Detailed information for compound 1549455

Basic information

Technical information
  • TDR Targets ID: 1549455
  • Name: N-[2-[(4-fluorophenyl)methylamino]-2-oxo-1-py ridin-3-ylethyl]-N-phenylthiadiazole-4-carbox amide
  • MW: 447.485 | Formula: C23H18FN5O2S
  • H donors: 1 H acceptors: 5 LogP: 3.36 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CNC(=O)C(N(C(=O)c1nnsc1)c1ccccc1)c1cccnc1
  • InChi: 1S/C23H18FN5O2S/c24-18-10-8-16(9-11-18)13-26-22(30)21(17-5-4-12-25-14-17)29(19-6-2-1-3-7-19)23(31)20-15-32-28-27-20/h1-12,14-15,21H,13H2,(H,26,30)
  • InChiKey: JDJPYHZOZADGOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(4-fluorophenyl)methylamino]-2-oxo-1-(3-pyridyl)ethyl]-N-phenyl-thiadiazole-4-carboxamide
  • N-[2-[(4-fluorophenyl)methylamino]-2-oxo-1-(3-pyridyl)ethyl]-N-phenyl-4-thiadiazolecarboxamide
  • N-[2-[(4-fluorobenzyl)amino]-2-keto-1-(3-pyridyl)ethyl]-N-phenyl-thiadiazole-4-carboxamide
  • N-[2-[(4-fluorophenyl)methylamino]-2-oxo-1-pyridin-3-yl-ethyl]-N-phenyl-1,2,3-thiadiazole-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0147 0.1595 0.5
Loa Loa (eye worm) hypothetical protein 0.0872 1 1
Onchocerca volvulus 0.0147 0.1595 0.5
Echinococcus granulosus para nitrobenzyl esterase 0.0147 0.1595 0.1595
Echinococcus granulosus acetylcholinesterase 0.0872 1 1
Brugia malayi Carboxylesterase family protein 0.0147 0.1595 0.1595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0527 0.0527
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.1595 0.1595
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.1595 0.1595
Echinococcus multilocularis acetylcholinesterase 0.0872 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0149 0.3852
Schistosoma mansoni neuroligin 3 (S09 family) 0.0147 0.1595 0.1595
Brugia malayi Carboxylesterase family protein 0.0147 0.1595 0.1595
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0343 1
Onchocerca volvulus 0.0147 0.1595 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0527 0.0527
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0149 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0147 0.1595 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0149 0.3852
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0343 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0149 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Echinococcus multilocularis carboxylesterase 5A 0.0872 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0343 1
Schistosoma mansoni gliotactin 0.0147 0.1595 0.1595
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0354 0.0354
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0149 0.3852
Schistosoma mansoni ap endonuclease 0.0023 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0527 0.0527
Brugia malayi Carboxylesterase family protein 0.0872 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0527 0.0527
Loa Loa (eye worm) acetylcholinesterase 1 0.0872 1 1
Brugia malayi MH2 domain containing protein 0.0144 0.1558 0.1558
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1558 0.1558
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0147 0.1595 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0149 0.5
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0343 1
Onchocerca volvulus 0.0147 0.1595 0.5
Toxoplasma gondii exonuclease III APE 0.0023 0.0149 0.3852
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0147 0.1595 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0354 0.1414
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Echinococcus granulosus expressed protein 0.004 0.0354 0.0354
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0343 1
Schistosoma mansoni ap endonuclease 0.0023 0.0149 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0527 0.0527
Echinococcus multilocularis para nitrobenzyl esterase 0.0147 0.1595 0.1595
Echinococcus granulosus neuroligin 0.0147 0.1595 0.1595
Trichomonas vaginalis rotamase, putative 0.004 0.0354 0.1414
Brugia malayi hypothetical protein 0.0147 0.1595 0.1595
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0527 0.0527
Brugia malayi Carboxylesterase family protein 0.0147 0.1595 0.1595
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0147 0.1595 0.1595
Trichomonas vaginalis rotamase, putative 0.0039 0.0343 0.1338
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0147 0.1595 0.1595
Echinococcus granulosus carboxylesterase 5A 0.0872 1 1
Loa Loa (eye worm) carboxylesterase 0.0872 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0872 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0527 0.0527
Brugia malayi Carboxylesterase family protein 0.0147 0.1595 0.1595
Onchocerca volvulus 0.0147 0.1595 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0149 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0149 0.0149
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0149 0.0149
Echinococcus multilocularis BC026374 protein (S09 family) 0.0147 0.1595 0.1595
Loa Loa (eye worm) carboxylesterase 0.0147 0.1595 0.1595
Trichomonas vaginalis spcc417.12 protein, putative 0.0147 0.1595 1
Schistosoma mansoni acetylcholinesterase 0.0147 0.1595 0.1595
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0147 0.1595 0.1595
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1558 0.1558
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0354 0.0354
Mycobacterium tuberculosis Carboxylesterase LipT 0.0147 0.1595 1
Loa Loa (eye worm) hypothetical protein 0.0872 1 1
Loa Loa (eye worm) carboxylesterase 0.0147 0.1595 0.1595
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0149 0.3852
Mycobacterium ulcerans carboxylesterase, LipT 0.0147 0.1595 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0149 0.0149
Echinococcus granulosus BC026374 protein S09 family 0.0147 0.1595 0.1595
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0149 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0147 0.1595 0.1595
Echinococcus granulosus acetylcholinesterase 0.0872 1 1
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0343 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0147 0.1595 0.1595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0527 0.0527
Echinococcus multilocularis acetylcholinesterase 0.0872 1 1
Echinococcus multilocularis neuroligin 0.0147 0.1595 0.1595
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0149 0.0149
Schistosoma mansoni rotamase 0.004 0.0354 0.0354
Echinococcus multilocularis expressed protein 0.004 0.0354 0.0354

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2378 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.1014 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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