TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.594 | Formula: C25H40N2O7
H donors: 2 H acceptors: 5 LogP: 1.69 Rotable bonds: 19
Rule of 5 violations (Lipinski): 1
SMILES: C=CC[C@H](C(=O)N1CCC[C@@H]1COC(=O)[C@H](CC(=O)OC(C)(C)C)CC=C)CC(=O)NCCO
InChi: 1S/C25H40N2O7/c1-6-9-18(15-21(29)26-12-14-28)23(31)27-13-8-11-20(27)17-33-24(32)19(10-7-2)16-22(30)34-25(3,4)5/h6-7,18-20,28H,1-2,8-17H2,3-5H3,(H,26,29)/t18-,19-,20+/m0/s1
InChiKey: JLFMGPYHFLZUQH-SLFFLAALSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Loa Loa (eye worm)	Smad1	0.001	0.0026	0.0026
Loa Loa (eye worm)	nuclear hormone receptor	0.0246	0.2421	0.2421
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0026	0.0193	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0522	0.5215	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0026	0.0193	0.0322
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0163	0.8436
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0193	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0522	0.5215	0.5215
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0026	0.0193	0.0322
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0026	0.0193	0.0193
Schistosoma mansoni	thyroid hormone receptor	0.0522	0.5215	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0026	0.0193	1
Brugia malayi	hypothetical protein	0.0246	0.2421	0.2421
Brugia malayi	nuclear hormone receptor	0.0246	0.2421	0.2421
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0246	0.2421	0.4616
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0026	0.0193	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0163	0.8436
Brugia malayi	MH2 domain containing protein	0.001	0.0026	0.0026
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0163	0.0263
Schistosoma mansoni	smad1 5 8 and	0.001	0.0026	0.005
Loa Loa (eye worm)	hypothetical protein	0.0276	0.272	0.272
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0522	0.5215	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0163	0.0312
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0163	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0193	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0522	0.5215	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0522	0.5215	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0246	0.2421	0.4616
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0026	0.0193	0.0322
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	ecdysteroid receptor	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Brugia malayi	Nuclear hormone receptor E75	0.0246	0.2421	0.2421
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0026	0.0193	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0522	0.5215	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Loa Loa (eye worm)	steroid hormone receptor	0.0522	0.5215	0.5215
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0026	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0193	0.0193
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0522	0.5215	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0522	0.5215	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0522	0.5215	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0193	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0026	0.0193	0.0322
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0026	0.0193	0.0322
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0026	0.0193	0.0322
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0276	0.272	0.272
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0026	0.0193	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0522	0.5215	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0026	0.0193	0.0322
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0163	0.5
Echinococcus granulosus	dna polymerase eta	0.0023	0.0163	0.0263
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0246	0.2421	0.2421
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0026	0.0193	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Echinococcus granulosus	FTZ F1 alpha	0.0522	0.5215	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0522	0.5215	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0163	0.0263
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0276	0.272	0.5217
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	nuclear receptor RXR	0.0276	0.272	0.272
Brugia malayi	nuclear receptor NHR-67	0.0246	0.2421	0.2421
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0246	0.2421	0.4616
Echinococcus granulosus	nuclear receptor nhr 48	0.0246	0.2421	0.4616
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0246	0.2421	0.4643
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0193	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Plasmodium vivax	phosphodiesterase gamma, putative	0.0026	0.0193	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1388	0.1388
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0163	0.0263
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0163	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0193	0.0193
Trypanosoma brucei	unspecified product	0.0023	0.0163	0.8436
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0522	0.5215	0.5215
Schistosoma mansoni	smad1 5 8 and	0.001	0.0026	0.005
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Trypanosoma brucei	unspecified product	0.0016	0.009	0.4639
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0193	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0026	0.0193	0.0322
Schistosoma mansoni	coup transcription factor	0.0522	0.5215	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0522	0.5215	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0026	0.0193	0.0322
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0026	0.0193	1
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0276	0.272	0.272
Schistosoma mansoni	nuclear receptor	0.0246	0.2421	0.4643
Schistosoma mansoni	retinoic acid receptor RXR	0.0522	0.5215	1
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0163	0.8436
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0163	0.0163
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0522	0.5215	1
Brugia malayi	hypothetical protein	0.0246	0.2421	0.2421
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0522	0.5215	1
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0163	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Schistosoma mansoni	nuclear hormone receptor	0.0522	0.5215	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0246	0.2421	0.4616
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0026	0.0193	0.0193
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.009	0.4639
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0026	0.0193	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0522	0.5215	0.5215
Schistosoma mansoni	smad1 5 8 and	0.001	0.0026	0.005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Brugia malayi	hypothetical protein	0.0276	0.272	0.272
Plasmodium falciparum	phosphodiesterase delta, putative	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0522	0.5215	0.5215
Onchocerca volvulus		0.0522	0.5215	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0522	0.5215	1
Brugia malayi	MH2 domain containing protein	0.0144	0.1388	0.1388
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0246	0.2421	0.4643
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0967	0.9734	0.9734
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0522	0.5215	1
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0163	0.0163
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0193	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0994	1	1
Brugia malayi	conserved hypotetical protein	0.0246	0.2421	0.2421
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0026	0.0193	1
Trypanosoma brucei	unspecified product	0.0016	0.009	0.4639
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0246	0.2421	0.2421
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0026	0.0193	1
Leishmania major	DNA polymerase eta, putative	0.0023	0.0163	0.8436
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0163	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0246	0.2421	0.2421
Brugia malayi	MH1 domain containing protein	0.001	0.0026	0.0026
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0026	0.0193	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0193	1
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0163	0.8436
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0246	0.2421	0.4616
Brugia malayi	Nuclear hormone receptor-like 1	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Onchocerca volvulus	Protein ultraspiracle homolog	0.0522	0.5215	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Echinococcus multilocularis	FTZ F1 alpha	0.0522	0.5215	1
Brugia malayi	tailless protein	0.0246	0.2421	0.2421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0026	0.0193	0.0193
Brugia malayi	Nuclear hormone receptor E75	0.0246	0.2421	0.2421
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0193	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0522	0.5215	0.5215
Brugia malayi	ecdysone receptor	0.0246	0.2421	0.2421
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0522	0.5215	0.5215
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0026	0.0193	0.037
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0163	0.8436
Giardia lamblia	Hypothetical protein	0.0026	0.0193	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0522	0.5215	0.5215
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0522	0.5215	0.5215
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.009	0.4639
Schistosoma mansoni	nuclear receptor	0.0246	0.2421	0.4643
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0163	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0522	0.5215	0.5215
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0163	0.8436
Brugia malayi	MH1 domain containing protein	0.001	0.0026	0.0026
Echinococcus multilocularis	nuclear receptor nhr 48	0.0246	0.2421	0.4616
Brugia malayi	nuclear receptor RXR	0.0246	0.2421	0.2421
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0026	0.0193	0.037
Brugia malayi	nuclear hormone receptor family member odr-7	0.0246	0.2421	0.2421
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0276	0.272	0.5192
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0522	0.5215	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0276	0.272	0.5217
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0026	0.0193	0.0322
Schistosoma mansoni	smad	0.001	0.0026	0.005
Brugia malayi	Nuclear hormone receptor-like 1	0.0276	0.272	0.272
Brugia malayi	Smad1	0.001	0.0026	0.0026
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Loa Loa (eye worm)	DR-78	0.0246	0.2421	0.2421
Brugia malayi	steroid hormone receptor	0.0522	0.5215	0.5215
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0522	0.5215	0.5215
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0026	0.0193	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0246	0.2421	0.4616
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0026	0.0193	0.0322
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Brugia malayi	nuclear receptor NHR-88	0.0246	0.2421	0.2421
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0246	0.2421	0.4616
Echinococcus granulosus	thyroid hormone receptor alpha	0.0246	0.2421	0.4616
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0163	0.8436
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0246	0.2421	0.2421
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Brugia malayi	nuclear hormone receptor	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0522	0.5215	1
Schistosoma mansoni	thyroid hormone receptor	0.0522	0.5215	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0163	0.0312
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0163	0.0163
Loa Loa (eye worm)	PDE1B protein	0.0026	0.0193	0.0193
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0276	0.272	0.5192
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0522	0.5215	0.5215
Brugia malayi	Steroid receptor seven-up type 2	0.0522	0.5215	0.5215
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0522	0.5215	0.5215
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0193	0.0193
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0026	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0276	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.009	0.4639
Schistosoma mansoni	nuclear hormone receptor	0.0246	0.2421	0.4643
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0163	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0522	0.5215	0.5215
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1388	0.1388
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0522	0.5215	0.5215
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0522	0.5215	1
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0163	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0193	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Loa Loa (eye worm)	hypothetical protein	0.0276	0.272	0.272
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0026	0.0193	0.037
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0522	0.5215	1
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0522	0.5215	0.5215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0246	0.2421	0.4616
Brugia malayi	photoreceptor-specific nuclear receptor	0.0522	0.5215	0.5215
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0246	0.2421	0.4643
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0026	0.0193	1
Schistosoma mansoni	zinc finger protein	0.0246	0.2421	0.4643
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0522	0.5215	1
Onchocerca volvulus	Bile acid receptor homolog	0.0522	0.5215	1
Brugia malayi	hypothetical protein	0.0276	0.272	0.272
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0522	0.5215	0.5215
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0276	0.272	0.272
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0522	0.5215	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0026	0.0193	0.0193
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0026	0.0193	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0276	0.272	0.272
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.0193	1
Schistosoma mansoni	Smad4	0.001	0.0026	0.005
Loa Loa (eye worm)	hypothetical protein	0.0522	0.5215	0.5215
Loa Loa (eye worm)	hypothetical protein	0.0246	0.2421	0.2421
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0026	0.0193	0.0322
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0026	0.0026
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0026	0.0193	0.0193
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0522	0.5215	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0522	0.5215	0.5215
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Brugia malayi	MH2 domain containing protein	0.001	0.0026	0.0026
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0026	0.0193	0.037
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0246	0.2421	0.4616
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0026	0.0193	0.0193
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0026	0.0193	0.0322
Schistosoma mansoni	nuclear hormone receptor	0.0246	0.2421	0.4643
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0522	0.5215	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0246	0.2421	0.2421
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0193	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0026	0.0193	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0522	0.5215	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0163	0.8436
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0026	0.0193	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0026	0.005
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0193	1
Brugia malayi	nuclear receptor NHR-88	0.0522	0.5215	0.5215
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0522	0.5215	0.5215
Giardia lamblia	hypothetical protein	0.0026	0.0193	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0522	0.5215	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1882288

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1550500