Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.359 | 0.4353 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7984 | 1 | 1 |
Onchocerca volvulus | 0.043 | 0.029 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.043 | 0.029 | 0.029 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.359 | 0.4353 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.359 | 0.4353 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7984 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.7984 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.359 | 0.4353 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.7984 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7984 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7984 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7984 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.359 | 0.4353 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.7984 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.359 | 0.4353 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.043 | 0.029 | 0.029 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7984 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.