Detailed information for compound 1551301

Basic information

Technical information
  • TDR Targets ID: 1551301
  • Name: (1,3-dioxoisoindol-2-yl)methyl 2-[(2,4-dichlo robenzoyl)amino]acetate
  • MW: 407.204 | Formula: C18H12Cl2N2O5
  • H donors: 1 H acceptors: 4 LogP: 3.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccc(cc1Cl)Cl)OCN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C18H12Cl2N2O5/c19-10-5-6-13(14(20)7-10)16(24)21-8-15(23)27-9-22-17(25)11-3-1-2-4-12(11)18(22)26/h1-7H,8-9H2,(H,21,24)
  • InChiKey: PAOPAMPPXRTONK-UHFFFAOYSA-N  

Network

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Synonyms

  • (1,3-dioxoisoindolin-2-yl)methyl 2-[(2,4-dichlorobenzoyl)amino]acetate
  • 2-[[(2,4-dichlorophenyl)-oxomethyl]amino]acetic acid (1,3-dioxo-2-isoindolinyl)methyl ester
  • 2-[(2,4-dichlorobenzoyl)amino]acetic acid (1,3-diketoisoindolin-2-yl)methyl ester
  • (1,3-dioxoisoindol-2-yl)methyl 2-[(2,4-dichlorophenyl)carbonylamino]ethanoate
  • ZINC05991470
  • T5511722

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium vivax proteasome subunit beta type-2, putative 0.0108 0.3164 0.4641
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0113 0.3336 0.4892
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0033 0.0562 0.0562
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0108 0.3164 0.3164
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0025 0.0289 0.0423
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0108 0.3164 0.4641
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0017 0.0017 0.0025
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0273 0.0273
Brugia malayi Probable 26S protease regulatory subunit 4 0.0017 0.0017 0.0017
Brugia malayi 20S proteasome alpha5 subunit 0.0123 0.3674 0.3674
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0108 0.3164 0.3164
Echinococcus multilocularis proteasome subunit alpha type 6 0.0124 0.3702 0.3702
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0319 0.0319
Leishmania major proteasome alpha 3 subunit, putative 0.0113 0.3336 0.4892
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0371 0.0371
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0109 0.3191 0.3191
Echinococcus multilocularis proteasome subunit beta type 7 0.0306 1 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0114 0.3349 0.4911
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0156 0.4797 0.7035
Echinococcus granulosus adhesion regulating molecule 1 0.0164 0.5071 0.5071
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0115 0.3384 0.3384
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0107 0.3115 0.4568
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0118 0.3484 0.5109
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0018 0.0034 0.005
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0104 0.3001 0.4402
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0395 0.058
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0124 0.3702 0.5429
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0034 0.058 0.085
Trichomonas vaginalis 26S proteasome subunit, putative 0.0026 0.0314 0.0461
Trypanosoma brucei proteasome alpha 7 subunit 0.0115 0.3384 0.4963
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0034 0.058 0.058
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0037 0.0703 0.1031
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0124 0.3702 0.3702
Loa Loa (eye worm) proteasome subunit beta type 1 0.0132 0.3981 0.5839
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0123 0.3674 0.5387
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0026 0.0319 0.0468
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.0498 0.0731
Echinococcus multilocularis adhesion regulating molecule 1 0.0164 0.5071 0.5071
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0114 0.3349 0.4911
Leishmania major proteasome alpha 7 subunit, putative 0.0115 0.3384 0.4963
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0123 0.3674 0.3674
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0123 0.3674 0.5387
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0118 0.3484 0.3484
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0028 0.0371 0.0543
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0018 0.0053 0.0077
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0017 0.0017 0.0017
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0018 0.0052 0.0076
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0034 0.058 0.058
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0113 0.3336 0.4892
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0113 0.3321 0.4871
Schistosoma mansoni 26S protease regulatory subunit 0.0017 0.0017 0.0017
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0703 0.0703
Brugia malayi Proteasome A-type and B-type family protein 0.0107 0.3115 0.3115
Echinococcus granulosus geminin 0.0205 0.6488 0.6488
Giardia lamblia 20S proteasome alpha subunit 3 0.0113 0.3336 0.4892
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0018 0.0051 0.0051
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0273 0.0273
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0113 0.3336 0.4892
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0108 0.3164 0.4641
Toxoplasma gondii proteasome subunit alpha1, putative 0.0124 0.3702 0.5429
Schistosoma mansoni hypothetical protein 0.0184 0.5786 0.5786
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0017 0.0017 0.0025
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0214 0.6819 0.6819
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0214 0.6819 1
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0028 0.0399 0.0585
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0108 0.3164 0.4641
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0399 0.0585
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0025 0.0273 0.0273
Mycobacterium ulcerans proteasome PrcB 0.0214 0.6819 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.3115 0.4568
Brugia malayi proteasome subunit alpha type 6 0.0124 0.3702 0.3702
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0108 0.3164 0.4641
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0114 0.3349 0.4911
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0156 0.4797 0.4797
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0108 0.3164 0.4641
Leishmania major proteasome alpha 2 subunit, putative 0.0118 0.3484 0.5109
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0028 0.0399 0.0399
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0108 0.3164 0.4641
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0017 0.0017 0.0025
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0033 0.0562 0.0824
Brugia malayi Proteasome A-type and B-type family protein 0.0114 0.3349 0.3349
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0114 0.3349 0.4911
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0033 0.0562 0.0824
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0017 0.0017 0.0025
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0086 0.2377 0.3486
Brugia malayi Proteasome/cyclosome repeat family protein 0.0028 0.0371 0.0371
Brugia malayi proteasome subunit alpha type 4 0.0099 0.2854 0.2854
Echinococcus granulosus proteasome subunit beta type 7 0.0306 1 1
Brugia malayi proteasome subunit alpha type 3 0.0115 0.3384 0.3384
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0108 0.3164 0.3164
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0086 0.2377 0.3486
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0026 0.0314 0.0461
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0273 0.0401
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0214 0.6819 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0028 0.0399 0.0585
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0086 0.2377 0.3486
Onchocerca volvulus Notchless protein homolog 0.0115 0.3384 1
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0118 0.3484 0.5109
Plasmodium vivax proteasome subunit beta type-6, putative 0.0114 0.3349 0.4911
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0164 0.5071 0.5071
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0017 0.0025
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0053 0.0053
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0017 0.0017 0.0017
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0025 0.03 0.044
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0018 0.0053 0.0053
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0017 0.0017 0.0025
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0031 0.0498 0.0731
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0108 0.3164 0.4641
Leishmania major proteasome beta 5 subunit, putative 0.0214 0.6819 1
Leishmania major proteasome beta 2 subunit, putative 0.0104 0.3001 0.4402
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0107 0.3115 0.4568
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0034 0.058 0.058
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0028 0.0399 0.0585
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0118 0.3484 0.5109
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0086 0.2377 0.3486
Onchocerca volvulus 0.0017 0.0017 0.005
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0017 0.0017 0.0025
Onchocerca volvulus 0.0017 0.0017 0.005
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0113 0.3321 0.4871
Loa Loa (eye worm) proteasome regulatory particle 0.0031 0.0498 0.0731
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0114 0.3349 0.3349
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0033 0.0562 0.0562
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0026 0.0319 0.0319
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0132 0.3981 0.3981
Toxoplasma gondii SAC3/GANP family protein 0.0025 0.0273 0.0401
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0124 0.3702 0.5429
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0395 0.0395
Trypanosoma brucei proteasome beta 7 subunit 0.0107 0.3115 0.4568
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0037 0.0703 0.1031
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0017 0.0017 0.0025
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0108 0.3164 0.3164
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0025 0.03 0.044
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0184 0.5786 0.5786
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0075 0.2013 0.2013
Loa Loa (eye worm) proteasome subunit beta type 2 0.0108 0.3164 0.4641
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0115 0.3384 0.4963
Loa Loa (eye worm) hypothetical protein 0.0164 0.5071 0.7437
Loa Loa (eye worm) RPT-2 protein 0.0017 0.0017 0.0025
Giardia lamblia Proteasome subunit beta type 2 0.0108 0.3164 0.4641
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0123 0.3674 0.5387
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0028 0.0395 0.058
Toxoplasma gondii heat shock protein hslv, putative 0.0086 0.2377 0.3486
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0273 0.0273
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0113 0.3336 0.3336
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0025 0.0273 0.0401
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0132 0.3981 0.5839
Brugia malayi 26S protease regulatory subunit 6A 0.0018 0.0053 0.0053
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0107 0.3115 0.3115
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0108 0.3164 0.4641
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0124 0.3702 0.5429
Plasmodium falciparum proteasome subunit beta type-5 0.0214 0.6819 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0319 0.0468
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0113 0.3336 0.3336
Loa Loa (eye worm) hypothetical protein 0.0184 0.5786 0.8485
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0703 0.1031
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0314 0.0461
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0107 0.3115 0.4568
Brugia malayi proteasome subunit beta type 1 0.0132 0.3981 0.3981
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0026 0.0314 0.0461
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0319 0.0468
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0037 0.0703 0.0703
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0156 0.4797 0.7035
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0115 0.3384 0.4963
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.3115 0.4568
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0017 0.0017 0.0025
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0113 0.3321 0.4871
Toxoplasma gondii proteasome regulatory subunit 0.0026 0.0319 0.0468
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.2859 0.4193
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0026 0.0319 0.0468
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0118 0.3484 0.5109
Leishmania major proteasome beta 3 subunit, putative 0.0108 0.3164 0.4641
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0214 0.6819 1
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0017 0.0017 0.0025
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0114 0.3349 0.4911
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0273 0.0401
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0113 0.3321 0.4871
Leishmania major proteasome beta 7 subunit, putative 0.0107 0.3115 0.4568
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0051 0.0051
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0123 0.3674 0.5387
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0017 0.0017 0.0025
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.058 0.058
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0037 0.0703 0.1031
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0132 0.3981 0.5839
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0017 0.0017 0.0025
Echinococcus granulosus proteasome prosome macropain 0.0214 0.6819 0.6819
Toxoplasma gondii proteasome 26S regulatory subunit 0.0018 0.0034 0.005
Plasmodium vivax proteasome subunit beta type-5, putative 0.0214 0.6819 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0273 0.0401
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0028 0.0399 0.0399
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.3115 0.4568
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0156 0.4797 0.7035
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0113 0.3336 0.4892
Giardia lamblia 20S proteasome alpha subunit 6 0.0113 0.3321 0.4871
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0034 0.058 0.085
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0156 0.4797 0.7035
Leishmania major proteasome beta-1 subunit, putative 0.0114 0.3349 0.4911
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0086 0.2377 0.5
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0026 0.0314 0.0314
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0031 0.0498 0.0731
Giardia lamblia 20S proteasome alpha subunit 5 0.0123 0.3674 0.5387
Echinococcus granulosus Proteasome subunit alpha type 7 0.0156 0.4797 0.4797
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0107 0.3115 0.3115
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0018 0.0053 0.0077
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0018 0.0053 0.0053
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0113 0.3336 0.4892
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0028 0.0395 0.0395
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0123 0.3674 0.3674
Echinococcus multilocularis proteasome subunit alpha type 2 0.0118 0.3484 0.3484
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0018 0.0053 0.0077
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0108 0.3164 0.3164
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0086 0.2377 0.3486
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0108 0.3164 0.4641
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0025 0.0273 0.0273
Leishmania major proteasome alpha 1 subunit, putative 0.0113 0.3321 0.4871
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0124 0.3702 0.5429
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0034 0.058 0.085
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0113 0.3321 0.4871
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0017 0.0017 0.0025
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0025 0.0273 0.0401
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0085 0.2363 0.3466
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0028 0.0395 0.058
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0132 0.3981 0.5839
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0017 0.0017 0.0025
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0017 0.0017 0.0017
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0113 0.3321 0.4871
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0028 0.0395 0.058
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0026 0.0319 0.0468
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0025 0.0273 0.0401
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0115 0.3384 0.4963
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0164 0.5071 0.5071
Entamoeba histolytica proteasome regulatory subunit, putative 0.0034 0.058 0.085
Toxoplasma gondii hypothetical protein 0.0023 0.0208 0.0304
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0017 0.0017 0.0017
Loa Loa (eye worm) proteasome Regulatory Particle 0.0028 0.0395 0.058
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0156 0.4797 0.4797
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0018 0.0053 0.0077
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0075 0.2013 0.2013
Toxoplasma gondii proteasome subunit alpha type, putative 0.007 0.184 0.2699
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0123 0.3674 0.5387
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0123 0.3674 0.5387
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0703 0.0703
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0156 0.4797 0.7035
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0026 0.0314 0.0314
Giardia lamblia Proteasome subunit beta type 1 0.0132 0.3981 0.5839
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0053 0.0053
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0018 0.0053 0.0077
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.3115 0.4568
Toxoplasma gondii proteasome subunit beta type, putative 0.0214 0.6819 1
Plasmodium vivax proteasome subunit beta type-7, putative 0.0104 0.3001 0.4402
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0123 0.3674 0.5387
Brugia malayi PCI domain containing protein 0.0026 0.0314 0.0314
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0028 0.0399 0.0585
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0025 0.03 0.044
Brugia malayi Proteasome subunit alpha type 7-1 0.0156 0.4797 0.4797
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0034 0.058 0.085
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0214 0.6819 1
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0034 0.058 0.058
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0113 0.3336 0.4892
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0118 0.3484 0.5109
Toxoplasma gondii PCI domain-containing protein 0.0026 0.0314 0.0461
Giardia lamblia 26S protease regulatory subunit 6A 0.0018 0.0053 0.0077
Plasmodium vivax proteasome subunit beta type-1, putative 0.0132 0.3981 0.5839
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0113 0.3321 0.4871
Toxoplasma gondii PCI domain-containing protein 0.0031 0.0498 0.0731
Loa Loa (eye worm) PAS-3 protein 0.0099 0.2854 0.4185
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0124 0.3702 0.5429
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0214 0.6819 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0214 0.6819 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0214 0.6819 0.6819
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0113 0.3321 0.3321
Leishmania major proteasome beta 2 subunit, putative 0.0108 0.3164 0.4641
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0156 0.4797 0.7035
Brugia malayi proteasome subunit beta type 3 0.0108 0.3164 0.3164
Giardia lamblia Hypothetical protein 0.0031 0.0498 0.0731
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0319 0.0468
Loa Loa (eye worm) hypothetical protein 0.0025 0.0273 0.0401
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0107 0.3115 0.4568
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0018 0.0053 0.0053
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.3981 0.5839
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0037 0.0703 0.0703
Brugia malayi 26S proteasome subunit P45 family protein 0.0017 0.0017 0.0017
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0113 0.3336 0.3336
Toxoplasma gondii peptidase, T1 family protein 0.0115 0.3384 0.4963
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0026 0.0319 0.0468
Leishmania major hypothetical protein, conserved 0.0085 0.2363 0.3466
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0017 0.0017 0.0025
Brugia malayi proteasome subunit alpha type 1 0.0113 0.3321 0.3321
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0037 0.0703 0.1031
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0037 0.0703 0.0703
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0108 0.3164 0.4641
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0319 0.0468
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0108 0.3164 0.4641
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0164 0.5071 0.7437
Echinococcus multilocularis geminin 0.0205 0.6488 0.6488
Trypanosoma cruzi 20S proteasome subunit 0.0108 0.3164 0.4641
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0018 0.0034 0.005
Giardia lamblia 20S proteasome alpha subunit 2 0.0118 0.3484 0.5109
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0104 0.3008 0.8888
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0028 0.0399 0.0585
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0026 0.0314 0.0461
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0026 0.0314 0.0461
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0113 0.3321 0.4871
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0031 0.0498 0.0731
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0086 0.2377 0.2377
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0273 0.0401
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0123 0.3674 0.5387
Plasmodium vivax proteasome subunit beta type-4, putative 0.0107 0.3115 0.4568
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0132 0.3981 0.3981
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0156 0.4797 0.4797
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0104 0.3001 0.4402
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0115 0.3384 0.4963
Entamoeba histolytica proteasome regulatory subunit, putative 0.0018 0.0051 0.0074
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0028 0.0399 0.0585
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0115 0.3384 0.4963
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0025 0.03 0.044
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0115 0.3384 0.4963
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0031 0.0498 0.0498
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0104 0.3001 0.4402
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0026 0.0319 0.0468
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0319 0.0468
Giardia lamblia 20S proteasome alpha subunit 4 0.0156 0.4797 0.7035
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0104 0.3001 0.4402
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0395 0.058
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0113 0.3336 0.4892
Giardia lamblia Proteasome subunit beta type 3 0.0108 0.3164 0.4641
Leishmania major proteasome alpha 7 subunit, putative 0.0156 0.4797 0.7035
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0028 0.0395 0.058
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0037 0.0703 0.1031
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0028 0.0395 0.058
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0026 0.0319 0.0319
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0104 0.3001 0.4402
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.0025 0.03 0.044
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0108 0.3164 0.4641
Echinococcus granulosus Proteasome subunit alpha beta 0.0115 0.3384 0.3384
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0113 0.3336 0.4892
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0114 0.3349 0.4911
Brugia malayi Proteasome subunit alpha type 1 0.0099 0.2839 0.2839
Loa Loa (eye worm) PCI domain-containing protein 0.0026 0.0314 0.0461
Toxoplasma gondii proteasome subunit 0.0114 0.3349 0.4911
Schistosoma mansoni multiubiquitin binding protein S5a 0.0018 0.0051 0.0051
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0017 0.0017 0.0025
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0107 0.3115 0.4568
Trypanosoma brucei proteasome beta 6 subunit 0.0132 0.3981 0.5839
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0395 0.058
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0028 0.0395 0.058
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0124 0.3702 0.5429
Echinococcus granulosus subfamily T1A non peptidase ue 0.0123 0.3674 0.3674
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0118 0.3484 0.5109
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0104 0.3001 0.4402
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0033 0.0562 0.0562
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0498 0.0731
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0028 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0025
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0026 0.0319 0.0468
Schistosoma mansoni hypothetical protein 0.0205 0.6488 0.6488
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0017 0.0017 0.0025
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0115 0.3384 0.3384
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0033 0.0562 0.0824
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0118 0.3484 0.5109
Brugia malayi proteasome subunit beta type 2 0.0108 0.3164 0.3164
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0214 0.6819 1
Echinococcus granulosus proteasome subunit beta type 6 0.0114 0.3349 0.3349
Brugia malayi Ubiquitin interaction motif family protein 0.0018 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0025
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0156 0.4797 0.4797
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0124 0.3702 0.5429
Brugia malayi PCI domain containing protein 0.0028 0.0399 0.0399
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0031 0.0498 0.0498
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0018 0.0053 0.0077
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0031 0.0498 0.0498
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0028 0.0395 0.0395
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0025 0.03 0.044
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0026 0.0319 0.0468
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0104 0.3001 0.4402
Schistosoma mansoni hypothetical protein 0.0205 0.6488 0.6488
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0273 0.0401
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0037 0.0703 0.1031
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0113 0.3321 0.3321
Schistosoma mansoni hypothetical protein 0.0075 0.2013 0.2013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0208 0.0304
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0104 0.3001 0.4402
Schistosoma mansoni proteasome regulatory subunit-related 0.0028 0.0399 0.0399
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0025 0.0273 0.0401
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0107 0.3115 0.4568
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0031 0.0498 0.0731
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0156 0.4797 0.7035
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0019 0.0089 0.013
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0132 0.3981 0.5839
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0026 0.0319 0.0468
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0108 0.3164 0.4641
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0114 0.3349 0.4911
Toxoplasma gondii proteasome beta subunit 0.0108 0.3164 0.4641
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0104 0.3001 0.4402
Brugia malayi Proteasome A-type and B-type family protein 0.0214 0.6819 0.6819
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0026 0.0319 0.0319
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0031 0.0498 0.0731
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0026 0.0319 0.0319
Echinococcus granulosus proteasome subunit alpha type 6 0.0124 0.3702 0.3702
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0017 0.0017 0.0025
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0026 0.0319 0.0468
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0017 0.0017 0.0025
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.0025 0.03 0.044
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0026 0.0319 0.0468
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0051 0.0074
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0018 0.0051 0.0051
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0132 0.3981 0.5839
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0107 0.3115 0.3115
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0306 1 1
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0123 0.3674 0.5387
Echinococcus granulosus proteasome subunit beta t family 0.0108 0.3164 0.3164
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0053 0.0077
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0115 0.3384 0.4963
Leishmania major proteasome alpha 1 subunit, putative 0.0124 0.3702 0.5429
Entamoeba histolytica hypothetical protein 0.0033 0.0562 0.0824
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0017 0.0017 0.0017
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0132 0.3981 0.5839
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0132 0.3981 0.3981
Loa Loa (eye worm) proteasome subunit beta type 3 0.0108 0.3164 0.4641
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0018 0.0051 0.0074
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0115 0.3384 0.4963
Plasmodium falciparum proteasome subunit beta type-4 0.0107 0.3115 0.4568
Echinococcus granulosus proteasome subunit alpha type 2 0.0118 0.3484 0.3484
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0026 0.0319 0.0319
Echinococcus multilocularis proteasome subunit beta type 6 0.0114 0.3349 0.3349
Loa Loa (eye worm) PCI domain-containing protein 0.0028 0.0399 0.0585
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.3115 0.4568
Brugia malayi proteasome subunit alpha type 2 0.0118 0.3484 0.3484
Giardia lamblia 20S proteasome alpha subunit 7 0.0115 0.3384 0.4963
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0086 0.2377 0.3486
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0018 0.0053 0.0077
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0018 0.0051 0.0074
Loa Loa (eye worm) RPN-3 protein 0.0034 0.058 0.085
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0123 0.3674 0.3674
Entamoeba histolytica proteasome regulatory subunit, putative 0.0026 0.0314 0.0461
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0123 0.3674 0.5387
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0026 0.0319 0.0319
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0214 0.6819 1
Toxoplasma gondii proteasome subunit alpha type, putative 0.0113 0.3336 0.4892
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0113 0.3321 0.3321
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0028 0.0399 0.0585
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0108 0.3164 0.3164
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0028 0.0371 0.0543
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0017 0.0017 0.0025
Giardia lamblia 26S protease regulatory subunit 6B 0.0017 0.0017 0.0025
Plasmodium vivax proteasome subunit beta type-3, putative 0.0108 0.3164 0.4641
Schistosoma mansoni 26S proteasome subunit S9 0.0031 0.0498 0.0498
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0018 0.0053 0.0077
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0018 0.0053 0.0077
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0033 0.0562 0.0824
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0114 0.3349 0.4911
Toxoplasma gondii PCI domain-containing protein 0.0034 0.058 0.085
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0108 0.3164 0.3164
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0123 0.3674 0.5387
Giardia lamblia 20S proteasome alpha subunit 1 0.0124 0.3702 0.5429
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0156 0.4797 0.7035
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0124 0.3702 0.5429
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.3115 0.4568
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0026 0.0319 0.0319
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0026 0.0314 0.0461
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0086 0.2377 0.3486
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0104 0.3001 0.4402
Loa Loa (eye worm) hypothetical protein 0.0025 0.0273 0.0401
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0019 0.0089 0.013
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0037 0.0703 0.1031
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0037 0.0703 0.0703
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0214 0.6819 1
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0156 0.4797 0.7035

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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