Detailed information for compound 1551296

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 451.945 | Formula: C25H26ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 5.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1noc(c1)C1CCCN(C1)C(=O)c1ccc(cc1)C(C)C)Nc1ccccc1Cl
  • InChi: 1S/C25H26ClN3O3/c1-16(2)17-9-11-18(12-10-17)25(31)29-13-5-6-19(15-29)23-14-22(28-32-23)24(30)27-21-8-4-3-7-20(21)26/h3-4,7-12,14,16,19H,5-6,13,15H2,1-2H3,(H,27,30)
  • InChiKey: GYVYSUOUJCNBJM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0255 0.3687 0.5402
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0054 0.034 0.0408
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0046 0.0217 0.0318
Leishmania major hypothetical protein, conserved 0.0277 0.4063 0.5953
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0054 0.0335 0.0461
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0038 0.0072 0.0106
Toxoplasma gondii proteasome regulatory subunit 0.0054 0.034 0.0384
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0054 0.034 0.0468
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0054 0.034 0.034
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0215 0.3016 0.4419
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0237 0.3398 0.4963
Loa Loa (eye worm) PCI domain-containing protein 0.0059 0.0419 0.0504
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0058 0.0416 0.0609
Brugia malayi proteasome subunit beta type 2 0.0224 0.3179 0.3164
Leishmania major proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Leishmania major proteasome beta 2 subunit, putative 0.0224 0.3179 0.4658
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0069 0.0591 0.0837
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0069 0.0591 0.0866
Giardia lamblia 26S protease regulatory subunit 6B 0.0036 0.0038 0.0056
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Echinococcus granulosus proteasome subunit alpha type 2 0.0243 0.3498 0.3498
Giardia lamblia 26S protease regulatory subunit 8 0.0035 0.0021 0.0031
Giardia lamblia 26S protease regulatory subunit 6A 0.0038 0.0074 0.0108
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0255 0.3687 0.3687
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0069 0.06 0.058
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0634 1 1
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0054 0.034 0.0468
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0038 0.0056
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.002
Schistosoma mansoni hypothetical protein 0.0155 0.2031 0.2013
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0273 0.3994 0.5839
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0038 0.0074 0.0108
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0257 0.3715 0.4469
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0051 0.0294 0.0401
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0054 0.0335 0.0461
Brugia malayi Proteasome subunit alpha type 1 0.0205 0.2854 0.2839
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0234 0.3335 0.3335
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0036 0.0038 0.0056
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0058 0.0416 0.058
Toxoplasma gondii heat shock protein hslv, putative 0.0177 0.2393 0.286
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0224 0.3179 0.3179
Giardia lamblia 20S proteasome alpha subunit 1 0.0257 0.3715 0.5443
Echinococcus granulosus subfamily T1A non peptidase ue 0.0255 0.3687 0.3687
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0059 0.0419 0.0585
Brugia malayi proteasome subunit beta type 1 0.0273 0.3994 0.3981
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0036 0.0038 0.0038
Entamoeba histolytica proteasome regulatory subunit, putative 0.0059 0.0419 0.0585
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0038 0.0074 0.0074
Brugia malayi proteasome subunit alpha type 4 0.0206 0.2869 0.2854
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0255 0.3687 0.4435
Brugia malayi 26S proteasome subunit P45 family protein 0.0036 0.0038 0.0017
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0035 0.0021 0.0031
Echinococcus multilocularis proteasome subunit alpha type 6 0.0257 0.3715 0.3715
Leishmania major proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0058 0.0416 0.0395
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0215 0.3016 0.4419
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0221 0.313 0.313
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0257 0.3715 0.3702
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0051 0.0294 0.0431
Loa Loa (eye worm) proteasome regulatory particle 0.0065 0.0519 0.0624
Trypanosoma brucei proteasome alpha 7 subunit 0.0237 0.3398 0.4979
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0234 0.3335 0.4887
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0069 0.06 0.06
Leishmania major proteasome beta 5 subunit, putative 0.0443 0.6826 1
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0069 0.06 0.058
Leishmania major proteasome alpha 2 subunit, putative 0.0243 0.3498 0.5124
Giardia lamblia 26S protease regulatory subunit 7 0.0035 0.0021 0.0031
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0224 0.3179 0.3179
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0036 0.0038 0.0017
Entamoeba histolytica proteasome regulatory subunit, putative 0.0051 0.0294 0.0401
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0234 0.3335 0.4871
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0243 0.3498 0.4192
Leishmania major proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0052 0.0309 0.0453
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0224 0.3179 0.4641
Giardia lamblia 20S proteasome alpha subunit 7 0.0237 0.3398 0.4979
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0058 0.0416 0.0609
Loa Loa (eye worm) PAS-3 protein 0.0206 0.2869 0.3451
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0237 0.3398 0.4979
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Leishmania major proteasome alpha 1 subunit, putative 0.0234 0.3335 0.4887
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0235 0.335 0.335
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0054 0.0335 0.0491
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0255 0.3687 0.5387
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0056 0.0082
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5387
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0036 0.0038 0.0056
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0591
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0038 0.0072 0.0051
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0046 0.0217 0.0287
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0221 0.313 0.4585
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0054 0.034 0.0319
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0065 0.0519 0.0498
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0065 0.0519 0.0519
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0243 0.3498 0.3484
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0443 0.6826 1
Giardia lamblia Proteasome subunit beta type 2 0.0224 0.3179 0.4658
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0237 0.3398 0.3384
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0058 0.0416 0.0416
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0051 0.0294 0.0401
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0035 0.0021 0.0031
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Giardia lamblia Proteasome subunit beta type 1 0.0273 0.3994 0.5852
Echinococcus multilocularis proteasome (prosome, macropain) 0.0443 0.6826 0.6826
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Toxoplasma gondii proteasome subunit alpha type, putative 0.0235 0.335 0.4014
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0054 0.034 0.0468
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0177 0.2393 0.5
Onchocerca volvulus Notchless protein homolog 0.0237 0.3398 0.6683
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0273 0.3994 0.5852
Loa Loa (eye worm) proteasome subunit beta type 2 0.0224 0.3179 0.3824
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0059 0.0419 0.0585
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0036 0.0038 0.0056
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0255 0.3687 0.3674
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0224 0.3179 0.4641
Brugia malayi proteasome subunit alpha type 1 0.0234 0.3335 0.3321
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0273 0.3994 0.3981
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0255 0.3687 0.3674
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Plasmodium falciparum proteasome subunit beta type-5 0.0443 0.6826 1
Giardia lamblia Proteasome subunit beta type 3 0.0224 0.3179 0.4658
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0234 0.3335 0.3997
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0059 0.0419 0.0614
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0054 0.034 0.0468
Brugia malayi PCI domain containing protein 0.0054 0.0335 0.0314
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0255 0.3687 0.5402
Toxoplasma gondii SAC3/GANP family protein 0.0051 0.0294 0.0329
Plasmodium falciparum proteasome subunit beta type-4 0.0221 0.313 0.4568
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0065 0.0519 0.076
Entamoeba histolytica hypothetical protein 0.0046 0.0217 0.0287
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0221 0.313 0.4585
Schistosoma mansoni hypothetical protein 0.0381 0.5795 0.5786
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0221 0.313 0.3115
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0443 0.6826 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0354
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0443 0.6826 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0051 0.0294 0.0273
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0533 0.8314 0.831
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0255 0.3687 0.4421
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.0025
Schistosoma mansoni proteasome regulatory subunit-related 0.0059 0.0419 0.0399
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0443 0.6826 1
Echinococcus multilocularis proteasome subunit beta type 7 0.0634 1 1
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0038 0.0074 0.0077
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0054 0.034 0.0319
Brugia malayi PCI domain containing protein 0.0059 0.0419 0.0399
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0036 0.0038 0.0038
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0054 0.0335 0.0491
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0051 0.0294 0.0431
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0224 0.3179 0.3164
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0322 0.4808 0.7035
Toxoplasma gondii PCI domain-containing protein 0.0065 0.0519 0.06
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0036 0.0038 0.0025
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0235 0.335 0.4892
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Entamoeba histolytica proteasome regulatory subunit, putative 0.0065 0.0519 0.0731
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0215 0.3016 0.4419
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0054 0.034 0.0468
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0155 0.2031 0.2031
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0533 0.8314 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Schistosoma mansoni hypothetical protein 0.0054 0.0335 0.0314
Brugia malayi Ubiquitin interaction motif family protein 0.0038 0.0072 0.0051
Toxoplasma gondii proteasome 26S regulatory subunit 0.0037 0.0056 0.0041
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0038 0.0072 0.0072
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0069 0.0591 0.0866
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0035 0.0021 0.0031
Giardia lamblia 20S proteasome alpha subunit 2 0.0243 0.3498 0.5124
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0069 0.0591 0.0866
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0058 0.0416 0.0476
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0058 0.0416 0.0395
Echinococcus granulosus adhesion regulating molecule 1 0.0533 0.8314 0.8314
Schistosoma mansoni 26S protease regulatory subunit 0.0036 0.0038 0.0017
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0226 0.3206 0.3191
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0235 0.3363 0.4911
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0046
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0273 0.3994 0.3994
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Entamoeba histolytica proteasome regulatory subunit, putative 0.0038 0.0072 0.0074
Trypanosoma cruzi 20S proteasome subunit 0.0224 0.3179 0.4658
Loa Loa (eye worm) RPT-2 protein 0.0036 0.0038 0.0046
Loa Loa (eye worm) proteasome Regulatory Particle 0.0058 0.0416 0.05
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0035 0.0021 0.0031
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0035 0.0021 0.0031
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0069 0.0591 0.0711
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0243 0.3498 0.5109
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0177 0.2393 0.3506
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0054 0.034 0.034
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0221 0.313 0.4568
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0177 0.2393 0.3486
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0069 0.0591 0.0866
Toxoplasma gondii PCI domain-containing protein 0.0069 0.06 0.0698
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0035 0.0021 0.0021
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0221 0.313 0.3748
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0257 0.3715 0.5443
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0035 0.0021 0.0031
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0051 0.0294 0.0273
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0322 0.4808 0.5784
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0026
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0177 0.2393 0.2377
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0338 0.5075 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0273 0.3994 0.4791
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0036 0.0038 0.0025
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0038 0.0074 0.0089
Giardia lamblia Hypothetical protein 0.0065 0.0519 0.076
Loa Loa (eye worm) proteasome subunit beta type 1 0.0273 0.3994 0.4805
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0038 0.0072 0.0106
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0224 0.3179 0.3164
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0224 0.3179 0.3808
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0221 0.313 0.313
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0054 0.034 0.0384
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0322 0.4808 0.7035
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0533 0.8314 0.831
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0036 0.0038 0.0038
Echinococcus granulosus 26S protease regulatory subunit 8 0.0035 0.0021 0.0021
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0224 0.3179 0.3179
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0235 0.335 0.4908
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4871
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0054 0.034 0.034
Loa Loa (eye worm) proteasome subunit beta type 3 0.0224 0.3179 0.3824
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0224 0.3179 0.4658
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0322 0.4808 0.7035
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0243 0.3498 0.5109
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Toxoplasma gondii proteasome subunit 0.0235 0.3363 0.403
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0054 0.034 0.0497
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0036 0.0038 0.0038
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0277 0.4063 0.594
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0069 0.06 0.06
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0083 0.0824 0.118
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0036 0.0038 0.0025
Giardia lamblia 20S proteasome alpha subunit 3 0.0235 0.335 0.4908
Brugia malayi 26S protease regulatory subunit 6A 0.0038 0.0074 0.0053
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0234 0.3335 0.3335
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0054 0.034 0.0319
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0035 0.0021 0.0026
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0035 0.0021 0.0031
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0054 0.034 0.0468
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0234 0.3335 0.3321
Toxoplasma gondii PCI domain-containing protein 0.0054 0.0335 0.0378
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0037 0.0056 0.005
Giardia lamblia 20S proteasome alpha subunit 4 0.0322 0.4808 0.7045
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0058 0.0416 0.0609
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0041 0.012 0.0145
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0155 0.2031 0.2031
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0069 0.0591 0.0571
Giardia lamblia 20S proteasome alpha subunit 5 0.0255 0.3687 0.5402
Onchocerca volvulus 0.0036 0.0038 0.0033
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0046 0.0217 0.0196
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0235 0.3363 0.4045
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0224 0.3179 0.4658
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0224 0.3179 0.3164
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0243 0.3498 0.4207
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0046 0.0217 0.0236
Brugia malayi Proteasome subunit alpha type 7-1 0.0322 0.4808 0.4797
Loa Loa (eye worm) proteasome 26S subunit 0.0035 0.0021 0.0026
Loa Loa (eye worm) RPN-3 protein 0.0069 0.06 0.0722
Trichomonas vaginalis 26S proteasome subunit, putative 0.0054 0.0335 0.0491
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0177 0.2393 0.3486
Trypanosoma brucei proteasome beta 6 subunit 0.0273 0.3994 0.5852
Plasmodium vivax proteasome subunit beta type-3, putative 0.0224 0.3179 0.4641
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0051 0.0294 0.0294
Toxoplasma gondii proteasome subunit alpha1, putative 0.0257 0.3715 0.4455
Loa Loa (eye worm) hypothetical protein 0.0533 0.8314 1
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0058 0.0416 0.0416
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0221 0.313 0.4585
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0224 0.3179 0.4641
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0234 0.3335 0.4012
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0235 0.3363 0.4911
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0054 0.0335 0.0335
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0065 0.0519 0.076
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0257 0.3715 0.5429
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0237 0.3398 0.4963
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0036 0.0038 0.0056
Echinococcus granulosus Proteasome subunit alpha beta 0.0237 0.3398 0.3398
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Echinococcus multilocularis adhesion regulating molecule 1 0.0533 0.8314 0.8314
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0038 0.0074 0.0074
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0036 0.0038 0.0025
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Plasmodium vivax proteasome subunit beta type-2, putative 0.0224 0.3179 0.4641
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0036 0.0038 0.0025
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0177 0.2393 0.3506
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0065 0.0519 0.0519
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0235 0.3363 0.3349
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0035 0.0021 0.0031
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0237 0.3398 0.4963
Brugia malayi 20S proteasome alpha5 subunit 0.0255 0.3687 0.3674
Brugia malayi Probable 26S protease regulatory subunit 4 0.0036 0.0038 0.0017
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0215 0.3016 0.3628
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0065 0.0519 0.0731
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0036 0.0038 0.0056
Leishmania major proteasome alpha 7 subunit, putative 0.0322 0.4808 0.7045
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0046 0.0217 0.0217
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0036 0.0038 0.0056
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0322 0.4808 0.7045
Leishmania major proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Mycobacterium ulcerans proteasome PrcB 0.0443 0.6826 1
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0215 0.3016 0.3612
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0038 0.0056
Brugia malayi Proteasome A-type and B-type family protein 0.0221 0.313 0.3115
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0177 0.2393 0.3506
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0591
Loa Loa (eye worm) PCI domain-containing protein 0.0054 0.0335 0.0403
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0177 0.2393 0.3506
Schistosoma mansoni multiubiquitin binding protein S5a 0.0038 0.0072 0.0051
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0065 0.0519 0.0731
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0059 0.0419 0.0614
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0065 0.0519 0.076
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0036 0.0038 0.002
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0054 0.034 0.0497
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0273 0.3994 0.3994
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0069 0.0591 0.0866
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0059 0.0419 0.0419
Echinococcus granulosus proteasome subunit beta type 7 0.0634 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0354
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0054 0.0335 0.0335
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0069 0.06 0.0879
Toxoplasma gondii proteasome subunit beta type, putative 0.0443 0.6826 0.8206
Plasmodium vivax proteasome subunit beta type-7, putative 0.0215 0.3016 0.4402
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0046 0.0217 0.0217
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0058 0.0416 0.0609
Brugia malayi proteasome subunit beta type 3 0.0224 0.3179 0.3164
Loa Loa (eye worm) hypothetical protein 0.0047 0.0229 0.0275
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5387
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0054 0.034 0.0497
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0273 0.3994 0.5839
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Loa Loa (eye worm) hypothetical protein 0.0381 0.5795 0.697
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0051 0.0294 0.0431
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0235 0.3363 0.4927
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0206 0.2875 0.4211
Brugia malayi Proteasome A-type and B-type family protein 0.0443 0.6826 0.6819
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0235 0.335 0.3336
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Echinococcus multilocularis proteasome subunit alpha type 2 0.0243 0.3498 0.3498
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0038 0.0074 0.0077
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0036 0.0038 0.0056
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0059 0.0419 0.0614
Giardia lamblia 20S proteasome alpha subunit 6 0.0234 0.3335 0.4887
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0069 0.0591 0.0837
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0235 0.3363 0.4927
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0443 0.6826 1
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0322 0.4808 0.4797
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0322 0.4808 0.7035
Brugia malayi Proteasome/cyclosome repeat family protein 0.0041 0.012 0.0099
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0069 0.06 0.058
Entamoeba histolytica proteasome regulatory subunit, putative 0.0069 0.06 0.085
Leishmania major proteasome alpha 1 subunit, putative 0.0257 0.3715 0.5443
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0257 0.3715 0.5429
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0443 0.6826 0.821
Toxoplasma gondii proteasome beta subunit 0.0224 0.3179 0.3808
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0177 0.2393 0.3486
Entamoeba histolytica proteasome regulatory subunit, putative 0.0054 0.0335 0.0461
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0443 0.6826 0.6819
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0054 0.034 0.0319
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0215 0.3016 0.4402
Plasmodium vivax proteasome subunit beta type-6, putative 0.0235 0.3363 0.4911
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0058 0.0416 0.0609
Leishmania major proteasome beta 7 subunit, putative 0.0221 0.313 0.4585
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0224 0.3179 0.4658
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0069 0.06 0.085
Toxoplasma gondii peptidase, T1 family protein 0.0237 0.3398 0.4073
Brugia malayi proteasome subunit alpha type 2 0.0243 0.3498 0.3484
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0069 0.0591 0.0571
Trypanosoma brucei proteasome beta 7 subunit 0.0221 0.313 0.4585
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0235 0.335 0.4908
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0038 0.0074 0.0063
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0235 0.335 0.4892
Echinococcus granulosus proteasome subunit beta t family 0.0224 0.3179 0.3179
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0443 0.6826 1
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0224 0.3179 0.4641
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0035 0.0021 0.0021
Leishmania major proteasome alpha 7 subunit, putative 0.0237 0.3398 0.4979
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0215 0.3016 0.4402
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0069 0.06 0.0879
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0221 0.313 0.4585
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0054 0.0335 0.0491
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0235 0.335 0.4892
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0065 0.0519 0.076
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0235 0.335 0.335
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0058 0.0416 0.058
Echinococcus granulosus proteasome prosome macropain 0.0443 0.6826 0.6826
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0381 0.5795 0.5786
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0054 0.034 0.034
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0255 0.3687 0.5387
Plasmodium vivax proteasome subunit beta type-4, putative 0.0221 0.313 0.4568
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0083 0.0824 0.1208
Echinococcus granulosus proteasome subunit alpha type 6 0.0257 0.3715 0.3715
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0215 0.3016 0.4419
Echinococcus granulosus Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0221 0.313 0.3764
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0036 0.0038 0.0056
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0046 0.0217 0.0287
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0038 0.0074 0.0053
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0234 0.3335 0.4887
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0038 0.0072 0.0106
Onchocerca volvulus 0.0036 0.0038 0.0033
Brugia malayi proteasome subunit alpha type 6 0.0257 0.3715 0.3702
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0215 0.3016 0.4419
Toxoplasma gondii hypothetical protein 0.0047 0.0229 0.025
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0038 0.0072 0.0072
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0059 0.0419 0.0614
Entamoeba histolytica proteasome regulatory subunit, putative 0.0058 0.0416 0.058
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0235 0.335 0.4892
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0059 0.0419 0.048
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0054 0.034 0.0497
Toxoplasma gondii proteasome subunit alpha type, putative 0.0145 0.1858 0.2215
Echinococcus granulosus proteasome subunit beta type 6 0.0235 0.3363 0.3363
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0054 0.034 0.0408
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0224 0.3179 0.4658
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0443 0.6826 1
Schistosoma mansoni 26S proteasome subunit S9 0.0065 0.0519 0.0498
Brugia malayi Proteasome A-type and B-type family protein 0.0235 0.3363 0.3349
Plasmodium vivax proteasome subunit beta type-5, putative 0.0443 0.6826 1
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0243 0.3498 0.5109
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0237 0.3398 0.4088
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0038 0.0073 0.0107
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0069 0.06 0.0879
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0041 0.012 0.0176
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0038 0.0074 0.0108
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0051 0.0294 0.0273
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0038 0.0074 0.0077
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0237 0.3398 0.3398
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0235 0.3363 0.4927
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0054 0.0335 0.0491
Leishmania major proteasome regulatory ATPase subunit 0.0035 0.0021 0.0031
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0038 0.0074 0.0108
Plasmodium vivax proteasome subunit beta type-1, putative 0.0273 0.3994 0.5839
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4871
Brugia malayi Proteasome/cyclosome repeat family protein 0.0041 0.012 0.0099
Echinococcus multilocularis proteasome subunit beta type 6 0.0235 0.3363 0.3363
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0035 0.0021 0.0021
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0051 0.0294 0.0431
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0443 0.6826 1
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0051 0.0294 0.0294
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0255 0.3687 0.5402
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0273 0.3994 0.5852
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0234 0.3335 0.4887
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0046
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0237 0.3398 0.4963
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0224 0.3179 0.3164
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0322 0.4808 0.4808
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0059 0.0419 0.0419
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0257 0.3715 0.5429
Brugia malayi proteasome subunit alpha type 3 0.0237 0.3398 0.3384

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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