Detailed information for compound 1549790

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.378 | Formula: C20H20NO2+
  • H donors: 0 H acceptors: 0 LogP: 4.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1/C=C/c1cc2ccccc2c[n+]1C)OC
  • InChi: 1S/C20H20NO2/c1-21-14-17-7-5-4-6-15(17)12-18(21)9-8-16-13-19(22-2)10-11-20(16)23-3/h4-14H,1-3H3/q+1/b9-8+
  • InChiKey: JFYHPNHNNNHAFM-CMDGGOBGSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0024 0.0186 0.0356
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0189 0.2265 0.5183
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0036 0.0341 0.0702
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0071 0.0645
Echinococcus granulosus acyl carrier protein mitochondrial 0.0024 0.0186 0.041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0613 0.7792
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0023 0.005
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Schistosoma mansoni ap endonuclease 0.0058 0.0613 0.1352
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0036 0.0341 0.0637
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0034 0.0194
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0126 0.0126
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0058
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0028 0.0058
Toxoplasma gondii type I fatty acid synthase 0.0036 0.0341 0.1102
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0034 0.0199
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0015 0.0071 0.0087
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0028 0.0028
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Toxoplasma gondii acyl transferase domain-containing protein 0.0015 0.0074 0.0218
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0186 0.0271
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0106 0.0106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0216 0.0393
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Leishmania major quinone oxidoreductase, putative 0.0015 0.0071 0.0497
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0034 0.0194
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0219 0.2648 0.5459
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0478 0.6032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0219 0.2648 0.6123
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0015 0.0071 0.0087
Loa Loa (eye worm) acetyltransferase 0.0159 0.1895 0.3907
Schistosoma mansoni hypothetical protein 0.0024 0.0186 0.041
Mycobacterium ulcerans Type I modular polyketide synthase 0.0234 0.2842 0.6547
Brugia malayi Alcohol dehydrogenase class III 0.0015 0.0071 0.0129
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0186 0.0271
Onchocerca volvulus 0.0015 0.0071 0.0121
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0059 0.0629 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0023 0.0028
Mycobacterium ulcerans acyl carrier protein 0.0024 0.0186 0.0271
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0024 0.0186 0.0271
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0024 0.0186 0.2697
Toxoplasma gondii type I fatty acid synthase, putative 0.0249 0.3026 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0613 0.9737
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0015 0.0071 0.0087
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0186 0.0271
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0023 0.0028
Brugia malayi Methyltransferase-like protein 4 0.0071 0.0777 0.1417
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0015 0.0074 0.0074
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0008 0.0008
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0015 0.0071 0.0825
Toxoplasma gondii exonuclease III APE 0.0058 0.0613 0.2006
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0015 0.0071 0.0208
Leishmania major hypothetical protein, conserved 0.0015 0.0074 0.0537
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0034 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1541 0.3177
Loa Loa (eye worm) fatty acid synthase 0.0231 0.2803 0.5778
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0023 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0023 0.005
Echinococcus granulosus geminin 0.0369 0.4535 1
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Echinococcus multilocularis cpg binding protein 0.0032 0.0294 0.0294
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0071 0.0645
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0034 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0023 0.0041
Plasmodium vivax acyl carrier protein, putative 0.0024 0.0186 0.2552
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0059 0.0629 0.1387
Entamoeba histolytica hypothetical protein 0.0026 0.0216 0.3273
Brugia malayi MH2 domain containing protein 0.0131 0.1541 0.2808
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0703 0.155
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0106
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0435 0.0959
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0015 0.0074 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0023 0.005
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0036 0.0341 0.0718
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0023 0.005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0023 0.005
Brugia malayi transcription factor E74 isoform 0.0011 0.0028 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0008 0.0015
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0023 0.005
Mycobacterium ulcerans thioesterase 0.0195 0.2349 0.5384
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0249 0.3026 0.7007
Echinococcus granulosus NADH dehydrogenase 0.0024 0.0186 0.041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0613 0.9719
Echinococcus multilocularis ets variant gene 4 0.0011 0.0028 0.0028
Echinococcus granulosus cpg binding protein 0.0032 0.0294 0.0648
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0857 0.1767
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0234
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0126 0.1717
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Loa Loa (eye worm) fli-1 protein 0.0234 0.2832 0.5838
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0186 0.2768
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0008 0.0018
Schistosoma mansoni alcohol dehydrogenase 0.0015 0.0071 0.0156
Onchocerca volvulus 0.0219 0.2648 0.5071
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0234 0.2842 0.6547
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0106 0.0193
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0024 0.0186 0.0339
Mycobacterium ulcerans thioesterase TesA 0.0195 0.2349 0.5384
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0133 0.1567 0.3591
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0034 0.0194
Onchocerca volvulus 0.0408 0.503 0.9647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Giardia lamblia GTOR 0.0019 0.0126 0.1243
Leishmania major acyl carrier protein, putative 0.0024 0.0186 0.2043
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0074 0.0815 0.1759
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0106 0.0219
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0126 0.0278
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0106 0.1215
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0071 0.0087
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0126 0.1553
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0023 0.0041
Trypanosoma cruzi oxidoreductase, putative 0.0015 0.0071 0.0803
Leishmania major nuclear receptor binding factor-like protein 0.0015 0.0071 0.0497
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0015 0.0071 0.0071
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0429 0.5308
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0023 0.0041
Mycobacterium ulcerans fatty acid synthase Fas 0.0074 0.0815 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0106 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0126 0.1717
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0126 0.0126
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.1895 0.4178
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1553
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0106 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0168 0.201 0.4628
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0126 0.023
Schistosoma mansoni dishevelled 0.001 0.0008 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0106 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0023 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0186 0.0356
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0023 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0023 0.0047
Mycobacterium ulcerans polyketide synthase 0.0234 0.2842 0.6547
Mycobacterium ulcerans polyketide synthase Pks9 0.0155 0.1841 0.4183
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0106 0.1215
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0435 0.0959
Mycobacterium ulcerans polyketide synthase 0.0249 0.3026 0.6981
Schistosoma mansoni regulator of G protein signaling 0.001 0.0008 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0106 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0023 0.0047
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0126 0.1763
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0028 0.0028
Trypanosoma brucei oxidoreductase, putative 0.0015 0.0071 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0665 0.2178
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0023 0.005
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0227 0.2751 0.6365
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0023 0.005
Brugia malayi isocitrate dehydrogenase 0.0017 0.0106 0.0193
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0008 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0106 0.0325
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0062
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0022 0.0022
Mycobacterium tuberculosis Probable thioesterase TesA 0.0195 0.2349 0.5424
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0015 0.0074 0.0135
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0015 0.0074 0.0007
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0059 0.0629 1
Schistosoma mansoni cript-related 0.0012 0.0034 0.0075
Schistosoma mansoni hypothetical protein 0.0369 0.4535 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0015 0.0071 0.0825
Schistosoma mansoni gabp alpha 0.0077 0.0857 0.189
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0015 0.0071 0.0129
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0022 0.0049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0023 0.005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0613 0.1282
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Schistosoma mansoni hypothetical protein 0.0012 0.0034 0.0075
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0249 0.3026 0.7007
Mycobacterium tuberculosis Possible dehydrogenase 0.0015 0.0071 0.0087
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0234 0.2842 0.5179
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0046
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0186 0.0271
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0024 0.0186 0.0356
Schistosoma mansoni synaptojanin 0.0012 0.0034 0.0075
Brugia malayi DIX domain containing protein 0.001 0.0008 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0023 0.0023
Plasmodium falciparum acyl carrier protein 0.0024 0.0186 0.2552
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0023 0.005
Schistosoma mansoni [ACP] S-malonyltransferase 0.0015 0.0074 0.0163
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0126 0.026
Brugia malayi steroid hormone receptor 0.0011 0.0023 0.0041
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0216 0.0475
Onchocerca volvulus 0.0012 0.0034 0.005
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0008
Schistosoma mansoni dishevelled 0.001 0.0008 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0216 0.3188
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0796 0.145
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0613 1
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0028 0.0058
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0024 0.0186 0.0356
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0023 0.0023
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Brugia malayi hypothetical protein 0.001 0.0008 0.0015
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0127 0.1249
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0095 0.1082 0.2455
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0034 0.0156
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0126 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0216 0.2561
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0058
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0015 0.0071 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0023 0.0041
Echinococcus multilocularis synaptojanin 1 0.0012 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0034 0.0075
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0022 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Onchocerca volvulus Putative alcohol dehydrogenase 0.0015 0.0071 0.0121
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0015 0.0071 0.0825
Schistosoma mansoni [ACP] S-malonyltransferase 0.0015 0.0074 0.0163
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0015 0.0071 0.0087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0186 0.2768
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0192 0.2304 0.5316
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0613 0.7792
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0106 0.0169
Trypanosoma cruzi acyl transferase-like protein 0.0015 0.0074 0.0852
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0028 0.0062
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.017 0.243
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0216 0.0688
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0059 0.0629 1
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0012 0.0034 0.0194
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0034 0.0034
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0613 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0023 0.005
Schistosoma mansoni [ACP] S-malonyltransferase 0.0015 0.0074 0.0163
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0012 0.0034 0.0194
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0478 0.1053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0023 0.0041
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0008 0.0008
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0311 0.4654
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0034 0.0199
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0126 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0023 0.0028
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0126 0.0392
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0127 0.1725
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.2339 0.4477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0038 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0023 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0613 0.7827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0023 0.005
Schistosoma mansoni ets 0.0011 0.0028 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0034 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0023 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0219 0.2648 0.4825
Mycobacterium tuberculosis Conserved protein 0.0071 0.0777 0.1742
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0106
Onchocerca volvulus Fatty acid synthase homolog 0.0423 0.5214 1
Echinococcus granulosus synaptojanin 1 0.0012 0.0034 0.0075
Brugia malayi hypothetical protein 0.001 0.0008 0.0015
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0186 0.0356
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0249 0.3026 0.6981
Echinococcus multilocularis AMP dependent ligase 0.0024 0.0186 0.0186
Entamoeba histolytica hypothetical protein 0.0043 0.0435 0.6982
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0028 0.0058
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0429 0.6875
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0059 0.0629 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0186 0.0271
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0152 0.1804 0.5952
Brugia malayi nuclear receptor NHR-88 0.0011 0.0023 0.0041
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0059 0.0629 0.2058
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0028 0.0062
Mycobacterium leprae Probable polyketide synthase Pks1 0.0249 0.3026 0.6981
Brugia malayi Ets-domain containing protein 0.0077 0.0857 0.1562
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0036 0.0341 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0023 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0023 0.005
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0012 0.0034 0.0194
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Leishmania major d-xylulose reductase, putative 0.0015 0.0071 0.0497
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Brugia malayi ecdysteroid receptor 0.0011 0.0023 0.0041
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0059 0.0629 0.0629
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0613 0.7827
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0015 0.0071 0.0087
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0072 0.0796 0.1784
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0018
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0199
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.1895 0.1895
Toxoplasma gondii acyl carrier protein ACP 0.0024 0.0186 0.0589
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0028 0.0062
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0015 0.0071 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0077
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0015 0.0074 0.0671
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0059 0.0629 0.1319
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0195 0.2349 0.5384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0249 0.3026 0.7007
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0249 0.3026 0.6981
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0478 0.1557
Mycobacterium tuberculosis Hypothetical protein 0.0071 0.0777 0.1742
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0186 0.0383
Schistosoma mansoni dep domain containing protein 0.001 0.0008 0.0018
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0015 0.0074 0.0163
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0015 0.0071 0.0803
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0028 0.0028
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0015 0.0071 0.0156
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0272 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.1895 0.3453
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0186 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Schistosoma mansoni hypothetical protein 0.0043 0.0435 0.0959
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0015 0.0071 0.0146
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0023 0.0023
Trypanosoma cruzi mitochondrial protein 99, putative 0.0012 0.0034 0.0194
Giardia lamblia Methyltransferase like 2 0.0071 0.0777 1
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0648
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0227 0.2751 0.6365
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0249 0.3026 0.6981
Echinococcus granulosus protein C ets 2 0.0011 0.0028 0.0062
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0613 0.1357
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0034 0.0156
Brugia malayi Ets-domain containing protein 0.0077 0.0857 0.1562
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0186 0.0271
Trypanosoma brucei oxidoreductase, putative 0.0015 0.0071 0.0621
Mycobacterium ulcerans hypothetical protein 0.0024 0.0186 0.0271
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0216 0.0475
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0023 0.005
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0034 0.0034
Brugia malayi N-terminal motif family protein 0.0195 0.2339 0.4262
Schistosoma mansoni ap endonuclease 0.0058 0.0613 0.1352
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0234 0.2842 0.6547
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0023 0.0041
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0015 0.0071 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0341 0.0702
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0126 0.0278
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0234 0.2842 0.6577
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0062
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0126 0.1553
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0038 0.0098
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0023 0.005
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0152
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0074 0.0815 0.1831
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0106 0.1385
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0059 0.0629 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.2339 0.4821
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0613 0.1118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0126 0.1553
Schistosoma mansoni ets-related 0.0011 0.0028 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0023 0.0041
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0234 0.2842 0.6577
Loa Loa (eye worm) hypothetical protein 0.0066 0.0717 0.1477
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0034 0.0156
Brugia malayi hypothetical protein 0.0043 0.0435 0.0792
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0012 0.0034 0.0194
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0155 0.1841 0.4183
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0059 0.0629 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0126 0.023
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0059 0.0629 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Leishmania major oxidoreductase-like protein 0.0015 0.0071 0.0497
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1243
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.1839 0.4054
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0008 0.0016
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0613 0.1264
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0024 0.0186 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0777 1
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0024 0.0186 0.2059
Trypanosoma cruzi oxidoreductase, putative 0.0015 0.0071 0.0803
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0478 0.6032
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0015 0.0071 0.0645
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1541 0.3177
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0059 0.0629 0.8003
Onchocerca volvulus 0.0031 0.0272 0.0507
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0028 0.0062
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0015 0.0071 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Loa Loa (eye worm) hypothetical protein 0.0131 0.1543 0.318
Echinococcus multilocularis protein C ets 2 0.0011 0.0028 0.0028
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0034 0.0075
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0023 0.0023
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0028 0.0062
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0034 0.0034
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0059 0.0629 0.1319
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0034 0.0086
Chlamydia trachomatis acyl carrier protein 0.0024 0.0186 0.2016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0106 0.0106
Brugia malayi CXXC zinc finger family protein 0.0031 0.0272 0.0496
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0023 0.0041
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0008 0.0018
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0186 0.0271
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0023 0.0023
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0034 0.0199
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0613 0.1352
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0015 0.0071 0.0087
Echinococcus multilocularis NADH dehydrogenase 0.0024 0.0186 0.0186
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0015 0.0071 0.0497
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0015 0.0071 0.0803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0613 0.9737
Leishmania major zinc binding dehydrogenase-like protein 0.0015 0.0071 0.0497
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0126 0.1717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Loa Loa (eye worm) hypothetical protein 0.0394 0.4851 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0038 0.0204
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0034 0.0034
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Schistosoma mansoni cpg binding protein 0.0031 0.0272 0.06
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0023 0.0041
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0126 0.1243
Leishmania major hypothetical protein, conserved 0.0071 0.0777 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0106 0.0972
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0023 0.005
Loa Loa (eye worm) acyl carrier protein 0.0108 0.1246 0.2569
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0023 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0023 0.0047
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0234 0.2842 0.6547
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0015 0.0071 0.0087
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0189 0.2265 0.5183
Brugia malayi Ets-domain containing protein 0.0011 0.0028 0.0051
Leishmania major oxidoreductase, putative 0.0015 0.0071 0.0497
Mycobacterium ulcerans polyketide synthase Pks13 0.035 0.4303 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0036 0.0341 0.0718
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Onchocerca volvulus 0.0012 0.0034 0.005
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0034 0.007
Brugia malayi Fli-1 protein 0.0234 0.2832 0.516
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0015 0.0074 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Leishmania major zinc-binding dehydrogenase-like protein 0.0015 0.0071 0.0497
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0034 0.007
Mycobacterium tuberculosis Polyketide synthase Pks13 0.035 0.4303 1
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0024 0.0186 0.2552
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0034 0.0199
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0024 0.0186 0.0271
Trypanosoma cruzi acyl transferase-like protein, putative 0.0015 0.0074 0.0852
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0022 0.004
Schistosoma mansoni hypothetical protein 0.0369 0.4535 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0023 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Brugia malayi nuclear hormone receptor 0.0011 0.0023 0.0041
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0126 0.026
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0249 0.3026 0.6981
Trypanosoma brucei acyl transferase-like protein 0.0015 0.0074 0.0671
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0023 0.0041
Schistosoma mansoni nocturnin 0.0012 0.0034 0.0075
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0018
Mycobacterium ulcerans polyketide synthase MbtC 0.0059 0.0629 0.1319
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0034 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0028 0.0062
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0186 0.0339
Schistosoma mansoni acyl carrier protein 0.0024 0.0186 0.041
Mycobacterium ulcerans acyl carrier protein 0.0024 0.0186 0.0271
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0081 0.0903 0.2036
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0023 0.0047
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0478 0.7459
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0216 0.3053
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0126 0.0278
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0016
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0126 0.1243
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0186 0.0356
Schistosoma mansoni synaptojanin 0.0012 0.0034 0.0075
Trypanosoma cruzi oxidoreductase, putative 0.0015 0.0071 0.0803
Schistosoma mansoni coup transcription factor 0.0011 0.0023 0.005
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0015 0.0071 0.0621
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0015 0.0071 0.0803
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0216 0.0216
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0024 0.0186 0.0342
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0613 0.9742
Onchocerca volvulus 0.0015 0.0071 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0023 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0014
Brugia malayi Phosphopantetheine attachment site family protein 0.0024 0.0186 0.0339
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0126 0.1717
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0444 0.5488 1
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0857 0.189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0023 0.0047
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0008 0.0016
Toxoplasma gondii quinone oxidoreductase, putative 0.0015 0.0071 0.0208
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0106 0.1385
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0038 0.0061
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0028 0.0058
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0034 0.0156
Schistosoma mansoni elf1 0.0011 0.0028 0.0062
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0034 0.0075
Mycobacterium ulcerans polyketide synthase MbtD 0.0072 0.0796 0.1713
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0034 0.0199
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0028 0.0028
Mycobacterium ulcerans Type I modular polyketide synthase 0.0234 0.2842 0.6547
Mycobacterium tuberculosis Possible dehydrogenase 0.0015 0.0071 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0023 0.0047
Schistosoma mansoni zinc binding dehydrogenase 0.0015 0.0071 0.0156
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.035 0.4303 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0613 0.9742
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0023 0.0023
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0028 0.0028
Onchocerca volvulus 0.0024 0.0186 0.0342
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0036 0.0341 0.0718
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0023 0.005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0234 0.2842 0.6577
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0189 0.2265 0.5183
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Onchocerca volvulus 0.0011 0.0023 0.0028
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0034 0.0075
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0186 0.0356
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0034 0.0075
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0059 0.0629 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0435 0.0435
Echinococcus granulosus AMP dependent ligase 0.0024 0.0186 0.041
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0034 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0106 0.0325
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0613 0.9737
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0034 0.0075
Schistosoma mansoni methyltransferase-related 0.0071 0.0777 0.1714
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0023 0.0023
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0126 0.1553
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0059 0.0629 0.1297
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0028 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0146
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0023 0.005
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0648
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0155 0.1841 0.4183
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0034 0.0062
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0009
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0057 0.0609 0.1348
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0008 0.0008
Toxoplasma gondii type I fatty acid synthase, putative 0.0167 0.1991 0.657
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0311 0.4654
Schistosoma mansoni ets-related 0.0234 0.2832 0.6244
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0034 0.0034
Mycobacterium leprae Polyketide synthase Pks13 0.035 0.4303 1
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0024 0.0186 0.0186
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0028 0.0028
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0059 0.0629 0.1387
Brugia malayi CCR4 0.0012 0.0034 0.0062
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0047
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0012 0.0034 0.0194
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0478 0.1557
Echinococcus multilocularis geminin 0.0369 0.4535 0.4535
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0013
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0126 0.1763
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0118 0.1381 0.4549
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0186 0.0356
Treponema pallidum acyl carrier protein 0.0024 0.0186 0.2621
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0023 0.0041
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0008 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0126 0.138
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0126 0.1243
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0034 0.0075
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0429 0.6632
Mycobacterium ulcerans Type I modular polyketide synthase 0.0234 0.2842 0.6547
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0186 0.0356

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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