Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2995 | 0.7105 |
Trichomonas vaginalis | hypothetical protein | 0.0554 | 1 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0646 | 0.1532 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.0646 | 0.1532 |
Brugia malayi | Fli-1 protein | 0.0265 | 0.4215 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0554 | 1 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.0646 | 0.2156 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0554 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2995 | 0.7105 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0554 | 1 | 0.5 |
Schistosoma mansoni | ets-related | 0.0265 | 0.4215 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0554 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0554 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0392 | 0.0929 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.0646 | 0.1532 |
Echinococcus granulosus | geminin | 0.0205 | 0.2995 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2995 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.0646 | 0.1532 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0554 | 1 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 0.4215 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0554 | 1 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.0646 | 0.2156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0291 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.