Detailed information for compound 1549425

Basic information

Technical information
  • TDR Targets ID: 1549425
  • Name: N-[2-(cyclohexylamino)-2-oxo-1-pyridin-2-ylet hyl]-N-(3,4-dimethylphenyl)thiadiazole-4-carb oxamide
  • MW: 449.568 | Formula: C24H27N5O2S
  • H donors: 1 H acceptors: 5 LogP: 4.34 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(N(C(=O)c1csnn1)c1ccc(c(c1)C)C)c1ccccn1)NC1CCCCC1
  • InChi: 1S/C24H27N5O2S/c1-16-11-12-19(14-17(16)2)29(24(31)21-15-32-28-27-21)22(20-10-6-7-13-25-20)23(30)26-18-8-4-3-5-9-18/h6-7,10-15,18,22H,3-5,8-9H2,1-2H3,(H,26,30)
  • InChiKey: IPRJYORZQPLONB-UHFFFAOYSA-N  


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Synonyms

  • N-[2-(cyclohexylamino)-2-oxo-1-(2-pyridyl)ethyl]-N-(3,4-dimethylphenyl)thiadiazole-4-carboxamide
  • N-[2-(cyclohexylamino)-2-oxo-1-(2-pyridyl)ethyl]-N-(3,4-dimethylphenyl)-4-thiadiazolecarboxamide
  • N-[2-(cyclohexylamino)-2-keto-1-(2-pyridyl)ethyl]-N-(3,4-dimethylphenyl)thiadiazole-4-carboxamide
  • N-[2-(cyclohexylamino)-2-oxo-1-pyridin-2-yl-ethyl]-N-(3,4-dimethylphenyl)-1,2,3-thiadiazole-4-carboxamide
  • ASN 06547881

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 related 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Toxoplasma gondii chaperonin protein BiP 0.0002 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 0.0002 1 1
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Entamoeba histolytica heat shock protein 70, putative 0.0002 1 0.5
Echinococcus granulosus Heat Shock protein family member hsp 3 0.0002 1 0.5
Schistosoma mansoni heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein kDa 0.0002 1 0.5
Echinococcus granulosus heat shock kda protein 0.0002 1 0.5
Echinococcus multilocularis heat shock 70 kda protein 1a 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 1 0.5
Plasmodium vivax heat shock protein 70, putative 0.0002 1 0.5
Trypanosoma brucei heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Toxoplasma gondii heat shock protein HSP70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 71 kDa protein 0.0002 1 0.5
Onchocerca volvulus 0.0002 1 0.5
Trypanosoma brucei heat shock 70 kDa protein, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Trichomonas vaginalis heat shock protein 70kD, putative 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Trypanosoma brucei heat shock protein 70 (hsp70), putative 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus multilocularis heat shock kda protein 0.0002 1 1
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 1 0.5
Echinococcus multilocularis Heat Shock protein family member (hsp 3) 0.0002 1 1
Echinococcus granulosus heat shock protein 71 kDa protein 0.0002 1 0.5
Entamoeba histolytica heat shock protein 70 family 0.0002 1 0.5
Schistosoma mansoni heat shock protein 70 0.0002 1 0.5
Plasmodium falciparum heat shock protein 70 0.0002 1 0.5
Trypanosoma cruzi heat shock protein 70 (hsp70), putative 0.0002 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 0.0002 1 0.5
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70b 0.0002 1 1
Plasmodium vivax heat shock 70 kDa protein, putative 0.0002 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0002 1 1
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Entamoeba histolytica heat shock protein 70, putative 0.0002 1 0.5
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B 0.0002 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 1 1
Trypanosoma cruzi glucose-regulated protein 78, putative 0.0002 1 0.5
Giardia lamblia Bip 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70b 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0002 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Entamoeba histolytica heat shock protein 70, putative 0.0002 1 0.5
Echinococcus multilocularis 0.0002 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 1 1
Echinococcus granulosus Heat shock 70 kDa protein 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 1 1
Entamoeba histolytica heat shock protein 70, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Entamoeba histolytica hypothetical protein 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus multilocularis 0.0002 1 1
Trichomonas vaginalis heat shock protein 70kD, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 0.0002 1 0.5
Loa Loa (eye worm) heat shock 70kDa protein 5 0.0002 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0002 1 0.5
Plasmodium falciparum heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 related 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 related 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus multilocularis heat shock protein 71 kDa protein 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Plasmodium falciparum heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis heat shock 70 kDa protein 1 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Giardia lamblia Cytosolic HSP70 0.0002 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0002 1 0.5
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 1 1
Echinococcus multilocularis 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 4 0.0002 1 1
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 1 1
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein 0.0002 1 1
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein 0.0002 1 1
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Entamoeba histolytica 70 kDa heat shock protein, putative 0.0002 1 0.5
Leishmania major heat-shock protein hsp70, putative 0.0002 1 0.5
Trypanosoma brucei luminal binding protein 1 (BiP), putative 0.0002 1 0.5
Schistosoma mansoni heat shock protein 70 0.0002 1 0.5
Trypanosoma cruzi heat shock protein 70 (hsp70), putative 0.0002 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Trypanosoma brucei luminal binding protein 1 (BiP), putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Entamoeba histolytica heat shock protein 70 family 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Leishmania major heat shock protein 70-related protein 0.0002 1 0.5
Echinococcus multilocularis heat shock protein 71 kDa protein 0.0002 1 1
Leishmania major glucose-regulated protein 78, putative 0.0002 1 0.5
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 1 0.5
Echinococcus granulosus Heat shock 70 kDa protein 4 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5
Echinococcus granulosus heat shock protein 0.0002 1 0.5
Brugia malayi heat shock 70 kDa protein C precursor 0.0002 1 0.5
Echinococcus multilocularis Heat shock 70 kDa protein 0.0002 1 1
Echinococcus multilocularis heat shock protein 70 0.0002 1 1
Leishmania major heat-shock protein hsp70, putative 0.0002 1 0.5
Trichomonas vaginalis heat shock protein, putative 0.0002 1 0.5
Echinococcus granulosus heat shock protein 70 0.0002 1 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.