Detailed information for compound 1551295

Basic information

Technical information
  • TDR Targets ID: 1551295
  • Name: 4-methoxy-N-[(2-methoxyphenyl)methyl]benzamid e
  • MW: 271.311 | Formula: C16H17NO3
  • H donors: 1 H acceptors: 1 LogP: 2.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)NCc1ccccc1OC
  • InChi: 1S/C16H17NO3/c1-19-14-9-7-12(8-10-14)16(18)17-11-13-5-3-4-6-15(13)20-2/h3-10H,11H2,1-2H3,(H,17,18)
  • InChiKey: OCHBASPTHVVGMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methoxy-N-(2-methoxybenzyl)benzamide
  • ZINC00299873
  • MLS000058877
  • SMR000069446
  • Oprea1_317179
  • STK213455

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Hypothetical protein 0.0073 0.0535 0.079
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0043 0.0095 0.0052
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Brugia malayi Proteasome A-type and B-type family protein 0.0501 0.6769 0.6755
Giardia lamblia 26S protease regulatory subunit 7 0.0039 0.0043 0.0064
Giardia lamblia 20S proteasome alpha subunit 2 0.0275 0.3479 0.514
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.004 0.006 0.0038
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.004 0.006 0.0056
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0501 0.6769 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Toxoplasma gondii hypothetical protein 0.0053 0.0248 0.0206
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0288 0.3667 0.3639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0275 0.0254
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0073 0.0535 0.076
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0431 0.575 0.5732
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0066 0.0433 0.0392
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0594
Brugia malayi MH2 domain containing protein 0.0144 0.1569 0.1533
Echinococcus granulosus proteasome prosome macropain 0.0501 0.6769 0.6762
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0066 0.0433 0.0609
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0266 0.3346 0.4911
Brugia malayi proteasome subunit alpha type 4 0.0233 0.2858 0.2827
Leishmania major proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.025 0.3116 0.4585
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0066 0.0436 0.0614
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0043 0.0094 0.0139
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0061 0.0358 0.0336
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0309 0.397 0.5852
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0043 0.0095 0.0108
Toxoplasma gondii SAC3/GANP family protein 0.0058 0.0313 0.0271
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0061 0.0353 0.0332
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.004 0.006 0.0088
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.004 0.006 0.0056
Giardia lamblia Proteasome subunit beta type 4 precursor 0.025 0.3116 0.4603
Echinococcus granulosus Proteasome subunit alpha beta 0.0269 0.3381 0.3367
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0078 0.0606 0.0837
Giardia lamblia Proteasome subunit beta type 3 0.0254 0.3165 0.4675
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0058 0.0313 0.0431
Leishmania major proteasome beta 7 subunit, putative 0.025 0.3116 0.4585
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0066 0.0433 0.0609
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5387
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0039 0.0043 0.0064
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0061 0.0358 0.0468
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0066 0.0436 0.0395
Brugia malayi 26S protease regulatory subunit 6A 0.0043 0.0095 0.0052
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0058 0.0313 0.0401
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0254 0.3165 0.4641
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.025 0.3116 0.31
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0264 0.3319 0.3304
Brugia malayi PCI domain containing protein 0.0061 0.0353 0.0311
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0254 0.3165 0.3135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0275 0.0233
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0501 0.6769 0.6755
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0269 0.3381 0.4963
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0288 0.3667 0.5417
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0269 0.3381 0.4995
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.004 0.006 0.0025
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0053 0.0236 0.0214
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0265 0.3334 0.4925
Brugia malayi proteasome subunit alpha type 2 0.0275 0.3479 0.3451
Onchocerca volvulus 0.004 0.006 0.0027
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0078 0.0606 0.0895
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0275 0.3479 0.3451
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0309 0.397 0.5865
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0039 0.0043 0.0021
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0501 0.6769 1
Giardia lamblia 26S protease regulatory subunit 8 0.0039 0.0043 0.0064
Brugia malayi Proteasome A-type and B-type family protein 0.0717 0.9907 0.9907
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.025 0.3116 0.4568
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0078 0.0606 0.0865
Loa Loa (eye worm) hypothetical protein 0.0058 0.0313 0.0291
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0233 0.2864 0.423
Mycobacterium ulcerans proteasome PrcB 0.0501 0.6769 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0266 0.3346 0.4943
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0078 0.0606 0.0895
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0288 0.3667 0.5387
Brugia malayi proteasome subunit alpha type 6 0.029 0.3694 0.3667
Echinococcus granulosus proteasome subunit alpha type 6 0.029 0.3694 0.3681
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0364 0.4775 0.7035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0275 0.0254
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0058 0.0313 0.0271
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0269 0.3381 0.4979
Echinococcus multilocularis proteasome (prosome, macropain) 0.0501 0.6769 0.6762
Toxoplasma gondii PCI domain-containing protein 0.0079 0.0615 0.0574
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0061 0.0353 0.0461
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0269 0.3381 0.4963
Trypanosoma brucei proteasome alpha 7 subunit 0.0269 0.3381 0.4979
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0053 0.0236 0.0287
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0039 0.0043 0.0021
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0066 0.0433 0.058
Leishmania major proteasome beta 2 subunit, putative 0.0243 0.3004 0.4419
Loa Loa (eye worm) hypothetical protein 0.0058 0.0313 0.0291
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0243 0.3004 0.4402
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.025 0.3116 0.4603
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0061 0.0358 0.0316
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0288 0.3667 0.5402
Toxoplasma gondii proteasome subunit beta type, putative 0.0501 0.6769 0.6755
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0078 0.0606 0.0837
Leishmania major proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Toxoplasma gondii PCI domain-containing protein 0.0061 0.0353 0.0311
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.0038
Leishmania major proteasome alpha 1 subunit, putative 0.0264 0.3319 0.4887
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0066 0.0433 0.0412
Giardia lamblia 20S proteasome alpha subunit 1 0.029 0.3694 0.5458
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0061 0.0358 0.0528
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.3004 0.4437
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0061 0.0358 0.0316
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0039 0.0043 0.0031
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0243 0.3004 0.4437
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.004 0.006 0.0056
Plasmodium vivax proteasome subunit beta type-7, putative 0.0243 0.3004 0.4402
Brugia malayi PCI domain containing protein 0.0066 0.0436 0.0395
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0264 0.3319 0.4871
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0309 0.397 0.5852
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0254 0.3165 0.4658
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0254 0.3165 0.3135
Echinococcus granulosus 26S protease regulatory subunit 8 0.0039 0.0043 0.0021
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0058 0.0313 0.0431
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0058 0.0313 0.0462
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0288 0.3667 0.3653
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0039 0.0043 0.0031
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.02 0.2388 0.3506
Loa Loa (eye worm) hypothetical protein 0.0431 0.575 0.5741
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0364 0.4775 0.4753
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0585
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0254 0.3165 0.4675
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.004 0.006 0.0056
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0043 0.0095 0.0073
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0269 0.3381 0.4979
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0061 0.0353 0.0491
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1569 0.1551
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0594
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0061 0.0358 0.0336
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0501 0.6769 1
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0043 0.0093 0.0071
Entamoeba histolytica 26S protease regulatory subunit, putative 0.004 0.006 0.0025
Leishmania major proteasome beta 2 subunit, putative 0.0254 0.3165 0.4658
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0066 0.0436 0.0585
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0309 0.397 0.3957
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0254 0.3165 0.4675
Leishmania major proteasome alpha 7 subunit, putative 0.0269 0.3381 0.4979
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0309 0.397 0.3944
Plasmodium vivax proteasome subunit alpha type-6, putative 0.029 0.3694 0.5429
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0061 0.0353 0.0491
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0039 0.0043 0.0021
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0254 0.3165 0.4641
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0243 0.3004 0.4402
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0254 0.3165 0.315
Plasmodium vivax proteasome subunit beta type-6, putative 0.0266 0.3346 0.4911
Entamoeba histolytica proteasome regulatory subunit, putative 0.0043 0.0093 0.0074
Echinococcus granulosus proteasome subunit beta type 7 0.0717 0.9907 0.9907
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0243 0.3004 0.4419
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0066 0.0436 0.0614
Loa Loa (eye worm) RPT-2 protein 0.004 0.006 0.0038
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0459 0.6156 1
Echinococcus multilocularis proteasome subunit beta type 7 0.0717 0.9907 0.9907
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.004 0.006 0.0025
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0042 0.0077 0.0082
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0275 0.3479 0.5124
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0254 0.3165 0.315
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.004 0.006 0.0088
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0256 0.3191 0.3161
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0501 0.6769 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0058 0.0313 0.0291
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0061 0.0358 0.0336
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0061 0.0358 0.0497
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0275 0.0233
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0309 0.397 0.5852
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0061 0.0358 0.0497
Giardia lamblia Proteasome subunit beta type 1 0.0309 0.397 0.5865
Loa Loa (eye worm) proteasome 26S subunit 0.0039 0.0043 0.0021
Plasmodium falciparum proteasome subunit beta type-5 0.0501 0.6769 1
Giardia lamblia 20S proteasome alpha subunit 5 0.0288 0.3667 0.5417
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0079 0.0615 0.0879
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0038 0.0022 0.0032
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0264 0.3319 0.3304
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0585
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0243 0.3004 0.2988
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0254 0.3165 0.4658
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0723 1 1
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.004 0.006 0.0056
Plasmodium falciparum proteasome subunit beta type-4 0.025 0.3116 0.4568
Toxoplasma gondii proteasome subunit alpha type, putative 0.0265 0.3334 0.3305
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0061 0.0358 0.0316
Leishmania major hypothetical protein, conserved 0.0377 0.4955 0.7312
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0078 0.0606 0.0865
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0061 0.0358 0.0468
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.02 0.2388 0.3506
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.3004 0.4419
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0501 0.6769 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0066 0.0433 0.0609
Schistosoma mansoni hypothetical protein 0.0431 0.575 0.5732
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.029 0.3694 0.5458
Loa Loa (eye worm) proteasome subunit beta type 1 0.0309 0.397 0.3957
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0501 0.6769 1
Giardia lamblia 26S protease regulatory subunit 6B 0.004 0.006 0.0088
Giardia lamblia 26S protease regulatory subunit 6A 0.0043 0.0095 0.014
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0264 0.3319 0.4887
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0288 0.3667 0.5387
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0053 0.0236 0.0194
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0061 0.0353 0.0491
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0061 0.0358 0.0468
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.02 0.2388 0.3506
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0039 0.0043 0.0031
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0066 0.0433 0.0392
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0021
Brugia malayi 26S proteasome subunit P45 family protein 0.004 0.006 0.0017
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0073 0.0535 0.0731
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.004 0.006 0.0017
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0061 0.0358 0.0497
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.004 0.006 0.0056
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0043 0.0095 0.014
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0073 0.0535 0.0514
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0066 0.0436 0.0415
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0264 0.3319 0.329
Echinococcus granulosus proteasome subunit alpha type 2 0.0275 0.3479 0.3465
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0176 0.2029 0.2012
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5402
Entamoeba histolytica 26S protease regulatory subunit, putative 0.004 0.006 0.0025
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0066 0.0433 0.064
Entamoeba histolytica hypothetical protein 0.0053 0.0236 0.0287
Leishmania major proteasome beta 5 subunit, putative 0.0501 0.6769 1
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0254 0.3165 0.3135
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0266 0.3346 0.4943
Toxoplasma gondii peptidase, T1 family protein 0.0269 0.3381 0.3353
Loa Loa (eye worm) PCI domain-containing protein 0.0061 0.0353 0.0332
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0066 0.0433 0.058
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0043 0.0093 0.0106
Brugia malayi Proteasome A-type and B-type family protein 0.0266 0.3346 0.3317
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0176 0.2029 0.2012
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.004 0.006 0.0025
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0717 0.9907 0.9907
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0043 0.0093 0.005
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0043 0.0095 0.0052
Plasmodium vivax proteasome subunit beta type-1, putative 0.0309 0.397 0.5839
Leishmania major proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Toxoplasma gondii proteasome subunit alpha1, putative 0.029 0.3694 0.3667
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0061 0.0358 0.0528
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0043 0.0095 0.0108
Loa Loa (eye worm) hypothetical protein 0.0723 1 1
Schistosoma mansoni hypothetical protein 0.0061 0.0353 0.0311
Brugia malayi 20S proteasome alpha5 subunit 0.0288 0.3667 0.3639
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0275 0.0233
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0288 0.3667 0.3639
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0275 0.3479 0.5109
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0265 0.3334 0.4892
Giardia lamblia 20S proteasome alpha subunit 6 0.0264 0.3319 0.4903
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0078 0.0606 0.0585
Entamoeba histolytica proteasome regulatory subunit, putative 0.0061 0.0353 0.0461
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0066 0.0436 0.0614
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0079 0.0615 0.0879
Giardia lamblia Proteasome subunit beta type 2 0.0254 0.3165 0.4675
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0254 0.3165 0.4675
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5402
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0073 0.0535 0.0494
Schistosoma mansoni proteasome regulatory subunit-related 0.0066 0.0436 0.0395
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0043 0.0095 0.0108
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5402
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0275 0.3479 0.3451
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0265 0.3334 0.3319
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0269 0.3381 0.4963
Loa Loa (eye worm) hypothetical protein 0.0053 0.0248 0.0226
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0288 0.3667 0.3653
Loa Loa (eye worm) proteasome Regulatory Particle 0.0066 0.0433 0.0412
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0061 0.0358 0.0336
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0364 0.4775 0.7035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0275 0.0254
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0309 0.397 0.3957
Schistosoma mansoni 26S proteasome subunit S9 0.0073 0.0535 0.0494
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0038 0.0022 0.0032
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0039 0.0043 0.0031
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0038 0.0022 0.0032
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0565
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Entamoeba histolytica proteasome regulatory subunit, putative 0.0079 0.0615 0.085
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Toxoplasma gondii heat shock protein hslv, putative 0.02 0.2388 0.2355
Echinococcus granulosus Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0501 0.6769 0.6762
Entamoeba histolytica proteasome regulatory subunit, putative 0.0066 0.0433 0.058
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0066 0.0436 0.0585
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0243 0.3004 0.4419
Trypanosoma brucei proteasome beta 7 subunit 0.025 0.3116 0.4585
Brugia malayi Proteasome subunit alpha type 7-1 0.0364 0.4775 0.4753
Echinococcus multilocularis proteasome subunit alpha type 6 0.029 0.3694 0.3681
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0043 0.0095 0.0077
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0046 0.014 0.0208
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0269 0.3381 0.3367
Loa Loa (eye worm) proteasome subunit beta type 2 0.0254 0.3165 0.315
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0275 0.3479 0.3465
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0266 0.3346 0.4911
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0043 0.0093 0.0138
Brugia malayi proteasome subunit beta type 3 0.0254 0.3165 0.3135
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0364 0.4775 0.7054
Brugia malayi proteasome subunit beta type 1 0.0309 0.397 0.3944
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0243 0.3004 0.2973
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0073 0.0535 0.076
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0377 0.4955 0.7303
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0288 0.3667 0.5387
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0265 0.3334 0.3305
Loa Loa (eye worm) PCI domain-containing protein 0.0066 0.0436 0.0415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0275 0.0233
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0266 0.3346 0.3332
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0043 0.0093 0.0071
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0265 0.3334 0.3319
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.004 0.006 0.0056
Trypanosoma brucei ATP-dependent protease subunit HslV 0.02 0.2388 0.3506
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0073 0.0535 0.079
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.02 0.2388 0.3486
Echinococcus granulosus subfamily T1A non peptidase ue 0.0288 0.3667 0.3653
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.02 0.2388 0.5
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0073 0.0535 0.0514
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0574
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0043 0.0095 0.0077
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0043 0.0093 0.0106
Giardia lamblia 20S proteasome alpha subunit 3 0.0265 0.3334 0.4925
Toxoplasma gondii proteasome subunit alpha type, putative 0.0164 0.1858 0.1823
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0079 0.0615 0.0574
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0066 0.0436 0.0415
Entamoeba histolytica proteasome regulatory subunit, putative 0.0058 0.0313 0.0401
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0275 0.3479 0.5109
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0254 0.3165 0.3135
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0058 0.0313 0.0462
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0254 0.3165 0.315
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.004 0.006 0.0038
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.025 0.3116 0.3086
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0042 0.0077 0.005
Loa Loa (eye worm) proteasome subunit alpha type 6 0.029 0.3694 0.3681
Leishmania major proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0254 0.3165 0.4641
Loa Loa (eye worm) PAS-3 protein 0.0233 0.2858 0.2842
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0079 0.0615 0.0879
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.004 0.006 0.0088
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0265 0.3334 0.4892
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0053 0.0236 0.0317
Toxoplasma gondii proteasome beta subunit 0.0254 0.3165 0.3135
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0565
Echinococcus granulosus proteasome subunit beta type 6 0.0266 0.3346 0.3332
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0058 0.0313 0.0271
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0061 0.0358 0.0468
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 7 0.0038 0.0022 0.0032
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0364 0.4775 0.4764
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0264 0.3319 0.329
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0269 0.3381 0.3367
Entamoeba histolytica proteasome regulatory subunit, putative 0.0066 0.0436 0.0585
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0254 0.3165 0.4658
Brugia malayi Proteasome/cyclosome repeat family protein 0.0046 0.014 0.0098
Trichomonas vaginalis 26S proteasome subunit, putative 0.0061 0.0353 0.0521
Plasmodium vivax proteasome subunit beta type-4, putative 0.025 0.3116 0.4568
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0043 0.0095 0.0077
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0061 0.0358 0.0336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0275 0.0254
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.02 0.2388 0.3486
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0059 0.0328 0.0453
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0043 0.0095 0.0052
Trypanosoma brucei proteasome beta 6 subunit 0.0309 0.397 0.5852
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.025 0.3116 0.3086
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0309 0.397 0.5839
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0058 0.0313 0.0462
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0269 0.3381 0.3353
Brugia malayi Proteasome/cyclosome repeat family protein 0.0046 0.014 0.0098
Echinococcus granulosus proteasome subunit beta t family 0.0254 0.3165 0.315
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0061 0.0358 0.0316
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0266 0.3346 0.4927
Plasmodium vivax proteasome subunit beta type-5, putative 0.0501 0.6769 1
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0309 0.397 0.5839
Giardia lamblia 20S proteasome alpha subunit 7 0.0269 0.3381 0.4995
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0061 0.0353 0.0521
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0501 0.6769 1
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0078 0.0606 0.0565
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0058 0.0313 0.0271
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0053 0.0236 0.0214
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.004 0.006 0.0017
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0043 0.0095 0.0073
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.029 0.3694 0.5443
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0058 0.0313 0.0291
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0113 0.1111 0.1588
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.004 0.006 0.0038
Toxoplasma gondii PCI domain-containing protein 0.0073 0.0535 0.0494
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Schistosoma mansoni hypothetical protein 0.0176 0.2029 0.1995
Onchocerca volvulus 0.004 0.006 0.0027
Loa Loa (eye worm) hypothetical protein 0.004 0.006 0.0038
Entamoeba histolytica proteasome regulatory subunit, putative 0.0073 0.0535 0.0731
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0043 0.0095 0.0073
Plasmodium vivax proteasome subunit beta type-2, putative 0.0254 0.3165 0.4641
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0288 0.3667 0.3639
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0079 0.0615 0.0574
Brugia malayi Probable 26S protease regulatory subunit 4 0.004 0.006 0.0017
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0046 0.014 0.0119
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.029 0.3694 0.3667
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0723 1 1
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0066 0.0436 0.0645
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.02 0.2388 0.2355
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0066 0.0433 0.0412
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Leishmania major proteasome alpha 2 subunit, putative 0.0275 0.3479 0.5124
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0053 0.0236 0.0194
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0078 0.0606 0.0865
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0364 0.4775 0.7035
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.02 0.2388 0.3486
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0073 0.0535 0.076
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0043 0.0064
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0264 0.3319 0.4903
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.025 0.3116 0.4585
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0275 0.0254
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0043 0.0095 0.0052
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0066 0.0433 0.0392
Brugia malayi Proteasome subunit alpha type 1 0.0232 0.2843 0.2812
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0079 0.0615 0.085
Loa Loa (eye worm) RPN-3 protein 0.0079 0.0615 0.0594
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0501 0.6769 1
Brugia malayi proteasome subunit alpha type 3 0.0269 0.3381 0.3353
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0254 0.3165 0.4641
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0269 0.3381 0.4963
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0265 0.3334 0.4892
Toxoplasma gondii proteasome subunit 0.0266 0.3346 0.3317
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0066 0.0433 0.064
Onchocerca volvulus Notchless protein homolog 0.0269 0.3381 0.5461
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0061 0.0358 0.0468
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0264 0.3319 0.4871
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0264 0.3319 0.4887
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0266 0.3346 0.3317
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0078 0.0606 0.0565
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.004 0.006 0.0025
Loa Loa (eye worm) proteasome regulatory particle 0.0073 0.0535 0.0514
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0061 0.0358 0.0316
Brugia malayi proteasome subunit beta type 2 0.0254 0.3165 0.3135
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.025 0.3116 0.31
Toxoplasma gondii proteasome 26S regulatory subunit 0.0042 0.0077 0.0034
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.004 0.006 0.0088
Trypanosoma cruzi 20S proteasome subunit 0.0254 0.3165 0.4658
Brugia malayi Ubiquitin interaction motif family protein 0.0043 0.0093 0.005
Toxoplasma gondii proteasome regulatory subunit 0.0061 0.0358 0.0316
Leishmania major proteasome regulatory ATPase subunit 0.0039 0.0043 0.0031
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0264 0.3319 0.4871
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0038 0.0022 0.0032
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.004 0.006 0.0056
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0364 0.4775 0.7035
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1569 0.1551
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0364 0.4775 0.4764
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0039 0.0043 0.0031
Echinococcus multilocularis proteasome subunit alpha type 2 0.0275 0.3479 0.3465
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.025 0.3116 0.31
Schistosoma mansoni 26S protease regulatory subunit 0.004 0.006 0.0017
Schistosoma mansoni 26S protease regulatory subunit 6b 0.004 0.006 0.0017
Schistosoma mansoni multiubiquitin binding protein S5a 0.0043 0.0093 0.005
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.029 0.3694 0.5429
Leishmania major proteasome alpha 3 subunit, putative 0.0265 0.3334 0.4908
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0061 0.0353 0.0332
Brugia malayi proteasome subunit alpha type 1 0.0264 0.3319 0.329
Echinococcus granulosus adhesion regulating molecule 1 0.0723 1 1
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0275 0.3479 0.5109
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0309 0.397 0.3944
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0243 0.3004 0.4437
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0113 0.1111 0.1614
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0061 0.0358 0.0468
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.004 0.006 0.0038
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0061 0.0353 0.0461
Echinococcus multilocularis adhesion regulating molecule 1 0.0723 1 1
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0061 0.0358 0.0497
Giardia lamblia 20S proteasome alpha subunit 4 0.0364 0.4775 0.7054
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0043 0.0095 0.0108
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0364 0.4775 0.7045
Plasmodium vivax proteasome subunit beta type-3, putative 0.0254 0.3165 0.4641
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0039 0.0043 0.0031
Echinococcus multilocularis proteasome subunit beta type 6 0.0266 0.3346 0.3332
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.029 0.3694 0.5429
Brugia malayi Proteasome A-type and B-type family protein 0.025 0.3116 0.3086
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0058 0.0313 0.0401
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0058 0.0313 0.0431
Loa Loa (eye worm) proteasome subunit beta type 3 0.0254 0.3165 0.315
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0061 0.0358 0.0336
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0039 0.0043 0.0021
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0275 0.3479 0.5124
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0265 0.3334 0.4892
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0264 0.3319 0.3304
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0073 0.0535 0.0731
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0254 0.3165 0.3135
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0053 0.0236 0.0287

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0126 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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