Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | steroid hormone receptor | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0375 | 0.0375 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0027 | 0.12 | 0.1349 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.1994 | 0.2241 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0022 | 0.0354 | 0.0398 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0027 | 0.12 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0042 | 0.3506 | 0.3941 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0032 | 0.1994 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.1994 | 0.2241 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0076 | 0.8895 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0354 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.3506 | 0.3941 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0027 | 0.12 | 0.5 |
Giardia lamblia | Rrm3p helicase | 0.0027 | 0.12 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0071 | 0.8104 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0083 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.3506 | 0.3506 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0375 | 0.0422 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0022 | 0.0354 | 0.0398 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0076 | 0.8895 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0042 | 0.3506 | 0.3506 |
Trypanosoma brucei | cytochrome P450, putative | 0.0032 | 0.1994 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0042 | 0.3506 | 0.3941 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.3506 | 0.3941 |
Leishmania major | cytochrome p450-like protein | 0.0032 | 0.1994 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | FTZ F1 alpha | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.1994 | 0.2241 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0071 | 0.8104 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | voltage gated potassium channel | 0.0022 | 0.0354 | 0.0398 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.3506 | 0.3941 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0042 | 0.3506 | 0.3506 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.1994 | 0.2241 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0042 | 0.3506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0042 | 0.3506 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0042 | 0.3506 | 0.3506 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.3506 | 0.3941 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0027 | 0.12 | 0.1349 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0042 | 0.3506 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0042 | 0.3506 | 0.3506 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0042 | 0.3506 | 0.3941 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0042 | 0.3506 | 0.3941 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0022 | 0.0354 | 0.0398 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0042 | 0.3506 | 0.3506 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0375 | 0.0422 |
Schistosoma mansoni | nuclear hormone receptor | 0.0042 | 0.3506 | 0.3506 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | nuclear receptor RXR | 0.0022 | 0.0375 | 0.0422 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.2221 | 0.2497 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0042 | 0.3506 | 0.3506 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0042 | 0.3506 | 0.3506 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.3506 | 0.3506 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0042 | 0.3506 | 0.3506 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | coup transcription factor | 0.0042 | 0.3506 | 0.3506 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0076 | 0.8895 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.7307 | 0.8215 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.12 | 0.12 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0022 | 0.0375 | 0.0422 |
Brugia malayi | nuclear receptor NHR-88 | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0042 | 0.3506 | 0.3506 |
Onchocerca volvulus | 0.0042 | 0.3506 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0032 | 0.1994 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0042 | 0.3506 | 0.3941 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0022 | 0.0375 | 0.0422 |
Brugia malayi | nuclear hormone receptor | 0.0042 | 0.3506 | 0.3941 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0022 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0022 | 0.0354 | 0.0398 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0076 | 0.8895 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0032 | 0.1994 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3506 | 0.3941 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0022 | 0.0375 | 0.0422 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.3506 | 0.3941 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.2221 | 0.2497 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0042 | 0.3506 | 0.3941 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0375 | 0.0422 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0032 | 0.1994 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.