Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0391 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0391 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0207 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0391 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0391 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0391 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0391 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0391 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0391 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0391 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0391 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0207 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0391 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0391 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0207 | 0.1071 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0391 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0391 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0391 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0391 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0391 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0391 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0391 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0207 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0391 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0207 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0391 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0391 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0391 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0391 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0391 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0391 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0207 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0391 | 1 | 1 |
Onchocerca volvulus | 0.0391 | 1 | 1 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0391 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0391 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0391 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0207 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0391 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0391 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0207 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0391 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0391 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0391 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0391 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0391 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0391 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.