Detailed information for compound 1551294

Basic information

Technical information
  • TDR Targets ID: 1551294
  • Name: [2-[[2-(4,6-dimethylpyrimidin-2-yl)-5-methylp yrazol-3-yl]amino]-2-oxoethyl] 4-oxo-4-thioph en-2-ylbutanoate
  • MW: 427.477 | Formula: C20H21N5O4S
  • H donors: 1 H acceptors: 6 LogP: 2.4 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(nn1c1nc(C)cc(n1)C)C)COC(=O)CCC(=O)c1cccs1
  • InChi: 1S/C20H21N5O4S/c1-12-9-13(2)22-20(21-12)25-17(10-14(3)24-25)23-18(27)11-29-19(28)7-6-15(26)16-5-4-8-30-16/h4-5,8-10H,6-7,11H2,1-3H3,(H,23,27)
  • InChiKey: VPECLPRIEROURB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[[2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-pyrazol-3-yl]amino]-2-oxo-ethyl] 4-oxo-4-(2-thienyl)butanoate
  • 4-oxo-4-(2-thienyl)butanoic acid [2-[[2-(4,6-dimethyl-2-pyrimidinyl)-5-methyl-3-pyrazolyl]amino]-2-oxoethyl] ester
  • 4-keto-4-(2-thienyl)butyric acid [2-[[2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-pyrazol-3-yl]amino]-2-keto-ethyl] ester
  • [2-[[2-(4,6-dimethylpyrimidin-2-yl)-5-methyl-pyrazol-3-yl]amino]-2-oxo-ethyl] 4-oxo-4-thiophen-2-yl-butanoate
  • T0512-8851
  • ZINC03256349
  • MLS000057052
  • SMR000062092

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0143 0.1538 0.1538
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0189 0.2121 0.7028
Toxoplasma gondii heat shock protein hslv, putative 0.0104 0.1047 0.1047
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0189 0.2121 0.2121
Schistosoma mansoni hypothetical protein 0.0091 0.0886 0.0886
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0091 0.0886 0.0886
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0137 0.1466 0.4858
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0168 0.0168
Schistosoma mansoni multiubiquitin binding protein S5a 0.0022 0.0015 0.0015
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.013 0.1375 0.1375
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0132 0.1397 0.4628
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0000020772 0.0000020772
Trypanosoma cruzi 20S proteasome subunit 0.0132 0.1397 0.4628
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0032 0.0134 0.0444
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0038 0.0214 0.0708
Loa Loa (eye worm) RPN-3 protein 0.0041 0.025 0.025
Echinococcus granulosus proteasome subunit beta type 6 0.0138 0.1478 0.1478
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0137 0.1466 0.2885
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0114 0.0114
Brugia malayi proteasome subunit beta type 2 0.0132 0.1397 0.1397
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0137 0.1466 0.4858
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0138 0.1473 0.1473
Toxoplasma gondii PCI domain-containing protein 0.0038 0.0214 0.0214
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0143 0.1538 0.3027
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0132 0.1397 0.4628
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0134 0.0134
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0134 0.0444
Brugia malayi PCI domain containing protein 0.0031 0.0132 0.0132
Loa Loa (eye worm) proteasome subunit alpha type 6 0.015 0.1635 0.1635
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1375 0.2705
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0132 0.1397 0.1397
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0138 0.1478 0.2909
Giardia lamblia 20S proteasome alpha subunit 4 0.0189 0.2121 0.7028
Brugia malayi Proteasome subunit alpha type 7-1 0.0189 0.2121 0.2121
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.0015 0.005
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0134 0.0444
Echinococcus granulosus adhesion regulating molecule 1 0.0813 1 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.0168 0.0556
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0134 0.0444
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0091 0.0886 0.0886
Entamoeba histolytica proteasome subunit beta type 1, putative 0.016 0.1759 0.5828
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0127 0.1334 0.442
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0143 0.1538 0.5097
Loa Loa (eye worm) hypothetical protein 0.0813 1 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0134 0.0264
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0137 0.1466 0.4858
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0138 0.1473 0.4879
Brugia malayi proteasome subunit alpha type 6 0.015 0.1635 0.1635
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0016 0.0016
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1375 0.2705
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0189 0.2121 0.2121
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.013 0.1375 0.1375
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0041 0.025 0.0492
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.003 0.0114 0.0114
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0138 0.1473 0.1473
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0143 0.1538 0.5097
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0168 0.033
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0126 0.1324 0.4388
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0186 0.0186
Echinococcus multilocularis adhesion regulating molecule 1 0.0813 1 1
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.015 0.1635 0.5417
Echinococcus granulosus chromobox protein 1 0.0084 0.0798 0.0798
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0016 0.0016
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0149 0.1623 0.1623
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0041 0.025 0.025
Leishmania major proteasome beta 3 subunit, putative 0.0132 0.1397 0.2748
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0022 0.0016 0.0016
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0104 0.1047 0.2061
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0189 0.2121 0.7028
Entamoeba histolytica proteasome regulatory subunit, putative 0.0038 0.0214 0.0708
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0798 0.0798
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0132 0.0437
Plasmodium vivax proteasome subunit alpha type-6, putative 0.015 0.1635 0.5417
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0022 0.0016 0.0053
Toxoplasma gondii SAC3/GANP family protein 0.003 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0031 0.0132 0.0132
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0137 0.1466 0.4858
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0034 0.0168 0.0168
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0139 0.1494 0.4951
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0202
Giardia lamblia 20S proteasome alpha subunit 3 0.0138 0.1473 0.4879
Brugia malayi proteasome subunit alpha type 3 0.0139 0.1494 0.1494
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0138 0.1473 0.4879
Leishmania major proteasome beta 2 subunit, putative 0.0132 0.1397 0.2748
Toxoplasma gondii peptidase, T1 family protein 0.0139 0.1494 0.1494
Echinococcus granulosus proteasome subunit beta type 7 0.0372 0.443 0.443
Loa Loa (eye worm) hypothetical protein 0.0047 0.0331 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0331 0.1096
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0126 0.1324 0.4388
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0038 0.0214 0.0708
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0022 0.0016 0.0031
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0114 0.0377
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.013 0.1375 0.4555
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0137 0.1466 0.1466
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0038 0.0214 0.042
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0121 0.1261 0.4179
Plasmodium vivax proteasome subunit beta type-3, putative 0.0132 0.1397 0.4628
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.003 0.0114 0.0224
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0138 0.1473 0.4879
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0376 0.0601
Echinococcus multilocularis chromobox protein 1 0.0084 0.0798 0.0798
Plasmodium vivax proteasome subunit beta type-7, putative 0.0126 0.1324 0.4388
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0132 0.1397 0.1397
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.2121 0.7028
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.015 0.1635 0.5417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0000020772 0.0000020772
Trypanosoma brucei proteasome beta 7 subunit 0.013 0.1375 0.4555
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0132 0.1397 0.1397
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0132 0.0132
Echinococcus granulosus proteasome subunit beta t family 0.0132 0.1397 0.1397
Echinococcus granulosus proteasome subunit alpha type 2 0.0143 0.1538 0.1538
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0036 0.0186 0.0615
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0031 0.0132 0.0132
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0138 0.1473 0.2898
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0376 0.1245
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0104 0.1047 0.5
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0138 0.1478 0.4898
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0041 0.025 0.0828
Echinococcus granulosus proteasome prosome macropain 0.026 0.3018 0.3018
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0134 0.0134
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.016 0.1759 0.5828
Brugia malayi Proteasome A-type and B-type family protein 0.0138 0.1478 0.1478
Leishmania major proteasome beta 5 subunit, putative 0.026 0.3018 0.5939
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0139 0.1494 0.4951
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0134 0.0134
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0132 0.1397 0.4628
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0015 0.0015
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0139 0.1494 0.1494
Plasmodium falciparum proteasome subunit beta type-1, putative 0.016 0.1759 0.3462
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0032 0.0134 0.0134
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.016 0.1759 0.5828
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.013 0.1375 0.4555
Toxoplasma gondii proteasome 26S regulatory subunit 0.0022 0.0008 0.0008
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0032 0.0134 0.0444
Brugia malayi Proteasome subunit alpha type 1 0.012 0.1252 0.1252
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0138 0.1473 0.4879
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.003 0.0114 0.0114
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0134 0.0134
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0022 0.0015 0.0015
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.013 0.1375 0.1375
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0085
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0132 0.1397 0.1397
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0036 0.0186 0.0615
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0139 0.1494 0.4951
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0189 0.2121 0.7028
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0137 0.1466 0.1466
Toxoplasma gondii proteasome subunit 0.0138 0.1478 0.1478
Brugia malayi PCI domain containing protein 0.0034 0.017 0.0169
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0031 0.0132 0.0437
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0041 0.025 0.025
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0016 0.0053
Leishmania major proteasome alpha 1 subunit, putative 0.015 0.1635 0.3217
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0189 0.2121 0.2121
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1375 0.2705
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0126 0.1324 0.4388
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0034 0.017 0.0334
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0036 0.0186 0.0186
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.026 0.3018 1
Brugia malayi Heterochromatin protein 1 0.0084 0.0798 0.0798
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0104 0.1047 0.347
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0189 0.2121 0.7028
Echinococcus granulosus chromobox protein 1 0.0084 0.0798 0.0798
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0138 0.1473 0.4879
Brugia malayi chromobox protein homolog 3 0.0047 0.0331 0.0331
Schistosoma mansoni 26S proteasome subunit S9 0.0038 0.0214 0.0214
Plasmodium vivax proteasome subunit beta type-1, putative 0.016 0.1759 0.5828
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.003 0.0114 0.0377
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0189 0.2121 0.7028
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0036 0.0186 0.0186
Schistosoma mansoni proteasome regulatory subunit-related 0.0034 0.017 0.0169
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0114 0.0377
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0149 0.1623 0.1623
Onchocerca volvulus Notchless protein homolog 0.0139 0.1494 0.239
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0138 0.1478 0.4898
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0143 0.1538 0.1538
Echinococcus granulosus subfamily T1A non peptidase ue 0.0149 0.1623 0.1623
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0022 0.0008 0.0026
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0036 0.0186 0.0615
Giardia lamblia Hypothetical protein 0.0038 0.0214 0.0708
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0149 0.1623 0.5376
Brugia malayi proteasome subunit beta type 3 0.0132 0.1397 0.1397
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0132 0.1397 0.1397
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0022 0.0016 0.0016
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0022 0.0016 0.0031
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0038 0.0214 0.0708
Schistosoma mansoni chromobox protein 0.0084 0.0798 0.0798
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0104 0.1047 0.2061
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0149 0.1623 0.5376
Loa Loa (eye worm) PAS-3 protein 0.0121 0.1259 0.1259
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0038 0.0214 0.0708
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0126 0.1324 0.1324
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0138 0.1478 0.1478
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0022 0.0016 0.0053
Trichomonas vaginalis 26S proteasome subunit, putative 0.0031 0.0132 0.0437
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0138 0.1478 0.1478
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0034 0.0168 0.0168
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0149 0.1623 0.5376
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0138 0.1473 0.4879
Schistosoma mansoni hypothetical protein 0.0224 0.256 0.256
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0038 0.0214 0.0214
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0126 0.1324 0.1324
Trypanosoma brucei proteasome beta 6 subunit 0.016 0.1759 0.5828
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0189 0.2121 0.2121
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0132 0.1397 0.4628
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0022 0.0015 0.0015
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0132 0.1397 0.2748
Leishmania major proteasome beta-1 subunit, putative 0.0138 0.1478 0.2909
Echinococcus multilocularis proteasome subunit alpha type 2 0.0143 0.1538 0.1538
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0139 0.1494 0.294
Toxoplasma gondii hypothetical protein 0.0028 0.0085 0.0085
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0034 0.017 0.0334
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0022 0.0016 0.0053
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0038 0.0214 0.0214
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.2121 0.7028
Loa Loa (eye worm) PCI domain-containing protein 0.0034 0.017 0.017
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0038 0.0214 0.042
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0034 0.017 0.0169
Leishmania major proteasome beta 2 subunit, putative 0.0126 0.1324 0.2606
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.017 0.0562
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0114
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0034 0.017 0.0562
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0149 0.1623 0.3193
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0022 0.0008 0.0026
Brugia malayi proteasome subunit alpha type 1 0.0137 0.1466 0.1466
Trypanosoma brucei proteasome subunit beta type-5, putative 0.026 0.3018 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.256 0.256
Loa Loa (eye worm) proteasome subunit beta type 1 0.016 0.1759 0.1759
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.015 0.1635 0.3217
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0036 0.0186 0.0186
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0126 0.1324 0.4388
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.026 0.3018 0.3018
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.013 0.1375 0.1375
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0104 0.1047 0.347
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0134 0.0444
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0331 0.0529
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0224 0.256 0.256
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0034 0.0168 0.0168
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0138 0.1478 0.4898
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1375 0.2705
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0813 1 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0798 0.0798
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0186 0.0186
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0134 0.0444
Toxoplasma gondii PCI domain-containing protein 0.0041 0.025 0.025
Toxoplasma gondii proteasome subunit alpha type, putative 0.0138 0.1473 0.1473
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0137 0.1466 0.1466
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0143 0.1538 0.5097
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0149 0.1623 0.1623
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0034 0.0168 0.0556
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0149 0.1623 0.1623
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0031 0.0132 0.0437
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0813 1 1
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0022 0.0016 0.0016
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0168 0.0168
Echinococcus granulosus proteasome subunit alpha type 6 0.015 0.1635 0.1635
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.015 0.1635 0.5417
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.016 0.1759 0.1759
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0022 0.0016 0.0053
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0104 0.1047 0.347
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0423 0.5082 1
Brugia malayi Ubiquitin interaction motif family protein 0.0022 0.0015 0.0015
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0138 0.1478 0.4898
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0015 0.005
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0036 0.0186 0.0366
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0134 0.0134
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0139 0.1494 0.1494
Brugia malayi Proteasome A-type and B-type family protein 0.026 0.3018 0.3018
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0036 0.0186 0.0186
Loa Loa (eye worm) proteasome subunit beta type 3 0.0132 0.1397 0.1397
Loa Loa (eye worm) hypothetical protein 0.003 0.0114 0.0114
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0138 0.1478 0.4898
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0149 0.1623 0.3193
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0104 0.1047 0.347
Giardia lamblia 20S proteasome alpha subunit 2 0.0143 0.1538 0.5097
Leishmania major proteasome alpha 1 subunit, putative 0.0137 0.1466 0.2885
Leishmania major hypothetical protein, conserved 0.0423 0.5082 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0022 0.0015 0.005
Echinococcus multilocularis proteasome subunit beta type 6 0.0138 0.1478 0.1478
Giardia lamblia Proteasome subunit beta type 3 0.0132 0.1397 0.4628
Toxoplasma gondii proteasome subunit alpha type, putative 0.0085 0.0809 0.0809
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0127 0.1334 0.442
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0132 0.1397 0.2748
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0134 0.0134
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.015 0.1635 0.5417
Giardia lamblia 20S proteasome alpha subunit 7 0.0139 0.1494 0.4951
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.016 0.1759 0.1759
Toxoplasma gondii proteasome beta subunit 0.0132 0.1397 0.1397
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.016 0.1759 0.5828
Giardia lamblia Proteasome subunit beta type 2 0.0132 0.1397 0.4628
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0034 0.017 0.0562
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0189 0.2121 0.2121
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0138 0.1473 0.4879
Brugia malayi 26S protease regulatory subunit 6A 0.0022 0.0016 0.0016
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.026 0.3018 1
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0034 0.0168 0.033
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0798 0.2642
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0104 0.1047 0.1047
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0034 0.0168 0.0556
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0139 0.1494 0.4951
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0022 0.0015 0.0051
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.1397 0.4628
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0041 0.025 0.025
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0189 0.2121 0.4174
Echinococcus multilocularis proteasome (prosome, macropain) 0.026 0.3018 0.3018
Brugia malayi proteasome subunit alpha type 4 0.0121 0.1259 0.1259
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0149 0.1623 0.1623
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0132 0.026
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0134 0.0134
Echinococcus multilocularis proteasome subunit alpha type 6 0.015 0.1635 0.1635
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0132 0.1397 0.4628
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0127 0.1334 0.442
Entamoeba histolytica proteasome regulatory subunit, putative 0.0041 0.025 0.0828
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0137 0.1466 0.4858
Schistosoma mansoni chromobox protein 0.0084 0.0798 0.0798
Brugia malayi 20S proteasome alpha5 subunit 0.0149 0.1623 0.1623
Plasmodium falciparum proteasome subunit beta type-5 0.026 0.3018 0.5939
Giardia lamblia Proteasome subunit beta type 1 0.016 0.1759 0.5828
Echinococcus granulosus proteasome prosome macropain subunit beta 0.016 0.1759 0.1759
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0034 0.017 0.0562
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.003 0.0114 0.0114
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0134 0.0444
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0034 0.017 0.0169
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0031 0.0132 0.0437
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.026 0.3018 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0133 0.1409 0.1409
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0132 0.1397 0.4628
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.0015 0.005
Brugia malayi proteasome subunit alpha type 2 0.0143 0.1538 0.1538
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0372 0.443 0.443
Mycobacterium leprae proteasome (beta subunit) PrcB 0.026 0.3018 1
Onchocerca volvulus 0.0037 0.0202 0.0323
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0126 0.1324 0.4388
Echinococcus granulosus Proteasome subunit alpha beta 0.0139 0.1494 0.1494
Leishmania major proteasome alpha 7 subunit, putative 0.0139 0.1494 0.294
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0034 0.0168 0.0556
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0376 0.1245
Giardia lamblia Proteasome subunit beta type 5 precursor 0.026 0.3018 1
Loa Loa (eye worm) proteasome subunit beta type 2 0.0132 0.1397 0.1397
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0139 0.1494 0.4951
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.003 0.0114 0.0377
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0031 0.0132 0.0437
Toxoplasma gondii proteasome subunit alpha1, putative 0.015 0.1635 0.1635
Echinococcus granulosus Proteasome subunit alpha type 7 0.0189 0.2121 0.2121
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.015 0.1635 0.1635
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0149 0.1623 0.5376
Plasmodium vivax proteasome subunit beta type-6, putative 0.0138 0.1478 0.4898
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0041 0.025 0.0492
Echinococcus multilocularis proteasome subunit beta type 7 0.0372 0.443 0.443
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0126 0.1324 0.2606
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0134 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0331 0.1096
Plasmodium vivax proteasome subunit beta type-4, putative 0.013 0.1375 0.4555
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0516 0.6252 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.026 0.3018 1
Brugia malayi proteasome subunit beta type 1 0.016 0.1759 0.1759
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.1397 0.4628
Toxoplasma gondii proteasome subunit beta type 1, putative 0.016 0.1759 0.1759
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.1397 0.4628
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0137 0.1466 0.1466
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0034 0.017 0.0562
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0127 0.1334 0.442
Leishmania major proteasome alpha 7 subunit, putative 0.0189 0.2121 0.4174
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0127 0.1334 0.442
Plasmodium vivax proteasome subunit beta type-2, putative 0.0132 0.1397 0.4628
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0157 0.052
Giardia lamblia 20S proteasome alpha subunit 1 0.015 0.1635 0.5417
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0134 0.0134
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0127 0.1334 0.442
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0036 0.0186 0.0615
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0137 0.1466 0.1466
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0132 0.1397 0.1397
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0032 0.0134 0.0134
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0041 0.025 0.025
Toxoplasma gondii proteasome subunit beta type, putative 0.026 0.3018 0.3018
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0149 0.1623 0.5376
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0157 0.052
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0127 0.1334 0.442
Leishmania major proteasome beta 7 subunit, putative 0.013 0.1375 0.2705
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0132 0.026
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0126 0.1324 0.4388
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0036 0.0186 0.0615
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0114 0.0377
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.013 0.1375 0.1375
Loa Loa (eye worm) proteasome Regulatory Particle 0.0034 0.0168 0.0168
Loa Loa (eye worm) PCI domain-containing protein 0.0031 0.0132 0.0132
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0022 0.0016 0.0053
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.016 0.1759 0.3462
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0134 0.0444
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0022 0.0016 0.0016
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0034 0.0168 0.0556
Giardia lamblia Proteasome subunit beta type 4 precursor 0.013 0.1375 0.4555
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0138 0.1473 0.1473
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0126 0.1324 0.4388
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0138 0.1478 0.4898
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.026 0.3018 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0036 0.0186 0.0366
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0104 0.1047 0.347
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0798 0.2642
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0034 0.0168 0.0556
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.026 0.3018 0.3018
Loa Loa (eye worm) proteasome regulatory particle 0.0038 0.0214 0.0214
Giardia lamblia 20S proteasome alpha subunit 5 0.0149 0.1623 0.5376
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.003 0.0114 0.0377
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.003 0.0114 0.0114
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.015 0.1635 0.5417
Plasmodium vivax proteasome subunit beta type-5, putative 0.026 0.3018 1
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0143 0.1538 0.1538
Mycobacterium ulcerans proteasome PrcB 0.026 0.3018 1
Brugia malayi Proteasome A-type and B-type family protein 0.013 0.1375 0.1375
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1375 0.2705
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0022 0.0016 0.0016
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0038 0.0214 0.0214
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0143 0.1538 0.5097
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0041 0.025 0.025
Leishmania major proteasome alpha 2 subunit, putative 0.0143 0.1538 0.3027
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.003 0.0114 0.0224
Leishmania major proteasome alpha 3 subunit, putative 0.0138 0.1473 0.2898
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0139 0.1494 0.4951
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0149 0.1623 0.5376
Trypanosoma brucei proteasome alpha 7 subunit 0.0139 0.1494 0.4951
Brugia malayi Proteasome A-type and B-type family protein 0.0372 0.443 0.443
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.003 0.0114 0.0377
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0132 0.1397 0.4628
Giardia lamblia 20S proteasome alpha subunit 6 0.0137 0.1466 0.4858
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0032 0.0134 0.0264
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.013 0.1375 0.4555
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0132 0.1397 0.1397
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0031 0.0132 0.0132
Giardia lamblia 26S protease regulatory subunit 6A 0.0022 0.0016 0.0053
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0034 0.017 0.0169
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0134 0.0134
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0186 0.0186
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0149 0.1623 0.5376
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0031 0.0121 0.04
Plasmodium falciparum proteasome subunit beta type-4 0.013 0.1375 0.2705
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0132 0.1397 0.1397
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0041 0.025 0.0828
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0139 0.1494 0.1494
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.013 0.1375 0.2705

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0586 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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