Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3075 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2278 | 0.2068 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0264 | 0.0859 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0821 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3075 | 0.2887 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0821 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0264 | 0.0859 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0264 | 0.0859 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3075 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3075 | 0.2887 |
Brugia malayi | hypothetical protein | 0.002 | 0.0294 | 0.003 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3075 | 0.2887 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3075 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2278 | 0.2068 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1346 | 0.4376 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0264 | 0.0859 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2278 | 0.2068 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0821 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3075 | 0.2887 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0821 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0264 | 0.0859 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0821 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0821 | 0.0573 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2278 | 0.2068 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0821 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0821 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0264 | 0.0859 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1346 | 0.1111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1346 | 0.1111 |
Brugia malayi | hypothetical protein | 0.003 | 0.0821 | 0.0573 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0821 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3075 | 0.2887 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.