Detailed information for compound 1551296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.945 | Formula: C25H26ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 5.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1noc(c1)C1CCCN(C1)C(=O)c1ccc(cc1)C(C)C)Nc1ccccc1Cl
  • InChi: 1S/C25H26ClN3O3/c1-16(2)17-9-11-18(12-10-17)25(31)29-13-5-6-19(15-29)23-14-22(28-32-23)24(30)27-21-8-4-3-7-20(21)26/h3-4,7-12,14,16,19H,5-6,13,15H2,1-2H3,(H,27,30)
  • InChiKey: GYVYSUOUJCNBJM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0036 0.0038 0.0056
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0036 0.0038 0.0056
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0443 0.6826 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0235 0.335 0.4892
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0038 0.0074 0.0108
Loa Loa (eye worm) PCI domain-containing protein 0.0054 0.0335 0.0403
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0054 0.034 0.0468
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0059 0.0419 0.0585
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0054 0.034 0.034
Leishmania major proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Brugia malayi Proteasome A-type and B-type family protein 0.0221 0.313 0.3115
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0235 0.335 0.4892
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0443 0.6826 0.821
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0058 0.0416 0.0476
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0036 0.0038 0.0056
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0215 0.3016 0.4419
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0322 0.4808 0.7035
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5387
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0054 0.0335 0.0461
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0237 0.3398 0.3398
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0234 0.3335 0.4887
Leishmania major proteasome beta 5 subunit, putative 0.0443 0.6826 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0046 0.0217 0.0318
Loa Loa (eye worm) proteasome subunit beta type 3 0.0224 0.3179 0.3824
Brugia malayi proteasome subunit alpha type 4 0.0206 0.2869 0.2854
Leishmania major proteasome alpha 1 subunit, putative 0.0234 0.3335 0.4887
Echinococcus granulosus Proteasome subunit alpha beta 0.0237 0.3398 0.3398
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0083 0.0824 0.118
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.002
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0054 0.034 0.0319
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Brugia malayi proteasome subunit alpha type 3 0.0237 0.3398 0.3384
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0069 0.0591 0.0866
Toxoplasma gondii proteasome subunit alpha type, putative 0.0145 0.1858 0.2215
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4887
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0038 0.0072 0.0051
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0069 0.06 0.0879
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0051 0.0294 0.0431
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0038 0.0074 0.0074
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0322 0.4808 0.7035
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0273 0.3994 0.3994
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0243 0.3498 0.4207
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0037 0.0056 0.005
Loa Loa (eye worm) PCI domain-containing protein 0.0059 0.0419 0.0504
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0237 0.3398 0.4088
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Loa Loa (eye worm) hypothetical protein 0.0533 0.8314 1
Schistosoma mansoni 26S protease regulatory subunit 0.0036 0.0038 0.0017
Echinococcus granulosus proteasome subunit beta t family 0.0224 0.3179 0.3179
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0035 0.0021 0.0031
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0069 0.06 0.06
Entamoeba histolytica hypothetical protein 0.0046 0.0217 0.0287
Brugia malayi proteasome subunit beta type 1 0.0273 0.3994 0.3981
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0224 0.3179 0.3179
Plasmodium vivax proteasome subunit beta type-6, putative 0.0235 0.3363 0.4911
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0255 0.3687 0.5387
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0234 0.3335 0.3335
Plasmodium vivax proteasome subunit beta type-3, putative 0.0224 0.3179 0.4641
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0046 0.0217 0.0236
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0634 1 1
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0322 0.4808 0.5784
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0059 0.0419 0.0419
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0035 0.0021 0.0031
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0215 0.3016 0.4419
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0224 0.3179 0.3164
Echinococcus multilocularis proteasome subunit beta type 7 0.0634 1 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0224 0.3179 0.4641
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0038 0.0074 0.0108
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4871
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0224 0.3179 0.4641
Brugia malayi Proteasome subunit alpha type 1 0.0205 0.2854 0.2839
Leishmania major proteasome regulatory ATPase subunit 0.0035 0.0021 0.0031
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Mycobacterium ulcerans proteasome PrcB 0.0443 0.6826 1
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0235 0.335 0.335
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Brugia malayi PCI domain containing protein 0.0054 0.0335 0.0314
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0255 0.3687 0.5387
Giardia lamblia 20S proteasome alpha subunit 4 0.0322 0.4808 0.7045
Plasmodium falciparum proteasome subunit beta type-4 0.0221 0.313 0.4568
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0052 0.0309 0.0453
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0065 0.0519 0.076
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0059 0.0419 0.0419
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0243 0.3498 0.5109
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0065 0.0519 0.0519
Leishmania major proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0036 0.0038 0.0017
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0035 0.0021 0.0031
Onchocerca volvulus 0.0036 0.0038 0.0033
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0354
Entamoeba histolytica proteasome regulatory subunit, putative 0.0059 0.0419 0.0585
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0443 0.6826 1
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0036 0.0038 0.0056
Plasmodium vivax proteasome subunit beta type-2, putative 0.0224 0.3179 0.4641
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0237 0.3398 0.3384
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0221 0.313 0.4585
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0054 0.0335 0.0491
Giardia lamblia 26S protease regulatory subunit 8 0.0035 0.0021 0.0031
Leishmania major proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5387
Brugia malayi Proteasome/cyclosome repeat family protein 0.0041 0.012 0.0099
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0069 0.0591 0.0837
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0224 0.3179 0.4658
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0322 0.4808 0.7035
Trypanosoma brucei proteasome alpha 7 subunit 0.0237 0.3398 0.4979
Toxoplasma gondii peptidase, T1 family protein 0.0237 0.3398 0.4073
Brugia malayi Proteasome A-type and B-type family protein 0.0443 0.6826 0.6819
Toxoplasma gondii proteasome subunit alpha1, putative 0.0257 0.3715 0.4455
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0054 0.034 0.0468
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Toxoplasma gondii heat shock protein hslv, putative 0.0177 0.2393 0.286
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0255 0.3687 0.3687
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0257 0.3715 0.5443
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0054 0.034 0.0384
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0237 0.3398 0.4963
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0038 0.0072 0.0106
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0036 0.0038 0.0038
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0221 0.313 0.4568
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0443 0.6826 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0273 0.3994 0.5852
Echinococcus multilocularis proteasome (prosome, macropain) 0.0443 0.6826 0.6826
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0069 0.06 0.0879
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0443 0.6826 1
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0381 0.5795 0.5786
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0058 0.0416 0.058
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4871
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0224 0.3179 0.3179
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0234 0.3335 0.3335
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0038 0.0072 0.0106
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0065 0.0519 0.076
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0058 0.0416 0.0609
Giardia lamblia 26S protease regulatory subunit 6B 0.0036 0.0038 0.0056
Giardia lamblia 20S proteasome alpha subunit 3 0.0235 0.335 0.4908
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0234 0.3335 0.4887
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0058 0.0416 0.0416
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Plasmodium vivax proteasome subunit beta type-4, putative 0.0221 0.313 0.4568
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0221 0.313 0.3748
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0235 0.335 0.4908
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0235 0.335 0.335
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0054 0.034 0.0468
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0237 0.3398 0.4963
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0224 0.3179 0.3164
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0069 0.0591 0.0711
Brugia malayi Proteasome/cyclosome repeat family protein 0.0041 0.012 0.0099
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0255 0.3687 0.5402
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0235 0.3363 0.3349
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0221 0.313 0.4585
Toxoplasma gondii proteasome 26S regulatory subunit 0.0037 0.0056 0.0041
Echinococcus granulosus 26S protease regulatory subunit 8 0.0035 0.0021 0.0021
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0051 0.0294 0.0401
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0046 0.0217 0.0196
Trypanosoma brucei proteasome beta 7 subunit 0.0221 0.313 0.4585
Giardia lamblia 20S proteasome alpha subunit 6 0.0234 0.3335 0.4887
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0235 0.3363 0.4911
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0035 0.0021 0.0031
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.0025
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0035 0.0021 0.0031
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0054 0.034 0.0497
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0051 0.0294 0.0273
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0069 0.0591 0.0837
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0273 0.3994 0.4791
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0322 0.4808 0.4797
Leishmania major proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0155 0.2031 0.2031
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0443 0.6826 1
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.0025
Giardia lamblia 26S protease regulatory subunit 6A 0.0038 0.0074 0.0108
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0224 0.3179 0.4641
Echinococcus granulosus adhesion regulating molecule 1 0.0533 0.8314 0.8314
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0051 0.0294 0.0431
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0155 0.2031 0.2031
Loa Loa (eye worm) proteasome Regulatory Particle 0.0058 0.0416 0.05
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0255 0.3687 0.5402
Entamoeba histolytica proteasome regulatory subunit, putative 0.0038 0.0072 0.0074
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Loa Loa (eye worm) hypothetical protein 0.0047 0.0229 0.0275
Schistosoma mansoni hypothetical protein 0.0155 0.2031 0.2013
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0177 0.2393 0.3486
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0054 0.034 0.0408
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Echinococcus granulosus Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0235 0.3363 0.4927
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0221 0.313 0.4585
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0054 0.034 0.0319
Trypanosoma brucei proteasome beta 6 subunit 0.0273 0.3994 0.5852
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Loa Loa (eye worm) RPT-2 protein 0.0036 0.0038 0.0046
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0056 0.0082
Echinococcus granulosus proteasome subunit alpha type 6 0.0257 0.3715 0.3715
Onchocerca volvulus 0.0036 0.0038 0.0033
Toxoplasma gondii PCI domain-containing protein 0.0054 0.0335 0.0378
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0054 0.034 0.034
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0036 0.0038 0.0025
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0059 0.0419 0.0614
Toxoplasma gondii PCI domain-containing protein 0.0069 0.06 0.0698
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0533 0.8314 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0065 0.0519 0.0731
Entamoeba histolytica proteasome regulatory subunit, putative 0.0058 0.0416 0.058
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0234 0.3335 0.3321
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0038 0.0072 0.0072
Echinococcus granulosus proteasome subunit beta type 7 0.0634 1 1
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0215 0.3016 0.4402
Entamoeba histolytica proteasome regulatory subunit, putative 0.0069 0.06 0.085
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0036 0.0038 0.0038
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0224 0.3179 0.3164
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0069 0.0591 0.0866
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0354
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0215 0.3016 0.3628
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0237 0.3398 0.4963
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0533 0.8314 0.831
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0443 0.6826 1
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0235 0.335 0.4892
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Schistosoma mansoni hypothetical protein 0.0381 0.5795 0.5786
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0046 0.0217 0.0287
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0257 0.3715 0.4469
Toxoplasma gondii proteasome subunit 0.0235 0.3363 0.403
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0046 0.0217 0.0217
Echinococcus granulosus subfamily T1A non peptidase ue 0.0255 0.3687 0.3687
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0054 0.0335 0.0461
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0234 0.3335 0.4871
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0224 0.3179 0.4641
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0036 0.0038 0.0038
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0038 0.0056
Toxoplasma gondii proteasome beta subunit 0.0224 0.3179 0.3808
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0036 0.0038 0.0056
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0443 0.6826 0.6819
Brugia malayi 20S proteasome alpha5 subunit 0.0255 0.3687 0.3674
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Brugia malayi Ubiquitin interaction motif family protein 0.0038 0.0072 0.0051
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0054 0.034 0.0319
Leishmania major hypothetical protein, conserved 0.0277 0.4063 0.5953
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0226 0.3206 0.3191
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0221 0.313 0.3764
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0255 0.3687 0.4421
Loa Loa (eye worm) PAS-3 protein 0.0206 0.2869 0.3451
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0243 0.3498 0.4192
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0038 0.0074 0.0077
Toxoplasma gondii SAC3/GANP family protein 0.0051 0.0294 0.0329
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0036 0.0038 0.0025
Giardia lamblia 20S proteasome alpha subunit 7 0.0237 0.3398 0.4979
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0058 0.0416 0.0395
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Brugia malayi PCI domain containing protein 0.0059 0.0419 0.0399
Echinococcus granulosus proteasome subunit alpha type 2 0.0243 0.3498 0.3498
Echinococcus granulosus proteasome subunit beta type 6 0.0235 0.3363 0.3363
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Loa Loa (eye worm) hypothetical protein 0.0381 0.5795 0.697
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0038 0.0074 0.0077
Leishmania major proteasome beta 2 subunit, putative 0.0224 0.3179 0.4658
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0051 0.0294 0.0431
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0069 0.0591 0.0866
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0054 0.034 0.034
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0273 0.3994 0.3981
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0041 0.012 0.0176
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0058 0.0416 0.0609
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0177 0.2393 0.3486
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0059 0.0419 0.0585
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0065 0.0519 0.0498
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0255 0.3687 0.3674
Brugia malayi Proteasome A-type and B-type family protein 0.0235 0.3363 0.3349
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0038 0.0074 0.0074
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0036 0.0038 0.0025
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0243 0.3498 0.5109
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0237 0.3398 0.4979
Loa Loa (eye worm) proteasome regulatory particle 0.0065 0.0519 0.0624
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0257 0.3715 0.5429
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0215 0.3016 0.4402
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0054 0.034 0.0468
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0221 0.313 0.313
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0224 0.3179 0.3808
Echinococcus multilocularis proteasome subunit alpha type 6 0.0257 0.3715 0.3715
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0035 0.0021 0.0021
Plasmodium vivax proteasome subunit beta type-1, putative 0.0273 0.3994 0.5839
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0338 0.5075 1
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0069 0.0591 0.0571
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Trichomonas vaginalis 26S proteasome subunit, putative 0.0054 0.0335 0.0491
Leishmania major proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0237 0.3398 0.4963
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Echinococcus multilocularis proteasome subunit alpha type 2 0.0243 0.3498 0.3498
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0046 0.0217 0.0217
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0058 0.0416 0.0609
Schistosoma mansoni hypothetical protein 0.0054 0.0335 0.0314
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0059 0.0419 0.0614
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0277 0.4063 0.594
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0243 0.3498 0.3484
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0322 0.4808 0.7045
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0243 0.3498 0.5109
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0069 0.06 0.0879
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0177 0.2393 0.3486
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0054 0.0335 0.0491
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0054 0.034 0.0468
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0038 0.0056
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0322 0.4808 0.7035
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0036 0.0038 0.0038
Brugia malayi proteasome subunit alpha type 1 0.0234 0.3335 0.3321
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0273 0.3994 0.5839
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Schistosoma mansoni 26S proteasome subunit S9 0.0065 0.0519 0.0498
Plasmodium vivax proteasome subunit beta type-5, putative 0.0443 0.6826 1
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0059 0.0419 0.0614
Echinococcus multilocularis adhesion regulating molecule 1 0.0533 0.8314 0.8314
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0041 0.012 0.0145
Giardia lamblia Proteasome subunit beta type 3 0.0224 0.3179 0.4658
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0224 0.3179 0.4658
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0054 0.034 0.0468
Leishmania major proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0035 0.0021 0.0026
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0054 0.0335 0.0335
Entamoeba histolytica proteasome regulatory subunit, putative 0.0051 0.0294 0.0401
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0177 0.2393 0.3506
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0177 0.2393 0.3506
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0443 0.6826 1
Giardia lamblia Proteasome subunit beta type 1 0.0273 0.3994 0.5852
Trypanosoma cruzi 20S proteasome subunit 0.0224 0.3179 0.4658
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0035 0.0021 0.0021
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0443 0.6826 1
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0273 0.3994 0.5839
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0058 0.0416 0.0416
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0036 0.0038 0.0056
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0038 0.0074 0.0089
Giardia lamblia Proteasome subunit beta type 2 0.0224 0.3179 0.4658
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Brugia malayi Probable 26S protease regulatory subunit 4 0.0036 0.0038 0.0017
Giardia lamblia 20S proteasome alpha subunit 1 0.0257 0.3715 0.5443
Leishmania major proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0069 0.06 0.058
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0038 0.0073 0.0107
Loa Loa (eye worm) proteasome subunit beta type 1 0.0273 0.3994 0.4805
Leishmania major proteasome beta 7 subunit, putative 0.0221 0.313 0.4585
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0235 0.3363 0.4911
Toxoplasma gondii hypothetical protein 0.0047 0.0229 0.025
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Loa Loa (eye worm) RPN-3 protein 0.0069 0.06 0.0722
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0224 0.3179 0.3179
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0046
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0257 0.3715 0.3702
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0036 0.0038 0.002
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0038 0.0072 0.0106
Onchocerca volvulus Notchless protein homolog 0.0237 0.3398 0.6683
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0234 0.3335 0.4012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0046
Plasmodium vivax proteasome subunit beta type-7, putative 0.0215 0.3016 0.4402
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Toxoplasma gondii proteasome regulatory subunit 0.0054 0.034 0.0384
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0054 0.0335 0.0335
Brugia malayi proteasome subunit alpha type 2 0.0243 0.3498 0.3484
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0054 0.034 0.0319
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0036 0.0038 0.0025
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0069 0.06 0.06
Toxoplasma gondii PCI domain-containing protein 0.0065 0.0519 0.06
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0059 0.0419 0.0614
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Giardia lamblia 26S protease regulatory subunit 7 0.0035 0.0021 0.0031
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0069 0.06 0.058
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0058 0.0416 0.0395
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Brugia malayi proteasome subunit alpha type 6 0.0257 0.3715 0.3702
Leishmania major proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0257 0.3715 0.5429
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0273 0.3994 0.3994
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0038 0.0072 0.0072
Toxoplasma gondii proteasome subunit alpha type, putative 0.0235 0.335 0.4014
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0046 0.0217 0.0287
Schistosoma mansoni proteasome regulatory subunit-related 0.0059 0.0419 0.0399
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0051 0.0294 0.0273
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0215 0.3016 0.3612
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0533 0.8314 0.831
Giardia lamblia Hypothetical protein 0.0065 0.0519 0.076
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0035 0.0021 0.0031
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0054 0.034 0.034
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0234 0.3335 0.3997
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0069 0.0591 0.0866
Brugia malayi 26S protease regulatory subunit 6A 0.0038 0.0074 0.0053
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0059 0.0419 0.048
Giardia lamblia 20S proteasome alpha subunit 5 0.0255 0.3687 0.5402
Echinococcus granulosus proteasome prosome macropain 0.0443 0.6826 0.6826
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0054 0.034 0.0497
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0058 0.0416 0.058
Loa Loa (eye worm) proteasome subunit beta type 2 0.0224 0.3179 0.3824
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0054 0.034 0.0497
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0069 0.06 0.085
Plasmodium falciparum proteasome subunit beta type-5 0.0443 0.6826 1
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0177 0.2393 0.3506
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0051 0.0294 0.0294
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0035 0.0021 0.0031
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0255 0.3687 0.3674
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0221 0.313 0.313
Giardia lamblia 20S proteasome alpha subunit 2 0.0243 0.3498 0.5124
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0177 0.2393 0.2377
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0206 0.2875 0.4211
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0035 0.0021 0.0021
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0065 0.0519 0.0519
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0235 0.3363 0.4927
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0069 0.06 0.058
Brugia malayi proteasome subunit beta type 3 0.0224 0.3179 0.3164
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0058 0.0416 0.0609
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0051 0.0294 0.0273
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0054 0.0335 0.0491
Toxoplasma gondii proteasome subunit beta type, putative 0.0443 0.6826 0.8206
Loa Loa (eye worm) proteasome 26S subunit 0.0035 0.0021 0.0026
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0257 0.3715 0.5429
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0255 0.3687 0.4435
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0036 0.0038 0.0056
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0051 0.0294 0.0401
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0054 0.0335 0.0491
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0221 0.313 0.3115
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0035 0.0021 0.0031
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0177 0.2393 0.5
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0065 0.0519 0.076
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0054 0.034 0.0408
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0591
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0215 0.3016 0.4419
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0235 0.335 0.4892
Entamoeba histolytica proteasome regulatory subunit, putative 0.0054 0.0335 0.0461
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0069 0.0591 0.0866
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0065 0.0519 0.076
Brugia malayi 26S proteasome subunit P45 family protein 0.0036 0.0038 0.0017
Schistosoma mansoni multiubiquitin binding protein S5a 0.0038 0.0072 0.0051
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0065 0.0519 0.0731
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Echinococcus multilocularis proteasome subunit beta type 6 0.0235 0.3363 0.3363
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0026
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0038 0.0074 0.0063
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0224 0.3179 0.3164
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0235 0.335 0.3336
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0074 0.0077
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0065 0.0519 0.0731
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0177 0.2393 0.3506
Brugia malayi proteasome subunit beta type 2 0.0224 0.3179 0.3164
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0235 0.3363 0.4045
Brugia malayi Proteasome subunit alpha type 7-1 0.0322 0.4808 0.4797
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0051 0.0294 0.0294
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0215 0.3016 0.4419
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0058 0.0416 0.0609

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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