Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.0612 | 0.0462 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.038 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.0612 | 0.0462 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0449 | 0.0449 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0157 | 0.0157 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0157 | 0.4422 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.038 | 1 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.0612 | 0.0462 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0251 | 0.0251 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.038 | 1 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.038 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.025 | 0.6514 | 0.6425 |
Leishmania major | N-myristoyl transferase, putative | 0.038 | 1 | 1 |
Giardia lamblia | CDC72 | 0.038 | 1 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.038 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.0612 | 0.037 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.038 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0157 | 0.0157 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.038 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0355 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0518 | 0.0367 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.038 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.0612 | 0.0462 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.038 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0157 | 0.4422 |
Trypanosoma brucei | N-myristoyltransferase | 0.038 | 1 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.038 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.0612 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3738 | 0.3639 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.038 | 1 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.