Detailed information for compound 1551105

Basic information

Technical information
  • TDR Targets ID: 1551105
  • Name: N-[4-(1-ethylsulfonyl-5-thiophen-2-yl-4,5-dih ydropyrazol-3-yl)phenyl]ethanesulfonamide
  • MW: 427.561 | Formula: C17H21N3O4S3
  • H donors: 1 H acceptors: 4 LogP: 1.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1cccs1)S(=O)(=O)CC
  • InChi: 1S/C17H21N3O4S3/c1-3-26(21,22)19-14-9-7-13(8-10-14)15-12-16(17-6-5-11-25-17)20(18-15)27(23,24)4-2/h5-11,16,19H,3-4,12H2,1-2H3
  • InChiKey: RBAZFRPDHIPUDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[1-ethylsulfonyl-5-(2-thienyl)-4,5-dihydropyrazol-3-yl]phenyl]ethanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax importin-beta 2, putative 0.0028 0.0239 0.0749
Schistosoma mansoni lamin 0.0026 0.0206 0.0202
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0188
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0026 0.0207 0.0647
Mycobacterium tuberculosis Probable reductase 0.0085 0.11 0.3486
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0026 0.0207 0.0203
Echinococcus multilocularis GPCR, family 2 0.0031 0.0275 0.0275
Loa Loa (eye worm) acetyltransferase 0.014 0.1943 0.3009
Brugia malayi Importin beta-1 subunit 0.0028 0.0239 0.0365
Giardia lamblia 20S proteasome alpha subunit 7 0.0026 0.0207 0.0647
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.4416 0.684
Giardia lamblia 20S proteasome alpha subunit 5 0.0026 0.0207 0.0647
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0026 0.0207 0.0207
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.11 0.304
Leishmania major importin beta-1 subunit, putative 0.0023 0.0158 0.0489
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0119 0.1624 0.5154
Onchocerca volvulus Notchless protein homolog 0.0026 0.0207 1
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0042 0.0066
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0026 0.0207 0.0395
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.0319
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0026 0.0207 0.0395
Plasmodium vivax proteasome subunit beta type-7, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis muscleblind protein 1 0.0436 0.6457 0.6457
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0026 0.0207 0.0395
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0048 0.0044
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0339 0.0339
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1943 0.3004
Brugia malayi MH2 domain containing protein 0.0016 0.0048 0.0069
Trichomonas vaginalis ran, putative 0.0021 0.0126 0.0387
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0026 0.0207 0.0647
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0042 0.0122
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0275 0.0275
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0126 0.0387
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0026 0.0207 0.0647
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0026 0.0207 0.0647
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0026 0.0207 0.0203
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0026 0.0207 0.0395
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0026 0.0207 0.0647
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0026 0.0207 0.0647
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0086 0.0858
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0026 0.0207 0.0647
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0339 0.0339
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0382 0.0382
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0262
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0119 0.1624 0.5154
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0963 0.0959
Brugia malayi proteasome subunit beta type 1 0.0119 0.1624 0.251
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.0826
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0026 0.0207 0.0647
Schistosoma mansoni lamin 0.0026 0.0206 0.0202
Trypanosoma brucei proteasome beta 6 subunit 0.0119 0.1624 0.5154
Echinococcus granulosus proteasome prosome macropain 0.0219 0.3147 0.3147
Echinococcus granulosus GPCR family 2 0.0031 0.0275 0.0275
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0026 0.0207 0.0203
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0374 0.1178
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0374 0.0579
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0565 0.1784
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0207 0.0647
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0086 0.0262
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0026 0.0207 0.0207
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0026 0.0207 0.0395
Echinococcus granulosus Proteasome subunit alpha beta 0.0026 0.0207 0.0207
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0119 0.1624 0.5154
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0026 0.0207 0.0321
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0026 0.0207 0.0321
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0026 0.0207 0.0647
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.0387
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0817 0.126
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0119 0.1624 0.1624
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0119 0.1624 0.1624
Schistosoma mansoni hypothetical protein 0.0031 0.0275 0.0271
Brugia malayi Probable ClpP-like protease 0.0076 0.0963 0.1486
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0339 0.0335
Echinococcus multilocularis proteasome subunit beta type 6 0.0026 0.0207 0.0207
Brugia malayi Proteasome A-type and B-type family protein 0.0219 0.3147 0.487
Leishmania major proteasome beta 2 subunit, putative 0.0026 0.0207 0.0647
Brugia malayi proteasome subunit alpha type 1 0.0026 0.0207 0.0315
Toxoplasma gondii proteasome subunit beta type, putative 0.0219 0.3147 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0275 0.0426
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0963 0.3051
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0382 0.0382
Echinococcus multilocularis proteasome (prosome, macropain) 0.0219 0.3147 0.3147
Plasmodium falciparum thioredoxin reductase 0.0037 0.0374 0.1178
Echinococcus multilocularis lamin dm0 0.0026 0.0206 0.0206
Plasmodium vivax proteasome subunit beta type-3, putative 0.0026 0.0207 0.0647
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0239 0.0749
Brugia malayi proteasome subunit alpha type 2 0.0026 0.0207 0.0315
Entamoeba histolytica Ran family GTPase 0.0021 0.0126 0.0128
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0026 0.0207 0.0395
Brugia malayi hypothetical protein 0.0035 0.0339 0.0519
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0026 0.0207 0.0207
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0026 0.0207 0.0395
Plasmodium vivax glutathione reductase, putative 0.0037 0.0374 0.1178
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Echinococcus granulosus proteasome subunit alpha type 2 0.0026 0.0207 0.0207
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 1
Leishmania major GTP-binding protein, putative 0.0021 0.0126 0.0387
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0219 0.3147 0.4874
Leishmania major proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis snurportin 1 0.0302 0.4416 0.4416
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0026 0.0207 0.0647
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Brugia malayi Proteasome A-type and B-type family protein 0.0026 0.0207 0.0315
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0206 0.0319
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0262
Schistosoma mansoni smad1 5 8 and 0.0016 0.0048 0.0044
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0026 0.0207 0.0203
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0387
Giardia lamblia Proteasome subunit beta type 2 0.0026 0.0207 0.0647
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0387
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0158 0.0489
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1244 0.3945
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0026 0.0207 0.0207
Leishmania major proteasome beta 3 subunit, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0026 0.0207 0.0207
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0026 0.0207 0.0647
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0126 0.0126
Plasmodium vivax proteasome subunit beta type-6, putative 0.0026 0.0207 0.0647
Trypanosoma brucei trypanothione reductase 0.0037 0.0374 0.1178
Schistosoma mansoni Smad4 0.0016 0.0048 0.0044
Plasmodium falciparum glutathione reductase 0.0037 0.0374 0.1178
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0026 0.0207 0.0203
Giardia lamblia 20S proteasome alpha subunit 6 0.0026 0.0207 0.0647
Entamoeba histolytica hypothetical protein 0.0023 0.0158 0.0234
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0026 0.0207 0.0207
Leishmania major proteasome alpha 1 subunit, putative 0.0026 0.0207 0.0647
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0086 0.0086
Echinococcus multilocularis proteasome subunit alpha type 6 0.0026 0.0207 0.0207
Brugia malayi intermediate filament protein 0.0026 0.0206 0.0313
Giardia lamblia 20S proteasome alpha subunit 2 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0026 0.0207 0.0647
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0158 0.0489
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0026 0.0207 0.0647
Schistosoma mansoni smad 0.0016 0.0048 0.0044
Toxoplasma gondii exonuclease III APE 0.0018 0.0086 0.0262
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0219 0.3147 1
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0026 0.0207 0.0207
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0436 0.1373
Leishmania major trypanothione reductase 0.0037 0.0374 0.1178
Echinococcus multilocularis musashi 0.0026 0.0206 0.0206
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Brugia malayi Muscleblind-like protein 0.0436 0.6457 1
Echinococcus granulosus proteasome subunit beta t family 0.0026 0.0207 0.0207
Plasmodium vivax proteasome subunit beta type-1, putative 0.0119 0.1624 0.5154
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0042 0.0066
Brugia malayi MH2 domain containing protein 0.0016 0.0048 0.0069
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0026 0.0207 0.0647
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0026 0.0207 0.0395
Trypanosoma cruzi 20S proteasome subunit 0.0026 0.0207 0.0647
Mycobacterium ulcerans proteasome PrcA 0.0026 0.0207 0.0647
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0963 0.3051
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.11 0.3486
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0026 0.0207 0.0203
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0042 0.0122
Schistosoma mansoni hypothetical protein 0.0031 0.0275 0.0271
Brugia malayi MH2 domain containing protein 0.0232 0.3339 0.5168
Echinococcus granulosus snurportin 1 0.0302 0.4416 0.4416
Schistosoma mansoni ran 0.0021 0.0126 0.0122
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0026 0.0207 0.212
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0206 0.0642
Loa Loa (eye worm) hypothetical protein 0.0066 0.0817 0.1266
Echinococcus granulosus Smad4 0.0016 0.0048 0.0048
Loa Loa (eye worm) glutathione reductase 0.0037 0.0374 0.0579
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0026 0.0207 0.0203
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0026 0.0207 0.0647
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1244 0.3945
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.0262
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0026 0.0207 0.0647
Echinococcus granulosus proteasome subunit beta type 7 0.0026 0.0207 0.0207
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0004
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0436 0.1373
Giardia lamblia 20S proteasome alpha subunit 3 0.0026 0.0207 0.0647
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0436 0.1373
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.0826
Echinococcus granulosus muscleblind protein 0.0436 0.6457 0.6457
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0031 0.0275 0.0271
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0206 0.0313
Mycobacterium ulcerans proteasome PrcB 0.0219 0.3147 1
Echinococcus multilocularis proteasome subunit beta type 7 0.0026 0.0207 0.0207
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0026 0.0207 0.0647
Brugia malayi MH1 domain containing protein 0.0016 0.0048 0.0069
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0042 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.0669 1 1
Brugia malayi glutathione reductase 0.0037 0.0374 0.0574
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0565 0.0565
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0436 0.1373
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0239 0.0239
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0026 0.0207 0.0395
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0275 0.042
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0207 0.0647
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0026 0.0207 0.0647
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0026 0.0207 0.0647
Plasmodium falciparum importin beta, putative 0.0028 0.0239 0.0749
Leishmania major proteasome beta 5 subunit, putative 0.0219 0.3147 1
Schistosoma mansoni hypothetical protein 0.0302 0.4416 0.4414
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.0308
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0026 0.0207 0.0647
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0086 0.0262
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0086 0.0262
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0026 0.0207 0.0395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1284 0.1984
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0383 0.1207
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0206 0.2103
Schistosoma mansoni ran 0.0021 0.0126 0.0122
Leishmania major proteasome alpha 2 subunit, putative 0.0026 0.0207 0.0647
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0026 0.0207 0.0647
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0119 0.1624 0.5154
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.0387
Giardia lamblia Proteasome subunit beta type 3 0.0026 0.0207 0.0647
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0021 0.0033
Echinococcus granulosus Proteasome subunit alpha type 7 0.0026 0.0207 0.0207
Echinococcus multilocularis muscleblind protein 0.0436 0.6457 0.6457
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0026 0.0207 0.0647
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0026 0.0207 0.0203
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0026 0.0207 0.0207
Echinococcus multilocularis smad 0.0016 0.0048 0.0048
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0963 0.2574
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 1
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0026 0.0207 0.0207
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0219 0.3147 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0219 0.3147 1
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0026 0.0207 0.0203
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0086 0.0262
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0026 0.0207 0.0647
Trypanosoma brucei proteasome beta 7 subunit 0.0026 0.0207 0.0647
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0963 0.3051
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0026 0.0207 0.0207
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0026 0.0207 0.0647
Toxoplasma gondii proteasome subunit 0.0026 0.0207 0.0647
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0206 0.0642
Toxoplasma gondii thioredoxin reductase 0.0037 0.0374 0.1178
Brugia malayi MH1 domain containing protein 0.0016 0.0048 0.0069
Leishmania major proteasome alpha 1 subunit, putative 0.0026 0.0207 0.0647
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0158 0.0489
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0119 0.1624 0.5154
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0239 0.0749
Plasmodium vivax proteasome subunit beta type-4, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.3339 0.5171
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0048 0.0075
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0565 0.1784
Leishmania major proteasome alpha 3 subunit, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0004 0.0004
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0219 0.3147 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.11 0.3486
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0963 0.0963
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0026 0.0207 0.0395
Brugia malayi proteasome subunit alpha type 6 0.0026 0.0207 0.0315
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0026 0.0207 0.0395
Plasmodium vivax proteasome subunit beta type-2, putative 0.0026 0.0207 0.0647
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0275 0.0275
Echinococcus granulosus proteasome subunit alpha type 6 0.0026 0.0207 0.0207
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0436 0.1373
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.11 0.3486
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0086 0.0086
Brugia malayi Proteasome subunit alpha type 7-1 0.0026 0.0207 0.0315
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0383 0.1207
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0086 0.0262
Echinococcus granulosus lamin 0.0026 0.0206 0.0206
Brugia malayi 20S proteasome alpha5 subunit 0.0026 0.0207 0.0315
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0275 0.0275
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0565 0.1221
Leishmania major proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0086 0.0262
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0119 0.1624 0.5154
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0026 0.0207 0.0647
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.0826
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0119 0.1624 0.1621
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0026 0.0207 0.0647
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0026 0.0207 0.0203
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0207 0.0647
Brugia malayi Proteasome A-type and B-type family protein 0.0026 0.0207 0.0315
Schistosoma mansoni importin beta-1 0.0028 0.0239 0.0236
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0026 0.0207 0.0647
Loa Loa (eye worm) hypothetical protein 0.0436 0.6457 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0206 0.0206
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0026 0.0207 0.0647
Brugia malayi proteasome subunit alpha type 3 0.0026 0.0207 0.0315
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0086 0.0858
Brugia malayi Proteasome A-type and B-type family protein 0.0026 0.0207 0.0315
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0026 0.0207 0.0395
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0436 0.6457 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0565 0.0565
Giardia lamblia 20S proteasome alpha subunit 1 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0219 0.3147 1
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0026 0.0207 0.0203
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0026 0.0207 0.0647
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0126 0.0194
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.11 0.3486
Brugia malayi Thioredoxin reductase 0.0037 0.0374 0.0574
Brugia malayi Cytochrome P450 family protein 0.0015 0.0042 0.0059
Brugia malayi Proteasome subunit alpha type 1 0.0026 0.0207 0.0315
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.0026 0.0207 0.0647
Echinococcus granulosus proteasome subunit beta type 6 0.0026 0.0207 0.0207
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0026 0.0207 0.0203
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1284 0.1989
Toxoplasma gondii peptidase, T1 family protein 0.0026 0.0207 0.0647
Brugia malayi proteasome subunit alpha type 4 0.0026 0.0207 0.0315
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0026 0.0207 0.0395
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0219 0.3147 1
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0042 0.0122
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1943 0.1943
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.11 0.3486
Loa Loa (eye worm) Smad1 0.0016 0.0048 0.0075
Loa Loa (eye worm) proteasome subunit beta type 1 0.0119 0.1624 0.2515
Plasmodium falciparum proteasome subunit beta type-5 0.0219 0.3147 1
Trypanosoma brucei proteasome alpha 7 subunit 0.0026 0.0207 0.0647
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0436 0.0436
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0026 0.0207 0.0647
Brugia malayi RNA, U transporter 1 0.0081 0.1035 0.1598
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0026 0.0207 0.0647
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0026 0.0207 0.0647
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0026 0.0207 0.0005
Brugia malayi proteasome subunit beta type 3 0.0026 0.0207 0.0315
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0026 0.0207 0.0647
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0026 0.0207 0.0321
Loa Loa (eye worm) hypothetical protein 0.0076 0.0963 0.1491
Echinococcus multilocularis proteasome subunit alpha type 2 0.0026 0.0207 0.0207
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0219 0.3147 0.3144
Toxoplasma gondii proteasome subunit alpha type, putative 0.0026 0.0207 0.0647
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0026 0.0207 0.0647
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0021 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.0275 0.0271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0086 0.0262
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 0.3051
Brugia malayi Cytochrome P450 family protein 0.0015 0.0042 0.0059
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 0.3051
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0026 0.0207 0.0647
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1943 0.1939
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1244 0.3945
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0275 0.0275
Schistosoma mansoni intermediate filament proteins 0.0026 0.0206 0.0202
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0963 0.3051
Echinococcus granulosus lamin dm0 0.0026 0.0206 0.0206
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0026 0.0207 0.0647
Toxoplasma gondii proteasome beta subunit 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0026 0.0207 0.0395
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0158 0.0489
Schistosoma mansoni smad1 5 8 and 0.0016 0.0048 0.0044
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0026 0.0207 0.0207
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0126 0.0387
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) proteasome subunit beta type 3 0.0026 0.0207 0.0321
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0026 0.0207 0.0203
Brugia malayi proteasome subunit beta type 2 0.0026 0.0207 0.0315
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0026 0.0207 0.0203
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0026 0.0207 0.0321
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Brugia malayi Smad1 0.0016 0.0048 0.0069
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0026 0.0207 0.0395
Schistosoma mansoni hypothetical protein 0.0035 0.0339 0.0335
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0374 0.1178
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0026 0.0207 0.0647
Toxoplasma gondii heat shock protein hslv, putative 0.0026 0.0207 0.0647
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.3339 0.5171
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0119 0.1624 0.5024
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0026 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0066 0.0817 0.0813
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0026 0.0207 0.0647
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0207 0.0647
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0206 0.0319
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0026 0.0207 0.0647
Leishmania major proteasome beta 2 subunit, putative 0.0026 0.0207 0.0647
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1883 0.1883
Schistosoma mansoni smad1 5 8 and 0.0016 0.0048 0.0044
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0026 0.0207 0.0647
Plasmodium vivax proteasome subunit beta type-5, putative 0.0219 0.3147 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0086 0.0262
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0026 0.0207 0.0203
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.0371
Loa Loa (eye worm) PAS-3 protein 0.0026 0.0207 0.0321
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0026 0.0207 0.0647
Loa Loa (eye worm) proteasome subunit beta type 2 0.0026 0.0207 0.0321
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0275 0.042
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0026 0.0207 0.0321
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0026 0.0207 0.0647
Schistosoma mansoni microtubule-associated protein tau 0.0669 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0042 0.0122
Entamoeba histolytica hypothetical protein 0.0035 0.0339 0.0826
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0026 0.0207 0.0321
Leishmania major proteasome beta 7 subunit, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0048 0.0048
Leishmania major proteasome beta-1 subunit, putative 0.0026 0.0207 0.0647
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0026 0.0207 0.0647
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0048 0.0048
Plasmodium falciparum proteasome subunit beta type-4 0.0026 0.0207 0.0647
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1284 0.1984
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0026 0.0207 0.0203
Loa Loa (eye worm) hypothetical protein 0.0031 0.0275 0.0426
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0026 0.0207 0.0647
Echinococcus multilocularis Smad4 0.0016 0.0048 0.0048
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0026 0.0207 0.0321
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0048 0.0048
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0963 0.0963
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0239 0.0749
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0026 0.0207 0.0647
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0026 0.0207 0.0395
Schistosoma mansoni ap endonuclease 0.0018 0.0086 0.0082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1244 0.353
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0086 0.0127
Giardia lamblia 20S proteasome alpha subunit 4 0.0026 0.0207 0.0647
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0026 0.0207 0.0207
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0026 0.0207 0.0321
Echinococcus granulosus subfamily T1A non peptidase ue 0.0026 0.0207 0.0207
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0026 0.0207 0.0647
Echinococcus granulosus smad 0.0016 0.0048 0.0048
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0383 0.097
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0219 0.3147 1
Toxoplasma gondii hypothetical protein 0.0026 0.0206 0.0642
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0086 0.0134
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0207 0.0647
Loa Loa (eye worm) hypothetical protein 0.0097 0.1284 0.1989
Echinococcus multilocularis lamin 0.0026 0.0206 0.0206
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0026 0.0207 0.0647
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0026 0.0207 0.0203
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0026 0.0207 0.0647
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0126 0.0387
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0026 0.0207 0.0647
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0219 0.3147 1
Leishmania major cytochrome p450-like protein 0.0015 0.0042 0.0122
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0026 0.0207 0.0321
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0026 0.0207 0.0647
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0374 0.1178
Echinococcus granulosus importin subunit beta 1 0.0028 0.0239 0.0239
Giardia lamblia Proteasome subunit beta type 1 0.0119 0.1624 0.5154
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0026 0.0207 0.0207

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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