TDR Targets

Basic information

Technical information

TDR Targets ID: 1551105
Name: N-[4-(1-ethylsulfonyl-5-thiophen-2-yl-4,5-dih ydropyrazol-3-yl)phenyl]ethanesulfonamide
MW: 427.561 | Formula: C17H21N3O4S3
H donors: 1 H acceptors: 4 LogP: 1.91 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1cccs1)S(=O)(=O)CC
InChi: 1S/C17H21N3O4S3/c1-3-26(21,22)19-14-9-7-13(8-10-14)15-12-16(17-6-5-11-25-17)20(18-15)27(23,24)4-2/h5-11,16,19H,3-4,12H2,1-2H3
InChiKey: RBAZFRPDHIPUDD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[4-[1-ethylsulfonyl-5-(2-thienyl)-4,5-dihydropyrazol-3-yl]phenyl]ethanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0086	0.0262
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0374	0.1178
Plasmodium falciparum	proteasome subunit beta type-4	0.0026	0.0207	0.0647
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0026	0.0207	0.0647
Brugia malayi	proteasome subunit beta type 2	0.0026	0.0207	0.0315
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0026	0.0207	0.0203
Brugia malayi	Proteasome A-type and B-type family protein	0.0219	0.3147	0.487
Loa Loa (eye worm)	Smad1	0.0016	0.0048	0.0075
Schistosoma mansoni	hypothetical protein	0.0066	0.0817	0.0813
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0026	0.0207	0.0647
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0026	0.0207	0.0647
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0026	0.0207	0.0395
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0219	0.3147	1
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0119	0.1624	0.5154
Leishmania major	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Giardia lamblia	20S proteasome alpha subunit 4	0.0026	0.0207	0.0647
Giardia lamblia	20S proteasome alpha subunit 2	0.0026	0.0207	0.0647
Mycobacterium ulcerans	proteasome PrcA	0.0026	0.0207	0.0647
Leishmania major	proteasome alpha 1 subunit, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0026	0.0207	0.0321
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0275	0.0275
Echinococcus granulosus	Smad4	0.0016	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0436	0.6457	1
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0026	0.0207	0.0207
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0026	0.0207	0.0321
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0119	0.1624	0.2515
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.11	0.3486
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0026	0.0207	0.0321
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0374	0.1178
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0119	0.1624	0.1624
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0026	0.0207	0.0647
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0963	0.3051
Brugia malayi	MH2 domain containing protein	0.0016	0.0048	0.0069
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0382	0.0382
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0026	0.0207	0.0647
Echinococcus granulosus	proteasome subunit beta type 6	0.0026	0.0207	0.0207
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0158	0.0489
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0219	0.3147	1
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0026	0.0207	0.0321
Echinococcus granulosus	snurportin 1	0.0302	0.4416	0.4416
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0219	0.3147	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0042	0.0066
Leishmania major	proteasome beta 5 subunit, putative	0.0219	0.3147	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0436	0.1373
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	intermediate filament protein	0.0026	0.0206	0.0206
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0026	0.0207	0.0647
Onchocerca volvulus	Notchless protein homolog	0.0026	0.0207	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	0.3051
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0206	0.0319
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0026	0.0207	0.0203
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0026	0.0207	0.0647
Trichomonas vaginalis	ran, putative	0.0021	0.0126	0.0387
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0026	0.0207	0.0647
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.1244	0.3945
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0119	0.1624	0.5024
Mycobacterium ulcerans	proteasome PrcB	0.0219	0.3147	1
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0026	0.0207	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1284	0.1989
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	0.3051
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0219	0.3147	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0232	0.3339	0.5171
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0026	0.0207	0.0647
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0048	0.0048
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0026	0.0207	0.0207
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0963	0.0963
Brugia malayi	Muscleblind-like protein	0.0436	0.6457	1
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0026	0.0207	0.0647
Brugia malayi	Importin beta-1 subunit	0.0028	0.0239	0.0365
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0026	0.0207	0.0203
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0219	0.3147	1
Brugia malayi	Proteasome subunit alpha type 1	0.0026	0.0207	0.0315
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0026	0.0207	0.0647
Brugia malayi	proteasome subunit alpha type 3	0.0026	0.0207	0.0315
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0026	0.0207	0.0647
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0206	0.0642
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0042	0.0059
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0119	0.1624	0.1621
Brugia malayi	MH1 domain containing protein	0.0016	0.0048	0.0069
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	lamin	0.0026	0.0206	0.0202
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0086	0.0262
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0026	0.0207	0.0203
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0026	0.0207	0.0647
Giardia lamblia	Proteasome subunit beta type 3	0.0026	0.0207	0.0647
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0004	0.0004
Trypanosoma cruzi	20S proteasome subunit	0.0026	0.0207	0.0647
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0026	0.0207	0.0647
Toxoplasma gondii	proteasome beta subunit	0.0026	0.0207	0.0647
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0239	0.0239
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0048	0.0044
Echinococcus multilocularis	Smad4	0.0016	0.0048	0.0048
Echinococcus multilocularis	muscleblind protein	0.0436	0.6457	0.6457
Brugia malayi	Proteasome A-type and B-type family protein	0.0026	0.0207	0.0315
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0086	0.0262
Mycobacterium tuberculosis	Probable reductase	0.0085	0.11	0.3486
Echinococcus multilocularis	lamin dm0	0.0026	0.0206	0.0206
Brugia malayi	Thioredoxin reductase	0.0037	0.0374	0.0574
Brugia malayi	proteasome subunit alpha type 1	0.0026	0.0207	0.0315
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0565	0.0565
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0026	0.0207	0.0395
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0275	0.042
Schistosoma mansoni	lamin	0.0026	0.0206	0.0202
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0086	0.0086
Loa Loa (eye worm)	MH2 domain-containing protein	0.0232	0.3339	0.5171
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0374	0.1178
Plasmodium falciparum	glutathione reductase	0.0037	0.0374	0.1178
Plasmodium falciparum	importin beta, putative	0.0028	0.0239	0.0749
Echinococcus multilocularis	proteasome subunit beta type 6	0.0026	0.0207	0.0207
Leishmania major	proteasome alpha 3 subunit, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0206	0.0202
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0026	0.0207	0.0647
Toxoplasma gondii	proteasome subunit	0.0026	0.0207	0.0647
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0963	0.2574
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0026	0.0207	0.0203
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0048	0.0044
Echinococcus multilocularis	microtubule associated protein 2	0.0669	1	1
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0565	0.0565
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0126	0.0194
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.0817	0.126
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0219	0.3147	1
Schistosoma mansoni	ran	0.0021	0.0126	0.0122
Brugia malayi	Probable ClpP-like protease	0.0076	0.0963	0.1486
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0436	0.0436
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0126	0.0387
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0219	0.3147	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0026	0.0207	0.0203
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0026	0.0207	0.0005
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0086	0.0262
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0219	0.3147	0.4874
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0374	0.0579
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0021	0.0027
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0048	0.0048
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0026	0.0207	0.0203
Schistosoma mansoni	Smad4	0.0016	0.0048	0.0044
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.11	0.3486
Entamoeba histolytica	hypothetical protein	0.0023	0.0158	0.0234
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0026	0.0207	0.0203
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Leishmania major	proteasome beta-1 subunit, putative	0.0026	0.0207	0.0647
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0219	0.3147	0.3147
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	hypothetical protein	0.0031	0.0275	0.0271
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0275	0.0275
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0026	0.0207	0.0321
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0026	0.0207	0.0203
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	lamin	0.0026	0.0206	0.0206
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0126	0.0126
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0026	0.0207	0.0647
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0026	0.0207	0.0647
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0436	0.1373
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0026	0.0207	0.0203
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0086	0.0262
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0026	0.0207	0.0321
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0374	0.0579
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0565	0.1784
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.0826
Toxoplasma gondii	exonuclease III APE	0.0018	0.0086	0.0262
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0042	0.0066
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0239	0.0749
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0374	0.1178
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.0042	0.0066
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0374	0.1178
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0026	0.0207	0.0647
Echinococcus granulosus	proteasome subunit alpha type 2	0.0026	0.0207	0.0207
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0158	0.0489
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0026	0.0207	0.0647
Echinococcus multilocularis	musashi	0.0026	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0199	0.0308
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0126	0.0387
Schistosoma mansoni	hypothetical protein	0.0302	0.4416	0.4414
Leishmania major	trypanothione reductase	0.0037	0.0374	0.1178
Giardia lamblia	Proteasome subunit beta type 2	0.0026	0.0207	0.0647
Echinococcus multilocularis	snurportin 1	0.0302	0.4416	0.4416
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0275	0.0426
Leishmania major	proteasome beta 2 subunit, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0817	0.1266
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.1284	0.1984
Brugia malayi	MH2 domain containing protein	0.0232	0.3339	0.5168
Loa Loa (eye worm)	hypothetical protein	0.0436	0.6457	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0026	0.0207	0.0647
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0026	0.0207	0.0647
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0026	0.0207	0.0647
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0026	0.0207	0.0647
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.0826
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.0826
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.11	0.3486
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0119	0.1624	0.1624
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0158	0.0489
Entamoeba histolytica	Ran family GTPase	0.0021	0.0126	0.0128
Echinococcus granulosus	proteasome subunit alpha type 6	0.0026	0.0207	0.0207
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0339	0.0339
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0026	0.0207	0.0647
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0219	0.3147	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	1
Echinococcus granulosus	proteasome prosome macropain	0.0219	0.3147	0.3147
Leishmania major	proteasome beta 3 subunit, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0026	0.0207	0.0321
Toxoplasma gondii	peptidase, T1 family protein	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0026	0.0207	0.0203
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0086	0.0858
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0026	0.0207	0.0321
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0026	0.0207	0.0647
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0026	0.0207	0.0395
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0026	0.0207	0.0395
Trypanosoma brucei	proteasome beta 7 subunit	0.0026	0.0207	0.0647
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.1943	0.3004
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0206	0.0319
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0026	0.0207	0.0203
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0026	0.0207	0.0207
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0026	0.0207	0.0395
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.1244	0.3945
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0026	0.0207	0.0207
Echinococcus granulosus	Proteasome subunit alpha beta	0.0026	0.0207	0.0207
Toxoplasma gondii	hypothetical protein	0.0026	0.0206	0.0642
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0026	0.0207	0.0647
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.11	0.3486
Toxoplasma gondii	heat shock protein hslv, putative	0.0026	0.0207	0.0647
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0026	0.0207	0.0647
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0026	0.0207	0.0647
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0026	0.0207	0.0395
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0158	0.0489
Brugia malayi	Smad1	0.0016	0.0048	0.0069
Brugia malayi	proteasome subunit alpha type 6	0.0026	0.0207	0.0315
Leishmania major	proteasome beta 7 subunit, putative	0.0026	0.0207	0.0647
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0158	0.0489
Schistosoma mansoni	ap endonuclease	0.0018	0.0086	0.0082
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0015	0.0042	0.0122
Brugia malayi	MH1 domain containing protein	0.0016	0.0048	0.0069
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0963	0.3051
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0026	0.0207	0.0395
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0026	0.0207	0.0647
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0436	0.1373
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0026	0.0207	0.0207
Leishmania major	proteasome alpha 2 subunit, putative	0.0026	0.0207	0.0647
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0086	0.0262
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0119	0.1624	0.5154
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.1943	0.1939
Leishmania major	proteasome beta 2 subunit, putative	0.0026	0.0207	0.0647
Trypanosoma cruzi	cytochrome P450, putative	0.0015	0.0042	0.0122
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0026	0.0207	0.0647
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0026	0.0207	0.0207
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0048	0.0048
Schistosoma mansoni	smad	0.0016	0.0048	0.0044
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0963	0.0963
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0206	0.0313
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0004	0.0004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0086	0.0262
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	1
Schistosoma mansoni	microtubule-associated protein tau	0.0669	1	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0026	0.0207	0.0647
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0126	0.0387
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0086	0.0134
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0026	0.0207	0.0647
Giardia lamblia	20S proteasome alpha subunit 6	0.0026	0.0207	0.0647
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0026	0.0207	0.0395
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0026	0.0207	0.0207
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0026	0.0207	0.0321
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0026	0.0207	0.0207
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0339	0.0339
Echinococcus granulosus	GPCR family 2	0.0031	0.0275	0.0275
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	hypothetical protein	0.0035	0.0339	0.0335
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0026	0.0207	0.0203
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0026	0.0207	0.0395
Brugia malayi	20S proteasome alpha5 subunit	0.0026	0.0207	0.0315
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0026	0.0207	0.0647
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.4416	0.684
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0374	0.1178
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0026	0.0207	0.0207
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0026	0.0207	0.0647
Giardia lamblia	20S proteasome alpha subunit 5	0.0026	0.0207	0.0647
Echinococcus multilocularis	smad	0.0016	0.0048	0.0048
Echinococcus multilocularis	proteasome subunit beta type 7	0.0026	0.0207	0.0207
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0026	0.0207	0.0647
Echinococcus multilocularis	lamin	0.0026	0.0206	0.0206
Schistosoma mansoni	importin beta-1	0.0028	0.0239	0.0236
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0026	0.0207	0.0647
Leishmania major	cytochrome p450-like protein	0.0015	0.0042	0.0122
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0026	0.0207	0.0647
Brugia malayi	Proteasome subunit alpha type 7-1	0.0026	0.0207	0.0315
Loa Loa (eye worm)	acetyltransferase	0.014	0.1943	0.3009
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0119	0.1624	0.5154
Brugia malayi	proteasome subunit alpha type 2	0.0026	0.0207	0.0315
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0383	0.1207
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0048	0.0075
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0026	0.0207	0.0203
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0206	0.2103
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0026	0.0207	0.0647
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0026	0.0207	0.0207
Echinococcus granulosus	muscleblind protein	0.0436	0.6457	0.6457
Brugia malayi	glutathione reductase	0.0037	0.0374	0.0574
Trypanosoma brucei	proteasome beta 6 subunit	0.0119	0.1624	0.5154
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0026	0.0207	0.0321
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0026	0.0207	0.0647
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0026	0.0207	0.0647
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0021	0.0033
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0026	0.0207	0.0203
Echinococcus multilocularis	muscleblind protein 1	0.0436	0.6457	0.6457
Trypanosoma brucei	proteasome alpha 7 subunit	0.0026	0.0207	0.0647
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0042	0.0059
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0026	0.0207	0.0395
Trypanosoma brucei	cytochrome P450, putative	0.0015	0.0042	0.0122
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0086	0.0858
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0239	0.0749
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0085	0.11	0.304
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0026	0.0207	0.0203
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0026	0.0207	0.0207
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0382	0.0382
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	lamin dm0	0.0026	0.0206	0.0206
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0239	0.0239
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0026	0.0207	0.0647
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0126	0.0126
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.1883	0.1883
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0048	0.0048
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0119	0.1624	0.5154
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0026	0.0207	0.0207
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0275	0.042
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0026	0.0207	0.0395
Brugia malayi	RNA, U transporter 1	0.0081	0.1035	0.1598
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0126	0.0387
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0048	0.0044
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0565	0.1221
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0436	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0239	0.0371
Brugia malayi	hypothetical protein	0.0035	0.0339	0.0519
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0565	0.1784
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0126	0.0387
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0026	0.0207	0.0207
Giardia lamblia	20S proteasome alpha subunit 3	0.0026	0.0207	0.0647
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0963	0.0959
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0026	0.0207	0.0647
Brugia malayi	proteasome subunit beta type 3	0.0026	0.0207	0.0315
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0026	0.0207	0.212
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.1943	0.1943
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0219	0.3147	1
Leishmania major	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0026	0.0207	0.0647
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0026	0.0207	0.0647
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0206	0.0319
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0963	0.3051
Giardia lamblia	Proteasome subunit beta type 1	0.0119	0.1624	0.5154
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0086	0.0262
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0026	0.0207	0.0203
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0119	0.1624	0.5154
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0126	0.0387
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.1284	0.1989
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	hypothetical protein	0.0031	0.0275	0.0271
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0026	0.0207	0.0647
Brugia malayi	Proteasome A-type and B-type family protein	0.0026	0.0207	0.0315
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.1244	0.3945
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0026	0.0207	0.0395
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0026	0.0207	0.0647
Plasmodium falciparum	proteasome subunit beta type-5	0.0219	0.3147	1
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0026	0.0207	0.0395
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0963	0.3051
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0026	0.0207	0.0647
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0086	0.0127
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0339	0.0335
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0026	0.0207	0.0207
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0383	0.1207
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0275	0.0275
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0026	0.0207	0.0647
Brugia malayi	MH2 domain containing protein	0.0016	0.0048	0.0069
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0119	0.1624	0.5154
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0026	0.0207	0.0647
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0026	0.0207	0.0647
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0026	0.0207	0.0647
Schistosoma mansoni	ap endonuclease	0.0018	0.0086	0.0082
Echinococcus granulosus	smad	0.0016	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0275	0.0426
Leishmania major	GTP-binding protein, putative	0.0021	0.0126	0.0387
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0048	0.0044
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0239	0.0749
Loa Loa (eye worm)	PAS-3 protein	0.0026	0.0207	0.0321
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0026	0.0207	0.0647
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0026	0.0207	0.0395
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0436	0.1373
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0383	0.097
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0026	0.0207	0.0207
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0026	0.0207	0.0207
Trypanosoma cruzi	cytochrome P450, putative	0.0015	0.0042	0.0122
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0239	0.0749
Brugia malayi	Proteasome A-type and B-type family protein	0.0026	0.0207	0.0315
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0275	0.0275
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0026	0.0207	0.0647
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0026	0.0207	0.0647
Brugia malayi	proteasome subunit alpha type 4	0.0026	0.0207	0.0315
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0026	0.0207	0.0395
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0126	0.0188
Echinococcus granulosus	proteasome subunit beta t family	0.0026	0.0207	0.0207
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0048	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0963	0.1491
Brugia malayi	proteasome subunit beta type 1	0.0119	0.1624	0.251
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0026	0.0207	0.0207
Giardia lamblia	20S proteasome alpha subunit 1	0.0026	0.0207	0.0647
Brugia malayi	intermediate filament protein	0.0026	0.0206	0.0313
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0026	0.0207	0.0647
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0026	0.0207	0.0647
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0026	0.0207	0.0647
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0086	0.0262
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0026	0.0207	0.0647
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0026	0.0207	0.0647
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0126	0.0387
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0275	0.0275
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0119	0.1624	0.5154
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0026	0.0207	0.0395
Schistosoma mansoni	hypothetical protein	0.0031	0.0275	0.0271
Leishmania major	proteasome alpha 1 subunit, putative	0.0026	0.0207	0.0647
Echinococcus granulosus	proteasome subunit beta type 7	0.0026	0.0207	0.0207
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0086	0.0262
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0086	0.0086
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0026	0.0207	0.0647
Giardia lamblia	20S proteasome alpha subunit 7	0.0026	0.0207	0.0647
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0219	0.3147	0.3144
Entamoeba histolytica	hypothetical protein	0.0035	0.0339	0.0826
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.11	0.3486
Schistosoma mansoni	hypothetical protein	0.0031	0.0275	0.0271
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0026	0.0207	0.0647
Toxoplasma gondii	proteasome subunit beta type, putative	0.0219	0.3147	1
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0026	0.0207	0.0647
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0026	0.0207	0.0395
Schistosoma mansoni	ran	0.0021	0.0126	0.0122
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0026	0.0207	0.0207
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0086	0.0262
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0026	0.0207	0.0647
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.1244	0.353
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0206	0.0642
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.1284	0.1984
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0026	0.0207	0.0647
Trypanosoma brucei	trypanothione reductase	0.0037	0.0374	0.1178

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1904750

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1551105