Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3445 | 0.3445 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3445 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3445 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3445 | 0.3445 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kcat (binding) | = 0.76 /min | Activity of Escherichia coli K12 CoaA | ChEMBL. | 18701278 |
Kcat/Km (binding) | = 21.13 /mM/min | Ratio of kcat to Km for Escherichia coli K12 CoaA | ChEMBL. | 18701278 |
Km (binding) | = 35.81 uM | Activity of Escherichia coli K12 CoaA | ChEMBL. | 18701278 |
Potency (functional) | 0.4467 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.4978 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.4392 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.9301 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Vmax (binding) | = 0.31 microM/s | Activity of Escherichia coli K12 CoaA | ChEMBL. | 18701278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.