Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.0085 | 0.326 | 0.495 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0085 | 0.326 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.326 | 0.495 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0085 | 0.326 | 0.495 |
Brugia malayi | Peroxidasin | 0.0085 | 0.326 | 0.495 |
Onchocerca volvulus | Peroxidase homolog | 0.0085 | 0.326 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Brugia malayi | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6586 | 1 |
Giardia lamblia | High cysteine protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.326 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.326 | 0.495 |
Schistosoma mansoni | peroxidasin | 0.0085 | 0.326 | 0.326 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Onchocerca volvulus | Peroxidasin homolog | 0.0085 | 0.326 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Onchocerca volvulus | Dual oxidase homolog | 0.0085 | 0.326 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0085 | 0.326 | 0.326 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.326 | 0.495 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.326 | 0.495 |
Echinococcus multilocularis | peroxidasin | 0.0085 | 0.326 | 0.326 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.326 | 0.495 |
Onchocerca volvulus | Peroxidase homolog | 0.0085 | 0.326 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0085 | 0.326 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.326 | 0.495 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6586 | 1 |
Onchocerca volvulus | 0.0085 | 0.326 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6586 | 1 |
Onchocerca volvulus | 0.0085 | 0.326 | 1 | |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0085 | 0.326 | 0.495 |
Echinococcus granulosus | peroxidasin | 0.0085 | 0.326 | 0.326 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.