Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.0042 | 0.3484 | 0.3484 |
Brugia malayi | nuclear hormone receptor | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0042 | 0.3484 | 0.3484 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0368 | 0.0368 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | FTZ F1 alpha | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | coup transcription factor | 0.0042 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0042 | 0.3484 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.1976 | 0.2221 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.3484 | 0.3484 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0022 | 0.0373 | 0.0419 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0373 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0028 | 0.121 | 0.136 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0022 | 0.0368 | 0.0414 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0028 | 0.121 | 0.136 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.1976 | 0.2221 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0022 | 0.0368 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.2187 | 0.2458 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0373 | 0.0419 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0.121 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0042 | 0.3484 | 0.3484 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0077 | 0.8897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.7311 | 0.8218 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0072 | 0.8107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0072 | 0.8107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.2187 | 0.2458 |
Echinococcus granulosus | voltage gated potassium channel | 0.0022 | 0.0368 | 0.0414 |
Trypanosoma brucei | cytochrome P450, putative | 0.0033 | 0.1976 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.3484 | 0.3916 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.1976 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0022 | 0.0373 | 0.0419 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0022 | 0.0373 | 0.0419 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.1976 | 0.2221 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0373 | 0.0419 |
Schistosoma mansoni | nuclear hormone receptor | 0.0042 | 0.3484 | 0.3484 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0042 | 0.3484 | 0.3484 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0042 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0033 | 0.1976 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.121 | 0.121 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0022 | 0.0373 | 0.0373 |
Brugia malayi | steroid hormone receptor | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | ecdysteroid receptor | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0042 | 0.3484 | 0.3484 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | nuclear receptor RXR | 0.0022 | 0.0373 | 0.0419 |
Onchocerca volvulus | 0.0042 | 0.3484 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.1976 | 0.2221 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0042 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | nuclear receptor NHR-88 | 0.0042 | 0.3484 | 0.3916 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0.121 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0042 | 0.3484 | 0.3916 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0042 | 0.3484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0368 | 0.0414 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0077 | 0.8897 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0033 | 0.1976 | 0.2221 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0042 | 0.3484 | 0.3916 |
Giardia lamblia | Rrm3p helicase | 0.0028 | 0.121 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0077 | 0.8897 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0042 | 0.3484 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0022 | 0.0368 | 0.0414 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.3484 | 0.3484 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0042 | 0.3484 | 0.3916 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0042 | 0.3484 | 0.3484 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0042 | 0.3484 | 0.3484 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0042 | 0.3484 | 0.3916 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0042 | 0.3484 | 0.3916 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.1976 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0373 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0042 | 0.3484 | 0.3916 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0022 | 0.0368 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3484 | 0.3916 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0077 | 0.8897 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.3484 | 0.3916 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.1976 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.