Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0148 | 0.4092 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0148 | 0.4092 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0148 | 0.4092 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0148 | 0.4092 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0065 | 0.1149 | 0.2808 |
Echinococcus granulosus | proteasome prosome macropain | 0.0148 | 0.4092 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0148 | 0.4092 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0065 | 0.1149 | 0.1981 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0148 | 0.4092 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0148 | 0.4092 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0065 | 0.1149 | 0.2529 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0148 | 0.4092 | 0.4 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0045 | 0.0422 | 0.0683 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0065 | 0.1149 | 0.2529 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0045 | 0.0422 | 0.0273 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0148 | 0.4092 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0045 | 0.0422 | 0.0683 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0065 | 0.1149 | 0.1012 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0045 | 0.0422 | 0.1031 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0148 | 0.4092 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0148 | 0.4092 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0148 | 0.4092 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0065 | 0.1149 | 0.2808 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0148 | 0.4092 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0036 | 0.0112 | 0.0275 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0148 | 0.4092 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0148 | 0.4092 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0148 | 0.4092 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0148 | 0.4092 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.