Detailed information for compound 1549828

Basic information

Technical information
  • TDR Targets ID: 1549828
  • Name: 2-methylsulfanyl-N-(3-pyrrolidin-1-ylsulfonyl phenyl)pyridine-3-carboxamide
  • MW: 377.481 | Formula: C17H19N3O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ncccc1C(=O)Nc1cccc(c1)S(=O)(=O)N1CCCC1
  • InChi: 1S/C17H19N3O3S2/c1-24-17-15(8-5-9-18-17)16(21)19-13-6-4-7-14(12-13)25(22,23)20-10-2-3-11-20/h4-9,12H,2-3,10-11H2,1H3,(H,19,21)
  • InChiKey: FVMPUWJDPPNAHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(methylthio)-N-(3-1-pyrrolidinylsulfonylphenyl)-3-pyridinecarboxamide
  • 2-(methylthio)-N-(3-pyrrolidin-1-ylsulfonylphenyl)nicotinamide
  • ZINC05839822

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0358 0.0441
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0087 0.1664 0.497
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0283 0.0283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0012 0.0014
Plasmodium vivax importin-beta 2, putative 0.0035 0.0491 0.0538
Loa Loa (eye worm) hypothetical protein 0.0035 0.0491 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.0439
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0839 0.1033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0114
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0342 0.0086
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0012 0.0014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0012 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0041 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0342 0.073
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1237 0.8929
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0071 0.1309 0.1611
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.0123 0.0152
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.1436 0.1768
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0342 0.073
Brugia malayi hypothetical protein 0.0156 0.3231 0.3231
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0565 0.0696
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0019 0.0123 0.0152
Echinococcus granulosus Ankyrin 0.0015 0.0044 0.0054
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0012 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0839 0.1178
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0012 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0133 0.2722 0.2722
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0744 0.3343
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0114
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0358 0.0441
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0155 0.3204 0.3204
Echinococcus granulosus protein kinase c iota type 0.0032 0.0421 0.0518
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0171 0.3568 0.4393
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0358 0.0358
Brugia malayi nuclear receptor RXR 0.0015 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0358 0.0358
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0358 0.0358
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0254 0.0199
Onchocerca volvulus 0.0024 0.0254 0.0254
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0254
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0049 0.006
Echinococcus granulosus Protein kinase C brain isozyme 0.0071 0.1311 0.1614
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0283 0.0228
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0012 0.0012
Brugia malayi RNA, U transporter 1 0.0099 0.1945 0.1945
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0358 0.0358
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.054
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0041 0.0041
Echinococcus multilocularis serine threonine protein kinase 0.0058 0.1014 0.1248
Entamoeba histolytica hypothetical protein 0.0028 0.0342 0.2468
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0041 0.0041
Brugia malayi conserved hypotetical protein 0.0014 0.0012 0.0012
Brugia malayi ecdysteroid receptor 0.0029 0.0358 0.0358
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0215 0.4576 0.5634
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0283 0.0348
Schistosoma mansoni atypical protein kinase C 0.0032 0.0421 0.0518
Echinococcus multilocularis jun protein 0.0087 0.1679 0.2067
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0087 0.1664 0.497
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0012 0.0014
Brugia malayi nuclear hormone receptor 0.0014 0.0012 0.0012
Echinococcus granulosus protein kinase C gamma type 0.0058 0.1014 0.1248
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0123 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0358 0.0358
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0019 0.0123 0.0123
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0328 0.712 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0012 0.0014
Brugia malayi Muscleblind-like protein 0.0155 0.3204 0.3204
Echinococcus granulosus protein kinase c epsilon type 0.0033 0.0448 0.0552
Echinococcus granulosus importin subunit beta 1 0.0035 0.0491 0.0605
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0254 0.0199
Loa Loa (eye worm) hypothetical protein 0.0087 0.1664 0.1664
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0019 0.0123 0.0152
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0358 0.0441
Brugia malayi protein kinase C3,putative 0.0014 0.0009 0.0009
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0328 0.712 1
Echinococcus multilocularis muscleblind protein 1 0.0155 0.3204 0.3946
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Echinococcus granulosus snurportin 1 0.0372 0.8122 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0328 0.712 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0358 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0358 0.0358
Loa Loa (eye worm) AGC/NDR protein kinase 0.0019 0.0123 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0439 0.0439
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0012 0.0012
Echinococcus multilocularis serine:threonine protein kinase 38 0.0019 0.0123 0.0152
Brugia malayi nuclear hormone receptor 0.0029 0.0358 0.0358
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0019 0.0123 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0358 0.0358
Echinococcus granulosus serine:threonine protein kinase N2 0.0019 0.0123 0.0152
Mycobacterium ulcerans thymidylate synthase 0.0328 0.712 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0044 0.0054
Onchocerca volvulus 0.0069 0.1254 0.1254
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Echinococcus granulosus GPCR family 2 0.0033 0.0439 0.054
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0146 0.302 0.302
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0328 0.712 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0254 0.023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0123 0.0152
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0283 0.0348
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0014 0.0009 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0358 0.0441
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.1386 0.1706
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1237 0.1396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0012 0.0014
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0012 0.0012
Brugia malayi NAD-dependent deacetylase SIRT1 0.0087 0.1664 0.1664
Loa Loa (eye worm) hypothetical protein 0.0152 0.3143 0.3143
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0358 0.0358
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.203 0.203
Brugia malayi steroid hormone receptor 0.0029 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0087 0.1664 0.497
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0565 0.0696
Entamoeba histolytica hypothetical protein 0.0074 0.1386 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0123 0.0152
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0019 0.0123 0.0152
Brugia malayi nuclear receptor RXR 0.0014 0.0012 0.0012
Onchocerca volvulus 0.0014 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.1311 0.1614
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0839 0.1178
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0254 0.0254
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0448 0.0552
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0358 0.0441
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1237 0.1523
Brugia malayi Protein kinase domain containing protein 0.0015 0.005 0.005
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0591 0.0727
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1237 0.1237
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0012 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0358 0.0441
Toxoplasma gondii AGC kinase 0.0019 0.0123 0.0173
Entamoeba histolytica hypothetical protein 0.0074 0.1386 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0049 0.006
Schistosoma mansoni ran 0.0026 0.0283 0.0348
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0328 0.712 0.8767
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0012 0.0014
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0012 0.0014
Schistosoma mansoni chromatin regulatory protein sir2 0.0087 0.1664 0.2048
Brugia malayi nuclear receptor NHR-67 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0133 0.2722 0.2722
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0033 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0358 0.0358
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0358 0.0441
Loa Loa (eye worm) hypothetical protein 0.007 0.1294 0.1294
Brugia malayi bZIP transcription factor family protein 0.0087 0.1679 0.1679
Loa Loa (eye worm) hypothetical protein 0.0455 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0358 0.0441
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0014 0.0009 0.0009
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0014 0.0009 0.0009
Onchocerca volvulus 0.0014 0.0027 0.0027
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Loa Loa (eye worm) hypothetical protein 0.0155 0.3204 0.3204
Brugia malayi Death domain containing protein 0.0015 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0085 0.1625 0.1625
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Plasmodium falciparum importin beta, putative 0.0035 0.0491 0.0538
Loa Loa (eye worm) thymidylate synthase 0.0328 0.712 0.712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0358 0.0358
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0602 0.0602
Brugia malayi Protein kinase domain containing protein 0.0019 0.0123 0.0123
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0328 0.712 1
Echinococcus multilocularis Protein lozenge 0.0057 0.0994 0.1224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0358 0.0441
Entamoeba histolytica protein kinase, putative 0.0019 0.0123 0.089
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0041 0.005
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0358 0.0441
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0254 0.0199
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0019 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0012 0.0014
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0342 0.073
Echinococcus multilocularis Ankyrin 0.0015 0.0044 0.0054
Loa Loa (eye worm) hypothetical protein 0.0215 0.4576 0.4576
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0012 0.0014
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0012 0.0014
Brugia malayi Uncoordinated protein 44 0.0015 0.0041 0.0041
Onchocerca volvulus 0.0014 0.0012 0.0012
Echinococcus granulosus jun protein 0.0087 0.1679 0.2067
Entamoeba histolytica protein kinase, putative 0.0019 0.0123 0.089
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.1436 0.1768
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0027 0.0034
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0491 0.0526
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0358 0.0441
Loa Loa (eye worm) hypothetical protein 0.0051 0.0863 0.0863
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0254 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0358 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.3231 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0839 0.2325
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0358 0.0358
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0012 0.0012
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0215 0.4576 0.5634
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0254 0.0199
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Schistosoma mansoni serine/threonine kinase 0.0019 0.0123 0.0152
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0254 0.0199
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0358 0.0441
Brugia malayi thymidylate synthase 0.0328 0.712 0.712
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0254 0.0254
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0839 0.1035
Loa Loa (eye worm) hypothetical protein 0.0455 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0358 0.0358
Brugia malayi hypothetical protein 0.0015 0.0049 0.0049
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0283 0.0241
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0012 0.0012
Brugia malayi protein kinase C II. 0.0033 0.0448 0.0448
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0283 0.0241
Entamoeba histolytica protein kinase, putative 0.0019 0.0123 0.089
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0358 0.0358
Schistosoma mansoni lozenge 0.0057 0.0994 0.1224
Brugia malayi p70 ribosomal S6 kinase beta 0.0019 0.0123 0.0123
Entamoeba histolytica protein kinase, putative 0.0019 0.0123 0.089
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0491 0.069
Brugia malayi hypothetical protein 0.0015 0.0049 0.0049
Loa Loa (eye worm) AGC/AKT protein kinase 0.0019 0.0123 0.0123
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0358 0.0441
Trichomonas vaginalis ran, putative 0.0026 0.0283 0.0541
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Schistosoma mansoni protein kinase C 0.0014 0.0027 0.0034
Brugia malayi C1-like domain containing protein 0.0014 0.0009 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0358 0.0358
Onchocerca volvulus 0.0328 0.712 0.712
Loa Loa (eye worm) runx1 0.0057 0.0994 0.0994
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0744 0.5372
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0171 0.3568 0.4393
Brugia malayi Importin beta-1 subunit 0.0035 0.0491 0.0491
Mycobacterium ulcerans hypothetical protein 0.0024 0.0254 0.0199
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0439 0.054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0019 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Brugia malayi hypothetical protein 0.0069 0.1254 0.1254
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0839 0.2325
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1237 0.1523
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0114 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.8122 0.8122
Loa Loa (eye worm) hypothetical protein 0.0075 0.1406 0.1406
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0358 0.0441
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0358 0.0441
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.203 0.203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0114 0.0114
Echinococcus multilocularis thymidylate synthase 0.0328 0.712 0.8767
Echinococcus granulosus NDR protein kinase 0.0019 0.0123 0.0152
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0012 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0358 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0358 0.0358
Schistosoma mansoni hypothetical protein 0.0074 0.1386 0.1706
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0358 0.0441
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0328 0.712 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0215 0.4576 0.5634
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0012 0.0012
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0358 0.0358
Echinococcus multilocularis protein kinase c iota type 0.0032 0.0421 0.0518
Echinococcus multilocularis hormone sensitive lipase 0.0215 0.4576 0.5634
Schistosoma mansoni protein kinase C mu 0.0014 0.0009 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0358 0.0441
Brugia malayi nuclear receptor NHR-88 0.0014 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0358 0.0441
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0087 0.1664 0.2048
Schistosoma mansoni importin beta-1 0.0035 0.0491 0.0605
Onchocerca volvulus 0.0455 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0358 0.0441
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0049 0.0049
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0012 0.0014
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1237 0.1396
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0358 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0358 0.0358
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0358 0.0441
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Loa Loa (eye worm) acetyltransferase 0.0171 0.3568 0.3568
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0049 0.0049
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0591 0.0727
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0491 0.0605
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.0123 0.0152
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0491 0.0526
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.1386 0.1706
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0019 0.0123 0.0123
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.1679 0.2067
Entamoeba histolytica hypothetical protein 0.0074 0.1386 1
Entamoeba histolytica hypothetical protein 0.0074 0.1386 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0041
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0041 0.005
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0019 0.0123 0.0152
Loa Loa (eye worm) hypothetical protein 0.0038 0.0565 0.0565
Echinococcus granulosus histone acetyltransferase KAT2B 0.0166 0.3459 0.4259
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0156 0.3231 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Leishmania major GTP-binding protein, putative 0.0026 0.0283 0.0043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0358 0.0441
Brugia malayi Protein kinase c protein 2 0.0053 0.0899 0.0899
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0254 0.0199
Brugia malayi ecdysone receptor 0.0014 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0123 0.0152
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0114 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.203 0.203
Echinococcus multilocularis unc 13 (munc13) 0.0014 0.0027 0.0034
Echinococcus granulosus death domain containing protein 0.0015 0.0041 0.005
Brugia malayi acetyltransferase, GNAT family protein 0.0171 0.3568 0.3568
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0565 0.0696
Schistosoma mansoni nuclear receptor 0.0014 0.0012 0.0014
Echinococcus multilocularis snurportin 1 0.0372 0.8122 1
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0358 0.0441
Brugia malayi hypothetical protein 0.0014 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.007 0.1294 0.1593
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0019 0.0123 0.0152
Leishmania major importin beta-1 subunit, putative 0.0028 0.0342 0.0129
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0254 0.0254
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1237 0.1523
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0087 0.1664 0.2048
Echinococcus granulosus muscleblind protein 0.0155 0.3204 0.3946
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0014 0.0009 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.1311 0.1614
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0254 0.0199
Loa Loa (eye worm) hypothetical protein 0.0024 0.0254 0.0254
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0358 0.0441
Brugia malayi Protein kinase domain containing protein 0.0014 0.0009 0.0009
Loa Loa (eye worm) DR-78 0.0014 0.0012 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0439 0.054
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1237 0.1237
Schistosoma mansoni jun-related protein 0.0071 0.1309 0.1611
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0041 0.005
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0123 0.0029
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1237 0.1432
Schistosoma mansoni coup transcription factor 0.0029 0.0358 0.0441
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Mycobacterium tuberculosis Hypothetical protein 0.0156 0.3231 0.4467
Echinococcus multilocularis GPCR, family 2 0.0033 0.0439 0.054
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0283 0.0397
Echinococcus multilocularis muscleblind protein 0.0155 0.3204 0.3946
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0014 0.0009 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.1679 0.2067
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0049 0.006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0358 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0358 0.0358
Brugia malayi hypothetical protein 0.0014 0.0012 0.0012
Brugia malayi Hr1 repeat family protein 0.0019 0.0123 0.0123
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0254 0.183
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0439 0.054
Brugia malayi tailless protein 0.0014 0.0012 0.0012
Brugia malayi hypothetical protein 0.0074 0.1386 0.1386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0358
Loa Loa (eye worm) AGC/PKN protein kinase 0.0019 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1294 0.1294
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0358 0.0358
Onchocerca volvulus 0.0029 0.0358 0.0358
Schistosoma mansoni nuclear receptor 0.0014 0.0012 0.0014
Brugia malayi nuclear receptor NHR-88 0.0029 0.0358 0.0358
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1237 0.1592
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0328 0.712 1
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.054
Schistosoma mansoni zinc finger protein 0.0014 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0033 0.0439 0.054
Schistosoma mansoni ran 0.0026 0.0283 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0009 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0439 0.054
Onchocerca volvulus 0.0133 0.2722 0.2722
Brugia malayi Protein kinase domain containing protein 0.0019 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0358 0.0358
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0049 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0358 0.0441
Schistosoma mansoni hypothetical protein 0.0372 0.8122 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0012 0.0014
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0328 0.712 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0014 0.0027 0.0034
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0254 0.183
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0087 0.1664 0.497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0358 0.0358
Echinococcus granulosus thymidylate synthase 0.0328 0.712 0.8767
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.1386 0.1706
Echinococcus granulosus unc 13 munc13 0.0014 0.0027 0.0034
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0087 0.1664 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0014 0.0027 0.0034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0358 0.0441
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0027 0.0034
Echinococcus multilocularis protein kinase c epsilon type 0.0033 0.0448 0.0552
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0071 0.1311 0.1614
Entamoeba histolytica Ran family GTPase 0.0026 0.0283 0.2041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0133 0.2722 0.2722
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0744 0.0899
Schistosoma mansoni netrin receptor unc5 0.0015 0.0041 0.005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0254 0.183
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0358 0.0441
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0358 0.0441
Loa Loa (eye worm) hypothetical protein 0.0103 0.203 0.203
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0012 0.0014
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.005
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0019 0.0123 0.0123
Echinococcus granulosus hormone sensitive lipase 0.0215 0.4576 0.5634
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0041 0.005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0358 0.0441

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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