TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 283.279 | Formula: C16H13NO4
H donors: 0 H acceptors: 3 LogP: 3.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C=CC(=O)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C16H13NO4/c1-21-15-9-2-12(3-10-15)4-11-16(18)13-5-7-14(8-6-13)17(19)20/h2-11H,1H3
InChiKey: OEFOVQFJRDIUTL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Bibliographic reference
Homo sapiens	RAN, member RAS oncogene family	No references
Homo sapiens	snurportin 1	No references
Homo sapiens	karyopherin (importin) beta 1	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0018	0.0033	0.0042
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1094	0.7876	1
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0018	0.0033	0.2795
Onchocerca volvulus		0.074	0.5296	0.6724
Loa Loa (eye worm)	hypothetical protein	0.1076	0.7742	0.9829
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0023	0.0029
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0085	0.0108
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0171	0.0319
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0168	0.1127	0.1111
Echinococcus granulosus	6 phosphofructo 2 kinase:fructose 2	0.1094	0.7876	0.7873
Schistosoma mansoni	hypothetical protein	0.0018	0.0033	0.0016
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0018	0.0033	0.0062
Trichomonas vaginalis	CK1 family protein kinase	0.0749	0.5362	1
Leishmania major	hypothetical protein, conserved	0.0018	0.0033	0.0042
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0085	0.0068
Plasmodium vivax	casein kinase 1, putative	0.0749	0.5362	1
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0467	0.3303	0.4193
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0104	0.0132
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0104	0.0195
Brugia malayi	phosphoglycerate mutase family protein	0.0018	0.0033	0.0062
Schistosoma mansoni	hypothetical protein	0.0018	0.0033	0.0016
Schistosoma mansoni	hypothetical protein	0.0018	0.0033	0.0016
Onchocerca volvulus	Protein UBASH3A homolog	0.0018	0.0033	0.0042
Onchocerca volvulus		0.0017	0.0023	0.0029
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0274	0.0512
Trypanosoma cruzi	casein kinase, putative	0.0749	0.5362	0.6808
Mycobacterium ulcerans	phosphoglycerate mutase	0.0018	0.0033	0.0015
Schistosoma mansoni	hypothetical protein	0.0018	0.0033	0.0016
Plasmodium vivax	phosphoglycerate mutase, putative	0.0018	0.0033	0.0013
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2609	0.3313
Brugia malayi	plexin A	0.002	0.0045	0.0085
Mycobacterium ulcerans	lipoprotein LpqD	0.0018	0.0033	0.0015
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0646	0.4607	0.8591
Mycobacterium ulcerans	phosphoglycerate mutase	0.0018	0.0033	0.0015
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0069	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0033	0.0062
Entamoeba histolytica	casein kinase, putative	0.0749	0.5362	1
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0152	0.0135
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0018	0.0033	0.2795
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0827	0.5926	0.5919
Onchocerca volvulus	Protein UBASH3A homolog	0.0018	0.0033	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0042
Trichomonas vaginalis	CK1 family protein kinase	0.0749	0.5362	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0168	0.1127	0.1111
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0171	0.0319
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0749	0.5362	0.6808
Echinococcus multilocularis	phosphoglycerate mutase	0.0018	0.0033	0.0016
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0069	0.0129
Echinococcus granulosus	phosphoglycerate mutase	0.0018	0.0033	0.0016
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0085	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0033
Loa Loa (eye worm)	CK1/CK1/CK1-D protein kinase	0.0749	0.5362	0.6808
Mycobacterium tuberculosis	Conserved protein	0.0018	0.0033	0.2795
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0467	0.3303	0.4193
Plasmodium falciparum	importin beta, putative	0.0035	0.0152	0.0237
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0018	0.0033	0.2795
Schistosoma mansoni	alpha glucosidase	0.0037	0.0171	0.0154
Leishmania major	glycerolphosphate mutase, putative	0.0018	0.0033	0.0042
Echinococcus multilocularis	phosphoglycerate mutase	0.0018	0.0033	0.0016
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1076	0.7742	0.9829
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0152	0.0193
Onchocerca volvulus	Protein UBASH3A homolog	0.0018	0.0033	0.0042
Onchocerca volvulus		0.0018	0.0033	0.0042
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Mycobacterium ulcerans	acid phosphatase	0.0018	0.0033	0.0015
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0152	0.0193
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0069	0.0094
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0152	0.0237
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0104	0.0195
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0171	0.0154
Schistosoma mansoni	hypothetical protein	0.0018	0.0033	0.0016
Echinococcus multilocularis	phosphoglycerate mutase	0.0018	0.0033	0.0016
Schistosoma mansoni	plexin	0.0017	0.0023	0.0005
Onchocerca volvulus		0.0018	0.0033	0.0042
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0069	0.0094
Echinococcus granulosus	casein kinase I alpha	0.0749	0.5362	0.5354
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.1094	0.7876	0.7873
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0171	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0069	0.0088
Trypanosoma cruzi	casein kinase, putative	0.0749	0.5362	0.6808
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0018	0.0033	0.0062
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.074	0.5296	0.6724
Echinococcus granulosus	casein kinase I alpha	0.0749	0.5362	0.5354
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1076	0.7742	0.9829
Brugia malayi	RNA, U transporter 1	0.0099	0.0621	0.1157
Echinococcus granulosus	phosphoglycerate mutase	0.0018	0.0033	0.0016
Echinococcus granulosus	casein kinase I alpha	0.0749	0.5362	0.5354
Leishmania major	fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein	0.0018	0.0033	0.0042
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0085	0.0108
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.1076	0.7742	0.9829
Schistosoma mansoni	importin beta-1	0.0035	0.0152	0.0135
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0171	0.0259
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0018	0.0033	0.0062
Echinococcus granulosus	plexin a4	0.002	0.0045	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0152	0.0193
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.0467	0.3303	0.4193
Schistosoma mansoni	6-phosphofructokinase	0.1094	0.7876	0.7873
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0069	0.0094
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0171	0.0319
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0171	0.0319
Echinococcus multilocularis	microtubule associated protein 2	0.1385	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0168	0.1127	0.1431
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0168	0.1127	0.2102
Leishmania major	hypothetical protein, conserved	0.0018	0.0033	0.0042
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0069	0.0094
Trypanosoma brucei	phosphoglycerate mutase, putative	0.0018	0.0033	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0022
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0152	0.0135
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0016	0.0013	0.0016
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Echinococcus granulosus	casein kinase i	0.0749	0.5362	0.5354
Echinococcus multilocularis	casein kinase I alpha	0.0749	0.5362	0.5354
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0018	0.0033	0.0062
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0171	0.0319
Loa Loa (eye worm)	CK1/CK1/CK1-A protein kinase	0.0749	0.5362	0.6808
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0018	0.0033	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0042
Brugia malayi	Importin beta-1 subunit	0.0035	0.0152	0.0284
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0168	0.1127	0.1111
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0018	0.0033	0.2795
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0152	0.0224
Echinococcus multilocularis	casein kinase I alpha	0.0749	0.5362	0.5354
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0069	0.0129
Echinococcus multilocularis	casein kinase I delta	0.0749	0.5362	0.5354
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0018	0.0033	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0627	0.4472	0.5678
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1094	0.7876	1
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0018	0.0033	0.2795
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0085	0.0108
Onchocerca volvulus	Protein UBASH3A homolog	0.0018	0.0033	0.0042
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0018	0.0033	0.0062
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Loa Loa (eye worm)	hypothetical protein	0.1094	0.7876	1
Trypanosoma cruzi	casein kinase, putative	0.0749	0.5362	0.6808
Brugia malayi	UBASH3A protein homolog	0.0018	0.0033	0.0062
Onchocerca volvulus		0.0749	0.5362	0.6808
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0033	0.0015
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0171	0.0217
Plasmodium falciparum	phosphoglucomutase-2	0.0018	0.0033	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0749	0.5362	0.5354
Giardia lamblia	Hypothetical protein	0.0646	0.4607	0.8568
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0017	0.0032
Plasmodium vivax	phosphoglucomutase-2, putative	0.0018	0.0033	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0033
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0274	0.0512
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0069	0.0088
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Trypanosoma cruzi	casein kinase, putative	0.0749	0.5362	0.6808
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0171	0.0319
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0085	0.0159
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0018	0.0033	0.0042
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0018	0.0033	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0069	0.0129
Trypanosoma brucei	phosphoglycerate mutase protein, putative	0.0018	0.0033	0.0042
Leishmania major	phosphoglycerate mutase protein, putative	0.0018	0.0033	0.0042
Mycobacterium ulcerans	bifunctional RNase H/acid phosphatase	0.0018	0.0033	0.0015
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0171	0.0217
Leishmania major	hypothetical protein, unknown function	0.0018	0.0033	0.0042
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0018	0.0033	0.0042
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0018	0.0033	0.0062
Toxoplasma gondii	casein kinase I	0.0749	0.5362	1
Schistosoma mansoni	alpha-glucosidase	0.0145	0.0956	0.094
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0033	0.0015
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0069	1
Trypanosoma cruzi	phosphoglycerate mutase family member 5, putative	0.0018	0.0033	0.0042
Trypanosoma brucei	Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative	0.0018	0.0033	0.0042
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0069	1
Echinococcus granulosus	casein kinase I delta	0.0749	0.5362	0.5354
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0085	0.0111
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0085	0.0111
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0018	0.0033	0.0016
Giardia lamblia	Hypothetical protein	0.0646	0.4607	0.8568
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0155	0.029
Mycobacterium ulcerans	hypothetical protein	0.0646	0.4607	1
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0018	0.0033	0.2795
Schistosoma mansoni	phosphoglycerate mutase	0.0018	0.0033	0.0016
Onchocerca volvulus		0.0023	0.0069	0.0088
Trypanosoma cruzi	casein kinase, putative	0.0749	0.5362	0.6808
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0017	0.0032
Entamoeba histolytica	Ran family GTPase	0.0026	0.0085	0.0159
Trypanosoma cruzi	casein kinase, delta isoform, putative	0.0749	0.5362	0.6808
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.0467	0.3303	0.4193
Entamoeba histolytica	hypothetical protein	0.0028	0.0104	0.0195
Echinococcus multilocularis	phosphoglycerate mutase	0.0018	0.0033	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0274	0.0348
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0018	0.0033	0.2795
Mycobacterium ulcerans	hydrolase MutT1	0.0018	0.0033	0.0015
Leishmania major	GTP-binding protein, putative	0.0026	0.0085	0.0108
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0171	0.0319
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0171	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0069	0.0088
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0171	0.0154
Leishmania major	phosphoglycerate mutase, putative	0.0018	0.0033	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0033
Schistosoma mansoni	ran	0.0026	0.0085	0.0068
Echinococcus multilocularis	casein kinase i	0.0749	0.5362	0.5354
Trypanosoma brucei	casein kinase I, isoform 2	0.0749	0.5362	0.6808
Schistosoma mansoni	alpha-glucosidase	0.0145	0.0956	0.094
Trichomonas vaginalis	CK1 family protein kinase	0.0749	0.5362	1
Brugia malayi	phosphoglycerate mutase family protein	0.0018	0.0033	0.0062
Mycobacterium tuberculosis	Conserved protein	0.0018	0.0033	0.2795
Schistosoma mansoni	hypothetical protein	0.0018	0.0033	0.0016
Entamoeba histolytica	casein kinase 1, putative	0.0749	0.5362	1
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0018	0.0033	0.0042
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.1076	0.7742	0.9829
Leishmania major	casein kinase, putative	0.0749	0.5362	0.6808
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0069	0.0094
Mycobacterium ulcerans	phosphoglyceromutase	0.0018	0.0033	0.0015
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0171	0.0319
Echinococcus multilocularis	phosphoglycerate mutase	0.0018	0.0033	0.0016
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0104	0.0195
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0069	0.0129
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0171	0.0217
Echinococcus granulosus	casein kinase I delta	0.0749	0.5362	0.5354
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.0646	0.4607	1
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0018	0.0033	0.0062
Trypanosoma brucei	glucosidase, putative	0.0037	0.0171	0.0217
Treponema pallidum	phosphoglyceromutase	0.0018	0.0033	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0018	0.0033	0.0016
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0069	0.0129
Schistosoma mansoni	ran	0.0026	0.0085	0.0068
Loa Loa (eye worm)	phosphoglycerate mutase	0.0018	0.0033	0.0042
Schistosoma mansoni	phosphoglycerate mutase	0.0018	0.0033	0.0016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0017	0.0022
Trypanosoma brucei	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0069	0.0088
Echinococcus multilocularis	phosphoglycerate mutase	0.0018	0.0033	0.0016
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0018	0.0033	0.0042
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0026	0.139
Echinococcus multilocularis	plexin a4	0.002	0.0045	0.0028
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0171	0.0319
Brugia malayi	casein kinase 1, delta	0.0749	0.5362	1
Trypanosoma cruzi	glycerolphosphate mutase, putative	0.0018	0.0033	0.0042
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative	0.0018	0.0033	0.0042
Schistosoma mansoni	protein kinase	0.0749	0.5362	0.5354
Trypanosoma cruzi	phosphoglycerate mutase protein, putative	0.0018	0.0033	0.0042
Echinococcus multilocularis	snurportin 1	0.0372	0.2609	0.2596
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0069	0.0094
Echinococcus granulosus	phosphoglycerate mutase	0.0018	0.0033	0.0016
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1094	0.7876	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0042
Schistosoma mansoni	hypothetical protein	0.0035	0.0155	0.0138
Echinococcus multilocularis	casein kinase I alpha	0.0749	0.5362	0.5354
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0033	0.0062
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0069	1
Onchocerca volvulus		0.1094	0.7876	1
Echinococcus granulosus	snurportin 1	0.0372	0.2609	0.2596
Onchocerca volvulus		0.0018	0.0033	0.0042
Giardia lamblia	Kinase, CK1 Casein kinase	0.0749	0.5362	1
Brugia malayi	casein kinase I	0.0749	0.5362	1
Trichomonas vaginalis	ran, putative	0.0026	0.0085	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0033	0.0042
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0018	0.0033	0.0016
Loa Loa (eye worm)	plexin A	0.002	0.0045	0.0058
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0069	0.0094
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0171	0.0319
Leishmania major	phosphoglycerate mutase family member 5, putative	0.0018	0.0033	0.0042
Onchocerca volvulus		0.0097	0.0609	0.0773
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Schistosoma mansoni	hypothetical protein	0.0372	0.2609	0.2596
Schistosoma mansoni	microtubule-associated protein tau	0.1385	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0274	0.0348
Trypanosoma cruzi	Histidine phosphatase superfamily (branch 1), putative	0.0018	0.0033	0.0042
Leishmania major	hypothetical protein, conserved	0.0018	0.0033	0.0042
Plasmodium falciparum	casein kinase 1	0.0749	0.5362	1
Trypanosoma cruzi	phosphoglycerate mutase, putative	0.0018	0.0033	0.0042
Trypanosoma brucei	glycerolphosphate mutase, putative	0.0018	0.0033	0.0042
Echinococcus multilocularis	casein kinase I delta	0.0749	0.5362	0.5354
Brugia malayi	Plexin repeat family protein	0.0017	0.0023	0.0042
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0171	0.0217
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0069	1
Echinococcus granulosus	phosphoglycerate mutase	0.0018	0.0033	0.0016
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0018	0.0033	0.0016
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0069	0.0129
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0018	0.0033	0.0062
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0018	0.0033	0.0016
Mycobacterium ulcerans	phosphohistidine phosphatase SixA	0.0018	0.0033	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0155	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0026	0.0033
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1094	0.7876	1
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0104	0.0132
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0069	0.0088
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0085	0.0068
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0069	0.0094
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0085	0.0108

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.5481 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	75.6863 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1902478

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1550658