Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.1397 | 0.1397 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.5 |
Brugia malayi | RNA binding protein | 0.1257 | 0.6039 | 0.6039 |
Loa Loa (eye worm) | glutamate receptor | 0.0268 | 0.1088 | 0.1088 |
Brugia malayi | TAR-binding protein | 0.1257 | 0.6039 | 0.6039 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0365 | 0.1575 | 0.2608 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.013 | 0.0401 | 0.0401 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0379 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.2049 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0811 | 0.3806 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0648 | 0.2992 | 0.4955 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0811 | 0.3806 | 0.6302 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0268 | 0.1088 | 0.1088 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1237 | 0.5938 | 0.5938 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0229 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0379 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0069 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0069 | 0.0092 | 0.0092 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0224 | 0.087 | 0.1288 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0811 | 0.3806 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.1401 | 0.6756 | 0.6756 |
Schistosoma mansoni | tar DNA-binding protein | 0.1257 | 0.6039 | 0.8938 |
Schistosoma mansoni | tar DNA-binding protein | 0.1257 | 0.6039 | 0.8938 |
Loa Loa (eye worm) | hypothetical protein | 0.1401 | 0.6756 | 0.6756 |
Schistosoma mansoni | tar DNA-binding protein | 0.1257 | 0.6039 | 0.8938 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0573 | 0.2617 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0096 | 0.0229 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.1237 | 0.5938 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0229 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0379 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0096 | 0.0229 | 0.0379 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0224 | 0.087 | 0.1441 |
Brugia malayi | Isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0229 |
Schistosoma mansoni | hypothetical protein | 0.0648 | 0.2992 | 0.4429 |
Schistosoma mansoni | tar DNA-binding protein | 0.1257 | 0.6039 | 0.8938 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0648 | 0.2992 | 0.4955 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0365 | 0.1575 | 0.2608 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0429 | 0.1894 | 0.4655 |
Brugia malayi | N-terminal motif family protein | 0.0573 | 0.2617 | 0.2617 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0379 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.1237 | 0.5938 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0648 | 0.2992 | 0.4429 |
Echinococcus multilocularis | tar DNA binding protein | 0.1257 | 0.6039 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0648 | 0.2992 | 0.4429 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0224 | 0.087 | 0.1441 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0243 | 0.0962 | 0.0962 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.9833 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0229 |
Brugia malayi | RNA recognition motif domain containing protein | 0.1257 | 0.6039 | 0.6039 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.033 | 0.1397 | 0.2314 |
Brugia malayi | isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0229 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0426 | 0.1881 | 0.2893 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.1237 | 0.5938 | 0.8789 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0811 | 0.3806 | 0.6302 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.013 | 0.0401 | 0.0594 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0069 | 0.0092 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0648 | 0.2992 | 0.4429 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0648 | 0.2992 | 0.2992 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.1237 | 0.5938 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.1257 | 0.6039 | 0.6039 |
Brugia malayi | Probable ClpP-like protease | 0.1237 | 0.5938 | 0.5938 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0648 | 0.2992 | 0.4955 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.9833 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.1401 | 0.6756 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.033 | 0.1397 | 0.2314 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0648 | 0.2992 | 0.2992 |
Echinococcus multilocularis | GPCR, family 2 | 0.0648 | 0.2992 | 0.4955 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0811 | 0.3806 | 0.4744 |
Loa Loa (eye worm) | hypothetical protein | 0.0573 | 0.2617 | 0.2617 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.2049 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.2992 | 0.2992 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0648 | 0.2992 | 0.4955 |
Toxoplasma gondii | hypothetical protein | 0.0426 | 0.1881 | 0.2893 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0304 | 0.1271 | 0.1882 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0096 | 0.0229 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.1257 | 0.6039 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.1257 | 0.6039 | 0.6039 |
Loa Loa (eye worm) | glutamate receptor | 0.0105 | 0.0275 | 0.0275 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.1257 | 0.6039 | 0.6039 |
Schistosoma mansoni | tar DNA-binding protein | 0.1257 | 0.6039 | 0.8938 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0096 | 0.0229 | 0.0379 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.1237 | 0.5938 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2049 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0096 | 0.0229 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0648 | 0.2992 | 0.2992 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0426 | 0.1881 | 0.2893 |
Echinococcus granulosus | GPCR family 2 | 0.0648 | 0.2992 | 0.4955 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.1237 | 0.5938 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | 0 nM kg-1 | Dose of the compound inhibiting the response of a dose of oxytocin to half of the response in rat;NA means no activity. | ChEMBL. | 10522694 |
Ki (functional) | = 1000 nM | In vivo antagonistic activity against cloned human oxytocin receptor overexpressed in a stable HEK293 cell line | ChEMBL. | 10522694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.