Detailed information for compound 1551295

Basic information

Technical information
  • TDR Targets ID: 1551295
  • Name: 4-methoxy-N-[(2-methoxyphenyl)methyl]benzamid e
  • MW: 271.311 | Formula: C16H17NO3
  • H donors: 1 H acceptors: 1 LogP: 2.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)NCc1ccccc1OC
  • InChi: 1S/C16H17NO3/c1-19-14-9-7-12(8-10-14)16(18)17-11-13-5-3-4-6-15(13)20-2/h3-10H,11H2,1-2H3,(H,17,18)
  • InChiKey: OCHBASPTHVVGMS-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-methoxy-N-(2-methoxybenzyl)benzamide
  • ZINC00299873
  • MLS000058877
  • SMR000069446
  • Oprea1_317179
  • STK213455

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0594
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0066 0.0433 0.0609
Giardia lamblia 26S protease regulatory subunit 6B 0.004 0.006 0.0088
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0039 0.0043 0.0031
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.3004 0.2988
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0066 0.0433 0.0412
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0264 0.3319 0.3304
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Plasmodium vivax proteasome subunit beta type-3, putative 0.0254 0.3165 0.4641
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0269 0.3381 0.4963
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0066 0.0433 0.0392
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0243 0.3004 0.4402
Brugia malayi PCI domain containing protein 0.0061 0.0353 0.0311
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0039 0.0043 0.0021
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0061 0.0353 0.0491
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0364 0.4775 0.7035
Plasmodium vivax proteasome subunit beta type-7, putative 0.0243 0.3004 0.4402
Trypanosoma brucei proteasome alpha 7 subunit 0.0269 0.3381 0.4979
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0046 0.014 0.0119
Brugia malayi PCI domain containing protein 0.0066 0.0436 0.0395
Toxoplasma gondii peptidase, T1 family protein 0.0269 0.3381 0.3353
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0058 0.0313 0.0271
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0073 0.0535 0.076
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0061 0.0358 0.0497
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0061 0.0358 0.0316
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.004 0.006 0.0056
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0061 0.0353 0.0332
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0066 0.0433 0.0609
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0288 0.3667 0.5387
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0275 0.3479 0.3465
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0243 0.3004 0.4419
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0078 0.0606 0.0895
Plasmodium vivax proteasome subunit beta type-6, putative 0.0266 0.3346 0.4911
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0058 0.0313 0.0462
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0043 0.0095 0.014
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.02 0.2388 0.3506
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.004 0.006 0.0038
Plasmodium vivax proteasome subunit beta type-4, putative 0.025 0.3116 0.4568
Trypanosoma brucei proteasome beta 6 subunit 0.0309 0.397 0.5852
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0066 0.0433 0.058
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0061 0.0358 0.0468
Loa Loa (eye worm) hypothetical protein 0.0058 0.0313 0.0291
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0243 0.3004 0.2973
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0254 0.3165 0.315
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0269 0.3381 0.3353
Leishmania major proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0113 0.1111 0.1588
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0309 0.397 0.5852
Giardia lamblia 26S protease regulatory subunit 7 0.0039 0.0043 0.0064
Toxoplasma gondii proteasome 26S regulatory subunit 0.0042 0.0077 0.0034
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0266 0.3346 0.4943
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0265 0.3334 0.4925
Plasmodium vivax proteasome subunit beta type-5, putative 0.0501 0.6769 1
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0723 1 1
Brugia malayi Proteasome subunit alpha type 7-1 0.0364 0.4775 0.4753
Brugia malayi proteasome subunit beta type 3 0.0254 0.3165 0.3135
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0264 0.3319 0.329
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0501 0.6769 0.6755
Leishmania major proteasome beta 2 subunit, putative 0.0254 0.3165 0.4658
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0073 0.0535 0.0731
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0061 0.0358 0.0468
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0058 0.0313 0.0271
Entamoeba histolytica proteasome regulatory subunit, putative 0.0043 0.0093 0.0074
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 7 0.0038 0.0022 0.0032
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0275 0.3479 0.5124
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0043 0.0095 0.0052
Loa Loa (eye worm) proteasome subunit beta type 1 0.0309 0.397 0.3957
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0061 0.0358 0.0497
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0073 0.0535 0.0514
Trypanosoma brucei ATP-dependent protease subunit HslV 0.02 0.2388 0.3506
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.029 0.3694 0.5429
Loa Loa (eye worm) hypothetical protein 0.0053 0.0248 0.0226
Leishmania major proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0565
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0501 0.6769 0.6762
Loa Loa (eye worm) RPN-3 protein 0.0079 0.0615 0.0594
Giardia lamblia 20S proteasome alpha subunit 6 0.0264 0.3319 0.4903
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0061 0.0358 0.0336
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0265 0.3334 0.4892
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0073 0.0535 0.0731
Toxoplasma gondii PCI domain-containing protein 0.0061 0.0353 0.0311
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0053 0.0236 0.0317
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.02 0.2388 0.5
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0288 0.3667 0.3653
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.025 0.3116 0.3086
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0309 0.397 0.3957
Plasmodium falciparum proteasome subunit beta type-5 0.0501 0.6769 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0254 0.3165 0.4675
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0043 0.0095 0.0108
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0243 0.3004 0.4419
Echinococcus granulosus proteasome subunit alpha type 2 0.0275 0.3479 0.3465
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0066 0.0436 0.0585
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0061 0.0358 0.0316
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0254 0.3165 0.4658
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0061 0.0358 0.0528
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0254 0.3165 0.3135
Leishmania major hypothetical protein, conserved 0.0377 0.4955 0.7312
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0176 0.2029 0.2012
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0061 0.0358 0.0316
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0264 0.3319 0.3304
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.004 0.006 0.0056
Entamoeba histolytica proteasome regulatory subunit, putative 0.0079 0.0615 0.085
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Brugia malayi proteasome subunit alpha type 3 0.0269 0.3381 0.3353
Toxoplasma gondii heat shock protein hslv, putative 0.02 0.2388 0.2355
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0043 0.0095 0.0108
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0078 0.0606 0.0865
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0043 0.0095 0.0108
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0288 0.3667 0.3639
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0061 0.0358 0.0336
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0269 0.3381 0.3367
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.025 0.3116 0.31
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0275 0.3479 0.5109
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0058 0.0313 0.0462
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0266 0.3346 0.4943
Loa Loa (eye worm) proteasome Regulatory Particle 0.0066 0.0433 0.0412
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.025 0.3116 0.3086
Echinococcus multilocularis proteasome subunit alpha type 2 0.0275 0.3479 0.3465
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.004 0.006 0.0056
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0309 0.397 0.3944
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0309 0.397 0.5839
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0043 0.0095 0.0073
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Brugia malayi 26S protease regulatory subunit 6A 0.0043 0.0095 0.0052
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0269 0.3381 0.4963
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.029 0.3694 0.5458
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0078 0.0606 0.0565
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0043 0.0095 0.0073
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0053 0.0236 0.0214
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0079 0.0615 0.0879
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0574
Mycobacterium ulcerans proteasome PrcB 0.0501 0.6769 1
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0364 0.4775 0.4764
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0275 0.3479 0.3451
Loa Loa (eye worm) proteasome subunit alpha type 6 0.029 0.3694 0.3681
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.025 0.3116 0.4603
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Giardia lamblia 20S proteasome alpha subunit 1 0.029 0.3694 0.5458
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0061 0.0353 0.0521
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0061 0.0353 0.0491
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.02 0.2388 0.3486
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.3004 0.4437
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0058 0.0313 0.0291
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0254 0.3165 0.4658
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0066 0.0436 0.0614
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0043 0.0093 0.005
Schistosoma mansoni multiubiquitin binding protein S5a 0.0043 0.0093 0.005
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0565
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0265 0.3334 0.3319
Loa Loa (eye worm) proteasome subunit beta type 2 0.0254 0.3165 0.315
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0078 0.0606 0.0895
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0288 0.3667 0.5417
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0061 0.0358 0.0336
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0717 0.9907 0.9907
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0066 0.0436 0.0614
Leishmania major proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0066 0.0433 0.0609
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.004 0.006 0.0025
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.004 0.006 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1569 0.1551
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0265 0.3334 0.4892
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0079 0.0615 0.0879
Entamoeba histolytica hypothetical protein 0.0053 0.0236 0.0287
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0066 0.0436 0.0415
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0243 0.3004 0.4437
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0053 0.0236 0.0287
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.025 0.3116 0.4585
Loa Loa (eye worm) proteasome regulatory particle 0.0073 0.0535 0.0514
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0061 0.0353 0.0461
Entamoeba histolytica proteasome regulatory subunit, putative 0.0058 0.0313 0.0401
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0061 0.0358 0.0528
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0243 0.3004 0.4402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0275 0.0254
Toxoplasma gondii proteasome subunit beta type, putative 0.0501 0.6769 0.6755
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0039 0.0043 0.0031
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.004 0.006 0.0056
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.029 0.3694 0.3667
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0066 0.0433 0.0392
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0073 0.0535 0.0494
Brugia malayi Proteasome/cyclosome repeat family protein 0.0046 0.014 0.0098
Schistosoma mansoni 26S proteasome subunit S9 0.0073 0.0535 0.0494
Onchocerca volvulus 0.004 0.006 0.0027
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.0038
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0501 0.6769 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0078 0.0606 0.0837
Onchocerca volvulus Notchless protein homolog 0.0269 0.3381 0.5461
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0275 0.3479 0.5109
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0254 0.3165 0.4675
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0501 0.6769 1
Echinococcus multilocularis proteasome subunit beta type 6 0.0266 0.3346 0.3332
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0043 0.0095 0.0077
Loa Loa (eye worm) hypothetical protein 0.0723 1 1
Trypanosoma brucei proteasome beta 7 subunit 0.025 0.3116 0.4585
Brugia malayi proteasome subunit beta type 1 0.0309 0.397 0.3944
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0288 0.3667 0.3653
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.004 0.006 0.0088
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.004 0.006 0.0038
Trichomonas vaginalis 26S proteasome subunit, putative 0.0061 0.0353 0.0521
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.004 0.006 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0275 0.0254
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0061 0.0358 0.0336
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0043 0.0095 0.0073
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0043 0.0093 0.0106
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0233 0.2864 0.423
Loa Loa (eye worm) PCI domain-containing protein 0.0061 0.0353 0.0332
Brugia malayi Proteasome A-type and B-type family protein 0.0501 0.6769 0.6755
Toxoplasma gondii PCI domain-containing protein 0.0073 0.0535 0.0494
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0061 0.0358 0.0468
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0053 0.0236 0.0214
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Loa Loa (eye worm) hypothetical protein 0.0058 0.0313 0.0291
Echinococcus granulosus proteasome subunit alpha type 6 0.029 0.3694 0.3681
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0254 0.3165 0.4641
Brugia malayi Proteasome A-type and B-type family protein 0.0266 0.3346 0.3317
Leishmania major proteasome regulatory ATPase subunit 0.0039 0.0043 0.0031
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0254 0.3165 0.315
Loa Loa (eye worm) PAS-3 protein 0.0233 0.2858 0.2842
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.025 0.3116 0.31
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0078 0.0606 0.0837
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0061 0.0353 0.0491
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0269 0.3381 0.4995
Echinococcus granulosus 26S protease regulatory subunit 8 0.0039 0.0043 0.0021
Giardia lamblia 20S proteasome alpha subunit 2 0.0275 0.3479 0.514
Schistosoma mansoni hypothetical protein 0.0431 0.575 0.5732
Echinococcus granulosus proteasome subunit beta type 6 0.0266 0.3346 0.3332
Entamoeba histolytica 26S protease regulatory subunit, putative 0.004 0.006 0.0025
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0043 0.0093 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0275 0.0233
Entamoeba histolytica 26S protease regulatory subunit, putative 0.004 0.006 0.0025
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0053 0.0236 0.0194
Onchocerca volvulus 0.004 0.006 0.0027
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0073 0.0535 0.076
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0501 0.6769 1
Echinococcus granulosus proteasome subunit beta t family 0.0254 0.3165 0.315
Loa Loa (eye worm) PCI domain-containing protein 0.0066 0.0436 0.0415
Brugia malayi Proteasome subunit alpha type 1 0.0232 0.2843 0.2812
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0723 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0269 0.3381 0.4979
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0254 0.3165 0.3135
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.02 0.2388 0.3506
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0061 0.0358 0.0468
Toxoplasma gondii hypothetical protein 0.0053 0.0248 0.0206
Echinococcus granulosus proteasome prosome macropain 0.0501 0.6769 0.6762
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0066 0.0436 0.0415
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.02 0.2388 0.2355
Entamoeba histolytica proteasome regulatory subunit, putative 0.0066 0.0436 0.0585
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0275 0.3479 0.3451
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0254 0.3165 0.3135
Toxoplasma gondii proteasome subunit 0.0266 0.3346 0.3317
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.004 0.006 0.0017
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0585
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0266 0.3346 0.4911
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0039 0.0043 0.0021
Entamoeba histolytica proteasome regulatory subunit, putative 0.0073 0.0535 0.0731
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.004 0.006 0.0017
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.02 0.2388 0.3486
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0269 0.3381 0.4963
Echinococcus granulosus Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.004 0.006 0.0056
Trypanosoma cruzi 20S proteasome subunit 0.0254 0.3165 0.4658
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0038 0.0022 0.0032
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0066 0.0436 0.0645
Brugia malayi Proteasome A-type and B-type family protein 0.025 0.3116 0.3086
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.004 0.006 0.0025
Loa Loa (eye worm) proteasome subunit beta type 3 0.0254 0.3165 0.315
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0043 0.0064
Loa Loa (eye worm) RPT-2 protein 0.004 0.006 0.0038
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0058 0.0313 0.0291
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0501 0.6769 1
Giardia lamblia Proteasome subunit beta type 3 0.0254 0.3165 0.4675
Brugia malayi MH2 domain containing protein 0.0144 0.1569 0.1533
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0266 0.3346 0.4911
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0073 0.0535 0.076
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0309 0.397 0.5839
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0061 0.0358 0.0336
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0058 0.0313 0.0271
Plasmodium vivax proteasome subunit alpha type-6, putative 0.029 0.3694 0.5429
Brugia malayi proteasome subunit alpha type 2 0.0275 0.3479 0.3451
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0042 0.0077 0.005
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0176 0.2029 0.2012
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.0038
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0042 0.0077 0.0082
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0264 0.3319 0.3304
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0073 0.0535 0.079
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0079 0.0615 0.085
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0269 0.3381 0.3367
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0288 0.3667 0.3639
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0309 0.397 0.3957
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0079 0.0615 0.0574
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0288 0.3667 0.5402
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0061 0.0358 0.0468
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0431 0.575 0.5732
Giardia lamblia Hypothetical protein 0.0073 0.0535 0.079
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Giardia lamblia 20S proteasome alpha subunit 7 0.0269 0.3381 0.4995
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0364 0.4775 0.7035
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0269 0.3381 0.4979
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0377 0.4955 0.7303
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0275 0.3479 0.5109
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Leishmania major proteasome beta 2 subunit, putative 0.0243 0.3004 0.4419
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0043 0.0095 0.0052
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0061 0.0358 0.0497
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Toxoplasma gondii PCI domain-containing protein 0.0079 0.0615 0.0574
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0061 0.0353 0.0461
Schistosoma mansoni 26S protease regulatory subunit 6b 0.004 0.006 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0275 0.0254
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5387
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0043 0.0093 0.0138
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0039 0.0043 0.0031
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.029 0.3694 0.5429
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0039 0.0043 0.0031
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0061 0.0358 0.0468
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0264 0.3319 0.4887
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0066 0.0433 0.0392
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0039 0.0043 0.0031
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Giardia lamblia Proteasome subunit beta type 2 0.0254 0.3165 0.4675
Echinococcus granulosus adhesion regulating molecule 1 0.0723 1 1
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0254 0.3165 0.4641
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0254 0.3165 0.3135
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0565
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0264 0.3319 0.329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0275 0.0233
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Leishmania major proteasome beta 5 subunit, putative 0.0501 0.6769 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0066 0.0433 0.058
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0254 0.3165 0.4641
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0275 0.0233
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0066 0.0436 0.0614
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.025 0.3116 0.31
Brugia malayi Proteasome A-type and B-type family protein 0.0717 0.9907 0.9907
Leishmania major proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Leishmania major proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0254 0.3165 0.3135
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0309 0.397 0.3944
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0254 0.3165 0.4641
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0264 0.3319 0.4871
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.3004 0.4437
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0501 0.6769 1
Giardia lamblia 26S protease regulatory subunit 8 0.0039 0.0043 0.0064
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0043 0.0095 0.0052
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.004 0.006 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0275 0.0254
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0264 0.3319 0.4871
Toxoplasma gondii proteasome subunit alpha1, putative 0.029 0.3694 0.3667
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0254 0.3165 0.4675
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0459 0.6156 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0501 0.6769 1
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.004 0.006 0.0038
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0264 0.3319 0.4903
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.004 0.006 0.0038
Toxoplasma gondii proteasome subunit alpha type, putative 0.0265 0.3334 0.3305
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Giardia lamblia 20S proteasome alpha subunit 5 0.0288 0.3667 0.5417
Echinococcus granulosus Proteasome subunit alpha beta 0.0269 0.3381 0.3367
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5402
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0066 0.0433 0.058
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0043 0.0094 0.0139
Schistosoma mansoni 26S protease regulatory subunit 0.004 0.006 0.0017
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0078 0.0606 0.0585
Giardia lamblia 26S protease regulatory subunit 6A 0.0043 0.0095 0.014
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.004 0.006 0.0088
Brugia malayi proteasome subunit alpha type 1 0.0264 0.3319 0.329
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0078 0.0606 0.0865
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0058 0.0313 0.0401
Toxoplasma gondii proteasome subunit alpha type, putative 0.0164 0.1858 0.1823
Schistosoma mansoni proteasome regulatory subunit-related 0.0066 0.0436 0.0395
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0309 0.397 0.5852
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.004 0.006 0.0056
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0038 0.0022 0.0032
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.004 0.006 0.0025
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0256 0.3191 0.3161
Toxoplasma gondii proteasome beta subunit 0.0254 0.3165 0.3135
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0058 0.0313 0.0431
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0265 0.3334 0.3319
Echinococcus multilocularis proteasome subunit alpha type 6 0.029 0.3694 0.3681
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0038 0.0022 0.0032
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0043 0.0095 0.0077
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0265 0.3334 0.4892
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0066 0.0433 0.0412
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0288 0.3667 0.5387
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0275 0.3479 0.5124
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0038 0.0022 0.0032
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0043 0.0095 0.0108
Brugia malayi proteasome subunit beta type 2 0.0254 0.3165 0.3135
Schistosoma mansoni hypothetical protein 0.0176 0.2029 0.1995
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0039 0.0043 0.0021
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0266 0.3346 0.3317
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.02 0.2388 0.3486
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0364 0.4775 0.7035
Entamoeba histolytica proteasome regulatory subunit, putative 0.0061 0.0353 0.0461
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0288 0.3667 0.3639
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0073 0.0535 0.0514
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0039 0.0043 0.0064
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0046 0.014 0.0208
Giardia lamblia Proteasome subunit beta type 4 precursor 0.025 0.3116 0.4603
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0043 0.0095 0.0077
Brugia malayi Proteasome/cyclosome repeat family protein 0.0046 0.014 0.0098
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Echinococcus multilocularis adhesion regulating molecule 1 0.0723 1 1
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.3004 0.4419
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5402
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0058 0.0313 0.0462
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0066 0.0433 0.064
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5387
Echinococcus granulosus subfamily T1A non peptidase ue 0.0288 0.3667 0.3653
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Giardia lamblia 20S proteasome alpha subunit 4 0.0364 0.4775 0.7054
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0058 0.0313 0.0431
Plasmodium vivax proteasome subunit beta type-1, putative 0.0309 0.397 0.5839
Brugia malayi Ubiquitin interaction motif family protein 0.0043 0.0093 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1569 0.1551
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0066 0.0436 0.0395
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0061 0.0358 0.0497
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0269 0.3381 0.4963
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0058 0.0313 0.0401
Loa Loa (eye worm) hypothetical protein 0.0431 0.575 0.5741
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0053 0.0236 0.0194
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0078 0.0606 0.0865
Brugia malayi Probable 26S protease regulatory subunit 4 0.004 0.006 0.0017
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0066 0.0433 0.064
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0364 0.4775 0.7054
Giardia lamblia Proteasome subunit beta type 1 0.0309 0.397 0.5865
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.025 0.3116 0.4568
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0061 0.0358 0.0316
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Schistosoma mansoni hypothetical protein 0.0061 0.0353 0.0311
Leishmania major proteasome alpha 7 subunit, putative 0.0269 0.3381 0.4979
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0364 0.4775 0.4753
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.004 0.006 0.0056
Toxoplasma gondii proteasome regulatory subunit 0.0061 0.0358 0.0316
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0264 0.3319 0.4871
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0574
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0501 0.6769 1
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0061 0.0358 0.0316
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0058 0.0313 0.0431
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0309 0.397 0.5852
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0043 0.0095 0.0052
Leishmania major proteasome beta 7 subunit, putative 0.025 0.3116 0.4585
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0254 0.3165 0.315
Brugia malayi proteasome subunit alpha type 6 0.029 0.3694 0.3667
Echinococcus multilocularis proteasome subunit beta type 7 0.0717 0.9907 0.9907
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5402
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0061 0.0358 0.0336
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.02 0.2388 0.3506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0275 0.0254
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0039 0.0043 0.0021
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0265 0.3334 0.3305
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0066 0.0436 0.0585
Plasmodium falciparum proteasome subunit beta type-4 0.025 0.3116 0.4568
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0364 0.4775 0.7035
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0265 0.3334 0.4892
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0264 0.3319 0.4887
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0585
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0594
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0309 0.397 0.5865
Loa Loa (eye worm) proteasome 26S subunit 0.0039 0.0043 0.0021
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.004 0.006 0.0088
Echinococcus multilocularis proteasome (prosome, macropain) 0.0501 0.6769 0.6762
Echinococcus granulosus proteasome subunit beta type 7 0.0717 0.9907 0.9907
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0039 0.0043 0.0031
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0043 0.0093 0.0071
Toxoplasma gondii SAC3/GANP family protein 0.0058 0.0313 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0275 0.0233
Leishmania major proteasome alpha 1 subunit, putative 0.0264 0.3319 0.4887
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Brugia malayi 20S proteasome alpha5 subunit 0.0288 0.3667 0.3639
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0053 0.0236 0.0287
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0079 0.0615 0.0879
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0043 0.0093 0.0071
Giardia lamblia 20S proteasome alpha subunit 3 0.0265 0.3334 0.4925
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0061 0.0353 0.0332
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0021
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0059 0.0328 0.0453
Brugia malayi proteasome subunit alpha type 4 0.0233 0.2858 0.2827
Brugia malayi 26S proteasome subunit P45 family protein 0.004 0.006 0.0017
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0501 0.6769 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0254 0.3165 0.4641
Leishmania major proteasome alpha 2 subunit, putative 0.0275 0.3479 0.5124
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0266 0.3346 0.3332

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0126 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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