Detailed information for compound 1551293

Basic information

Technical information
  • TDR Targets ID: 1551293
  • Name: ethyl 2-[(2-acetamidoacetyl)amino]-3-(1H-indo l-3-yl)propanoate
  • MW: 331.366 | Formula: C17H21N3O4
  • H donors: 3 H acceptors: 3 LogP: 1.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)CNC(=O)C
  • InChi: 1S/C17H21N3O4/c1-3-24-17(23)15(20-16(22)10-18-11(2)21)8-12-9-19-14-7-5-4-6-13(12)14/h4-7,9,15,19H,3,8,10H2,1-2H3,(H,18,21)(H,20,22)
  • InChiKey: OSLMBHQGRIHGQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-acetamido-1-oxoethyl)amino]-3-(1H-indol-3-yl)propanoic acid ethyl ester
  • 2-[(2-acetamidoacetyl)amino]-3-(1H-indol-3-yl)propionic acid ethyl ester
  • ethyl 2-(2-acetamidoethanoylamino)-3-(1H-indol-3-yl)propanoate
  • BAS 01247741
  • 2-(2-Acetylamino-acetylamino)-3-(1H-indol-3-yl)-propionic acid ethyl ester
  • MLS000034739
  • SMR000010238

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0257 0.3456 0.5021
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0042 0.0254 0.0254
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0059 0.051 0.0741
Brugia malayi proteasome subunit beta type 3 0.0247 0.3303 0.3303
Toxoplasma gondii PCI domain-containing protein 0.0077 0.077 0.0861
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0042 0.0252 0.0252
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0076 0.0761 0.1106
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0244 0.3254 0.3254
Leishmania major proteasome alpha 1 subunit, putative 0.0257 0.3456 0.4993
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0281 0.3801 0.3674
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0039 0.0218 0.0317
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0064 0.0589 0.0805
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0488 0.6883 0.6819
Brugia malayi hypothetical protein 0.0252 0.3373 0.3373
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0258 0.347 0.347
Onchocerca volvulus 0.0039 0.0218 0.0031
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0037 0.0187 0.0217
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0076 0.0761 0.1056
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Leishmania major proteasome beta 5 subunit, putative 0.0488 0.6883 1
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0042 0.0254 0.0368
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0236 0.3143 0.4536
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0195 0.2531 0.3506
Plasmodium vivax proteasome subunit beta type-1, putative 0.0301 0.4103 0.5961
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0236 0.3143 0.4419
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0262 0.3518 0.3384
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0039 0.0218 0.0317
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0038 0.0202 0.0031
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0488 0.6883 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0301 0.4103 0.4589
Brugia malayi Proteasome subunit alpha type 7-1 0.0355 0.4902 0.4902
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0257 0.3456 0.4993
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0244 0.3254 0.4698
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0181 0.0209
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0059 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0056 0.047 0.0525
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0038 0.0202 0.0239
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0039 0.0218 0.0218
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0059 0.0514 0.0696
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0039 0.0218 0.0317
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5523
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0257 0.3456 0.4887
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0195 0.2531 0.3642
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0258 0.347 0.347
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0195 0.2531 0.3506
Toxoplasma gondii proteasome subunit alpha1, putative 0.0283 0.3829 0.4282
Onchocerca volvulus 0.0039 0.0218 0.0031
Giardia lamblia Proteasome subunit beta type 3 0.0247 0.3303 0.4675
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0262 0.3518 0.3935
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0039 0.0218 0.0317
Leishmania major proteasome beta 2 subunit, putative 0.0247 0.3303 0.4769
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0059 0.0514 0.0514
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0247 0.3303 0.3303
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0077 0.077 0.077
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0038 0.0202 0.0239
Echinococcus granulosus adhesion regulating molecule 1 0.0627 0.8941 0.8941
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0059 0.0514 0.0497
Plasmodium vivax proteasome subunit beta type-3, putative 0.0247 0.3303 0.4798
Plasmodium falciparum 26S protease regulatory subunit 8, putative 0.0038 0.0202 0.0294
Toxoplasma gondii hypothetical protein 0.0052 0.0405 0.0453
Loa Loa (eye worm) hypothetical protein 0.0252 0.3373 0.3773
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0171 0.2175 0.2175
Loa Loa (eye worm) proteasome Regulatory Particle 0.0064 0.0589 0.0659
Entamoeba histolytica proteasome regulatory subunit, putative 0.0077 0.077 0.1119
Loa Loa (eye worm) hypothetical protein 0.0252 0.3373 0.3773
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0247 0.3303 0.3694
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0247 0.3303 0.4769
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0627 0.8941 0.8919
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0268 0.3615 0.4044
Toxoplasma gondii PCI domain-containing protein 0.0071 0.069 0.0772
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0076 0.0761 0.1056
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7106
Loa Loa (eye worm) proteasome subunit beta type 3 0.0247 0.3303 0.3694
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0571
Trypanosoma cruzi 20S proteasome subunit 0.0247 0.3303 0.4658
Entamoeba histolytica hypothetical protein 0.0051 0.0394 0.0572
Mycobacterium ulcerans proteasome PrcB 0.0488 0.6883 1
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0038 0.0202 0.0202
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0258 0.347 0.5014
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0281 0.3801 0.5498
Toxoplasma gondii proteasome subunit alpha type, putative 0.016 0.2005 0.2243
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0236 0.3143 0.3515
Schistosoma mansoni 26S protease regulatory subunit 0.0039 0.0218 0.0017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0488 0.6883 1
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0042 0.0252 0.0312
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0571
Loa Loa (eye worm) hypothetical protein 0.0627 0.8941 1
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0065 0.0593 0.081
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0065 0.0593 0.0593
Schistosoma mansoni proteasome regulatory subunit-related 0.0065 0.0593 0.0399
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0247 0.3303 0.3164
Leishmania major proteasome regulatory ATPase subunit 0.0038 0.0202 0.0239
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0249 0.3329 0.3191
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0037 0.0181 0.0181
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0259 0.3483 0.4927
Echinococcus multilocularis cyclin 0.003 0.0086 0.0086
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0039 0.0218 0.0218
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0268 0.3615 0.5253
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0488 0.6883 1
Plasmodium vivax 26S proteasome regulatory subunit RPN10, putative 0.0027 0.0038 0.0056
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0056 0.047 0.047
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0259 0.3483 0.506
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0077 0.077 0.058
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0257 0.3456 0.3865
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0627 0.8941 0.8941
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0301 0.4103 0.5938
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0038 0.0202 0.0031
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0056 0.047 0.047
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0257 0.3456 0.3456
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0038 0.0202 0.0202
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0071 0.069 0.1003
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0064 0.0589 0.0805
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0039 0.0218 0.0056
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0039 0.0218 0.0017
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0042 0.0252 0.0051
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0488 0.6883 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0247 0.3303 0.4798
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0244 0.3254 0.3639
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0259 0.3483 0.4927
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0042 0.0254 0.0315
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0064 0.0589 0.0805
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0265 0.3568 0.5054
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0077 0.077 0.077
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1522 0.1702
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0051 0.0394 0.0394
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0281 0.3801 0.3801
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0059 0.0514 0.0514
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0247 0.3303 0.3164
Giardia lamblia 26S protease regulatory subunit 8 0.0038 0.0202 0.0064
Echinococcus granulosus Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Giardia lamblia 26S protease regulatory subunit 7 0.0038 0.0202 0.0064
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0059 0.051 0.051
Echinococcus granulosus Proteasome subunit alpha beta 0.0262 0.3518 0.3518
Leishmania major proteasome alpha 7 subunit, putative 0.0262 0.3518 0.5084
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0301 0.4103 0.5852
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0258 0.347 0.5042
Entamoeba histolytica proteasome regulatory subunit, putative 0.0056 0.047 0.0683
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0071 0.069 0.076
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0051 0.0394 0.044
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0038 0.0202 0.0226
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0059 0.051 0.0689
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0258 0.347 0.4908
Plasmodium vivax proteasome subunit beta type-5, putative 0.0488 0.6883 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0236 0.3143 0.4536
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0071 0.069 0.0953
Giardia lamblia 20S proteasome alpha subunit 7 0.0262 0.3518 0.4995
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0571
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0059 0.0514 0.0696
Brugia malayi Proteasome A-type and B-type family protein 0.0244 0.3254 0.3254
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0064 0.0589 0.0589
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0076 0.0761 0.1106
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0488 0.6883 0.7698
Echinococcus granulosus proteasome subunit beta t family 0.0247 0.3303 0.3303
Toxoplasma gondii hypothetical protein 0.0043 0.0268 0.03
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0042 0.0254 0.0108
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0244 0.3254 0.4603
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0761
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0283 0.3829 0.5563
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0247 0.3303 0.3164
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0247 0.3303 0.4798
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0059 0.0514 0.0514
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0262 0.3518 0.5111
Brugia malayi proteasome subunit beta type 2 0.0247 0.3303 0.3303
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0039 0.0218 0.0218
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0268 0.3615 0.3484
Toxoplasma gondii proteasome regulatory subunit 0.0059 0.0514 0.0575
Toxoplasma gondii proteasome subunit alpha type, putative 0.0258 0.347 0.3881
Giardia lamblia 26S protease regulatory subunit 6A 0.0042 0.0254 0.014
Brugia malayi Proteasome/cyclosome repeat family protein 0.0045 0.0299 0.0299
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0244 0.3254 0.3115
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0064 0.0589 0.0395
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0265 0.3568 0.5157
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0071 0.069 0.0953
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0247 0.3303 0.4769
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0488 0.6883 1
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0398 0.5543 1
Mycobacterium ulcerans proteasome PrcA 0.0195 0.2531 0.1593
Plasmodium falciparum proteasome subunit beta type-5 0.0488 0.6883 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0077 0.077 0.1069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0187 0.0009
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0039 0.0218 0.0244
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0064 0.0589 0.0856
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0195 0.2531 0.2377
Toxoplasma gondii SAC3/GANP family protein 0.0056 0.047 0.0525
Toxoplasma gondii proteasome 26S regulatory subunit 0.0041 0.0236 0.0264
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0327 0.4482 0.6511
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0244 0.3254 0.4727
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0262 0.3518 0.5084
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0037 0.0181 0.0209
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0257 0.3456 0.4993
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0268 0.3615 0.5253
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0071 0.069 0.0953
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0262 0.3518 0.5111
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0244 0.3254 0.4585
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0236 0.3143 0.4419
Entamoeba histolytica proteasome regulatory subunit, putative 0.0065 0.0593 0.0861
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0236 0.3143 0.4536
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0262 0.3518 0.4979
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0195 0.2531 0.3677
Brugia malayi proteasome subunit alpha type 3 0.0262 0.3518 0.3518
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0627 0.8941 1
Loa Loa (eye worm) RPT-2 protein 0.0039 0.0218 0.0244
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0051 0.0394 0.0519
Giardia lamblia 20S proteasome alpha subunit 6 0.0257 0.3456 0.4903
Onchocerca volvulus Notchless protein homolog 0.0262 0.3518 0.6209
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0281 0.3801 0.5498
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0064 0.0589 0.0609
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0071 0.069 0.069
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0037 0.0181 0.0209
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5538
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0042 0.0252 0.0252
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0268 0.3615 0.5124
Echinococcus granulosus proteasome subunit beta type 7 0.0698 1 1
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0037 0.0181 0.0209
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0077 0.077 0.077
Loa Loa (eye worm) proteasome 26S subunit 0.0037 0.0181 0.0202
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0301 0.4103 0.5961
Loa Loa (eye worm) PCI domain-containing protein 0.0065 0.0593 0.0663
Loa Loa (eye worm) hypothetical protein 0.0039 0.0218 0.0244
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0042 0.0254 0.0053
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.047 0.063
Schistosoma mansoni hypothetical protein 0.0171 0.2175 0.2013
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 7 0.0037 0.0181 0.0032
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0065 0.0593 0.0614
Leishmania major mitochondrial DNA polymerase beta 0.0265 0.3568 0.5157
Giardia lamblia Proteasome subunit beta type 2 0.0247 0.3303 0.4675
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0258 0.347 0.4908
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0039 0.0218 0.0218
Loa Loa (eye worm) PCI domain-containing protein 0.0059 0.051 0.057
Plasmodium vivax 26S protease regulatory subunit 8, putative 0.0038 0.0202 0.0294
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0281 0.3801 0.4252
Trichomonas vaginalis 26S proteasome subunit, putative 0.0059 0.051 0.0689
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0064 0.0589 0.0589
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0051 0.0394 0.0394
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0195 0.2531 0.3642
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0698 1 1
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0039 0.0218 0.0263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0218 0.0244
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0257 0.3456 0.5021
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0041 0.0236 0.0082
Echinococcus granulosus proteasome subunit beta type 6 0.0259 0.3483 0.3483
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0257 0.3456 0.3321
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1346
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0045 0.0299 0.0381
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Leishmania major proteasome beta 2 subunit, putative 0.0236 0.3143 0.4536
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0257 0.3456 0.3456
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0042 0.0254 0.0053
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0065 0.0593 0.081
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0077 0.077 0.0879
Brugia malayi proteasome subunit alpha type 4 0.0227 0.2998 0.2998
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0056 0.047 0.0431
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0038 0.0202 0.0202
Brugia malayi 26S proteasome subunit-like protein 0.0027 0.0038 0.0038
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0038 0.0202 0.0239
Giardia lamblia 26S protease regulatory subunit 6B 0.0039 0.0218 0.0088
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.0252 0.0366
Loa Loa (eye worm) hypothetical protein 0.042 0.5871 0.6566
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0202 0.0294
Brugia malayi 26S protease regulatory subunit 8 0.0038 0.0202 0.0202
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0218 0.0263
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0059 0.0514 0.0696
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0059 0.0514 0.0514
Entamoeba histolytica proteasome regulatory subunit, putative 0.0059 0.051 0.0741
Brugia malayi proteasome subunit alpha type 1 0.0257 0.3456 0.3456
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0247 0.3303 0.3164
Giardia lamblia 20S proteasome alpha subunit 4 0.0355 0.4902 0.7054
Leishmania major proteasome beta 3 subunit, putative 0.0247 0.3303 0.4769
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0355 0.4902 0.7122
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0195 0.2531 0.5
Brugia malayi Proteasome A-type and B-type family protein 0.0488 0.6883 0.6883
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0236 0.3143 0.3515
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5402
Echinococcus granulosus geminin 0.0329 0.4521 0.4521
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0056 0.047 0.063
Giardia lamblia 20S proteasome alpha subunit 3 0.0258 0.347 0.4925
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0247 0.3303 0.4658
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1522 0.1702
Schistosoma mansoni hypothetical protein 0.042 0.5871 0.5786
Loa Loa (eye worm) proteasome subunit beta type 1 0.0301 0.4103 0.4589
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0257 0.3456 0.3865
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0247 0.3303 0.4798
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0042 0.0254 0.0315
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0262 0.3518 0.5111
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0039 0.0218 0.0263
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0258 0.347 0.3336
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0077 0.077 0.058
Loa Loa (eye worm) PAS-3 protein 0.0227 0.2998 0.3353
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0355 0.4902 0.4797
Loa Loa (eye worm) proteasome subunit beta type 2 0.0247 0.3303 0.3694
Toxoplasma gondii 26S proteasome regulatory subunit 0.0038 0.0202 0.0226
Trypanosoma brucei proteasome beta 7 subunit 0.0244 0.3254 0.4698
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0202 0.0294
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.042 0.5871 0.5871
Onchocerca volvulus Huntingtin homolog 0.0252 0.3373 0.5937
Echinococcus granulosus proteasome prosome macropain 0.0488 0.6883 0.6883
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0265 0.3568 0.5054
Toxoplasma gondii proteasome beta subunit 0.0247 0.3303 0.3694
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0039 0.0218 0.0056
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0059 0.0514 0.0747
Toxoplasma gondii PCI domain-containing protein 0.0059 0.051 0.057
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0059 0.0514 0.0575
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1527
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0056 0.047 0.0683
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0283 0.3829 0.3702
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5443
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0059 0.051 0.0689
Leishmania major proteasome alpha 3 subunit, putative 0.0258 0.347 0.5014
Schistosoma mansoni 26S proteasome subunit S9 0.0071 0.069 0.0498
Brugia malayi PCI domain containing protein 0.0065 0.0593 0.0593
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0059 0.051 0.0689
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0071 0.069 0.1003
Plasmodium vivax proteasome subunit beta type-4, putative 0.0244 0.3254 0.4727
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0227 0.3004 0.4332
Brugia malayi 26S proteasome subunit P45 family protein 0.0039 0.0218 0.0218
Echinococcus granulosus 26S protease regulatory subunit 8 0.0038 0.0202 0.0202
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0258 0.347 0.5042
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0039 0.0218 0.0263
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0076 0.0761 0.0851
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0187 0.0009
Brugia malayi Probable 26S protease regulatory subunit 4 0.0039 0.0218 0.0218
Brugia malayi proteasome subunit alpha type 2 0.0268 0.3615 0.3615
Brugia malayi proteasome subunit alpha type 6 0.0283 0.3829 0.3829
Loa Loa (eye worm) proteasome regulatory particle 0.0071 0.069 0.0772
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0071 0.069 0.069
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Giardia lamblia 20S proteasome alpha subunit 5 0.0281 0.3801 0.5417
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0281 0.3801 0.4252
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0283 0.3829 0.4282
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0202 0.0294
Toxoplasma gondii peptidase, T1 family protein 0.0262 0.3518 0.3935
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0268 0.3615 0.5253
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0259 0.3483 0.506
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0042 0.0254 0.0315
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0064 0.0589 0.064
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0283 0.3829 0.5563
Brugia malayi Proteasome/cyclosome repeat family protein 0.0045 0.0299 0.0299
Entamoeba histolytica proteasome regulatory subunit, putative 0.0064 0.0589 0.0856
Plasmodium vivax 26S protease regulatory subunit 10B, putative 0.0038 0.0202 0.0294
Toxoplasma gondii proteasome subunit beta type, putative 0.0488 0.6883 0.7698
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0059 0.0514 0.0514
Brugia malayi Probable 26S protease regulatory subunit S10B 0.0038 0.0202 0.0202
Echinococcus multilocularis proteasome subunit beta type 7 0.0698 1 1
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0059 0.0514 0.0319
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0039 0.0218 0.0263
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0076 0.0761 0.0761
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0257 0.3456 0.5021
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0042 0.0254 0.0284
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0355 0.4902 0.4902
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0071 0.069 0.069
Brugia malayi PCI domain containing protein 0.0059 0.051 0.051
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0065 0.0593 0.0593
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0301 0.4103 0.4103
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0059 0.051 0.0741
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0056 0.047 0.0683
Giardia lamblia 20S proteasome alpha subunit 1 0.0283 0.3829 0.5458
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0064 0.0589 0.0659
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0039 0.0218 0.0088
Entamoeba histolytica proteasome regulatory subunit, putative 0.0071 0.069 0.1003
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0042 0.0254 0.0368
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.047 0.063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.1496 0.1962
Leishmania major proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5538
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0244 0.3254 0.3254
Toxoplasma gondii ubiquitin interaction motif family protein 0.0027 0.0038 0.0043
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0042 0.0254 0.0284
Echinococcus multilocularis proteasome (prosome, macropain) 0.0488 0.6883 0.6883
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0125 0.1496 0.2129
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0077 0.077 0.1069
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0247 0.3303 0.4798
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0038 0.0202 0.0239
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0077 0.077 0.1119
Echinococcus granulosus proteasome subunit alpha type 2 0.0268 0.3615 0.3615
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0187 0.0009
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0236 0.3143 0.4437
Trypanosoma brucei proteasome beta 6 subunit 0.0301 0.4103 0.5938
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0236 0.3143 0.4566
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0039 0.0218 0.0317
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0037 0.0181 0.0181
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0355 0.4902 0.7122
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0039 0.0218 0.0056
Plasmodium vivax proteasome subunit beta type-7, putative 0.0236 0.3143 0.4566
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0247 0.3303 0.4798
Loa Loa (eye worm) hypothetical protein 0.0038 0.0202 0.0226
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0039 0.0218 0.0056
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0247 0.3303 0.4769
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0065 0.0593 0.081
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0262 0.3518 0.5111
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0181 0.0209
Echinococcus granulosus subfamily T1A non peptidase ue 0.0281 0.3801 0.3801
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0038 0.0202 0.0239
Toxoplasma gondii heat shock protein hslv, putative 0.0195 0.2531 0.2831
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0355 0.4902 0.7106
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0283 0.3829 0.5443
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0057 0.0485 0.0453
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0301 0.4103 0.5961
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0247 0.3303 0.4658
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7045
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0171 0.2175 0.2175
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0247 0.3303 0.3303
Plasmodium vivax proteasome subunit beta type-6, putative 0.0259 0.3483 0.506
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0301 0.4103 0.5938
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0355 0.4902 0.7122
Brugia malayi Proteasome A-type and B-type family protein 0.0259 0.3483 0.3483
Leishmania major proteasome beta-1 subunit, putative 0.0259 0.3483 0.5033
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0268 0.3615 0.4044
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0042 0.0253 0.0313
Brugia malayi proteasome subunit beta type 1 0.0301 0.4103 0.4103
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0038 0.0202 0.0031
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0076 0.0761 0.0865
Plasmodium falciparum proteasome subunit beta type-4 0.0244 0.3254 0.4727
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0037 0.0181 0.0032
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0039 0.0218 0.0244
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0051 0.0394 0.0572
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0488 0.6883 1
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0059 0.0514 0.0575
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1083 0.1527
Brugia malayi 20S proteasome alpha5 subunit 0.0281 0.3801 0.3801
Plasmodium falciparum 26S proteasome regulatory subunit RPN10, putative 0.0027 0.0038 0.0056
Echinococcus multilocularis adhesion regulating molecule 1 0.0627 0.8941 0.8941
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0039 0.0218 0.0263
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0262 0.3518 0.4979
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0258 0.347 0.5042
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5523
Schistosoma mansoni hypothetical protein 0.0329 0.4521 0.4408
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0051 0.0394 0.0572
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0355 0.4902 0.5483
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0065 0.0593 0.0663
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0059 0.0514 0.0747
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0065 0.0593 0.0861
Echinococcus granulosus cyclin 0.003 0.0086 0.0086
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0042 0.0252 0.0106
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0258 0.347 0.5014
Brugia malayi 26S protease regulatory subunit 6A 0.0042 0.0254 0.0254
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0076 0.0761 0.0895
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0035 0.0159 0.0177
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0236 0.3143 0.4566
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0059 0.0514 0.0747
Loa Loa (eye worm) hypothetical protein 0.0056 0.047 0.0525
Schistosoma mansoni multiubiquitin binding protein S5a 0.0042 0.0252 0.0051
Echinococcus multilocularis proteasome subunit alpha type 6 0.0283 0.3829 0.3829
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.047 0.063
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0281 0.3801 0.3674
Leishmania major proteasome alpha 2 subunit, putative 0.0268 0.3615 0.5226
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0259 0.3483 0.3896
Toxoplasma gondii proteasome subunit 0.0259 0.3483 0.3896
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0488 0.6883 1
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0065 0.0593 0.0861
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0059 0.0514 0.0514
Giardia lamblia Hypothetical protein 0.0071 0.069 0.079
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0059 0.0514 0.0747
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0488 0.6883 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7045
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0059 0.051 0.0491
Loa Loa (eye worm) RPN-3 protein 0.0077 0.077 0.0861
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0056 0.047 0.063
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0268 0.3615 0.5226
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0059 0.0514 0.0696
Toxoplasma gondii tat-binding family protein, putative 0.0038 0.0202 0.0226
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0076 0.0761 0.1056
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0039 0.0218 0.0317
Loa Loa (eye worm) hypothetical protein 0.0052 0.0405 0.0453
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0195 0.2531 0.3677
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0259 0.3483 0.5033
Echinococcus granulosus proteasome subunit alpha type 6 0.0283 0.3829 0.3829
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0059 0.0514 0.0747
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0056 0.047 0.0273
Leishmania major proteasome alpha 7 subunit, putative 0.0355 0.4902 0.7106
Plasmodium falciparum 26S protease regulatory subunit 10B, putative 0.0038 0.0202 0.0294
Brugia malayi Ubiquitin interaction motif family protein 0.0042 0.0252 0.0252
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.1496 0.2129
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5402
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0308 0.019
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0041 0.0236 0.0342
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0051 0.0394 0.0196
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0247 0.3303 0.4769
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0244 0.3254 0.3639
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0056 0.047 0.047
Trypanosoma brucei proteasome alpha 7 subunit 0.0262 0.3518 0.5084
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0076 0.0761 0.0761
Leishmania major proteasome beta 7 subunit, putative 0.0244 0.3254 0.4698
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Giardia lamblia 20S proteasome alpha subunit 2 0.0268 0.3615 0.514
Loa Loa (eye worm) proteasome 26S subunit 0.0038 0.0202 0.0226
Echinococcus multilocularis proteasome subunit alpha type 2 0.0268 0.3615 0.3615
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0042 0.0254 0.0108
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0195 0.2531 0.3677
Echinococcus multilocularis geminin 0.0329 0.4521 0.4521
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0258 0.347 0.5042
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0064 0.0589 0.0589
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0218 0.0263
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0355 0.4902 0.7122
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0259 0.3483 0.4943
Brugia malayi MH2 domain containing protein 0.0127 0.1522 0.1522
Onchocerca volvulus Huntingtin homolog 0.0252 0.3373 0.5937
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0098 0.1083 0.1574
Echinococcus multilocularis proteasome subunit beta type 6 0.0259 0.3483 0.3483
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0042 0.0254 0.0254
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0045 0.0299 0.0334
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0042 0.0254 0.0053
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0059 0.0514 0.0497
Giardia lamblia Proteasome subunit beta type 1 0.0301 0.4103 0.5865
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0301 0.4103 0.3981
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0059 0.0514 0.0575
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0064 0.0589 0.0856
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0037 0.0181 0.0209
Schistosoma mansoni hypothetical protein 0.0059 0.051 0.0314
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0259 0.3483 0.5033
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0259 0.3483 0.3349
Leishmania major hypothetical protein, conserved 0.0327 0.4482 0.6492
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0281 0.3801 0.5498
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0059 0.0514 0.0747
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0281 0.3801 0.5523
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0301 0.4103 0.4103
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0042 0.0252 0.0106
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0195 0.2531 0.1593
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0281 0.3801 0.5523
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0247 0.3303 0.4769
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0301 0.4103 0.5852
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0056 0.047 0.047
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0247 0.3303 0.3303
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0283 0.3829 0.5563
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0262 0.3518 0.3518
Schistosoma mansoni hypothetical protein 0.0329 0.4521 0.4408
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0059 0.0514 0.0514
Brugia malayi Proteasome subunit alpha type 1 0.0226 0.2984 0.2984
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0283 0.3829 0.5538
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0244 0.3254 0.4698
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0042 0.0254 0.0368
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0247 0.3303 0.4658

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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