Detailed information for compound 1551296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.945 | Formula: C25H26ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 5.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1noc(c1)C1CCCN(C1)C(=O)c1ccc(cc1)C(C)C)Nc1ccccc1Cl
  • InChi: 1S/C25H26ClN3O3/c1-16(2)17-9-11-18(12-10-17)25(31)29-13-5-6-19(15-29)23-14-22(28-32-23)24(30)27-21-8-4-3-7-20(21)26/h3-4,7-12,14,16,19H,5-6,13,15H2,1-2H3,(H,27,30)
  • InChiKey: GYVYSUOUJCNBJM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0443 0.6826 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0221 0.313 0.4585
Plasmodium falciparum proteasome subunit beta type-5 0.0443 0.6826 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0234 0.3335 0.3997
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0035 0.0021 0.0031
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0234 0.3335 0.3335
Echinococcus multilocularis proteasome (prosome, macropain) 0.0443 0.6826 0.6826
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4887
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0035 0.0021 0.0031
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0224 0.3179 0.4641
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0177 0.2393 0.3486
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0255 0.3687 0.4421
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0054 0.034 0.034
Brugia malayi 20S proteasome alpha5 subunit 0.0255 0.3687 0.3674
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0443 0.6826 1
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0243 0.3498 0.5109
Toxoplasma gondii proteasome subunit 0.0235 0.3363 0.403
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Schistosoma mansoni proteasome regulatory subunit-related 0.0059 0.0419 0.0399
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0255 0.3687 0.3674
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0234 0.3335 0.4887
Giardia lamblia Proteasome subunit beta type 1 0.0273 0.3994 0.5852
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0177 0.2393 0.3506
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0206 0.2875 0.4211
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0058 0.0416 0.0395
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0224 0.3179 0.4641
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0059 0.0419 0.0614
Brugia malayi 26S protease regulatory subunit 6A 0.0038 0.0074 0.0053
Onchocerca volvulus Notchless protein homolog 0.0237 0.3398 0.6683
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0215 0.3016 0.4402
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0038 0.0072 0.0072
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0273 0.3994 0.3981
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0177 0.2393 0.2377
Loa Loa (eye worm) proteasome subunit beta type 3 0.0224 0.3179 0.3824
Entamoeba histolytica hypothetical protein 0.0046 0.0217 0.0287
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0038 0.0074 0.0074
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0235 0.335 0.3336
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0035 0.0021 0.0021
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0235 0.3363 0.4911
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0215 0.3016 0.3628
Echinococcus granulosus proteasome subunit alpha type 6 0.0257 0.3715 0.3715
Brugia malayi PCI domain containing protein 0.0054 0.0335 0.0314
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0069 0.06 0.0879
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Entamoeba histolytica proteasome regulatory subunit, putative 0.0054 0.0335 0.0461
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0237 0.3398 0.4963
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.0025
Loa Loa (eye worm) PAS-3 protein 0.0206 0.2869 0.3451
Giardia lamblia 26S protease regulatory subunit 7 0.0035 0.0021 0.0031
Brugia malayi Proteasome A-type and B-type family protein 0.0443 0.6826 0.6819
Loa Loa (eye worm) hypothetical protein 0.0533 0.8314 1
Brugia malayi proteasome subunit alpha type 1 0.0234 0.3335 0.3321
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0051 0.0294 0.0401
Leishmania major proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Brugia malayi proteasome subunit alpha type 4 0.0206 0.2869 0.2854
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0224 0.3179 0.3179
Toxoplasma gondii proteasome regulatory subunit 0.0054 0.034 0.0384
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Brugia malayi proteasome subunit alpha type 3 0.0237 0.3398 0.3384
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0035 0.0021 0.0031
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0234 0.3335 0.3335
Plasmodium vivax proteasome subunit beta type-1, putative 0.0273 0.3994 0.5839
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0634 1 1
Toxoplasma gondii PCI domain-containing protein 0.0069 0.06 0.0698
Trichomonas vaginalis 26S proteasome subunit, putative 0.0054 0.0335 0.0491
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0038 0.0074 0.0108
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0051 0.0294 0.0294
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0322 0.4808 0.5784
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0235 0.3363 0.4927
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0177 0.2393 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0354
Schistosoma mansoni hypothetical protein 0.0054 0.0335 0.0314
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0224 0.3179 0.4641
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0443 0.6826 1
Entamoeba histolytica proteasome regulatory subunit, putative 0.0038 0.0072 0.0074
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0235 0.335 0.335
Toxoplasma gondii hypothetical protein 0.0047 0.0229 0.025
Echinococcus granulosus proteasome subunit beta t family 0.0224 0.3179 0.3179
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0065 0.0519 0.0519
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0443 0.6826 0.821
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0221 0.313 0.4568
Brugia malayi proteasome subunit alpha type 2 0.0243 0.3498 0.3484
Giardia lamblia 20S proteasome alpha subunit 7 0.0237 0.3398 0.4979
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5387
Brugia malayi proteasome subunit beta type 1 0.0273 0.3994 0.3981
Echinococcus multilocularis proteasome subunit alpha type 6 0.0257 0.3715 0.3715
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0051 0.0294 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Loa Loa (eye worm) proteasome 26S subunit 0.0035 0.0021 0.0026
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0058 0.0416 0.058
Giardia lamblia 20S proteasome alpha subunit 4 0.0322 0.4808 0.7045
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0237 0.3398 0.4979
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0224 0.3179 0.3179
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0257 0.3715 0.5429
Loa Loa (eye worm) RPT-2 protein 0.0036 0.0038 0.0046
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0036 0.0038 0.0038
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0051 0.0294 0.0273
Brugia malayi Proteasome subunit alpha type 7-1 0.0322 0.4808 0.4797
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0235 0.335 0.4908
Brugia malayi Proteasome A-type and B-type family protein 0.0221 0.313 0.3115
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0035 0.0021 0.0026
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0046 0.0217 0.0318
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0065 0.0519 0.0498
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0069 0.0591 0.0837
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0224 0.3179 0.3164
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Loa Loa (eye worm) hypothetical protein 0.0381 0.5795 0.697
Schistosoma mansoni hypothetical protein 0.0155 0.2031 0.2013
Trypanosoma brucei proteasome beta 6 subunit 0.0273 0.3994 0.5852
Giardia lamblia 26S protease regulatory subunit 8 0.0035 0.0021 0.0031
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0177 0.2393 0.3506
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0054 0.034 0.0319
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0235 0.335 0.4892
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0041 0.012 0.0176
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0221 0.313 0.4585
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0065 0.0519 0.0731
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0037 0.0056 0.005
Echinococcus granulosus proteasome prosome macropain 0.0443 0.6826 0.6826
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0273 0.3994 0.5839
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0036 0.0038 0.0038
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4871
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5387
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0054 0.034 0.0408
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0054 0.0335 0.0491
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0235 0.3363 0.4045
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0322 0.4808 0.7035
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0054 0.0335 0.0461
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Plasmodium falciparum proteasome subunit beta type-4 0.0221 0.313 0.4568
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0533 0.8314 0.831
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0533 0.8314 1
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0591
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0054 0.0335 0.0491
Leishmania major proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4871
Toxoplasma gondii proteasome subunit alpha type, putative 0.0145 0.1858 0.2215
Brugia malayi Ubiquitin interaction motif family protein 0.0038 0.0072 0.0051
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0054 0.034 0.0319
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0038 0.0074 0.0089
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0255 0.3687 0.5387
Brugia malayi proteasome subunit alpha type 6 0.0257 0.3715 0.3702
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0036 0.0038 0.0038
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0069 0.06 0.058
Entamoeba histolytica proteasome regulatory subunit, putative 0.0059 0.0419 0.0585
Giardia lamblia Proteasome subunit beta type 3 0.0224 0.3179 0.4658
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0177 0.2393 0.3506
Leishmania major proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0051 0.0294 0.0431
Schistosoma mansoni hypothetical protein 0.0381 0.5795 0.5786
Loa Loa (eye worm) hypothetical protein 0.0047 0.0229 0.0275
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0257 0.3715 0.5429
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0046 0.0217 0.0287
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0235 0.3363 0.4911
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Plasmodium vivax proteasome subunit beta type-3, putative 0.0224 0.3179 0.4641
Brugia malayi Proteasome/cyclosome repeat family protein 0.0041 0.012 0.0099
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Loa Loa (eye worm) proteasome regulatory particle 0.0065 0.0519 0.0624
Leishmania major proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Echinococcus granulosus proteasome subunit alpha type 2 0.0243 0.3498 0.3498
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0054 0.034 0.0384
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0038 0.0072 0.0072
Plasmodium vivax proteasome subunit beta type-7, putative 0.0215 0.3016 0.4402
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0036 0.0038 0.002
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0257 0.3715 0.3702
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0051 0.0294 0.0273
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0338 0.5075 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0273 0.3994 0.4791
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0215 0.3016 0.3612
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0035 0.0021 0.0031
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0221 0.313 0.313
Entamoeba histolytica proteasome regulatory subunit, putative 0.0051 0.0294 0.0401
Echinococcus multilocularis proteasome subunit alpha type 2 0.0243 0.3498 0.3498
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0226 0.3206 0.3191
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0051 0.0294 0.0431
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0065 0.0519 0.076
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0054 0.034 0.0468
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0215 0.3016 0.4419
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0381 0.5795 0.5786
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0054 0.0335 0.0335
Leishmania major proteasome regulatory ATPase subunit 0.0035 0.0021 0.0031
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0046 0.0217 0.0287
Mycobacterium ulcerans proteasome PrcB 0.0443 0.6826 1
Echinococcus multilocularis adhesion regulating molecule 1 0.0533 0.8314 0.8314
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0036 0.0038 0.0025
Brugia malayi proteasome subunit beta type 3 0.0224 0.3179 0.3164
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0051 0.0294 0.0431
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0224 0.3179 0.3164
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Leishmania major hypothetical protein, conserved 0.0277 0.4063 0.5953
Brugia malayi Proteasome subunit alpha type 1 0.0205 0.2854 0.2839
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0059 0.0419 0.0614
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0243 0.3498 0.3484
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0069 0.06 0.058
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Echinococcus granulosus proteasome subunit beta type 6 0.0235 0.3363 0.3363
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0224 0.3179 0.3179
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0059 0.0419 0.0614
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0221 0.313 0.4585
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0056 0.0082
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0243 0.3498 0.4192
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0046 0.0217 0.0217
Giardia lamblia Proteasome subunit beta type 2 0.0224 0.3179 0.4658
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0035 0.0021 0.0031
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0235 0.3363 0.4927
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Giardia lamblia 20S proteasome alpha subunit 3 0.0235 0.335 0.4908
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0069 0.06 0.085
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0036 0.0038 0.0056
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0224 0.3179 0.3164
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0069 0.0591 0.0711
Plasmodium vivax proteasome subunit beta type-6, putative 0.0235 0.3363 0.4911
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0083 0.0824 0.118
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0054 0.0335 0.0491
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0058 0.0416 0.0416
Leishmania major proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Toxoplasma gondii proteasome subunit alpha type, putative 0.0235 0.335 0.4014
Leishmania major proteasome beta 2 subunit, putative 0.0224 0.3179 0.4658
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0054 0.034 0.0468
Giardia lamblia 20S proteasome alpha subunit 6 0.0234 0.3335 0.4887
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0069 0.0591 0.0866
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0065 0.0519 0.0519
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0054 0.0335 0.0335
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0322 0.4808 0.7035
Giardia lamblia 20S proteasome alpha subunit 5 0.0255 0.3687 0.5402
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0052 0.0309 0.0453
Giardia lamblia 26S protease regulatory subunit 6A 0.0038 0.0074 0.0108
Brugia malayi 26S proteasome subunit P45 family protein 0.0036 0.0038 0.0017
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Toxoplasma gondii proteasome subunit alpha1, putative 0.0257 0.3715 0.4455
Plasmodium vivax proteasome subunit beta type-4, putative 0.0221 0.313 0.4568
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0234 0.3335 0.4012
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0054 0.034 0.0468
Echinococcus multilocularis proteasome subunit beta type 6 0.0235 0.3363 0.3363
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0059 0.0419 0.0419
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0322 0.4808 0.7035
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0035 0.0021 0.0021
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0054 0.034 0.0497
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0035 0.0021 0.0021
Toxoplasma gondii proteasome beta subunit 0.0224 0.3179 0.3808
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0215 0.3016 0.4419
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0255 0.3687 0.3674
Leishmania major proteasome alpha 1 subunit, putative 0.0234 0.3335 0.4887
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0074 0.0077
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0224 0.3179 0.4658
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0235 0.335 0.4892
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Loa Loa (eye worm) PCI domain-containing protein 0.0054 0.0335 0.0403
Schistosoma mansoni 26S protease regulatory subunit 0.0036 0.0038 0.0017
Brugia malayi Probable 26S protease regulatory subunit 4 0.0036 0.0038 0.0017
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0036 0.0038 0.0025
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0051 0.0294 0.0273
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0054 0.034 0.0319
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0038 0.0072 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0026
Leishmania major proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0059 0.0419 0.0585
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0069 0.06 0.0879
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0046 0.0217 0.0196
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0221 0.313 0.3748
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0058 0.0416 0.058
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0322 0.4808 0.4797
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0069 0.0591 0.0571
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0255 0.3687 0.5402
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0443 0.6826 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0069 0.06 0.0879
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0069 0.06 0.058
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0069 0.0591 0.0866
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0224 0.3179 0.4641
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0041 0.012 0.0145
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0051 0.0294 0.0401
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0069 0.0591 0.0866
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0215 0.3016 0.4402
Giardia lamblia 20S proteasome alpha subunit 1 0.0257 0.3715 0.5443
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0054 0.034 0.034
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0065 0.0519 0.076
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0257 0.3715 0.5443
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Toxoplasma gondii PCI domain-containing protein 0.0054 0.0335 0.0378
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.0025
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0177 0.2393 0.3486
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0058 0.0416 0.0395
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0054 0.034 0.0497
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0059 0.0419 0.0614
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0277 0.4063 0.594
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0221 0.313 0.3115
Brugia malayi Proteasome A-type and B-type family protein 0.0235 0.3363 0.3349
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0054 0.034 0.0468
Toxoplasma gondii SAC3/GANP family protein 0.0051 0.0294 0.0329
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0038 0.0056
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0054 0.034 0.034
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0038 0.0074 0.0063
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0038 0.0056
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0069 0.06 0.06
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0054 0.034 0.0319
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Giardia lamblia 26S protease regulatory subunit 6B 0.0036 0.0038 0.0056
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0065 0.0519 0.0731
Loa Loa (eye worm) proteasome subunit beta type 2 0.0224 0.3179 0.3824
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0065 0.0519 0.076
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0255 0.3687 0.4435
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0443 0.6826 1
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0058 0.0416 0.0476
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0237 0.3398 0.4963
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0237 0.3398 0.3398
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0443 0.6826 1
Trypanosoma cruzi 20S proteasome subunit 0.0224 0.3179 0.4658
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0177 0.2393 0.3506
Toxoplasma gondii peptidase, T1 family protein 0.0237 0.3398 0.4073
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0155 0.2031 0.2031
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0224 0.3179 0.4658
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0058 0.0416 0.0609
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0069 0.0591 0.0866
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0038 0.0074 0.0108
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0058 0.0416 0.0609
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0224 0.3179 0.3164
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0054 0.034 0.0468
Loa Loa (eye worm) proteasome Regulatory Particle 0.0058 0.0416 0.05
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0443 0.6826 1
Leishmania major proteasome beta 5 subunit, putative 0.0443 0.6826 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Schistosoma mansoni 26S proteasome subunit S9 0.0065 0.0519 0.0498
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0038 0.0074 0.0074
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0059 0.0419 0.048
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0038 0.0073 0.0107
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0065 0.0519 0.076
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0036 0.0038 0.0056
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0237 0.3398 0.4963
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0443 0.6826 1
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0533 0.8314 0.831
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0273 0.3994 0.5852
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0255 0.3687 0.5387
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0443 0.6826 0.6819
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0035 0.0021 0.0031
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0059 0.0419 0.0585
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0243 0.3498 0.5109
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0257 0.3715 0.4469
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0234 0.3335 0.4887
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0038 0.0074 0.0077
Entamoeba histolytica proteasome regulatory subunit, putative 0.0065 0.0519 0.0731
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0054 0.034 0.0408
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0215 0.3016 0.4419
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0237 0.3398 0.4963
Echinococcus granulosus adhesion regulating molecule 1 0.0533 0.8314 0.8314
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0036 0.0038 0.0056
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0234 0.3335 0.3321
Trypanosoma brucei proteasome alpha 7 subunit 0.0237 0.3398 0.4979
Brugia malayi Proteasome/cyclosome repeat family protein 0.0041 0.012 0.0099
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0069 0.0591 0.0837
Entamoeba histolytica proteasome regulatory subunit, putative 0.0058 0.0416 0.058
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0046 0.0217 0.0236
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0035 0.0021 0.0031
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0234 0.3335 0.4871
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0235 0.3363 0.3349
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0273 0.3994 0.3994
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0221 0.313 0.313
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0036 0.0038 0.0056
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0036 0.0038 0.0056
Loa Loa (eye worm) RPN-3 protein 0.0069 0.06 0.0722
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0054 0.034 0.0468
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0058 0.0416 0.0416
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0215 0.3016 0.4419
Giardia lamblia 20S proteasome alpha subunit 2 0.0243 0.3498 0.5124
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0038 0.0074 0.0077
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0591
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0054 0.034 0.034
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Loa Loa (eye worm) PCI domain-containing protein 0.0059 0.0419 0.0504
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0257 0.3715 0.5429
Toxoplasma gondii proteasome subunit beta type, putative 0.0443 0.6826 0.8206
Echinococcus granulosus Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Toxoplasma gondii heat shock protein hslv, putative 0.0177 0.2393 0.286
Toxoplasma gondii PCI domain-containing protein 0.0065 0.0519 0.06
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0221 0.313 0.3764
Loa Loa (eye worm) proteasome subunit beta type 1 0.0273 0.3994 0.4805
Leishmania major proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0069 0.0591 0.0866
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0036 0.0038 0.0017
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0177 0.2393 0.3486
Trypanosoma brucei proteasome beta 7 subunit 0.0221 0.313 0.4585
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0235 0.335 0.4892
Echinococcus granulosus Proteasome subunit alpha beta 0.0237 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0046
Leishmania major proteasome beta 7 subunit, putative 0.0221 0.313 0.4585
Entamoeba histolytica proteasome regulatory subunit, putative 0.0069 0.06 0.085
Onchocerca volvulus 0.0036 0.0038 0.0033
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0058 0.0416 0.0609
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0038 0.0072 0.0106
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0036 0.0038 0.0056
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0035 0.0021 0.0031
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0036 0.0038 0.0038
Echinococcus multilocularis proteasome subunit beta type 7 0.0634 1 1
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Echinococcus granulosus 26S protease regulatory subunit 8 0.0035 0.0021 0.0021
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Brugia malayi PCI domain containing protein 0.0059 0.0419 0.0399
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0069 0.06 0.06
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0059 0.0419 0.0419
Leishmania major proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Toxoplasma gondii proteasome 26S regulatory subunit 0.0037 0.0056 0.0041
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0036 0.0038 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0046
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0054 0.0335 0.0491
Onchocerca volvulus 0.0036 0.0038 0.0033
Echinococcus granulosus proteasome subunit beta type 7 0.0634 1 1
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0054 0.0335 0.0461
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0036 0.0038 0.0056
Echinococcus granulosus subfamily T1A non peptidase ue 0.0255 0.3687 0.3687
Plasmodium vivax proteasome subunit beta type-5, putative 0.0443 0.6826 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0354
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0237 0.3398 0.4088
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0038 0.0072 0.0051
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0224 0.3179 0.3808
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0155 0.2031 0.2031
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0322 0.4808 0.7035
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0235 0.335 0.335
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0237 0.3398 0.3384
Giardia lamblia Hypothetical protein 0.0065 0.0519 0.076
Schistosoma mansoni multiubiquitin binding protein S5a 0.0038 0.0072 0.0051
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0243 0.3498 0.5109
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0046 0.0217 0.0217
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0255 0.3687 0.5402
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0235 0.335 0.4892
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0054 0.034 0.0497
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0038 0.0072 0.0106
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0255 0.3687 0.3687
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0058 0.0416 0.0609
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0273 0.3994 0.3994
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0273 0.3994 0.5839
Plasmodium vivax proteasome subunit beta type-2, putative 0.0224 0.3179 0.4641
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0058 0.0416 0.0609
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0036 0.0038 0.0025
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0322 0.4808 0.7045
Brugia malayi proteasome subunit beta type 2 0.0224 0.3179 0.3164
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.002
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0243 0.3498 0.4207

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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