0021	0.0062	0.055
Brugia malayi	Endoplasmin precursor	0.0131	0.1059	0.3974
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0021	0.0062	0.055
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.0093	0.0902
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1175	0.443
Trichomonas vaginalis	heat shock protein, putative	0.0115	0.0912	0.3418
Leishmania major	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0015	0.0012	0.0038
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Trypanosoma cruzi	heat shock protein 85, putative	0.0111	0.0872	0.7212
Loa Loa (eye worm)	heat shock protein 75	0.0061	0.0428	0.1613
Toxoplasma gondii	aspartate-tRNA ligase	0.0015	0.0012	0.0038
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0021	0.0062	0.055
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0061	0.0428	0.042
Leishmania major	replication factor A, 51kDa subunit, putative	0.0148	0.1206	1
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Trypanosoma cruzi	heat shock protein, putative	0.0061	0.0428	0.3503
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0021	0.0062	0.0204
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0017	0.0029	0.019
Loa Loa (eye worm)	63kd antigen	0.0015	0.0012	0.0046
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0008	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0475	0.1793
Mycobacterium ulcerans	polyketide synthase	0.003	0.0146	0.1491
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0021	0.0062	0.0204
Leishmania major	heat shock protein, putative	0.0061	0.0428	0.3503
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0021	0.0062	0.055
Trypanosoma brucei	Replication factor A protein 1	0.0148	0.1206	1
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.0138	0.1398
Plasmodium vivax	hypothetical protein, conserved	0.0067	0.0475	0.3879
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0021	0.0062	0.045
Brugia malayi	Hsp90 protein	0.0061	0.0428	0.1588
Brugia malayi	MH2 domain containing protein	0.0144	0.1175	0.4414
Echinococcus granulosus	chromobox protein 1	0.0123	0.0987	0.098
Loa Loa (eye worm)	TOPoisomerase family member	0.0021	0.0062	0.0233
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0021	0.0062	0.045
Mycobacterium ulcerans	polyketide synthase	0.0032	0.0163	0.1678
Giardia lamblia	Hypothetical protein	0.0045	0.0282	0.2605
Plasmodium falciparum	DNA topoisomerase 2	0.0021	0.0062	0.0414
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0008	0.0029
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.0163	0.1678
Echinococcus granulosus	asparaginyl tRNA synthetase, cytoplasmic	0.0015	0.0012	0.0005
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0067	0.0475	0.0468
Echinococcus multilocularis	heat shock protein 90	0.0131	0.1059	0.1052
Brugia malayi	hypothetical protein	0.0067	0.0475	0.1769
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Mycobacterium leprae	Probable two-component sensor kinase	0.0021	0.0062	0.055
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.0163	0.1678
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.0163	0.1297
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0021	0.0062	0.045
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0021	0.0062	0.055
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.028	0.2981
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0067	0.0475	0.1769
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0021	0.0062	0.045
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0293	0.2515	0.9482
Trypanosoma brucei	heat shock protein, putative	0.0131	0.1059	0.8766
Trypanosoma brucei	DNA topoisomerase ii	0.0021	0.0062	0.045
Schistosoma mansoni	chromobox protein	0.0123	0.0987	0.1146
Loa Loa (eye worm)	CHromoDomain protein family member	0.0067	0.0475	0.1793
Toxoplasma gondii	hypothetical protein	0.0032	0.0167	0.1329
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.0308	0.2652	0.2647
Plasmodium falciparum	heat shock protein 90, putative	0.0057	0.0388	0.3149
Chlamydia trachomatis	DNA gyrase subunit B	0.0021	0.0062	1
Giardia lamblia	Aspartyl-tRNA synthetase	0.0015	0.0012	0.0043
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0211	0.1775	0.1769
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Trypanosoma cruzi	heat shock protein 90, putative	0.0074	0.0546	0.4488
Trichomonas vaginalis	endoplasmin, putative	0.0078	0.0575	0.2144
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0021	0.0062	0.0204
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0475	0.1769
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0021	0.0062	0.045
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0148	0.1206	0.4533
Trypanosoma brucei	heat shock protein 90, putative	0.0131	0.1059	0.8766
Trypanosoma cruzi	heat shock protein 85, putative	0.0131	0.1059	0.8766
Giardia lamblia	Asparaginyl-tRNA synthetase	0.0015	0.0012	0.0043
Schistosoma mansoni	lysyl-tRNA synthetase	0.0015	0.0012	0.0005
Plasmodium falciparum	replication protein A1, large subunit	0.0148	0.1206	1
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Toxoplasma gondii	heat shock protein 75, putative	0.0061	0.0428	0.3503
Trichomonas vaginalis	heat shock protein, putative	0.0111	0.0872	0.3269
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0163	0.1678
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0021	0.0062	0.0054
Loa Loa (eye worm)	endoplasmin	0.0131	0.1059	0.3991
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.0308	0.2652	1
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0067	0.0475	0.0468
Echinococcus granulosus	heat shock protein	0.0131	0.1059	0.1052
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.028	0.2981
Brugia malayi	M-phase phosphoprotein, mpp8	0.0067	0.0475	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0062	0.0233
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0115	0.0912	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1175	0.443
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.0093	0.0902
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0021	0.0062	0.055
Plasmodium falciparum	heat shock protein 90	0.0131	0.1059	0.8762
Toxoplasma gondii	heat shock protein 90, putative	0.0131	0.1059	0.8766
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0021	0.0062	0.0204
Echinococcus granulosus	aspartyl tRNA synthetase cytoplasmic	0.0015	0.0012	0.0005
Schistosoma mansoni	pyruvate dehydrogenase	0.0021	0.0062	0.0063
Trichomonas vaginalis	receptor histidine kinase, putative	0.0021	0.0062	0.0204
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.0138	0.1398
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.0101	0.0988
Loa Loa (eye worm)	heat shock protein 90	0.0131	0.1059	0.3991
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0017
Brugia malayi	Probable DNA topoisomerase II	0.0021	0.0062	0.0204
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0093	0.0718	0.2855
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0131	0.1059	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.1769
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0021	0.0062	0.045
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0015	0.0012	0.0005
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Echinococcus multilocularis	chromobox protein 1	0.0123	0.0987	0.098
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0146	0.1491
Brugia malayi	replication factor A 73 kDa subunit	0.0308	0.2652	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0118	0.0417
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0163	0.1678
Loa Loa (eye worm)	BRCA2 repeat family protein	0.0062	0.0436	0.1645
Entamoeba histolytica	hypothetical protein	0.0067	0.0475	0.4405
Trichomonas vaginalis	Heterochromatin protein, putative	0.0067	0.0475	0.1769
Trichomonas vaginalis	heat shock protein, putative	0.0078	0.0575	0.2144
Plasmodium vivax	endoplasmin, putative	0.0131	0.1059	0.8762
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0021	0.0062	0.0054
Echinococcus multilocularis	heat shock protein	0.0131	0.1059	0.1052
Trypanosoma cruzi	heat shock protein 85, putative	0.0131	0.1059	0.8766
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0061	0.0428	0.1592
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0021	0.0062	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0475	0.1793
Schistosoma mansoni	replication factor A 1 rfa1	0.0308	0.2652	0.3097
Onchocerca volvulus		0.003	0.0144	0.0357
Echinococcus granulosus	heat shock protein 90	0.0131	0.1059	0.1052
Toxoplasma gondii	lysine-tRNA ligase	0.0015	0.0012	0.0038
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.002	0.0055	0.047
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0067	0.0475	0.0468
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0021	0.0062	0.045
Trichomonas vaginalis	chromobox protein, putative	0.0123	0.0987	0.3701
Brugia malayi	chromobox protein homolog 3	0.0093	0.0718	0.2686
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0067	0.0475	0.1769
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0021	0.0062	0.055
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0211	0.1775	0.1769
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.4405
Leishmania major	replication Factor A 28 kDa subunit, putative	0.0015	0.0012	0.0038
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0111	0.0872	0.0865
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0475	0.1769
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.003	0.0145	0.036
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0021	0.0062	0.055
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0103
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.0097	0.0941
Trichomonas vaginalis	chromobox protein, putative	0.0096	0.0744	0.2784
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0021	0.0062	0.045
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0475	0.1769
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0067	0.0475	0.3879
Brugia malayi	Aspartyl-tRNA synthetase	0.0015	0.0012	0.0017
Schistosoma mansoni	chromobox protein	0.0962	0.8546	1
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0021	0.0062	0.045
Schistosoma mansoni	chromobox protein	0.0123	0.0987	0.1146
Plasmodium vivax	DNA gyrase subunit B, putative	0.0021	0.0062	0.0414
Echinococcus granulosus	endoplasmin	0.0115	0.0912	0.0905
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0012	0.0005
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0067	0.0475	0.1769
Loa Loa (eye worm)	heterochromatin protein 1	0.0123	0.0987	0.372
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Schistosoma mansoni	heat shock protein	0.0131	0.1059	0.1231
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0021	0.0062	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0228	0.193	0.7276
Schistosoma mansoni	endoplasmin	0.0131	0.1059	0.1231
Trypanosoma cruzi	Replication factor A protein 1	0.0148	0.1206	1
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.0163	0.1678
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0021	0.0062	0.045
Trichomonas vaginalis	heat shock protein, putative	0.0057	0.0388	0.1439
Loa Loa (eye worm)	fatty acid synthase	0.003	0.0143	0.0538
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.002	0.0055	0.047
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0308	0.2652	1
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0021	0.0062	0.0204
Leishmania major	heat shock protein 83-1	0.0131	0.1059	0.8766
Plasmodium vivax	heat shock protein, putative	0.0061	0.0428	0.3479
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0067	0.0475	0.3879
Brugia malayi	kinase, mitochondrial precursor	0.0021	0.0062	0.0204
Trichomonas vaginalis	heat shock protein, putative	0.0131	0.1059	0.3974
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0021	0.0062	0.055
Mycobacterium tuberculosis	Conserved protein	0.0021	0.0062	0.055
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0021	0.0062	0.055
Giardia lamblia	Pms1-like protein	0.0021	0.0062	0.0514
Leishmania major	aspartyl-tRNA synthetase, putative	0.0015	0.0012	0.0038
Schistosoma mansoni	DNA topoisomerase II	0.0021	0.0062	0.0063
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0021	0.0062	0.0414
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0146	0.1491

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	16 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	16.5 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1877509

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1549357