Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3075 | 0.3075 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0137 | 0.9414 | 1 |
Echinococcus granulosus | macrophage expressed protein | 0.0115 | 0.7606 | 0.8079 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4419 | 0.4419 |
Schistosoma mansoni | lipoxygenase | 0.0137 | 0.9414 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.7606 | 0.8079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4419 | 0.4694 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4419 | 0.4419 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4419 | 0.4419 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4419 | 0.4694 |
Schistosoma mansoni | lipoxygenase | 0.0096 | 0.6012 | 0.6387 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4419 | 0.4419 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4419 | 0.4419 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3075 | 0.3075 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1504 | 0.1598 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4419 | 0.4419 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4419 | 0.4694 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3075 | 0.3075 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1504 | 0.1504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4419 | 0.4694 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0137 | 0.9414 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4419 | 0.4694 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3075 | 0.3075 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4419 | 0.4694 |
Echinococcus multilocularis | macrophage expressed protein | 0.0115 | 0.7606 | 0.8079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4419 | 0.4694 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1504 | 0.1504 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.