Detailed information for compound 1550928

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.694 | Formula: C25H43N3S
  • H donors: 1 H acceptors: 0 LogP: 6.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H]([C@H]1CNC(=S)N1CC1CCN(CC1)CCC12CC3CC(C2)CC(C1)C3)C
  • InChi: 1S/C25H43N3S/c1-3-18(2)23-16-26-24(29)28(23)17-19-4-7-27(8-5-19)9-6-25-13-20-10-21(14-25)12-22(11-20)15-25/h18-23H,3-17H2,1-2H3,(H,26,29)/t18-,20?,21?,22?,23+,25?/m0/s1
  • InChiKey: OTNDGINEQVCDCV-NLSIXXNJSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus orexin receptor type 2 0.0049 0.0248 0.0413
Onchocerca volvulus 0.0049 0.0248 0.2591
Onchocerca volvulus 0.0049 0.0248 0.2587
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0255 1
Echinococcus granulosus g protein coupled receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Echinococcus multilocularis muscleblind protein 0.015 0.0872 0.0861
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0248 0.0413
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0182 0.0319
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0299
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0032 0.0087
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0248 0.0433
Schistosoma mansoni opsin-like receptor 0.0049 0.0248 0.0413
Brugia malayi Dopamine receptor protein 1 0.0049 0.0248 0.0413
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0786 0.1355
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0309 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Echinococcus multilocularis para nitrobenzyl esterase 0.0159 0.0924 0.0913
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0255 1
Leishmania major hypothetical protein, conserved 0.005 0.0255 0.804
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0058 0.0943
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0285 0.0498
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0201 0.0332
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0434
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0182 0.0299
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0058 0.028
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0248 0.0236
Loa Loa (eye worm) hypothetical protein 0.0097 0.0546 0.0953
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0309 0.0298
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0248 0.2587
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus granulosus BC026374 protein S09 family 0.0159 0.0924 0.1597
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0058 0.028
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0091 0.2666
Echinococcus granulosus allatostatin A receptor 0.0049 0.0248 0.0413
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0234 0.2268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0248 0.0236
Schistosoma mansoni patched 1 0.0042 0.0204 0.0337
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0248 0.0236
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus multilocularis protein dispatched 1 0.0048 0.0241 0.0229
Schistosoma mansoni biogenic amine receptor 0.0049 0.0248 0.0413
Schistosoma mansoni DNA polymerase eta 0.0023 0.0091 0.0139
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0248 0.0413
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0182 0.0299
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0298
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0255 0.373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0298
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0309 0.2138
Schistosoma mansoni hypothetical protein 0.0018 0.0058 0.0081
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0032 0.0056
Echinococcus granulosus snurportin 1 0.0372 0.2236 0.3893
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0091 0.008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0058 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0047 0.0666
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2236 0.3906
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0248 0.0413
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0234 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.018 0.6657
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0091 0.2666
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0171 0.1113
Schistosoma mansoni opsin-like receptor 0.0049 0.0248 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Brugia malayi hypothetical protein 0.005 0.0255 0.0425
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0122 0.4028
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0032 0.0058
Trichomonas vaginalis esterase, putative 0.0036 0.0171 0.1602
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0248 0.2587
Onchocerca volvulus 0.0049 0.0248 0.2587
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.0283
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0299
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0182 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0047 0.0666
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Onchocerca volvulus 0.0159 0.0924 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0171 0.6848
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0032 0.0087
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0162 0.2182
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0319
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0248 0.0413
Loa Loa (eye worm) beta-lactamase 0.0036 0.0171 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0171 0.1602
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0234 0.2268
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0248 0.0236
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0938 0.5725 1
Onchocerca volvulus 0.0014 0.0032 0.0221
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0234 0.2268
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0159 0.0924 0.6694
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0087
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.0248 0.0236
Schistosoma mansoni amine GPCR 0.0049 0.0248 0.0413
Entamoeba histolytica hypothetical protein 0.0035 0.0166 0.2615
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0162 0.5849
Onchocerca volvulus 0.0049 0.0248 0.2587
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Brugia malayi Melatonin receptor type 1A 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0091 0.0139
Trichomonas vaginalis spcc417.12 protein, putative 0.0159 0.0924 1
Onchocerca volvulus 0.0014 0.0032 0.0221
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0058 0.0293
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0058 0.028
Schistosoma mansoni hypothetical protein 0.0022 0.0085 0.0129
Echinococcus granulosus g protein coupled receptor 0.0049 0.0248 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Echinococcus multilocularis somatostatin receptor 0.0049 0.0248 0.0236
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0962
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0162 0.1456
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0248 0.0413
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0248 0.0413
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0248 0.0413
Brugia malayi hypothetical protein 0.0035 0.0166 0.027
Echinococcus multilocularis tumor protein p63 0.0333 0.1999 0.199
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0171 0.1553
Echinococcus multilocularis dna polymerase eta 0.0023 0.0091 0.008
Mycobacterium tuberculosis Conserved protein 0.0036 0.0171 0.1113
Brugia malayi Carboxylesterase family protein 0.0159 0.0924 0.1597
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.0283
Mycobacterium ulcerans lipase LipD 0.0036 0.0171 0.1553
Brugia malayi GnHR receptor homolog 0.0049 0.0248 0.0413
Mycobacterium ulcerans carboxylesterase, LipT 0.0159 0.0924 1
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0248 0.0433
Mycobacterium tuberculosis Conserved protein 0.0036 0.0171 0.1113
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0201 0.1945
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0248 0.0236
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0058 0.0293
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0298
Schistosoma mansoni cpg binding protein 0.006 0.0316 0.0533
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0234 0.3939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0298
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0058 0.0293
Onchocerca volvulus 0.0049 0.0248 0.2587
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0299
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0012 0.0021
Mycobacterium tuberculosis Conserved protein 0.0036 0.0171 0.1113
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0054 0.0074
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0248 0.0413
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0058 0.1173
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0248 0.0413
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0171 0.1553
Onchocerca volvulus 0.0036 0.0171 0.174
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0032 0.0035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0159 0.0924 0.1597
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0021
Schistosoma mansoni adenoreceptor 0.0049 0.0248 0.0413
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0159 0.0924 0.0913
Entamoeba histolytica hypothetical protein 0.0035 0.0166 0.2615
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0058 0.028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0056 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Schistosoma mansoni importin beta-1 0.0035 0.0162 0.0263
Entamoeba histolytica hypothetical protein 0.0035 0.0166 0.2615
Schistosoma mansoni neuropeptide receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0938 0.5725 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0058 0.028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0034 0.0023
Leishmania major cytochrome p450-like protein 0.0026 0.011 0.2824
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0058 0.028
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0091 0.1156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0962
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Onchocerca volvulus 0.0014 0.0032 0.0221
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0091 0.2666
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0058 0.0293
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0248 0.0414
Echinococcus granulosus neuroligin 0.0159 0.0924 0.1597
Loa Loa (eye worm) oxidoreductase 0.0014 0.0032 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0248 0.0236
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0248 0.0413
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.011 0.3513
Schistosoma mansoni hypothetical protein 0.0035 0.0166 0.027
Loa Loa (eye worm) carboxylesterase 0.0938 0.5725 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0248 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0058 0.028
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0255 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0091 0.016
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0171 0.6221
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0035
Onchocerca volvulus 0.0159 0.0924 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0298
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0248 0.0413
Brugia malayi Dopamine receptor protein 2 0.0049 0.0248 0.0413
Brugia malayi Carboxylesterase family protein 0.0159 0.0924 0.1597
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0085 0.0074
Onchocerca volvulus 0.0049 0.0248 0.2587
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0248 0.0433
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0058 0.028
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0248 0.0413
Brugia malayi Cytochrome P450 family protein 0.0026 0.011 0.0172
Schistosoma mansoni cpg binding protein 0.006 0.0316 0.0533
Schistosoma mansoni hypothetical protein 0.0205 0.1207 0.2093
Echinococcus granulosus somatostatin receptor 0.0049 0.0248 0.0413
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0201 0.7606
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi Cytochrome P450 family protein 0.0026 0.011 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0962
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0087
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0159 0.0924 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0248 0.0413
Loa Loa (eye worm) cytochrome P450 0.0018 0.0058 0.0102
Onchocerca volvulus 0.0049 0.0248 0.2587
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0309 0.052
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0234 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0159 0.0924 0.1597
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0248 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0255 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0091 0.0526
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0248 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0034 0.004
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0032 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.015 0.0962
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0058 0.0293
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0248 0.0413
Schistosoma mansoni neuropeptide receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0248 0.0236
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0091 0.0719
Schistosoma mansoni biogenic amine receptor 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0058 0.028
Echinococcus granulosus fmrfamide receptor 0.0049 0.0248 0.0413
Schistosoma mansoni hypothetical protein 0.004 0.0195 0.0321
Onchocerca volvulus 0.0049 0.0248 0.2587
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0248 0.0433
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0032 0.0058
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0058 0.0293
Schistosoma mansoni hypothetical protein 0.0082 0.0455 0.0775
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0248 0.0236
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Mycobacterium leprae putative cytochrome p450 0.0018 0.0058 0.1291
Echinococcus granulosus carboxylesterase 5A 0.0938 0.5725 1
Onchocerca volvulus 0.0049 0.0248 0.2587
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0234 0.7304
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0309 0.464
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.018 0.2886
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0171 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0085 0.0129
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0091 0.0139
Schistosoma mansoni hypothetical protein 0.0049 0.0248 0.0413
Brugia malayi cytochrome P450 0.0018 0.0058 0.0081
Brugia malayi ORL1-like opioid receptor 0.0049 0.0248 0.0413
Echinococcus granulosus para nitrobenzyl esterase 0.0159 0.0924 0.1597
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0171 0.1113
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0032 0.0087
Echinococcus multilocularis geminin 0.0205 0.1207 0.1197
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0171 0.1602
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.0248 0.0236
Brugia malayi AKH receptor 0.0049 0.0248 0.0413
Schistosoma mansoni amine GPCR 0.0049 0.0248 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0248 0.0413
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.011 0.3513
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0248 0.0413
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0035
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0248 0.0236
Onchocerca volvulus 0.0049 0.0248 0.2587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0298
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0234 0.2268
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0248 0.0413
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0248 0.0236
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0248 0.0413
Leishmania major hypothetical protein, conserved 0.0036 0.0171 0.5002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0091 0.2143
Onchocerca volvulus 0.0159 0.0924 1
Echinococcus multilocularis sex peptide receptor 0.0049 0.0248 0.0236
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0035
Echinococcus multilocularis protein patched 0.0042 0.0204 0.0193
Schistosoma mansoni gliotactin 0.0159 0.0924 0.1597
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0204 0.0357
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0166 0.027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0171 0.0159
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0162 0.5
Brugia malayi G-protein coupled receptor 0.0049 0.0248 0.0413
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0455 0.0775
Onchocerca volvulus 0.0049 0.0248 0.2587
Leishmania major cytochrome p450-like protein 0.0018 0.0058 0.0943
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0091 0.008
Schistosoma mansoni neuropeptide receptor 0.0049 0.0248 0.0413
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0091 0.0666
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi CHE-14 protein 0.0042 0.0204 0.0337
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0248 0.0413
Mycobacterium ulcerans beta-lactamase 0.0036 0.0171 0.1553
Entamoeba histolytica hypothetical protein 0.0035 0.0166 0.2615
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Onchocerca volvulus 0.0049 0.0248 0.2587
Brugia malayi neuropeptide F receptor 0.0049 0.0248 0.0413
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0058 0.0293
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0546 0.0934
Brugia malayi Carboxylesterase family protein 0.0938 0.5725 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0162 0.0263
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0248 0.0433
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Brugia malayi putative neuropeptide receptor 0.0049 0.0248 0.0413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0234 0.3939
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0248 0.0236
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0248 0.0236
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0248 0.0236
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Schistosoma mansoni hypothetical protein 0.0049 0.0248 0.0413
Echinococcus granulosus expressed conserved protein 0.0091 0.0509 0.0871
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.081 0.1397
Brugia malayi Cytochrome P450 family protein 0.0018 0.0058 0.0081
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0159 0.0924 0.1597
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0234 0.3939
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0248 0.0236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0166 0.0155
Brugia malayi larval opioid receptor 0.0049 0.0248 0.0413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0171 0.0278
Echinococcus multilocularis acetylcholinesterase 0.0938 0.5725 0.572
Echinococcus granulosus neuropeptide receptor 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0171 0.1113
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0171 0.1602
Echinococcus granulosus neuropeptide s receptor 0.0049 0.0248 0.0413
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0546 0.0934
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0058 0.028
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0234 0.2268
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0091 0.0139
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Onchocerca volvulus 0.0047 0.0234 0.2439
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.011 0.0877
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.012 0.0689 0.1204
Echinococcus multilocularis neuroligin 0.0159 0.0924 0.0913
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0687 0.1182
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.0445
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0034 0.004
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0201 0.2837
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0056 0.0097
Echinococcus multilocularis expressed conserved protein 0.0091 0.0509 0.0498
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0058 0.0293
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.018 1
Onchocerca volvulus 0.0049 0.0248 0.2587
Echinococcus multilocularis GPCR, family 2 0.0038 0.0182 0.0171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0056
Echinococcus granulosus acetylcholinesterase 0.0938 0.5725 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.081 0.0799
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0171 0.1113
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.137 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0171 0.1602
Echinococcus granulosus serotonin receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) carboxylesterase 0.0159 0.0924 0.1614
Loa Loa (eye worm) acetylcholinesterase 1 0.0938 0.5725 1
Echinococcus multilocularis muscleblind protein 1 0.015 0.0872 0.0861
Onchocerca volvulus 0.0049 0.0248 0.2587
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Echinococcus granulosus dnaJ subfamily B 0.0806 0.4909 0.8573
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0248 0.0236
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0032 0.0087
Onchocerca volvulus 0.0049 0.0248 0.2587
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0248 0.0413
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.0248 0.0413
Schistosoma mansoni myosin xvIII 0.0049 0.0248 0.0413
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0248 0.0236
Echinococcus granulosus dna polymerase eta 0.0023 0.0091 0.0139
Loa Loa (eye worm) hypothetical protein 0.0047 0.0234 0.0409
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0248 0.0236
Loa Loa (eye worm) CYP4Cod1 0.0026 0.011 0.0193
Echinococcus multilocularis acetylcholinesterase 0.0938 0.5725 0.572
Onchocerca volvulus 0.0057 0.0296 0.3118
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0058 0.0293
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi Carboxylesterase family protein 0.0159 0.0924 0.1597
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0171 0.1113
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0201 0.2837
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0296 0.0518
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0309 0.3105
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0058 0.1173
Brugia malayi Serotonin receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0248 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0058 0.028
Schistosoma mansoni hypothetical protein 0.0038 0.0182 0.0299
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0091 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0309 0.3105
Schistosoma mansoni opsin-like receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.015 0.0872 0.1523
Schistosoma mansoni biogenic amine receptor 0.0049 0.0248 0.0413
Onchocerca volvulus 0.0049 0.0248 0.2587
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0058 0.0293
Onchocerca volvulus 0.0036 0.0171 0.174
Brugia malayi beta-lactamase 0.0036 0.0171 0.0278
Echinococcus granulosus geminin 0.0205 0.1207 0.2093
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0248 0.0433
Echinococcus granulosus g protein coupled receptor 0.0049 0.0248 0.0413
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus multilocularis BC026374 protein (S09 family) 0.0159 0.0924 0.0913
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0171 0.6221
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0248 0.0413
Echinococcus multilocularis 0.0018 0.0058 0.0046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0122 0.1057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0309 0.052
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0091 0.2666
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi G protein-coupled receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0689 0.1204
Schistosoma mansoni cytochrome P450 0.0018 0.0058 0.0081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.0283
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.081 0.1397
Leishmania major importin beta-1 subunit, putative 0.0028 0.0122 0.3239
Echinococcus granulosus hypothetical protein 0.0049 0.0248 0.0413
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0248 0.0236
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0248 0.0413
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0091 0.2666
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0035
Leishmania major cytochrome p450-like protein 0.0018 0.0058 0.0943
Schistosoma mansoni hypothetical protein 0.0205 0.1207 0.2093
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0032 0.0035
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0248 0.0413
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0248 0.0236
Onchocerca volvulus 0.0036 0.0171 0.174
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Schistosoma mansoni acetylcholinesterase 0.0159 0.0924 0.1597
Brugia malayi CXXC zinc finger family protein 0.0057 0.0296 0.0498
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0248 0.0236
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0058 0.0293
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0056 0.0077
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0248 0.0413
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.4909 0.4903
Loa Loa (eye worm) hypothetical protein 0.0082 0.0455 0.0794
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0171 0.6221
Schistosoma mansoni amine GPCR 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0171 0.1113
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0234 0.0389
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0555 0.0951
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0182 0.0299
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0248 0.0236
Brugia malayi Carboxylesterase family protein 0.0938 0.5725 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0201 0.1945
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0058 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0058 0.028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Onchocerca volvulus 0.0049 0.0248 0.2587
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0248 0.0236
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0058 0.0293
Brugia malayi beta-lactamase family protein 0.0036 0.0171 0.0278
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0234 0.7304
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0248 0.0433
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0546 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0171 0.1602
Schistosoma mansoni hypothetical protein 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0058 0.028
Echinococcus granulosus neuropeptide receptor 0.0049 0.0248 0.0413
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0689 0.1185
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) acetyltransferase 0.014 0.081 0.1415
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0122 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0058 0.1173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0171 0.0278
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0248 0.0413
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0159 0.0924 0.6694
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Mycobacterium ulcerans hypothetical protein 0.0047 0.0234 0.2268
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0058 0.028
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0058 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0255 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Schistosoma mansoni hypothetical protein 0.004 0.0195 0.0321
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0166 0.027
Schistosoma mansoni hypothetical protein 0.0049 0.0248 0.0413
Schistosoma mansoni neuroligin 3 (S09 family) 0.0159 0.0924 0.1597
Onchocerca volvulus 0.0159 0.0924 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0546 0.0534
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0034 0.004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0689 0.1185
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0058 0.028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0248 0.0413
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0629 1
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0248 0.0236
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0234 0.7304
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0204 0.198
Schistosoma mansoni hypothetical protein 0.0806 0.4909 0.8573
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0021
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0058 0.0293
Brugia malayi hypothetical protein 0.0159 0.0924 0.1597
Leishmania major DNA polymerase eta, putative 0.0023 0.0091 0.2143
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0234 0.0389
Echinococcus granulosus muscleblind protein 0.015 0.0872 0.1505
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0248 0.0413
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0248 0.0236
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0058 0.028
Echinococcus multilocularis cpg binding protein 0.006 0.0316 0.0305
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0091 0.0666
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0204 0.0193
Mycobacterium leprae Probable lipase LipE 0.0036 0.0171 0.6848
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0058 0.0293
Schistosoma mansoni hypothetical protein 0.004 0.0195 0.0321
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Schistosoma mansoni hypothetical protein 0.0372 0.2236 0.3893
Brugia malayi hypothetical protein 0.0032 0.0146 0.0235
Echinococcus granulosus acetylcholinesterase 0.0938 0.5725 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0058 0.0293
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0182 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0021
Onchocerca volvulus 0.0049 0.0248 0.2587
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.011 0.0193
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0032 0.002
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0248 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.0283
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0091 0.0139
Brugia malayi sulfakinin receptor protein 0.0049 0.0248 0.0413
Trypanosoma brucei unspecified product 0.0016 0.0047 0.0666
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0248 0.0236
Brugia malayi G-protein coupled receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0248 0.0433
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0058 0.0438
Loa Loa (eye worm) hypothetical protein 0.0047 0.0234 0.0409
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0673 0.1175
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0058 0.028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Onchocerca volvulus 0.0014 0.0032 0.0221
Schistosoma mansoni amine GPCR 0.0049 0.0248 0.0413
Brugia malayi Dopamine receptor 0.0049 0.0248 0.0413
Schistosoma mansoni cpg binding protein 0.0057 0.0296 0.0498
Trypanosoma brucei cytochrome P450, putative 0.0026 0.011 0.3513
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0034 0.0023
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0159 0.0924 0.1597
Toxoplasma gondii ABC1 family protein 0.0036 0.0171 0.2321
Brugia malayi RE15519p 0.0049 0.0248 0.0413
Schistosoma mansoni histamine h1 receptor 0.0049 0.0248 0.0413
Brugia malayi neuropeptide F receptor 0.0049 0.0248 0.0413
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0248 0.0413
Schistosoma mansoni BC026374 protein (S09 family) 0.0159 0.0924 0.1597
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0091 0.0139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0171 0.0278
Mycobacterium ulcerans hypothetical protein 0.0036 0.0171 0.1553
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0058 0.0293
Schistosoma mansoni amine GPCR 0.0049 0.0248 0.0413
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0309 0.052
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0248 0.0433
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0162 0.1049
Mycobacterium tuberculosis Carboxylesterase LipT 0.0159 0.0924 0.6694
Entamoeba histolytica hypothetical protein 0.0028 0.0122 0.1746
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Echinococcus multilocularis serotonin receptor 0.0049 0.0248 0.0236
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0058 0.1173
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0171 0.6221
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0248 0.0413
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0248 0.0236
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0162 0.5849
Loa Loa (eye worm) hypothetical protein 0.015 0.0872 0.1523
Echinococcus granulosus importin subunit beta 1 0.0035 0.0162 0.0263
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0673 0.1175
Brugia malayi Serotonin receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0171 0.0298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0056
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0248 0.0413
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0248 0.0413
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0162 0.0151
Echinococcus granulosus tumor protein p63 0.0333 0.1999 0.3479
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0087
Brugia malayi Cytochrome P450 family protein 0.0055 0.0285 0.0478
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0032 0.0056
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0047 0.0234 0.0409
Brugia malayi Muscleblind-like protein 0.015 0.0872 0.1505
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0234 0.1585
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0162 0.5833
Brugia malayi hypothetical protein 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.011 0.0193
Schistosoma mansoni neuropeptide receptor 0.0049 0.0248 0.0413
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0091 0.0526
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0032 0.0035
Plasmodium falciparum importin beta, putative 0.0035 0.0162 0.5849
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0234 0.1585
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0047 0.0666
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0234 0.2268
Echinococcus multilocularis serotonin receptor 0.0049 0.0248 0.0236
Echinococcus granulosus dna polymerase kappa 0.0023 0.0091 0.0139
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0058 0.0293
Loa Loa (eye worm) carboxylesterase 0.0159 0.0924 0.1614
Onchocerca volvulus 0.0159 0.0924 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0248 0.0413
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0058 0.0293
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0802 0.0791
Echinococcus multilocularis snurportin 1 0.0372 0.2236 0.2227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0248 0.0413
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0204 0.0337
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0204 0.0337
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0091 0.2666
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0234 0.2268
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0171 0.1113
Echinococcus granulosus sex peptide receptor 0.0049 0.0248 0.0413
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0162 0.5833
Brugia malayi RNA, U transporter 1 0.0099 0.0557 0.0955
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0248 0.0236
Brugia malayi beta-lactamase family protein 0.0036 0.0171 0.0278
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0938 0.5725 1
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0802 0.1383
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Plasmodium vivax importin-beta 2, putative 0.0035 0.0162 0.5849
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0182 0.0299
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.0283
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0255 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0248 0.0413
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0058 0.0293
Loa Loa (eye worm) hypothetical protein 0.0159 0.0924 0.1614
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0248 0.0236
Trypanosoma brucei unspecified product 0.0023 0.0091 0.2666
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0248 0.0236
Leishmania major DNA polymerase kappa, putative 0.0023 0.0091 0.2143
Echinococcus granulosus cpg binding protein 0.006 0.0316 0.0533
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.0458
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0058 0.028
Brugia malayi MH2 domain containing protein 0.0118 0.0673 0.1157
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.0042 0.0204 0.0357
Trypanosoma brucei unspecified product 0.0016 0.0047 0.0666
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0309 0.3105
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0032 0.0087
Echinococcus granulosus GPCR family 2 0.0038 0.0182 0.0299
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0248 0.0236
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0058 0.1291
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0248 0.0433
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0049 0.0248 0.0433
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0021
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0058 0.0293
Schistosoma mansoni hypothetical protein 0.004 0.0195 0.0321
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0248 0.0413
Brugia malayi Carboxylesterase family protein 0.0159 0.0924 0.1597
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0248 0.0413
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0091 0.0719
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0122 0.1057
Echinococcus multilocularis carboxylesterase 5A 0.0938 0.5725 0.572
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0234 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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