Detailed information for compound 1551298

Basic information

Technical information
  • TDR Targets ID: 1551298
  • Name: N-(2-Methoxyphenyl)acetamide
  • MW: 165.189 | Formula: C9H11NO2
  • H donors: 1 H acceptors: 1 LogP: 1.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)C
  • InChi: 1S/C9H11NO2/c1-7(11)10-8-5-3-4-6-9(8)12-2/h3-6H,1-2H3,(H,10,11)
  • InChiKey: FGOFNVXHDGQVBG-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(2-methoxyphenyl)ethanamide
  • 93-26-5
  • ARONIS008418
  • SDCCGMLS-0033745.P002
  • 485063_ALDRICH
  • ZINC00282251
  • o-Methoxyacetanilide
  • 4-13-00-00833 (Beilstein Handbook Reference)
  • AI3-00799
  • BRN 2091808
  • EINECS 202-233-5
  • NSC 4004
  • AIDS-019952
  • AIDS019952
  • ALD-N009431
  • 2'-Methoxyacetanilide
  • 2-Methoxyacetanilide
  • Acetamide, N-(2-methoxyphenyl)-
  • Acetanilide, 2'-methoxy-
  • NSC4004
  • WLN: 1VMR BO1
  • o-Acetanisidide
  • o-Acetanisidine
  • MLS000105047
  • SMR000054976

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0056 0.034 0.034
Entamoeba histolytica proteasome regulatory subunit, putative 0.0056 0.0335 0.0461
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0223 0.3016 0.4419
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0335 0.4808 0.7045
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0247 0.3398 0.4979
Loa Loa (eye worm) PCI domain-containing protein 0.0061 0.0419 0.0443
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0039 0.0072 0.0072
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0056 0.034 0.0497
Loa Loa (eye worm) hypothetical protein 0.0053 0.0294 0.0311
Leishmania major proteasome alpha 7 subunit, putative 0.0247 0.3398 0.4979
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0223 0.3016 0.3187
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0335 0.4808 0.7045
Brugia malayi proteasome subunit alpha type 3 0.0247 0.3398 0.3384
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0037 0.0038 0.0025
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0061 0.0419 0.0614
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0072 0.0591 0.0624
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0061 0.0419 0.0421
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0223 0.3016 0.4419
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0233 0.3179 0.3179
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0335 0.4808 0.7035
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0243 0.3335 0.4871
Brugia malayi Proteasome A-type and B-type family protein 0.023 0.313 0.3115
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0284 0.3994 0.5852
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0184 0.2393 0.3506
Giardia lamblia 26S protease regulatory subunit 6A 0.0039 0.0074 0.0108
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0245 0.3363 0.4927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0327 0.0306
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0245 0.3363 0.4927
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0037 0.0038 0.0038
Trypanosoma cruzi 20S proteasome subunit 0.0233 0.3179 0.4658
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0244 0.335 0.335
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0247 0.3398 0.4979
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0061 0.0416 0.0609
Leishmania major proteasome beta 2 subunit, putative 0.0223 0.3016 0.4419
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0054 0.0309 0.0453
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0056 0.0335 0.0335
Entamoeba histolytica proteasome regulatory subunit, putative 0.0067 0.0519 0.0731
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0056 0.034 0.0497
Giardia lamblia 26S protease regulatory subunit 6B 0.0037 0.0038 0.0056
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0056 0.0335 0.0491
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0223 0.3016 0.3171
Echinococcus multilocularis proteasome subunit alpha type 2 0.0253 0.3498 0.3498
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0067 0.0519 0.076
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0056 0.0335 0.0491
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0265 0.3687 0.5402
Echinococcus granulosus proteasome subunit alpha type 6 0.0267 0.3715 0.3715
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0061 0.0416 0.0609
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0184 0.2393 0.3486
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0067 0.0519 0.076
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0244 0.335 0.3336
Toxoplasma gondii proteasome subunit alpha1, putative 0.0267 0.3715 0.3911
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0039 0.0074 0.0108
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0284 0.3994 0.5852
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0056 0.0335 0.0461
Echinococcus granulosus proteasome subunit alpha type 2 0.0253 0.3498 0.3498
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0072 0.06 0.085
Brugia malayi proteasome subunit alpha type 1 0.0243 0.3335 0.3321
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0072 0.06 0.058
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0461 0.6826 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0048 0.0217 0.0318
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0335 0.4808 0.7035
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0037 0.0038 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0023
Echinococcus granulosus proteasome subunit beta type 6 0.0245 0.3363 0.3363
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0244 0.335 0.4908
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0072 0.0591 0.0571
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0284 0.3994 0.5839
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0056 0.0335 0.0461
Toxoplasma gondii PCI domain-containing protein 0.0067 0.0519 0.0527
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.023 0.313 0.4585
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0039 0.0072 0.0106
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0053 0.0294 0.0431
Echinococcus granulosus Proteasome subunit alpha type 7 0.0335 0.4808 0.4808
Brugia malayi proteasome subunit beta type 2 0.0233 0.3179 0.3164
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0243 0.3335 0.3335
Plasmodium vivax proteasome subunit beta type-5, putative 0.0461 0.6826 1
Leishmania major proteasome beta 5 subunit, putative 0.0461 0.6826 1
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0626 0.9465 1
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0233 0.3179 0.4641
Leishmania major proteasome alpha 7 subunit, putative 0.0335 0.4808 0.7045
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0233 0.3179 0.4658
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0056 0.034 0.0337
Plasmodium vivax proteasome subunit beta type-3, putative 0.0233 0.3179 0.4641
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0243 0.3335 0.4887
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0037 0.0038 0.0056
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1004 0.1471
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0072 0.0591 0.0837
Schistosoma mansoni hypothetical protein 0.0162 0.2031 0.2013
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0056 0.034 0.0319
Entamoeba histolytica hypothetical protein 0.0048 0.0217 0.0287
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0265 0.3687 0.3882
Toxoplasma gondii PCI domain-containing protein 0.0056 0.0335 0.0332
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0184 0.2393 0.2377
Giardia lamblia Proteasome subunit beta type 1 0.0284 0.3994 0.5852
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.023 0.313 0.4585
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0056 0.034 0.0359
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0244 0.335 0.4908
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0061 0.0416 0.058
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0061 0.0419 0.0614
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0253 0.3498 0.3695
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0223 0.3016 0.4402
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0056 0.0335 0.0491
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0039 0.0074 0.0108
Echinococcus multilocularis proteasome (prosome, macropain) 0.0461 0.6826 0.6826
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0233 0.3179 0.4658
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0284 0.3994 0.5852
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0039 0.0074 0.0074
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0233 0.3179 0.3179
Loa Loa (eye worm) proteasome subunit beta type 1 0.0284 0.3994 0.422
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0037 0.0038 0.0038
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0247 0.3398 0.4979
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0072 0.0074
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0038 0.0056 0.0082
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0072 0.0591 0.0866
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0267 0.3715 0.5443
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0039 0.0074 0.0108
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0072 0.0591 0.0866
Loa Loa (eye worm) PCI domain-containing protein 0.0056 0.0335 0.0354
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0265 0.3687 0.5402
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0247 0.3398 0.4963
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0039 0.0074 0.0053
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0184 0.2393 0.3506
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0245 0.3363 0.4911
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0253 0.3498 0.5109
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.023 0.313 0.4585
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0061 0.0419 0.0419
Giardia lamblia 20S proteasome alpha subunit 7 0.0247 0.3398 0.4979
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0327 0.0345
Brugia malayi proteasome subunit alpha type 2 0.0253 0.3498 0.3484
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.023 0.313 0.4585
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0072 0.0591 0.0591
Giardia lamblia Proteasome subunit beta type 2 0.0233 0.3179 0.4658
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0244 0.335 0.335
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0039 0.0072 0.0106
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0039 0.0074 0.0108
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0233 0.3179 0.3164
Schistosoma mansoni proteasome regulatory subunit-related 0.0061 0.0419 0.0399
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0067 0.0519 0.0731
Echinococcus granulosus proteasome subunit beta t family 0.0233 0.3179 0.3179
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0037 0.0038 0.0056
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0037 0.0038 0.0018
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0061 0.0416 0.0609
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0056 0.034 0.034
Echinococcus granulosus adhesion regulating molecule 1 0.0626 0.9465 0.9465
Echinococcus granulosus subfamily T1A non peptidase ue 0.0265 0.3687 0.3687
Brugia malayi PCI domain containing protein 0.0061 0.0419 0.0399
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0244 0.335 0.4908
Toxoplasma gondii proteasome subunit alpha type, putative 0.0244 0.335 0.3525
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0335 0.4808 0.7045
Toxoplasma gondii proteasome subunit beta type, putative 0.0461 0.6826 0.7205
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0072 0.0591 0.0866
Brugia malayi Proteasome/cyclosome repeat family protein 0.0042 0.012 0.0099
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0072 0.0591 0.0591
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0184 0.2393 0.5
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0053 0.0294 0.0431
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0223 0.3016 0.4419
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0267 0.3715 0.3925
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0253 0.3498 0.3681
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0056 0.034 0.0319
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0056 0.034 0.0468
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0335 0.4808 0.4808
Plasmodium falciparum proteasome subunit beta type-4 0.023 0.313 0.4568
Brugia malayi proteasome subunit alpha type 6 0.0267 0.3715 0.3702
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0039 0.0074 0.0074
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0067 0.0519 0.0519
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0067 0.0519 0.0731
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0037 0.0038 0.0056
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0335 0.4808 0.4797
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0061 0.0416 0.058
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0267 0.3715 0.5429
Toxoplasma gondii proteasome subunit 0.0245 0.3363 0.3538
Brugia malayi Ubiquitin interaction motif family protein 0.0039 0.0072 0.0051
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0233 0.3179 0.4658
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0461 0.6826 1
Onchocerca volvulus Notchless protein homolog 0.0247 0.3398 0.5838
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0067 0.0519 0.0519
Loa Loa (eye worm) proteasome 26S subunit 0.0036 0.0021 0.0023
Brugia malayi Proteasome A-type and B-type family protein 0.0461 0.6826 0.6819
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0037 0.0038 0.0018
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0253 0.3498 0.5109
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.023 0.313 0.4585
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0061 0.0416 0.0609
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0223 0.3016 0.4419
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0056 0.034 0.0468
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0098 0.1004 0.1444
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0072 0.06 0.0879
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0048 0.0217 0.0196
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0244 0.335 0.4892
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0048 0.0217 0.0287
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0223 0.3016 0.4419
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0056 0.034 0.0497
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0053 0.0294 0.0294
Plasmodium falciparum proteasome subunit beta type-5 0.0461 0.6826 1
Toxoplasma gondii SAC3/GANP family protein 0.0053 0.0294 0.0289
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0056 0.034 0.0319
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0061 0.0416 0.0416
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0267 0.3715 0.5429
Schistosoma mansoni hypothetical protein 0.0056 0.0335 0.0314
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0214 0.2875 0.4211
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0056 0.034 0.0497
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0461 0.6826 0.6819
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0267 0.3715 0.5443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0327 0.0306
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0335 0.4808 0.4808
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0048 0.0217 0.0217
Leishmania major 26S protease regulatory subunit, putative,serine peptidase, Clan SJ, family S16, putative 0.0036 0.0021 0.0031
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0233 0.3179 0.4641
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0245 0.3363 0.4927
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0233 0.3179 0.3344
Trypanosoma cruzi serine peptidase, Clan SJ, family S16, putative 0.0036 0.0021 0.0031
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.023 0.313 0.313
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0265 0.3687 0.5402
Echinococcus granulosus proteasome subunit beta type 7 0.066 1 1
Trypanosoma brucei proteasome beta 6 subunit 0.0284 0.3994 0.5852
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.023 0.313 0.3115
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0039 0.0074 0.0053
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0039 0.0074 0.0078
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0037 0.0038 0.0056
Schistosoma mansoni 26S protease regulatory subunit 0.0037 0.0038 0.0017
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0056 0.034 0.0468
Loa Loa (eye worm) hypothetical protein 0.0049 0.0229 0.0241
Toxoplasma gondii proteasome regulatory subunit 0.0056 0.034 0.0337
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0461 0.6826 1
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0184 0.2393 0.3486
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0061 0.0416 0.0416
Loa Loa (eye worm) proteasome subunit beta type 3 0.0233 0.3179 0.3359
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0184 0.2393 0.3486
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0247 0.3398 0.3398
Echinococcus multilocularis proteasome subunit beta type 7 0.066 1 1
Brugia malayi Proteasome subunit alpha type 1 0.0213 0.2854 0.2839
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0061 0.0419 0.0419
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0048 0.0217 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0327 0.0306
Trypanosoma brucei protease regulatory ATPase subunit 4 0.0036 0.0021 0.0031
Leishmania major proteasome beta-1 subunit, putative 0.0245 0.3363 0.4927
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0037 0.0038 0.0025
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0184 0.2393 0.3506
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0067 0.0519 0.0498
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0233 0.3179 0.4658
Giardia lamblia 20S proteasome alpha subunit 2 0.0253 0.3498 0.5124
Entamoeba histolytica proteasome regulatory subunit, putative 0.0061 0.0419 0.0585
Brugia malayi Probable 26S protease regulatory subunit 4 0.0037 0.0038 0.0017
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0245 0.3363 0.3553
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0072 0.0591 0.0866
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0056 0.034 0.0468
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0072 0.06 0.06
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.023 0.313 0.3306
Loa Loa (eye worm) PAS-3 protein 0.0214 0.2869 0.3031
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0067 0.0519 0.076
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0037 0.0038 0.0025
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0053 0.0294 0.0431
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0042 0.012 0.0176
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0037 0.0038 0.0025
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0233 0.3179 0.4641
Echinococcus granulosus proteasome prosome macropain 0.0461 0.6826 0.6826
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0253 0.3498 0.3484
Echinococcus multilocularis 26S protease regulatory subunit 8 0.0036 0.0021 0.0021
Trypanosoma brucei proteasome alpha 7 subunit 0.0247 0.3398 0.4979
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0039 0.0074 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0038 0.004
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0397 0.5795 0.5786
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0245 0.3363 0.4911
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0056 0.034 0.0319
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0284 0.3994 0.3981
Loa Loa (eye worm) proteasome regulatory particle 0.0067 0.0519 0.0548
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0267 0.3715 0.3702
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0053 0.0294 0.0431
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0245 0.3363 0.3349
Onchocerca volvulus 0.0037 0.0038 0.0029
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0037 0.0038 0.0056
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0067 0.0519 0.076
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243 0.3335 0.4887
Leishmania major proteasome alpha 2 subunit, putative 0.0253 0.3498 0.5124
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0037 0.0038 0.0038
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0162 0.2031 0.2031
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0233 0.3179 0.3164
Giardia lamblia 20S proteasome alpha subunit 4 0.0335 0.4808 0.7045
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0037 0.0038 0.0056
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0247 0.3398 0.4963
Toxoplasma gondii proteasome beta subunit 0.0233 0.3179 0.3344
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0037 0.0038 0.0056
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1004 0.1471
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0053 0.0294 0.0273
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0461 0.6826 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0233 0.3179 0.3164
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0036 0.0021 0.0023
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0037 0.0038 0.0038
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0061 0.0416 0.0418
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0072 0.06 0.06
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.023 0.313 0.3291
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0056 0.034 0.034
Trypanosoma cruzi 26S protease regulatory subunit, putative 0.0036 0.0021 0.0031
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0243 0.3335 0.4887
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0233 0.3179 0.4641
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0267 0.3715 0.5443
Trypanosoma brucei Regulatory particle triple-A ATPase subunit 6 0.0036 0.0021 0.0031
Leishmania major proteasome beta 2 subunit, putative 0.0233 0.3179 0.4658
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.066 1 1
Echinococcus multilocularis proteasome subunit beta type 6 0.0245 0.3363 0.3363
Echinococcus multilocularis 26s protease regulatory subunit s10b 0.0036 0.0021 0.0021
Loa Loa (eye worm) proteasome Regulatory Particle 0.0061 0.0416 0.0439
Toxoplasma gondii hypothetical protein 0.0049 0.0229 0.0219
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0037 0.0038 0.0056
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0265 0.3687 0.5402
Toxoplasma gondii proteasome 26S regulatory subunit 0.0038 0.0056 0.0036
Leishmania major proteasome beta 3 subunit, putative 0.0233 0.3179 0.4658
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0243 0.3335 0.3524
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0072 0.0591 0.0571
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0053 0.0294 0.0431
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0233 0.3179 0.3164
Giardia lamblia Proteasome subunit beta type 3 0.0233 0.3179 0.4658
Giardia lamblia Hypothetical protein 0.0067 0.0519 0.076
Schistosoma mansoni hypothetical protein 0.0397 0.5795 0.5786
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0056 0.034 0.0497
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0247 0.3398 0.3591
Plasmodium vivax proteasome subunit beta type-6, putative 0.0245 0.3363 0.4911
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0072 0.06 0.058
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0247 0.3398 0.4963
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0265 0.3687 0.3674
Brugia malayi proteasome subunit beta type 1 0.0284 0.3994 0.3981
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0265 0.3687 0.3895
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0072 0.0591 0.0571
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0267 0.3715 0.5429
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0056 0.034 0.0468
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0056 0.0335 0.0335
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0072 0.0591 0.0571
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0335 0.4808 0.7045
Toxoplasma gondii peptidase, T1 family protein 0.0247 0.3398 0.3576
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0335 0.4808 0.7035
Plasmodium vivax proteasome subunit beta type-7, putative 0.0223 0.3016 0.4402
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0039 0.0072 0.0072
Leishmania major proteasome beta 7 subunit, putative 0.023 0.313 0.4585
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0253 0.3498 0.5109
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1004 0.1471
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0037 0.0038 0.0056
Giardia lamblia 20S proteasome alpha subunit 3 0.0244 0.335 0.4908
Giardia lamblia 20S proteasome alpha subunit 6 0.0243 0.3335 0.4887
Onchocerca volvulus 0.0037 0.0038 0.0029
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0039 0.0074 0.0056
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0039 0.0073 0.0107
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0072 0.0591 0.0866
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0265 0.3687 0.5387
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0247 0.3398 0.3384
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0265 0.3687 0.5387
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0061 0.0419 0.0585
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0245 0.3363 0.4927
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0233 0.3179 0.4658
Leishmania major proteasome alpha 1 subunit, putative 0.0267 0.3715 0.5443
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0626 0.9465 0.9464
Trypanosoma brucei proteasome beta 7 subunit 0.023 0.313 0.4585
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0233 0.3179 0.4658
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0284 0.3994 0.5852
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0461 0.6826 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0061 0.0419 0.0614
Entamoeba histolytica proteasome regulatory subunit, putative 0.0061 0.0416 0.058
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0053 0.0294 0.0294
Brugia malayi proteasome subunit beta type 3 0.0233 0.3179 0.3164
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0267 0.3715 0.5443
Loa Loa (eye worm) proteasome subunit beta type 2 0.0233 0.3179 0.3359
Leishmania major proteasome alpha 1 subunit, putative 0.0243 0.3335 0.4887
Brugia malayi 26S proteasome subunit P45 family protein 0.0037 0.0038 0.0017
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0461 0.6826 0.7211
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0398 0.5806 1
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0039 0.0074 0.0077
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0223 0.3016 0.4402
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0243 0.3335 0.3335
Leishmania major proteasome regulatory ATPase subunit 0.0036 0.0021 0.0031
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0461 0.6826 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0294 0.0311
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0036 0.0021 0.0031
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0162 0.2031 0.2031
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0039 0.0072 0.0051
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0233 0.3179 0.4658
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0036 0.0021 0.0031
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0039 0.0074 0.0108
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0244 0.335 0.4892
Giardia lamblia 20S proteasome alpha subunit 5 0.0265 0.3687 0.5402
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0253 0.3498 0.5124
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0061 0.0419 0.0585
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0265 0.3687 0.3687
Giardia lamblia 26S protease regulatory subunit 8 0.0036 0.0021 0.0031
Schistosoma mansoni 26S proteasome subunit S9 0.0067 0.0519 0.0498
Brugia malayi Proteasome/cyclosome repeat family protein 0.0042 0.012 0.0099
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.023 0.313 0.313
Brugia malayi Proteasome subunit alpha type 7-1 0.0335 0.4808 0.4797
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0184 0.2393 0.3506
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0245 0.3363 0.4927
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0335 0.4808 0.7035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0327 0.0327
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0284 0.3994 0.3994
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0061 0.0416 0.0395
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0235 0.3206 0.3191
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0037 0.0038 0.0025
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0037 0.0038 0.0025
Entamoeba histolytica proteasome regulatory subunit, putative 0.0072 0.06 0.085
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0053 0.0294 0.0273
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0243 0.3335 0.3509
Loa Loa (eye worm) RPT-2 protein 0.0037 0.0038 0.004
Toxoplasma gondii proteasome subunit alpha type, putative 0.0151 0.1858 0.1945
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0053 0.0294 0.0431
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0244 0.335 0.4908
Giardia lamblia 20S proteasome alpha subunit 1 0.0267 0.3715 0.5443
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0233 0.3179 0.4658
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1004 0.1471
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0039 0.0072 0.0106
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0072 0.06 0.058
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0048 0.0217 0.0207
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0061 0.0416 0.0609
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0326 0.4663 0.6822
Loa Loa (eye worm) hypothetical protein 0.0037 0.0038 0.004
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0061 0.0416 0.0395
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0056 0.034 0.0359
Loa Loa (eye worm) hypothetical protein 0.0397 0.5795 0.6122
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0247 0.3398 0.4963
Entamoeba histolytica proteasome regulatory subunit, putative 0.0053 0.0294 0.0401
Echinococcus multilocularis adhesion regulating molecule 1 0.0626 0.9465 0.9465
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.023 0.313 0.4568
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0265 0.3687 0.5387
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0061 0.0419 0.0614
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0327 0.0327
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0223 0.3016 0.4419
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0039 0.0074 0.0077
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0039 0.0074 0.0077
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0072 0.06 0.0879
Brugia malayi 20S proteasome alpha5 subunit 0.0265 0.3687 0.3674
Plasmodium vivax proteasome subunit beta type-1, putative 0.0284 0.3994 0.5839
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0335 0.4808 0.4808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0327 0.0327
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0265 0.3687 0.3674
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1004 0.1471
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0233 0.3179 0.3179
Loa Loa (eye worm) hypothetical protein 0.0626 0.9465 1
Echinococcus multilocularis proteasome subunit alpha type 6 0.0267 0.3715 0.3715
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0284 0.3994 0.4207
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0053 0.0294 0.0401
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.023 0.313 0.4585
Schistosoma mansoni multiubiquitin binding protein S5a 0.0039 0.0072 0.0051
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0048 0.0217 0.0287
Leishmania major proteasome alpha 3 subunit, putative 0.0244 0.335 0.4908
Giardia lamblia 26S protease regulatory subunit 7 0.0036 0.0021 0.0031
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0265 0.3687 0.5402
Toxoplasma gondii heat shock protein hslv, putative 0.0184 0.2393 0.2512
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0056 0.034 0.0497
Echinococcus granulosus Proteasome subunit alpha beta 0.0247 0.3398 0.3398
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0335 0.4808 0.508
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0056 0.0335 0.0491
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0098 0.1004 0.1471
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0037 0.0038 0.0056
Plasmodium vivax proteasome subunit beta type-4, putative 0.023 0.313 0.4568
Giardia lamblia Proteasome subunit beta type 4 precursor 0.023 0.313 0.4585
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0284 0.3994 0.3994
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0056 0.034 0.0468
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0056 0.034 0.034
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0461 0.6826 1
Loa Loa (eye worm) RPN-3 protein 0.0072 0.06 0.0634
Trichomonas vaginalis 26S proteasome subunit, putative 0.0056 0.0335 0.0491
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0243 0.3335 0.4871
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0038 0.0056 0.005
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0072 0.06 0.0879
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0265 0.3687 0.5387
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0042 0.012 0.0127
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0243 0.3335 0.4871
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.023 0.313 0.4585
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0053 0.0294 0.0401
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0253 0.3498 0.5124
Plasmodium vivax proteasome subunit beta type-2, putative 0.0233 0.3179 0.4641
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0461 0.6826 1
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0037 0.0038 0.0056
Brugia malayi Proteasome A-type and B-type family protein 0.0245 0.3363 0.3349
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0327 0.0306
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0244 0.335 0.4892
Trypanosoma cruzi 19S proteasome regulatory subunit 0.0036 0.0021 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0327 0.0327
Brugia malayi proteasome subunit alpha type 4 0.0214 0.2869 0.2854
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0244 0.335 0.4892
Leishmania major hypothetical protein, conserved 0.0326 0.4663 0.6832
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0072 0.0591 0.0837
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0243 0.3335 0.3321
Brugia malayi PCI domain containing protein 0.0056 0.0335 0.0314
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.023 0.313 0.4585
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0626 0.9465 0.9464
Brugia malayi 26S protease regulatory subunit 6A 0.0039 0.0074 0.0053
Echinococcus granulosus 26S protease regulatory subunit 8 0.0036 0.0021 0.0021
Mycobacterium ulcerans proteasome PrcB 0.0461 0.6826 1
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0053 0.0294 0.0273
Toxoplasma gondii PCI domain-containing protein 0.0072 0.06 0.0613
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0037 0.0038 0.0056
Echinococcus granulosus 26s protease regulatory subunit s10b 0.0036 0.0021 0.0021
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0284 0.3994 0.5839

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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