Detailed information for compound 1551293

Basic information

Technical information
  • TDR Targets ID: 1551293
  • Name: ethyl 2-[(2-acetamidoacetyl)amino]-3-(1H-indo l-3-yl)propanoate
  • MW: 331.366 | Formula: C17H21N3O4
  • H donors: 3 H acceptors: 3 LogP: 1.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)CNC(=O)C
  • InChi: 1S/C17H21N3O4/c1-3-24-17(23)15(20-16(22)10-18-11(2)21)8-12-9-19-14-7-5-4-6-13(12)14/h4-7,9,15,19H,3,8,10H2,1-2H3,(H,18,21)(H,20,22)
  • InChiKey: OSLMBHQGRIHGQK-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(2-acetamido-1-oxoethyl)amino]-3-(1H-indol-3-yl)propanoic acid ethyl ester
  • 2-[(2-acetamidoacetyl)amino]-3-(1H-indol-3-yl)propionic acid ethyl ester
  • ethyl 2-(2-acetamidoethanoylamino)-3-(1H-indol-3-yl)propanoate
  • BAS 01247741
  • 2-(2-Acetylamino-acetylamino)-3-(1H-indol-3-yl)-propionic acid ethyl ester
  • MLS000034739
  • SMR000010238

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0571
Echinococcus granulosus proteasome prosome macropain 0.0488 0.6883 0.6883
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0244 0.3254 0.4603
Leishmania major proteasome regulatory ATPase subunit 0.0038 0.0202 0.0239
Toxoplasma gondii SAC3/GANP family protein 0.0056 0.047 0.0525
Plasmodium falciparum proteasome subunit beta type-5 0.0488 0.6883 1
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0059 0.0514 0.0747
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0301 0.4103 0.5961
Leishmania major proteasome beta 2 subunit, putative 0.0247 0.3303 0.4769
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0257 0.3456 0.3865
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0059 0.0514 0.0696
Onchocerca volvulus 0.0039 0.0218 0.0031
Toxoplasma gondii proteasome beta subunit 0.0247 0.3303 0.3694
Entamoeba histolytica proteasome regulatory subunit, putative 0.0059 0.051 0.0741
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0059 0.0514 0.0575
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0268 0.3615 0.4044
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0059 0.0514 0.0747
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0059 0.0514 0.0747
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0355 0.4902 0.7106
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0038 0.0202 0.0239
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0171 0.2175 0.2175
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0098 0.1083 0.1574
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0065 0.0593 0.0614
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0077 0.077 0.1069
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0244 0.3254 0.3115
Brugia malayi Probable 26S protease regulatory subunit 4 0.0039 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.042 0.5871 0.6566
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0195 0.2531 0.5
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0257 0.3456 0.4993
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0698 1 1
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0039 0.0218 0.0056
Loa Loa (eye worm) hypothetical protein 0.0038 0.0202 0.0226
Toxoplasma gondii hypothetical protein 0.0052 0.0405 0.0453
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0761
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0077 0.077 0.058
Entamoeba histolytica proteasome regulatory subunit, putative 0.0071 0.069 0.1003
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0045 0.0299 0.0381
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0039 0.0218 0.0263
Giardia lamblia Proteasome subunit beta type 2 0.0247 0.3303 0.4675
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5523
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0065 0.0593 0.081
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0059 0.0514 0.0514
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0039 0.0218 0.0263
Echinococcus multilocularis adhesion regulating molecule 1 0.0627 0.8941 0.8941
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0039 0.0218 0.0056
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0283 0.3829 0.5563
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.3254 0.3639
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0301 0.4103 0.5852
Echinococcus multilocularis geminin 0.0329 0.4521 0.4521
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7045
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0076 0.0761 0.0851
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0488 0.6883 1
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0244 0.3254 0.3639
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0281 0.3801 0.3801
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1527
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0262 0.3518 0.4979
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0308 0.019
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0355 0.4902 0.4797
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0064 0.0589 0.0805
Trypanosoma brucei proteasome beta 7 subunit 0.0244 0.3254 0.4698
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0042 0.0254 0.0315
Mycobacterium ulcerans proteasome PrcA 0.0195 0.2531 0.1593
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0077 0.077 0.1119
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0257 0.3456 0.5021
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0571
Echinococcus multilocularis cyclin 0.003 0.0086 0.0086
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5538
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0056 0.047 0.047
Brugia malayi Proteasome/cyclosome repeat family protein 0.0045 0.0299 0.0299
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0065 0.0593 0.0861
Toxoplasma gondii proteasome regulatory subunit 0.0059 0.0514 0.0575
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0059 0.0514 0.0696
Plasmodium vivax 26S proteasome regulatory subunit RPN10, putative 0.0027 0.0038 0.0056
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0258 0.347 0.5042
Giardia lamblia 26S protease regulatory subunit 6B 0.0039 0.0218 0.0088
Leishmania major proteasome beta 7 subunit, putative 0.0244 0.3254 0.4698
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0042 0.0254 0.0254
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0059 0.0514 0.0497
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0042 0.0254 0.0368
Brugia malayi proteasome subunit beta type 2 0.0247 0.3303 0.3303
Echinococcus granulosus Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0059 0.0514 0.0514
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.1496 0.1962
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0059 0.0514 0.0514
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.047 0.063
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0488 0.6883 1
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0039 0.0218 0.0263
Schistosoma mansoni hypothetical protein 0.042 0.5871 0.5786
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0071 0.069 0.1003
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5402
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0076 0.0761 0.1056
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0259 0.3483 0.506
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0281 0.3801 0.5498
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0038 0.0202 0.0202
Loa Loa (eye worm) proteasome regulatory particle 0.0071 0.069 0.0772
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0077 0.077 0.1069
Brugia malayi proteasome subunit alpha type 3 0.0262 0.3518 0.3518
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0071 0.069 0.069
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0247 0.3303 0.4769
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0262 0.3518 0.5111
Trypanosoma cruzi 20S proteasome subunit 0.0247 0.3303 0.4658
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0039 0.0218 0.0244
Brugia malayi Proteasome A-type and B-type family protein 0.0244 0.3254 0.3254
Plasmodium falciparum 26S protease regulatory subunit 10B, putative 0.0038 0.0202 0.0294
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0257 0.3456 0.5021
Schistosoma mansoni hypothetical protein 0.0059 0.051 0.0314
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0257 0.3456 0.4887
Loa Loa (eye worm) hypothetical protein 0.0627 0.8941 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0071 0.069 0.076
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0051 0.0394 0.0196
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0039 0.0218 0.0056
Plasmodium vivax proteasome subunit beta type-3, putative 0.0247 0.3303 0.4798
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0042 0.0254 0.0053
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0262 0.3518 0.5084
Brugia malayi Probable 26S protease regulatory subunit S10B 0.0038 0.0202 0.0202
Giardia lamblia 26S protease regulatory subunit 6A 0.0042 0.0254 0.014
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0265 0.3568 0.5157
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0247 0.3303 0.4798
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0247 0.3303 0.3303
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0236 0.3143 0.4536
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0247 0.3303 0.4798
Loa Loa (eye worm) PCI domain-containing protein 0.0059 0.051 0.057
Echinococcus granulosus cyclin 0.003 0.0086 0.0086
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0041 0.0236 0.0082
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0281 0.3801 0.4252
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0301 0.4103 0.4589
Echinococcus granulosus proteasome subunit beta t family 0.0247 0.3303 0.3303
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1522 0.1702
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0065 0.0593 0.081
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0039 0.0218 0.0263
Entamoeba histolytica hypothetical protein 0.0051 0.0394 0.0572
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0262 0.3518 0.5111
Brugia malayi 26S proteasome subunit P45 family protein 0.0039 0.0218 0.0218
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0076 0.0761 0.1056
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0064 0.0589 0.0395
Brugia malayi proteasome subunit alpha type 4 0.0227 0.2998 0.2998
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0301 0.4103 0.5938
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0257 0.3456 0.5021
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0056 0.047 0.047
Brugia malayi Ubiquitin interaction motif family protein 0.0042 0.0252 0.0252
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0037 0.0181 0.0032
Echinococcus granulosus Proteasome subunit alpha beta 0.0262 0.3518 0.3518
Toxoplasma gondii proteasome subunit alpha1, putative 0.0283 0.3829 0.4282
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0488 0.6883 0.7698
Plasmodium falciparum proteasome subunit beta type-4 0.0244 0.3254 0.4727
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0051 0.0394 0.0572
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0202 0.0294
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0037 0.0181 0.0181
Loa Loa (eye worm) proteasome subunit beta type 3 0.0247 0.3303 0.3694
Leishmania major proteasome alpha 2 subunit, putative 0.0268 0.3615 0.5226
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0257 0.3456 0.3456
Giardia lamblia Proteasome subunit beta type 1 0.0301 0.4103 0.5865
Toxoplasma gondii proteasome subunit alpha type, putative 0.0258 0.347 0.3881
Plasmodium falciparum 26S proteasome regulatory subunit RPN10, putative 0.0027 0.0038 0.0056
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0258 0.347 0.5014
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.042 0.5871 0.5871
Brugia malayi proteasome subunit beta type 1 0.0301 0.4103 0.4103
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0258 0.347 0.5042
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0077 0.077 0.058
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0262 0.3518 0.3935
Loa Loa (eye worm) hypothetical protein 0.0052 0.0405 0.0453
Brugia malayi MH2 domain containing protein 0.0127 0.1522 0.1522
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0039 0.0218 0.0317
Echinococcus granulosus proteasome subunit beta type 7 0.0698 1 1
Giardia lamblia Proteasome subunit beta type 3 0.0247 0.3303 0.4675
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0037 0.0187 0.0217
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0077 0.077 0.077
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0056 0.047 0.0683
Loa Loa (eye worm) proteasome Regulatory Particle 0.0064 0.0589 0.0659
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0247 0.3303 0.4798
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0571
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7045
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0258 0.347 0.5042
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0059 0.051 0.0491
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0181 0.0209
Toxoplasma gondii heat shock protein hslv, putative 0.0195 0.2531 0.2831
Plasmodium vivax 26S protease regulatory subunit 8, putative 0.0038 0.0202 0.0294
Onchocerca volvulus Notchless protein homolog 0.0262 0.3518 0.6209
Toxoplasma gondii proteasome subunit beta type, putative 0.0488 0.6883 0.7698
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0039 0.0218 0.0088
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0064 0.0589 0.0805
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0039 0.0218 0.0317
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0268 0.3615 0.5253
Loa Loa (eye worm) PCI domain-containing protein 0.0065 0.0593 0.0663
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0042 0.0254 0.0108
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0195 0.2531 0.3642
Plasmodium vivax proteasome subunit beta type-2, putative 0.0247 0.3303 0.4798
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0039 0.0218 0.0218
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0247 0.3303 0.3694
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0259 0.3483 0.3896
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0038 0.0202 0.0239
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0077 0.077 0.0879
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0039 0.0218 0.0017
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0051 0.0394 0.0519
Leishmania major proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7106
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0281 0.3801 0.5498
Loa Loa (eye worm) RPN-3 protein 0.0077 0.077 0.0861
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0259 0.3483 0.5033
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0236 0.3143 0.3515
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0488 0.6883 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5443
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0301 0.4103 0.4103
Schistosoma mansoni proteasome regulatory subunit-related 0.0065 0.0593 0.0399
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0355 0.4902 0.7122
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0076 0.0761 0.0895
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0076 0.0761 0.1106
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0042 0.0254 0.0108
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0627 0.8941 0.8919
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0268 0.3615 0.5253
Leishmania major proteasome beta-1 subunit, putative 0.0259 0.3483 0.5033
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0262 0.3518 0.5111
Schistosoma mansoni hypothetical protein 0.0329 0.4521 0.4408
Toxoplasma gondii 26S proteasome regulatory subunit 0.0038 0.0202 0.0226
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0262 0.3518 0.5111
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0247 0.3303 0.4798
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0301 0.4103 0.5852
Leishmania major hypothetical protein, conserved 0.0327 0.4482 0.6492
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0171 0.2175 0.2175
Giardia lamblia 26S protease regulatory subunit 8 0.0038 0.0202 0.0064
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0181 0.0209
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0064 0.0589 0.0856
Plasmodium vivax proteasome subunit beta type-5, putative 0.0488 0.6883 1
Toxoplasma gondii proteasome subunit alpha type, putative 0.016 0.2005 0.2243
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0059 0.0514 0.0747
Onchocerca volvulus Huntingtin homolog 0.0252 0.3373 0.5937
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0059 0.051 0.051
Toxoplasma gondii hypothetical protein 0.0043 0.0268 0.03
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0039 0.0218 0.0317
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0227 0.3004 0.4332
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0398 0.5543 1
Echinococcus multilocularis proteasome subunit beta type 6 0.0259 0.3483 0.3483
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0327 0.4482 0.6511
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0037 0.0181 0.0181
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0059 0.051 0.0689
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0038 0.0202 0.0031
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0258 0.347 0.4908
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0258 0.347 0.347
Toxoplasma gondii PCI domain-containing protein 0.0071 0.069 0.0772
Leishmania major proteasome beta 5 subunit, putative 0.0488 0.6883 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.047 0.0525
Toxoplasma gondii tat-binding family protein, putative 0.0038 0.0202 0.0226
Schistosoma mansoni hypothetical protein 0.0329 0.4521 0.4408
Trypanosoma brucei proteasome beta 6 subunit 0.0301 0.4103 0.5938
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0236 0.3143 0.4566
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0056 0.047 0.047
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0059 0.0514 0.0747
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0039 0.0218 0.0218
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0065 0.0593 0.0861
Echinococcus granulosus proteasome subunit alpha type 6 0.0283 0.3829 0.3829
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0059 0.051 0.0741
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0236 0.3143 0.4536
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0247 0.3303 0.3303
Giardia lamblia 26S protease regulatory subunit 7 0.0038 0.0202 0.0064
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0056 0.047 0.063
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1522 0.1702
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0065 0.0593 0.0593
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0247 0.3303 0.4658
Echinococcus multilocularis proteasome (prosome, macropain) 0.0488 0.6883 0.6883
Onchocerca volvulus Huntingtin homolog 0.0252 0.3373 0.5937
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0283 0.3829 0.3702
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0301 0.4103 0.5938
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0195 0.2531 0.2377
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0268 0.3615 0.4044
Giardia lamblia 20S proteasome alpha subunit 2 0.0268 0.3615 0.514
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0051 0.0394 0.0572
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0262 0.3518 0.4979
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.0252 0.0366
Brugia malayi PCI domain containing protein 0.0065 0.0593 0.0593
Echinococcus multilocularis proteasome subunit alpha type 2 0.0268 0.3615 0.3615
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0042 0.0254 0.0368
Giardia lamblia 20S proteasome alpha subunit 1 0.0283 0.3829 0.5458
Loa Loa (eye worm) proteasome 26S subunit 0.0038 0.0202 0.0226
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5402
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0056 0.047 0.063
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0038 0.0202 0.0239
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0039 0.0218 0.0244
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0042 0.0252 0.0106
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0042 0.0252 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0265 0.3568 0.5054
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0247 0.3303 0.4769
Trichomonas vaginalis 26S proteasome subunit, putative 0.0059 0.051 0.0689
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0071 0.069 0.0953
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0202 0.0294
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0488 0.6883 1
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0076 0.0761 0.1056
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0301 0.4103 0.5961
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0056 0.047 0.047
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.3254 0.4698
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0202 0.0294
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0355 0.4902 0.5483
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0247 0.3303 0.4658
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0071 0.069 0.0953
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0355 0.4902 0.7122
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0268 0.3615 0.5124
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0035 0.0159 0.0177
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0258 0.347 0.347
Giardia lamblia 20S proteasome alpha subunit 6 0.0257 0.3456 0.4903
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0259 0.3483 0.4927
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0247 0.3303 0.3164
Leishmania major proteasome beta 3 subunit, putative 0.0247 0.3303 0.4769
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0042 0.0252 0.0312
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0037 0.0181 0.0209
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0247 0.3303 0.4769
Brugia malayi 20S proteasome alpha5 subunit 0.0281 0.3801 0.3801
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0247 0.3303 0.3303
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0488 0.6883 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0077 0.077 0.077
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5523
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0195 0.2531 0.1593
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0039 0.0218 0.0317
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0059 0.0514 0.0514
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1527
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0281 0.3801 0.5523
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0258 0.347 0.3336
Loa Loa (eye worm) hypothetical protein 0.0056 0.047 0.0525
Brugia malayi Proteasome subunit alpha type 7-1 0.0355 0.4902 0.4902
Brugia malayi Proteasome A-type and B-type family protein 0.0488 0.6883 0.6883
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0039 0.0218 0.0317
Brugia malayi 26S proteasome subunit-like protein 0.0027 0.0038 0.0038
Brugia malayi 26S protease regulatory subunit 8 0.0038 0.0202 0.0202
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0355 0.4902 0.7122
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.047 0.063
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0076 0.0761 0.0761
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0064 0.0589 0.0659
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0042 0.0254 0.0284
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0247 0.3303 0.4769
Giardia lamblia Hypothetical protein 0.0071 0.069 0.079
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0268 0.3615 0.5253
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0037 0.0181 0.0209
Brugia malayi proteasome subunit alpha type 2 0.0268 0.3615 0.3615
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0039 0.0218 0.0218
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0042 0.0254 0.0315
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.047 0.063
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0761
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0259 0.3483 0.4927
Loa Loa (eye worm) hypothetical protein 0.0252 0.3373 0.3773
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0042 0.0252 0.0051
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0281 0.3801 0.3674
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.347 0.5014
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0059 0.0514 0.0514
Entamoeba histolytica proteasome regulatory subunit, putative 0.0064 0.0589 0.0856
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0247 0.3303 0.4769
Giardia lamblia 20S proteasome alpha subunit 5 0.0281 0.3801 0.5417
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0064 0.0589 0.0589
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0076 0.0761 0.0865
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0627 0.8941 1
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0268 0.3615 0.5226
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0059 0.051 0.0741
Loa Loa (eye worm) hypothetical protein 0.0252 0.3373 0.3773
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0059 0.051 0.0689
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0236 0.3143 0.4566
Loa Loa (eye worm) proteasome subunit beta type 1 0.0301 0.4103 0.4589
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0059 0.0514 0.0575
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0056 0.047 0.0431
Schistosoma mansoni 26S proteasome subunit S9 0.0071 0.069 0.0498
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0038 0.0202 0.0239
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0042 0.0254 0.0053
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0042 0.0254 0.0053
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0195 0.2531 0.3677
Toxoplasma gondii ubiquitin interaction motif family protein 0.0027 0.0038 0.0043
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0039 0.0218 0.0218
Leishmania major proteasome alpha 7 subunit, putative 0.0262 0.3518 0.5084
Echinococcus granulosus proteasome subunit alpha type 2 0.0268 0.3615 0.3615
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0038 0.0202 0.0202
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0259 0.3483 0.506
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0301 0.4103 0.3981
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0057 0.0485 0.0453
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0059 0.051 0.0689
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0077 0.077 0.077
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0042 0.0254 0.0284
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0064 0.0589 0.0589
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0038 0.0202 0.0239
Plasmodium vivax proteasome subunit beta type-4, putative 0.0244 0.3254 0.4727
Giardia lamblia 20S proteasome alpha subunit 4 0.0355 0.4902 0.7054
Entamoeba histolytica proteasome regulatory subunit, putative 0.0077 0.077 0.1119
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0195 0.2531 0.3506
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Plasmodium vivax proteasome subunit beta type-7, putative 0.0236 0.3143 0.4566
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0041 0.0236 0.0342
Loa Loa (eye worm) proteasome 26S subunit 0.0037 0.0181 0.0202
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0281 0.3801 0.4252
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0037 0.0181 0.0209
Echinococcus multilocularis proteasome subunit alpha type 6 0.0283 0.3829 0.3829
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0125 0.1496 0.2129
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0039 0.0218 0.0263
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0076 0.0761 0.1106
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0247 0.3303 0.4658
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0247 0.3303 0.3164
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0042 0.0252 0.0252
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0038 0.0202 0.0031
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0236 0.3143 0.4419
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0488 0.6883 0.6819
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0051 0.0394 0.044
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0247 0.3303 0.3164
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0071 0.069 0.1003
Toxoplasma gondii PCI domain-containing protein 0.0059 0.051 0.057
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7106
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0262 0.3518 0.3518
Plasmodium vivax proteasome subunit beta type-6, putative 0.0259 0.3483 0.506
Leishmania major mitochondrial DNA polymerase beta 0.0265 0.3568 0.5157
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0488 0.6883 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0065 0.0593 0.0861
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0259 0.3483 0.4943
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0244 0.3254 0.3254
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0045 0.0299 0.0334
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0051 0.0394 0.0394
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0259 0.3483 0.3349
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0281 0.3801 0.5523
Toxoplasma gondii proteasome 26S regulatory subunit 0.0041 0.0236 0.0264
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0283 0.3829 0.4282
Echinococcus granulosus proteasome subunit beta type 6 0.0259 0.3483 0.3483
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0488 0.6883 1
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0039 0.0218 0.0317
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0244 0.3254 0.4585
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0056 0.047 0.0273
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0071 0.069 0.069
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0195 0.2531 0.3677
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0065 0.0593 0.081
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 7 0.0037 0.0181 0.0032
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0281 0.3801 0.3674
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0051 0.0394 0.0394
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0257 0.3456 0.3321
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0187 0.0009
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0056 0.047 0.0683
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0042 0.0252 0.0252
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0065 0.0593 0.0663
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0038 0.0202 0.0031
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0218 0.0263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0218 0.0244
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0268 0.3615 0.3484
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0283 0.3829 0.5563
Leishmania major proteasome alpha 3 subunit, putative 0.0258 0.347 0.5014
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0059 0.0514 0.0497
Loa Loa (eye worm) PAS-3 protein 0.0227 0.2998 0.3353
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0355 0.4902 0.7122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0265 0.3568 0.5054
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0042 0.0254 0.0368
Echinococcus granulosus subfamily T1A non peptidase ue 0.0281 0.3801 0.3801
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0236 0.3143 0.4419
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0064 0.0589 0.0589
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0488 0.6883 1
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0064 0.0589 0.064
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0042 0.0254 0.0254
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0236 0.3143 0.3515
Giardia lamblia 20S proteasome alpha subunit 7 0.0262 0.3518 0.4995
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0059 0.0514 0.0696
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0195 0.2531 0.3506
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0187 0.0009
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0258 0.347 0.5042
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0244 0.3254 0.4727
Loa Loa (eye worm) proteasome subunit beta type 2 0.0247 0.3303 0.3694
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0262 0.3518 0.3384
Schistosoma mansoni multiubiquitin binding protein S5a 0.0042 0.0252 0.0051
Entamoeba histolytica proteasome regulatory subunit, putative 0.0056 0.047 0.0683
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0059 0.0514 0.0747
Toxoplasma gondii peptidase, T1 family protein 0.0262 0.3518 0.3935
Brugia malayi Proteasome/cyclosome repeat family protein 0.0045 0.0299 0.0299
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0283 0.3829 0.5538
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0181 0.0209
Echinococcus granulosus 26S protease regulatory subunit 8 0.0038 0.0202 0.0202
Echinococcus multilocularis proteasome subunit beta type 7 0.0698 1 1
Trypanosoma brucei proteasome alpha 7 subunit 0.0262 0.3518 0.5084
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0257 0.3456 0.4993
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0247 0.3303 0.3164
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0065 0.0593 0.0593
Plasmodium vivax 26S protease regulatory subunit 10B, putative 0.0038 0.0202 0.0294
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0218 0.0263
Brugia malayi PCI domain containing protein 0.0059 0.051 0.051
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Echinococcus granulosus geminin 0.0329 0.4521 0.4521
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0059 0.0514 0.0575
Toxoplasma gondii PCI domain-containing protein 0.0077 0.077 0.0861
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0071 0.069 0.0953
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0236 0.3143 0.4437
Loa Loa (eye worm) hypothetical protein 0.0039 0.0218 0.0244
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0038 0.0202 0.0226
Brugia malayi proteasome subunit alpha type 1 0.0257 0.3456 0.3456
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0257 0.3456 0.3456
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0195 0.2531 0.3677
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5443
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0236 0.3143 0.4536
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0042 0.0253 0.0313
Leishmania major proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5538
Loa Loa (eye worm) RPT-2 protein 0.0039 0.0218 0.0244
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0064 0.0589 0.0856
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0042 0.0254 0.0315
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0059 0.051 0.051
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0071 0.069 0.069
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0064 0.0589 0.0805
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5498
Schistosoma mansoni hypothetical protein 0.0171 0.2175 0.2013
Leishmania major proteasome alpha 1 subunit, putative 0.0257 0.3456 0.4993
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0301 0.4103 0.4103
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0059 0.0514 0.0514
Onchocerca volvulus 0.0039 0.0218 0.0031
Schistosoma mansoni 26S protease regulatory subunit 0.0039 0.0218 0.0017
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0064 0.0589 0.0609
Brugia malayi proteasome subunit alpha type 6 0.0283 0.3829 0.3829
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0059 0.0514 0.0696
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0244 0.3254 0.3254
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0195 0.2531 0.3642
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.1496 0.2129
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0038 0.0202 0.0202
Toxoplasma gondii proteasome subunit 0.0259 0.3483 0.3896
Plasmodium vivax proteasome subunit beta type-1, putative 0.0301 0.4103 0.5961
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0039 0.0218 0.0056
Plasmodium falciparum 26S protease regulatory subunit 8, putative 0.0038 0.0202 0.0294
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0059 0.0514 0.0514
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0627 0.8941 0.8941
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0283 0.3829 0.5563
Leishmania major proteasome beta 2 subunit, putative 0.0236 0.3143 0.4536
Brugia malayi Proteasome A-type and B-type family protein 0.0259 0.3483 0.3483
Brugia malayi proteasome subunit beta type 3 0.0247 0.3303 0.3303
Brugia malayi Proteasome subunit alpha type 1 0.0226 0.2984 0.2984
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0249 0.3329 0.3191
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0259 0.3483 0.5033
Brugia malayi 26S protease regulatory subunit 6A 0.0042 0.0254 0.0254
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0257 0.3456 0.3865
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0059 0.0514 0.0319
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0187 0.0009
Giardia lamblia 20S proteasome alpha subunit 3 0.0258 0.347 0.4925
Echinococcus granulosus adhesion regulating molecule 1 0.0627 0.8941 0.8941
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0258 0.347 0.4908
Brugia malayi hypothetical protein 0.0252 0.3373 0.3373
Mycobacterium ulcerans proteasome PrcB 0.0488 0.6883 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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