Detailed information for compound 1551137

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1114.34 | Formula: C49H75N15O11S2
  • H donors: 14 H acceptors: 11 LogP: -1.85 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2cc3c([nH]2)cccc3)NC(=O)[C@@H](N)C2(CCCCC2)SSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC1=O)[C@H](O)C)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)NCC(=O)N)CCCN=C(N)N)C
  • InChi: 1S/C49H75N15O11S2/c1-4-25(2)37-44(72)63-38(26(3)65)45(73)59-32(22-35(50)66)41(69)61-33(47(75)64-19-11-15-34(64)43(71)58-30(14-10-18-55-48(53)54)40(68)56-23-36(51)67)24-76-77-49(16-8-5-9-17-49)39(52)46(74)60-31(42(70)62-37)21-28-20-27-12-6-7-13-29(27)57-28/h6-7,12-13,20,25-26,30-34,37-39,57,65H,4-5,8-11,14-19,21-24,52H2,1-3H3,(H2,50,66)(H2,51,67)(H,56,68)(H,58,71)(H,59,73)(H,60,74)(H,61,69)(H,62,70)(H,63,72)(H4,53,54,55)/t25-,26+,30+,31+,32-,33-,34-,37-,38+,39+/m0/s1
  • InChiKey: GGEIIELFRIJRPU-SLUGROACSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0013 0.0013
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0013 0.0245
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0043 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0471 0.0472
Loa Loa (eye worm) hypothetical protein 0.407 0.9984 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0043 0.2747
Schistosoma mansoni microtubule-associated protein tau 0.1373 0.335 0.335
Toxoplasma gondii cathepsin CPL 0.0016 0.0013 0.0418
Onchocerca volvulus 0.023 0.0539 1
Giardia lamblia Kinase, CMGC MAPK 0.0066 0.0135 0.01
Entamoeba histolytica DNA repair and recombination protein, putative 0.3768 0.9241 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Schistosoma mansoni lipoxygenase 0.0114 0.0254 0.0254
Entamoeba histolytica hypothetical protein, conserved 0.3768 0.9241 1
Brugia malayi Pre-SET motif family protein 0.003 0.0046 0.0046
Onchocerca volvulus 0.0019 0.002 0.0376
Loa Loa (eye worm) hypothetical protein 0.0048 0.0092 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0029 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0118 1
Trypanosoma brucei protein kinase, putative 0.0066 0.0135 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Schistosoma mansoni hypothetical protein 0.3768 0.9241 0.9241
Schistosoma mansoni cpg binding protein 0.0029 0.0046 0.0046
Schistosoma mansoni ephrin receptor 0.0062 0.0127 0.0127
Leishmania major cathepsin L-like protease 0.0062 0.0125 0.0122
Schistosoma mansoni protein kinase 0.4077 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Echinococcus multilocularis mitogen activated protein kinase 3 0.0066 0.0135 0.0122
Schistosoma mansoni hypothetical protein 0.0028 0.0043 0.0043
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0029 0.6304
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0112 0.0107
Brugia malayi hypothetical protein 0.0019 0.002 0.002
Trichomonas vaginalis set domain proteins, putative 0.023 0.0539 0.0584
Onchocerca volvulus 0.0081 0.0171 0.3179
Loa Loa (eye worm) cysteine protease 0.0016 0.0013 0.0013
Echinococcus granulosus ephrin type A receptor 4 A 0.0062 0.0127 0.0127
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.0948 0.0936
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Echinococcus granulosus jumonji domain containing protein 0.0039 0.007 0.007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0066 0.0135 0.0132
Echinococcus multilocularis RUN 0.0019 0.002 0.0007
Loa Loa (eye worm) DEAH box polypeptide 35 0.0038 0.0067 0.0067
Loa Loa (eye worm) TK/EPH protein kinase 0.0079 0.0168 0.0169
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0171 0.0171
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0043 0.0043
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0066 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.3768 0.9241 1
Brugia malayi hypothetical protein 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0046
Onchocerca volvulus 0.0016 0.0013 0.0245
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0396 0.0948 0.0948
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.3768 0.9241 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.0013
Echinococcus multilocularis microtubule associated protein 2 0.1373 0.335 0.3341
Entamoeba histolytica hypothetical protein 0.0023 0.0029 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0118 0.0118
Onchocerca volvulus 0.0016 0.0013 0.0245
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0154 0.0154
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0066 0.0135 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.002 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0013 0.3057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0042 0.0042
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1234 0.3008 0.3246
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0121 0.0121
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0013 0.0013
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.3768 0.9241 1
Echinococcus multilocularis mitogen activated protein kinase 0.0066 0.0135 0.0122
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.3768 0.9241 0.9241
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0125 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0125 0.0122
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.3768 0.9241 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Echinococcus granulosus microtubule associated protein 2 0.1373 0.335 0.335
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.002 0.4394
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0057 0.0044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0254 0.0254
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0066 0.0135 0.0132
Brugia malayi Probable ATP-dependent helicase DHX35 0.0038 0.0067 0.0067
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0061 0.0061
Plasmodium vivax vivapain-2 0.0016 0.0013 0.2846
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Loa Loa (eye worm) ctsf protein 0.0016 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.1234 0.3008 0.3246
Schistosoma mansoni polycystin 1-related 0.0019 0.002 0.002
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0013 0.3057
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.0013
Brugia malayi MAP kinase sur-1 0.0066 0.0135 0.0135
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0029 0.0017
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.002 0.0007
Onchocerca volvulus 0.0019 0.002 0.0376
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0135 0.0132
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0043 0.0043
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0164 0.0377 0.0377
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0117 0.0117
Onchocerca volvulus 0.0016 0.0013 0.0245
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.3768 0.9241 1
Onchocerca volvulus 0.0016 0.0013 0.0245
Echinococcus granulosus dnaJ subfamily B 0.0396 0.0948 0.0948
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0135 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.1234 0.3008 0.3013
Onchocerca volvulus 0.0016 0.0013 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Echinococcus multilocularis cpg binding protein 0.0029 0.0046 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0013 0.0014
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.3768 0.9241 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0013 0.0245
Echinococcus granulosus mitogen activated protein kinase 3 0.0066 0.0135 0.0135
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0093 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0125 0.0122
Schistosoma mansoni rab6-interacting 0.0019 0.002 0.002
Loa Loa (eye worm) fibroinase 0.0016 0.0013 0.0013
Giardia lamblia Rrm3p helicase 0.3768 0.9241 1
Brugia malayi Cytochrome P450 family protein 0.0044 0.0083 0.0083
Onchocerca volvulus 0.0016 0.0013 0.0245
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0013 0.3057
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0029 0.5
Schistosoma mansoni rab6-interacting 0.0019 0.002 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0118 0.8671
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0043 0.0043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0106 0.7693
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0062 0.0125 0.0125
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0029 0.1664
Echinococcus granulosus cpg binding protein 0.0029 0.0046 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0029 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0118 0.0118
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0171 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Schistosoma mansoni hypothetical protein 0.0164 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0135 0.0146
Echinococcus multilocularis peregrin 0.0028 0.0043 0.003
Plasmodium vivax vivapain-2 0.0016 0.0013 0.2846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.4077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0118 0.0114
Brugia malayi Cathepsin L-like precursor 0.0016 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0135 0.0135
Brugia malayi Bromodomain containing protein 0.0028 0.0043 0.0043
Schistosoma mansoni protein kinase 0.4077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0135 0.0146
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0201 0.0201
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0254 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0046
Echinococcus granulosus RUN 0.0019 0.002 0.002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.002 0.0007
Brugia malayi CXXC zinc finger family protein 0.0028 0.0042 0.0042
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0029 0.6772
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0118 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0066 0.0135 0.0132
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.4077 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Schistosoma mansoni loxhd1 0.0019 0.002 0.002
Echinococcus granulosus geminin 0.0164 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0013 0.0013
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0118 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0042 0.0042
Entamoeba histolytica cysteine protease, putative 0.0016 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0083 0.0083
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.3768 0.9241 0.924
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0061 0.0061
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0043 0.2747
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0061 0.0061
Schistosoma mansoni cpg binding protein 0.0028 0.0042 0.0042
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0046 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0046 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Brugia malayi PHD-finger family protein 0.0028 0.0043 0.0043
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.002 0.002
Echinococcus granulosus cathepsin l1 0.0016 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0118 0.0118
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.002 0.472
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0013 0.0014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0201 0.0188
Onchocerca volvulus 0.0062 0.0125 0.2318
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.002 0.002
Echinococcus granulosus peregrin 0.0028 0.0043 0.0043
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0029 0.1664
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0043 0.931
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0171 0.0171
Plasmodium vivax SET domain protein, putative 0.003 0.0046 1
Brugia malayi ephrin receptor 1 precursor 0.003 0.0046 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0013 0.0245
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0066 0.0135 0.0115
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.007 0.0057
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0066 0.0135 0.0132
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0013 0.0014
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0013 0.0013
Plasmodium falciparum phd finger protein, putative 0.0028 0.0043 1
Loa Loa (eye worm) hypothetical protein 0.1227 0.2992 0.2997
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0046 0.2995
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.3768 0.9241 1
Echinococcus granulosus mitogen activated protein kinase 0.0066 0.0135 0.0135
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0061 0.0061
Brugia malayi Doublecortin family protein 0.0019 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Onchocerca volvulus 0.0016 0.0013 0.0245
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0029 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0051
Echinococcus multilocularis ephrin type A receptor 4 A 0.0062 0.0127 0.0114
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0118 1
Schistosoma mansoni cpg binding protein 0.0029 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0125 0.0122
Onchocerca volvulus 0.003 0.0046 0.0852
Loa Loa (eye worm) hypothetical protein 0.0081 0.0171 0.0172
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0135 0.0146
Brugia malayi jmjC domain containing protein 0.0093 0.0201 0.0201
Leishmania major cathepsin L-like protease 0.0062 0.0125 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Echinococcus multilocularis geminin 0.0164 0.0377 0.0364
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.3768 0.9241 1
Schistosoma mansoni lipoxygenase 0.008 0.017 0.017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0046 0.0046
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.002 0.002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0118 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.002 0.002
Brugia malayi jmjC domain containing protein 0.0036 0.0061 0.0061
Onchocerca volvulus Alhambra homolog 0.0028 0.0043 0.0793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0125 0.0105
Brugia malayi Pre-SET motif family protein 0.0202 0.0471 0.0471
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0066 0.0135 1
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.0062 0.0125 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0013 0.0014
Onchocerca volvulus 0.0028 0.0042 0.0774
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0013 0.0014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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