Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3286 | 0.3286 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6482 | 0.6482 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6482 | 0.6482 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6482 | 0.6482 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6482 | 0.6482 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6482 | 0.6482 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.3619 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6482 | 0.476 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 1 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.3619 | 0.3619 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.3619 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6482 | 0.476 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6482 | 0.6482 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6482 | 0.6482 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.3619 | 0.3619 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3286 | 0.3286 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6482 | 0.6482 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6482 | 0.476 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6482 | 0.6482 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6482 | 0.6482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.0131 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.