Detailed information for compound 1550818

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.382 | Formula: C17H22N4O2
  • H donors: 3 H acceptors: 2 LogP: 1.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=NN=C1CC(C)(C)CC(=C1CC(=O)c1ccccc1)O)N
  • InChi: 1S/C17H22N4O2/c1-17(2)9-13(20-21-16(18)19)12(15(23)10-17)8-14(22)11-6-4-3-5-7-11/h3-7,23H,8-10H2,1-2H3,(H4,18,19,21)
  • InChiKey: XHMOOVJSDVKISF-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0041 0.4573 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.4573 0.4573
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0813 0.0813
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.4668 0.4668
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus neuropeptide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni amine GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.4134 0.4134
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.4573 0.4573
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi Dopamine receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis g protein coupled receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.4573 0.4573
Brugia malayi TAR-binding protein 0.0076 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.2964 1
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine receptor 0.0041 0.4573 0.4573
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus multilocularis fmrfamide receptor 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis g protein coupled receptor 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.003 0.2964 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis neuropeptide receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Brugia malayi GnHR receptor homolog 0.0041 0.4573 0.4573
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0813 0.0813
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Leishmania major hypothetical protein, conserved 0.003 0.2964 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus g protein coupled receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.4573 0.4573
Echinococcus granulosus serotonin receptor 0.0041 0.4573 0.4573
Echinococcus granulosus g-protein coupled receptor 0.0041 0.4573 0.4573
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.4134 0.4134
Schistosoma mansoni histamine h1 receptor 0.0041 0.4573 0.4573
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.2964 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.003 0.2964 0.2964
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus granulosus g protein coupled receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni hypothetical protein 0.0014 0.0399 0.0399
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.4573 0.4573
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.4573 0.4573
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Brugia malayi sulfakinin receptor protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi Serotonin receptor 0.0041 0.4573 0.4573
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Echinococcus granulosus fmrfamide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni hypothetical protein 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.4573 0.4573
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.4573 0.4573
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.4573 0.4573
Brugia malayi G-protein coupled receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.4573 0.4573
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.4573 0.5
Schistosoma mansoni neuropeptide receptor 0.0041 0.4573 0.4573
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.4573 0.4573
Echinococcus granulosus hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.4573 0.4573
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis g protein coupled receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Brugia malayi Melatonin receptor type 1A 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus sex peptide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni amine GPCR 0.0041 0.4573 0.4573
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.4573 0.4573
Echinococcus multilocularis fmrfamide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine receptor 0.0041 0.4573 0.4573
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.4573 0.4573
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.4573 0.4573
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.4573 0.4573
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi larval opioid receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.4573 0.4573
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.4573 0.4573
Brugia malayi Cytochrome P450 family protein 0.0016 0.0813 0.0813
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.4573 0.4573
Schistosoma mansoni opsin-like receptor 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Brugia malayi RE15519p 0.0041 0.4573 0.4573
Schistosoma mansoni neuropeptide receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.4573 0.4573
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.4134 0.4134
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.4573 0.4573
Echinococcus granulosus g protein coupled receptor 0.0041 0.4573 0.4573
Brugia malayi neuropeptide F receptor 0.0041 0.4573 0.4573
Schistosoma mansoni adenoreceptor 0.0041 0.4573 0.4573
Echinococcus multilocularis serotonin receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.4573 0.4573
Echinococcus granulosus somatostatin receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Brugia malayi follicle stimulating hormone receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni neuropeptide receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.3751 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni opsin-like receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.4573 0.4573
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi Dopamine receptor protein 2 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.4573 0.4573
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.2964 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.4573 0.4573
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus neuropeptide receptor 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0399 0.0399
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus multilocularis sex peptide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.4573 0.4573
Brugia malayi AKH receptor 0.0041 0.4573 0.4573
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.4573 0.4573
Schistosoma mansoni myosin xvIII 0.0041 0.4573 0.4573
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.4573 0.5
Echinococcus multilocularis neuropeptide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni opsin-like receptor 0.0041 0.4573 0.4573
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.4573 0.4573
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.2964 1
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.4573 0.4573
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.2964 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.4573 0.4573
Echinococcus granulosus allatostatin A receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.4573 0.4573
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.4573 0.4573
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.4573 0.4573
Schistosoma mansoni hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni amine GPCR 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.002 0.1316 0.1316
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.4573 0.4573
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni hypothetical protein 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.4573 0.4573
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.4573 0.4573
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.3751 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.4134 0.4134
Echinococcus multilocularis orexin receptor type 2 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0033 0.3365 0.3365
Echinococcus multilocularis somatostatin receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Echinococcus multilocularis serotonin receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.4573 0.4573
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.2964 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.4573 0.4573
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.4573 0.4573
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni amine GPCR 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi Serotonin receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi G-protein coupled receptor 0.0041 0.4573 0.4573
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.4573 0.4573
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.4668 0.4668
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.4573 0.4573
Brugia malayi G protein-coupled receptor 0.0041 0.4573 0.4573
Echinococcus granulosus neuropeptide s receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.4573 0.4573
Brugia malayi ORL1-like opioid receptor 0.0041 0.4573 0.4573
Brugia malayi Cytochrome P450 family protein 0.0016 0.0813 0.0813
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Brugia malayi neuropeptide F receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0813 0.0813
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.4573 0.4573
Echinococcus granulosus orexin receptor type 2 0.0041 0.4573 0.4573
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.4573 0.4573
Schistosoma mansoni amine GPCR 0.0041 0.4573 0.4573
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi Dopamine receptor protein 1 0.0041 0.4573 0.4573
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.4573 0.4573
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus multilocularis allatostatin A receptor 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.4573 0.4573
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0399 0.0399
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.4573 0.4573
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.4573 0.4573
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.2964 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.4573 0.4573
Onchocerca volvulus 0.0041 0.4573 0.5
Schistosoma mansoni biogenic amine receptor 0.0041 0.4573 0.4573
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0813 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573
Brugia malayi putative neuropeptide receptor 0.0041 0.4573 0.4573
Schistosoma mansoni neuropeptide receptor 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Brugia malayi hypothetical protein 0.0041 0.4573 0.4573
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.4573 0.4573
Loa Loa (eye worm) hypothetical protein 0.0041 0.4573 0.4573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.4573 0.4573

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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