Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0067 | 0.0209 | 0.0128 |
Giardia lamblia | Kinase, PLK | 0.0098 | 0.0562 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.126 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0211 | 0.185 | 0.1822 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0629 | 0.6606 | 0.6533 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0209 | 0.0195 |
Brugia malayi | TAR-binding protein | 0.0269 | 0.2511 | 0.2485 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0927 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0285 | 0.2698 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0355 | 0.5664 |
Loa Loa (eye worm) | glutaminase | 0.0285 | 0.2698 | 0.2542 |
Loa Loa (eye worm) | RNA binding protein | 0.0269 | 0.2511 | 0.2351 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0085 | 0.0414 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0355 | 0.8197 |
Mycobacterium ulcerans | glutaminase | 0.0285 | 0.2698 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0927 | 1 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0056 | 0.0085 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0098 | 0.0562 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.126 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0098 | 0.0562 | 0.0548 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0098 | 0.0562 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0098 | 0.0562 | 0.0484 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0927 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0067 | 0.0209 | 0.0128 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0085 | 0.0414 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.0562 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0269 | 0.2511 | 0.2449 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.185 | 0.1676 |
Brugia malayi | glutaminase DH11.1 | 0.0285 | 0.2698 | 0.2673 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0211 | 0.185 | 0.1676 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0355 | 0.5664 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0067 | 0.0209 | 0.0128 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0098 | 0.0562 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0209 | 0.0195 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0098 | 0.0562 | 0.0529 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0269 | 0.2511 | 0.2485 |
Loa Loa (eye worm) | glutaminase 2 | 0.0285 | 0.2698 | 0.2542 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0098 | 0.0562 | 0.0484 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.0414 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0269 | 0.2511 | 0.2449 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0056 | 0.0085 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0209 | 0.0195 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.0335 |
Brugia malayi | RNA binding protein | 0.0269 | 0.2511 | 0.2485 |
Schistosoma mansoni | hypothetical protein | 0.0144 | 0.1091 | 0.1078 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.0335 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0355 | 0.8197 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0098 | 0.0562 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.2511 | 0.25 |
Brugia malayi | MH2 domain containing protein | 0.0629 | 0.6606 | 0.6594 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.0414 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.0355 | 0.8197 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0209 | 0.0195 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0056 | 0.0085 | 0.0071 |
Brugia malayi | hypothetical protein | 0.008 | 0.0355 | 0.0322 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0067 | 0.0209 | 0.0128 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0211 | 0.185 | 0.1822 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0067 | 0.0209 | 0.0176 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0098 | 0.0562 | 0.036 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0927 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0927 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0927 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0927 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0629 | 0.6606 | 0.6533 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.2511 | 0.25 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.1091 | 0.09 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0067 | 0.0209 | 0.0176 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.0355 | 0.8197 |
Echinococcus granulosus | GPCR family 2 | 0.0067 | 0.0209 | 0.0128 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0067 | 0.0209 | 0.0128 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0056 | 0.0085 | 0.0316 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0056 | 0.0085 | 0.0316 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.0355 | 0.5664 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0269 | 0.2511 | 0.2351 |
Loa Loa (eye worm) | TAR-binding protein | 0.0269 | 0.2511 | 0.2351 |
Brugia malayi | Probable ClpP-like protease | 0.0085 | 0.0414 | 0.0382 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.2511 | 0.25 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0098 | 0.0562 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0098 | 0.0562 | 0.2082 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0144 | 0.1091 | 0.106 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0355 | 0.5664 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0355 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0927 | 1 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0085 | 0.0414 | 0.04 |
Schistosoma mansoni | glutaminase | 0.0285 | 0.2698 | 0.2687 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0414 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0414 | 0.021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.2511 | 0.25 |
Schistosoma mansoni | tar DNA-binding protein | 0.0269 | 0.2511 | 0.25 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KB (binding) | = 9.29 | Binding affinity analysed for 5-HT 2B receptor in rat stomach fundus | ChEMBL. | 8709108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.